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Aliases for TMEM261 Gene

Aliases for TMEM261 Gene

  • Transmembrane Protein 261 2 3 5
  • C9orf123 3 4
  • Chromosome 9 Open Reading Frame 123 2
  • Transmembrane Protein C9orf123 3

External Ids for TMEM261 Gene

Previous HGNC Symbols for TMEM261 Gene

  • C9orf123

Summaries for TMEM261 Gene

GeneCards Summary for TMEM261 Gene

TMEM261 (Transmembrane Protein 261) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM261 Gene

Genomics for TMEM261 Gene

Regulatory Elements for TMEM261 Gene

Enhancers for TMEM261 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMEM261 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM261 Gene

7,796,490 bp from pter
7,888,380 bp from pter
91,891 bases
Minus strand

Genomic View for TMEM261 Gene

Genes around TMEM261 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM261 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM261 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM261 Gene

Proteins for TMEM261 Gene

  • Protein details for TMEM261 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 261
    Protein Accession:
    Secondary Accessions:
    • A8K9B7
    • Q5T6Y9
    • Q9NT74

    Protein attributes for TMEM261 Gene

    116 amino acids
    Molecular mass:
    12257 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM261 Gene


neXtProt entry for TMEM261 Gene

Post-translational modifications for TMEM261 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM261 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM261 Gene

Domains & Families for TMEM261 Gene

Protein Domains for TMEM261 Gene


Suggested Antigen Peptide Sequences for TMEM261 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM261: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM261 Gene

Function for TMEM261 Gene

genes like me logo Genes that share phenotypes with TMEM261: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM261 Gene

Localization for TMEM261 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM261 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM261 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM261: view

No data available for Subcellular locations from COMPARTMENTS for TMEM261 Gene

Pathways & Interactions for TMEM261 Gene

SuperPathways for TMEM261 Gene

No Data Available

Interacting Proteins for TMEM261 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350961 Q96GE9-TM261_HUMAN for TMEM261 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM261 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM261 Gene

Drugs & Compounds for TMEM261 Gene

No Compound Related Data Available

Transcripts for TMEM261 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM261 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d
SP1: -
SP2: - - -
SP3: - -
SP5: - - - -

Relevant External Links for TMEM261 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM261 Gene

mRNA expression in normal human tissues for TMEM261 Gene

Protein differential expression in normal tissues from HIPED for TMEM261 Gene

This gene is overexpressed in Fetal heart (48.6), Placenta (7.6), Islet of Langerhans (6.6), and Fetal Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM261 Gene

Protein tissue co-expression partners for TMEM261 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM261 Gene:

genes like me logo Genes that share expression patterns with TMEM261: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM261 Gene

Orthologs for TMEM261 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM261 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C8H9orf123 34
  • 74.36 (n)
  • 64.84 (a)
MGC127919 35
  • 57 (a)
(Canis familiaris)
Mammalia C11H9orf123 34
  • 73.87 (n)
  • 65.77 (a)
TMEM261 35
  • 66 (a)
(Mus musculus)
Mammalia Tmem261 34
  • 71.49 (n)
  • 65.79 (a)
Tmem261 16
Tmem261 35
  • 55 (a)
(Pan troglodytes)
Mammalia LOC100611439 34
  • 90.99 (n)
  • 82.88 (a)
(Rattus norvegicus)
Mammalia Tmem261 34
  • 71.05 (n)
  • 60.53 (a)
(Monodelphis domestica)
Mammalia TMEM261 35
  • 56 (a)
(Danio rerio)
Actinopterygii TMEM261 35
  • 36 (a)
Species where no ortholog for TMEM261 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM261 Gene

Gene Tree for TMEM261 (if available)
Gene Tree for TMEM261 (if available)

Paralogs for TMEM261 Gene Pseudogenes for TMEM261 Gene

genes like me logo Genes that share paralogs with TMEM261: view

No data available for Paralogs for TMEM261 Gene

Variants for TMEM261 Gene

Sequence variations from dbSNP and Humsavar for TMEM261 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1127430 - 7,799,653(-) CTGCG(A/C)CCCCA reference, missense
rs1254 -- 7,798,435(+) TTCTT(C/T)TCAGT utr-variant-3-prime
rs14059 -- 7,799,606(-) CGCCT(G/T)TTGAA reference, synonymous-codon
rs10121374 -- 7,801,572(+) atctt(G/T)tttct upstream-variant-2KB
rs138082452 -- 7,800,083(+) GCTCT(C/G)TTAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM261 Gene

Variant ID Type Subtype PubMed ID
nsv524896 CNV gain 19592680
nsv613266 CNV gain 21841781

Variation tolerance for TMEM261 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM261 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM261 Gene

Disorders for TMEM261 Gene

Relevant External Links for TMEM261

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM261 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM261 Gene

Publications for TMEM261 Gene

  1. Identification and functional analysis of 9p24 amplified genes in human breast cancer. (PMID: 21666724) Wu J. … Yang Z.Q. (Oncogene 2012) 2 3 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 65

Products for TMEM261 Gene

Sources for TMEM261 Gene

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