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Aliases for TMEM263 Gene

Aliases for TMEM263 Gene

  • Transmembrane Protein 263 2 3 5
  • C12orf23 3 4
  • UPF0444 Transmembrane Protein C12orf23 3
  • Chromosome 12 Open Reading Frame 23 2

External Ids for TMEM263 Gene

Previous HGNC Symbols for TMEM263 Gene

  • C12orf23

Previous GeneCards Identifiers for TMEM263 Gene

  • GC12P107350

Summaries for TMEM263 Gene

GeneCards Summary for TMEM263 Gene

TMEM263 (Transmembrane Protein 263) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM263 Gene

Genomics for TMEM263 Gene

Regulatory Elements for TMEM263 Gene

Enhancers for TMEM263 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G106903 0.9 Ensembl ENCODE 23.1 -49.8 -49805 0.8 PKNOX1 TFAP4 MAZ SP3 SP2 CEBPB JUND IKZF1 PATZ1 KLF9 TMEM263 ENSG00000260329 POLR3B RIC8B EEF1B2P4 RPL30P12
GH12G106954 1.1 ENCODE 13.8 +2.7 2692 4.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000260329 TMEM263 MTERF2 GC12M106953 GC12P106984
GH12G106299 1.8 FANTOM5 ENCODE dbSUPER 4.5 -651.1 -651058 5.7 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 ENSG00000260329 POLR3B MTERF2 TCP11L2 TMEM263 CKAP4
GH12G106672 1.4 ENCODE 5.6 -280.6 -280611 1.3 SPI1 EZH2 RFX4 POLR3B ENSG00000260329 TMEM263 PIR51055
GH12G106891 0.6 ENCODE 12.6 -61.0 -60976 1.1 ZFHX2 GLIS1 ZNF629 ZMYM3 KDM1A ZNF623 ATF2 EGR2 TMEM263 POLR3B GC12P106896 LOC105369961
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM263 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM263 Gene

Chromosome:
12
Start:
106,953,415 bp from pter
End:
106,978,778 bp from pter
Size:
25,364 bases
Orientation:
Plus strand

Genomic View for TMEM263 Gene

Genes around TMEM263 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM263 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM263 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM263 Gene

Proteins for TMEM263 Gene

  • Protein details for TMEM263 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUH6-TM263_HUMAN
    Recommended name:
    Transmembrane protein 263
    Protein Accession:
    Q8WUH6
    Secondary Accessions:
    • B3KMN9

    Protein attributes for TMEM263 Gene

    Size:
    116 amino acids
    Molecular mass:
    11748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM263 Gene

Post-translational modifications for TMEM263 Gene

  • Glycosylation at posLast=22
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM263 Gene

Domains & Families for TMEM263 Gene

Protein Domains for TMEM263 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM263 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUH6

UniProtKB/Swiss-Prot:

TM263_HUMAN :
  • Belongs to the TMEM263 family.
Family:
  • Belongs to the TMEM263 family.
genes like me logo Genes that share domains with TMEM263: view

No data available for Gene Families for TMEM263 Gene

Function for TMEM263 Gene

genes like me logo Genes that share phenotypes with TMEM263: view

Animal Model Products

CRISPR Products

miRNA for TMEM263 Gene

miRTarBase miRNAs that target TMEM263

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM263 Gene

Localization for TMEM263 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM263 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM263 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TMEM263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM263: view

Pathways & Interactions for TMEM263 Gene

SuperPathways for TMEM263 Gene

No Data Available

Interacting Proteins for TMEM263 Gene

Gene Ontology (GO) - Biological Process for TMEM263 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM263 Gene

Transcripts for TMEM263 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM263 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -

Relevant External Links for TMEM263 Gene

GeneLoc Exon Structure for
TMEM263
ECgene alternative splicing isoforms for
TMEM263

Expression for TMEM263 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM263 Gene

Protein differential expression in normal tissues from HIPED for TMEM263 Gene

This gene is overexpressed in Heart (12.5) and Fetal testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM263 Gene



Protein tissue co-expression partners for TMEM263 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM263 Gene:

TMEM263

Evidence on tissue expression from TISSUES for TMEM263 Gene

  • Skin(4.3)
  • Nervous system(3.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with TMEM263: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM263 Gene

Orthologs for TMEM263 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM263 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12orf23 35
  • 100 (a)
OneToOne
C12H12orf23 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia C12orf23 35
  • 97 (a)
OneToOne
C10H12orf23 34
  • 96.81 (n)
cow
(Bos Taurus)
Mammalia C5H12orf23 35 34
  • 96.55 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563325 34
  • 95.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C12orf23 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C12orf23 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI597468 35 34
  • 94.78 (n)
OneToOne
Tmem263 16
chicken
(Gallus gallus)
Aves C1H12ORF23 35 34
  • 84.48 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf23 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75626 34 34
  • 73.68 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:64098 34
  • 73.28 (n)
C18H12orf23 35
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5400 34
Species where no ortholog for TMEM263 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM263 Gene

ENSEMBL:
Gene Tree for TMEM263 (if available)
TreeFam:
Gene Tree for TMEM263 (if available)

Paralogs for TMEM263 Gene

No data available for Paralogs for TMEM263 Gene

Variants for TMEM263 Gene

Sequence variations from dbSNP and Humsavar for TMEM263 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000017557 -- 106,965,092(+) TCACT(C/G)TTTGT intron-variant
rs1000205854 -- 106,965,558(+) CTGAG(A/G)TCGCA intron-variant
rs1000338077 -- 106,968,307(+) ACTAT(C/T)GGAGA intron-variant
rs1000391548 -- 106,968,756(+) TCTTC(C/T)TTAAA intron-variant
rs1000399155 -- 106,961,255(+) TTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM263 Gene

Variant ID Type Subtype PubMed ID
dgv99n21 CNV loss 19592680
esv3411246 CNV insertion 20981092
nsv437155 CNV loss 16327808
nsv516865 CNV loss 19592680
nsv9005 CNV gain 18304495

Variation tolerance for TMEM263 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM263 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM263

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM263 Gene

Disorders for TMEM263 Gene

Relevant External Links for TMEM263

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM263

No disorders were found for TMEM263 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM263 Gene

Publications for TMEM263 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. (PMID: 26990986) Nguyen T.V. … Deshaies R.J. (Mol. Cell 2016) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for TMEM263 Gene

Sources for TMEM263 Gene

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