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Aliases for TMEM263 Gene

Aliases for TMEM263 Gene

  • Transmembrane Protein 263 2 3 5
  • C12orf23 3 4
  • UPF0444 Transmembrane Protein C12orf23 3
  • Chromosome 12 Open Reading Frame 23 2

External Ids for TMEM263 Gene

Previous HGNC Symbols for TMEM263 Gene

  • C12orf23

Previous GeneCards Identifiers for TMEM263 Gene

  • GC12P107350

Summaries for TMEM263 Gene

GeneCards Summary for TMEM263 Gene

TMEM263 (Transmembrane Protein 263) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM263 Gene

Genomics for TMEM263 Gene

Genomic Location for TMEM263 Gene

Chromosome:
12
Start:
106,953,415 bp from pter
End:
106,978,778 bp from pter
Size:
25,364 bases
Orientation:
Plus strand

Genomic View for TMEM263 Gene

Genes around TMEM263 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM263 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM263 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM263 Gene

No data available for Regulatory Elements for TMEM263 Gene

Proteins for TMEM263 Gene

  • Protein details for TMEM263 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUH6-TM263_HUMAN
    Recommended name:
    Transmembrane protein 263
    Protein Accession:
    Q8WUH6
    Secondary Accessions:
    • B3KMN9

    Protein attributes for TMEM263 Gene

    Size:
    116 amino acids
    Molecular mass:
    11748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM263 Gene

Proteomics data for TMEM263 Gene at MOPED

Post-translational modifications for TMEM263 Gene

  • Glycosylation at Asn 2
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM263 Gene

Domains & Families for TMEM263 Gene

Protein Domains for TMEM263 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM263 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUH6

UniProtKB/Swiss-Prot:

TM263_HUMAN :
  • Belongs to the TMEM263 family.
Family:
  • Belongs to the TMEM263 family.
genes like me logo Genes that share domains with TMEM263: view

No data available for Gene Families for TMEM263 Gene

Function for TMEM263 Gene

genes like me logo Genes that share phenotypes with TMEM263: view

Animal Model Products

CRISPR Products

miRNA for TMEM263 Gene

miRTarBase miRNAs that target TMEM263

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM263 Gene

Localization for TMEM263 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM263 Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TMEM263 Gene

Pathways & Interactions for TMEM263 Gene

SuperPathways for TMEM263 Gene

No Data Available

Interacting Proteins for TMEM263 Gene

Gene Ontology (GO) - Biological Process for TMEM263 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM263 Gene

Drugs & Compounds for TMEM263 Gene

No Compound Related Data Available

Transcripts for TMEM263 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM263 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - -

Relevant External Links for TMEM263 Gene

GeneLoc Exon Structure for
TMEM263
ECgene alternative splicing isoforms for
TMEM263

Expression for TMEM263 Gene

mRNA expression in normal human tissues for TMEM263 Gene

Protein differential expression in normal tissues from HIPED for TMEM263 Gene

This gene is overexpressed in Heart (12.5) and Fetal testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM263 Gene



genes like me logo Genes that share expression patterns with TMEM263: view

Protein tissue co-expression partners for TMEM263 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM263 Gene

Orthologs for TMEM263 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM263 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C5H12orf23 35
  • 96.55 (n)
  • 99.14 (a)
C5H12orf23 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10H12orf23 35
  • 96.81 (n)
  • 97.39 (a)
C12orf23 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI597468 35
  • 94.78 (n)
  • 97.39 (a)
Tmem263 16
AI597468 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf23 35
  • 100 (n)
  • 100 (a)
C12orf23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563325 35
  • 95.36 (n)
  • 97.39 (a)
oppossum
(Monodelphis domestica)
Mammalia C12orf23 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C12orf23 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF23 35
  • 84.48 (n)
  • 89.66 (a)
C1H12ORF23 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf23 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75626 35
MGC75626 35
  • 73.68 (n)
  • 77.19 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:64098 35
  • 73.28 (n)
  • 75 (a)
C18H12orf23 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5400 35
Species with no ortholog for TMEM263:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM263 Gene

ENSEMBL:
Gene Tree for TMEM263 (if available)
TreeFam:
Gene Tree for TMEM263 (if available)

Paralogs for TMEM263 Gene

No data available for Paralogs for TMEM263 Gene

Variants for TMEM263 Gene

Sequence variations from dbSNP and Humsavar for TMEM263 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs9720 -- 106,954,791(+) TCAAA(A/G)AAAAG nc-transcript-variant, upstream-variant-2KB
rs1053050 -- 106,973,446(+) CTTTG(C/T)TTGTC utr-variant-3-prime
rs1053051 -- 106,973,447(+) TTTGT(C/T)TGTCT utr-variant-3-prime
rs1053198 -- 106,973,970(+) AAAGC(A/C)CTATG utr-variant-3-prime
rs1055332 -- 106,954,847(-) ACGGG(A/T)GGAGA nc-transcript-variant, upstream-variant-2KB

Variation tolerance for TMEM263 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM263 Gene

HapMap Linkage Disequilibrium report
TMEM263

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM263 Gene

Disorders for TMEM263 Gene

Relevant External Links for TMEM263

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM263

No disorders were found for TMEM263 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM263 Gene

Publications for TMEM263 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K. … Rivadeneira F. (Nat. Genet. 2012) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM263 Gene

Sources for TMEM263 Gene

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