Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM261 Gene

Aliases for TMEM261 Gene

  • Transmembrane Protein 261 2 3 5
  • C9orf123 3 4
  • Chromosome 9 Open Reading Frame 123 2
  • Transmembrane Protein C9orf123 3

External Ids for TMEM261 Gene

Previous HGNC Symbols for TMEM261 Gene

  • C9orf123

Summaries for TMEM261 Gene

GeneCards Summary for TMEM261 Gene

TMEM261 (Transmembrane Protein 261) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM261 Gene

Genomics for TMEM261 Gene

Genomic Location for TMEM261 Gene

Chromosome:
9
Start:
7,796,490 bp from pter
End:
7,888,380 bp from pter
Size:
91,891 bases
Orientation:
Minus strand

Genomic View for TMEM261 Gene

Genes around TMEM261 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM261 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM261 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM261 Gene

No data available for Regulatory Elements for TMEM261 Gene

Proteins for TMEM261 Gene

  • Protein details for TMEM261 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GE9-TM261_HUMAN
    Recommended name:
    Transmembrane protein 261
    Protein Accession:
    Q96GE9
    Secondary Accessions:
    • A8K9B7
    • Q5T6Y9
    • Q9NT74

    Protein attributes for TMEM261 Gene

    Size:
    116 amino acids
    Molecular mass:
    12257 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM261 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM261 Gene

Proteomics data for TMEM261 Gene at MOPED

Post-translational modifications for TMEM261 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM261 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM261 Gene

Domains & Families for TMEM261 Gene

Protein Domains for TMEM261 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM261 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM261: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM261 Gene

Function for TMEM261 Gene

genes like me logo Genes that share phenotypes with TMEM261: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM261 Gene

Localization for TMEM261 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM261 Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TMEM261 Gene

Pathways & Interactions for TMEM261 Gene

SuperPathways for TMEM261 Gene

No Data Available

Interacting Proteins for TMEM261 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350961%0d%0a9606.ENSP00000313199%0d%0a
Selected Interacting proteins: Q96GE9-TM261_HUMAN ENSP00000350961 for TMEM261 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TMEM261 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM261 Gene

Drugs & Compounds for TMEM261 Gene

No Compound Related Data Available

Transcripts for TMEM261 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM261 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - - - -

Relevant External Links for TMEM261 Gene

GeneLoc Exon Structure for
TMEM261
ECgene alternative splicing isoforms for
TMEM261

Expression for TMEM261 Gene

mRNA expression in normal human tissues for TMEM261 Gene

Protein differential expression in normal tissues from HIPED for TMEM261 Gene

This gene is overexpressed in Fetal heart (48.6), Placenta (7.6), Islet of Langerhans (6.6), and Fetal Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM261 Gene



genes like me logo Genes that share expression patterns with TMEM261: view

Protein tissue co-expression partners for TMEM261 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM261 Gene

Orthologs for TMEM261 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM261 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C8H9orf123 35
  • 74.36 (n)
  • 64.84 (a)
MGC127919 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H9orf123 35
  • 73.87 (n)
  • 65.77 (a)
TMEM261 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem261 35
  • 71.49 (n)
  • 65.79 (a)
Tmem261 16
Tmem261 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100611439 35
  • 90.99 (n)
  • 82.88 (a)
rat
(Rattus norvegicus)
Mammalia Tmem261 35
  • 71.05 (n)
  • 60.53 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM261 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM261 36
  • 36 (a)
OneToOne
Species with no ortholog for TMEM261:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM261 Gene

ENSEMBL:
Gene Tree for TMEM261 (if available)
TreeFam:
Gene Tree for TMEM261 (if available)

Paralogs for TMEM261 Gene

Pseudogenes.org Pseudogenes for TMEM261 Gene

genes like me logo Genes that share paralogs with TMEM261: view

No data available for Paralogs for TMEM261 Gene

Variants for TMEM261 Gene

Sequence variations from dbSNP and Humsavar for TMEM261 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1127430 - 7,799,653(-) CTGCG(A/C)CCCCA reference, missense
rs1254 -- 7,798,435(+) TTCTT(C/T)TCAGT utr-variant-3-prime
rs14059 -- 7,799,606(-) CGCCT(G/T)TTGAA reference, synonymous-codon
rs1132047 -- 7,796,848(-) TAACA(C/T)ATTTT utr-variant-3-prime
rs2297554 -- 7,799,787(+) GTAAA(C/T)GACGC utr-variant-5-prime

Variation tolerance for TMEM261 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM261 Gene

HapMap Linkage Disequilibrium report
TMEM261

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM261 Gene

Disorders for TMEM261 Gene

Relevant External Links for TMEM261

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM261

No disorders were found for TMEM261 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM261 Gene

Publications for TMEM261 Gene

  1. Identification and functional analysis of 9p24 amplified genes in human breast cancer. (PMID: 21666724) Wu J. … Yang Z.Q. (Oncogene 2012) 2 3 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for TMEM261 Gene

Sources for TMEM261 Gene

Back to Top

Content