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Aliases for TMEM263 Gene

Aliases for TMEM263 Gene

  • Transmembrane Protein 263 2 3 5
  • C12orf23 3 4
  • UPF0444 Transmembrane Protein C12orf23 3
  • Chromosome 12 Open Reading Frame 23 2

External Ids for TMEM263 Gene

Previous HGNC Symbols for TMEM263 Gene

  • C12orf23

Previous GeneCards Identifiers for TMEM263 Gene

  • GC12P107350

Summaries for TMEM263 Gene

GeneCards Summary for TMEM263 Gene

TMEM263 (Transmembrane Protein 263) is a Protein Coding gene.

Additional gene information for TMEM263 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM263 Gene

Genomics for TMEM263 Gene

GeneHancer (GH) Regulatory Elements for TMEM263 Gene

Promoters and enhancers for TMEM263 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I106954 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 563.8 +2.7 2692 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 ENSG00000260329 TMEM263 GC12M106953 MTERF2 GC12P106984
GH12I106953 Enhancer 0.8 Ensembl ENCODE 550.8 +0.4 385 0.4 ZIC2 ZNF121 HIC1 PRDM6 JUND ADNP FOS WT1 ENSG00000260329 TMEM263 GC12M106953
GH12I106903 Enhancer 0.8 Ensembl ENCODE 23.1 -49.8 -49805 0.8 TFAP4 PKNOX1 MAZ SP3 SP2 SIN3A PATZ1 IKZF1 KLF9 ZBTB17 EEF1B2P4 TMEM263 ENSG00000260329 POLR3B RIC8B RPL30P12
GH12I106299 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.5 -651.1 -651058 5.7 PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 IRF4 YY1 TCP11L2 CKAP4 ENSG00000260329 POLR3B MTERF2 TMEM263
GH12I106919 Enhancer 0.6 ENCODE 12.5 -33.5 -33467 0.1 CTCF TRIM22 REST RAD21 RFX5 ZNF213 SMC3 ZNF143 TMEM263 MTERF2 RPL30P12 GC12P106941
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM263 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM263 Gene

Genomic Locations for TMEM263 Gene
chr12:106,953,415-106,978,778
(GRCh38/hg38)
Size:
25,364 bases
Orientation:
Plus strand
chr12:107,349,544-107,367,813
(GRCh37/hg19)

Genomic View for TMEM263 Gene

Genes around TMEM263 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM263 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM263 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM263 Gene

Proteins for TMEM263 Gene

  • Protein details for TMEM263 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUH6-TM263_HUMAN
    Recommended name:
    Transmembrane protein 263
    Protein Accession:
    Q8WUH6
    Secondary Accessions:
    • B3KMN9

    Protein attributes for TMEM263 Gene

    Size:
    116 amino acids
    Molecular mass:
    11748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM263 Gene

Post-translational modifications for TMEM263 Gene

No data available for DME Specific Peptides for TMEM263 Gene

Domains & Families for TMEM263 Gene

Gene Families for TMEM263 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMEM263 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM263 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUH6

UniProtKB/Swiss-Prot:

TM263_HUMAN :
  • Belongs to the TMEM263 family.
Family:
  • Belongs to the TMEM263 family.
genes like me logo Genes that share domains with TMEM263: view

Function for TMEM263 Gene

Phenotypes From GWAS Catalog for TMEM263 Gene

genes like me logo Genes that share phenotypes with TMEM263: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM263 Gene

Localization for TMEM263 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM263 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM263 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TMEM263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM263: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM263 Gene

Pathways & Interactions for TMEM263 Gene

SuperPathways for TMEM263 Gene

No Data Available

Interacting Proteins for TMEM263 Gene

Gene Ontology (GO) - Biological Process for TMEM263 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM263 Gene

Drugs & Compounds for TMEM263 Gene

No Compound Related Data Available

Transcripts for TMEM263 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM263 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -

Relevant External Links for TMEM263 Gene

GeneLoc Exon Structure for
TMEM263
ECgene alternative splicing isoforms for
TMEM263

Expression for TMEM263 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM263 Gene

Protein differential expression in normal tissues from HIPED for TMEM263 Gene

This gene is overexpressed in Heart (12.5) and Fetal testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM263 Gene



Protein tissue co-expression partners for TMEM263 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM263 Gene:

TMEM263

Evidence on tissue expression from TISSUES for TMEM263 Gene

  • Skin(4.3)
  • Nervous system(3.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with TMEM263: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM263 Gene

Orthologs for TMEM263 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM263 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf23 33
  • 100 (n)
C12orf23 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12orf23 34
  • 97 (a)
OneToOne
C10H12orf23 33
  • 96.81 (n)
cow
(Bos Taurus)
Mammalia C5H12orf23 33 34
  • 96.55 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563325 33
  • 95.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C12orf23 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C12orf23 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI597468 33 34
  • 94.78 (n)
Tmem263 16
chicken
(Gallus gallus)
Aves C1H12ORF23 33 34
  • 84.48 (n)
lizard
(Anolis carolinensis)
Reptilia C12orf23 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75626 33 33
  • 73.68 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:64098 33
  • 73.28 (n)
C18H12orf23 34
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5400 33
Species where no ortholog for TMEM263 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM263 Gene

ENSEMBL:
Gene Tree for TMEM263 (if available)
TreeFam:
Gene Tree for TMEM263 (if available)

Paralogs for TMEM263 Gene

No data available for Paralogs for TMEM263 Gene

Variants for TMEM263 Gene

Sequence variations from dbSNP and Humsavar for TMEM263 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000017557 -- 106,965,092(+) C/G intron_variant
rs1000205854 -- 106,965,558(+) A/G intron_variant
rs1000338077 -- 106,968,307(+) C/T intron_variant
rs1000391548 -- 106,968,756(+) T/C intron_variant
rs1000399155 -- 106,961,255(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM263 Gene

Variant ID Type Subtype PubMed ID
dgv99n21 CNV loss 19592680
esv3411246 CNV insertion 20981092
nsv437155 CNV loss 16327808
nsv516865 CNV loss 19592680
nsv9005 CNV gain 18304495

Variation tolerance for TMEM263 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM263 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM263

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM263 Gene

Disorders for TMEM263 Gene

Additional Disease Information for TMEM263

No disorders were found for TMEM263 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM263 Gene

Publications for TMEM263 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. (PMID: 26990986) Nguyen TV … Deshaies RJ (Molecular cell 2016) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for TMEM263 Gene

Sources for TMEM263 Gene

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