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TMEM261 Gene

protein-coding   GIFtS: 34
GCID: GC09M007797

Transmembrane Protein 261

(Previous name: chromosome 9 open reading frame 123)
(Previous symbol: C9orf123)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 2611 2
C9orf1231 2 3
Chromosome 9 Open Reading Frame 1231
Transmembrane Protein C9orf1232

External Ids:    HGNC: 305361   Entrez Gene: 908712   Ensembl: ENSG000001370387   UniProtKB: Q96GE93   
ORGUL members:         

Export aliases for TMEM261 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM261 Gene:
TMEM261 (transmembrane protein 261) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM261
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMEM261

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM261


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

TMEM261 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM261 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M007797:  view genomic region     (about GC identifiers)

Start:
7,796,490 bp from pter      End:
7,888,380 bp from pter
Size:
91,891 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM261_HUMAN, Q96GE9 (See protein sequence)
Recommended Name: Transmembrane protein 261  
Size: 116 amino acids; 12257 Da
Secondary accessions: A8K9B7 Q5T6Y9 Q9NT74
Alternative splicing: 2 isoforms:  Q96GE9-1   Q96GE9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM261: NX_Q96GE9

Explore proteomics data for TMEM261 at MOPED


See TMEM261 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_219500.1  
ENSEMBL proteins: 
 ENSP00000350961  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028036 DUF4536

Graphical View of Domain Structure for InterPro Entry Q96GE9

ProtoNet protein and cluster: Q96GE9


Find genes that share domains with TMEM261           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for TMEM261:
 Increased G1 DNA content  Increased cell size 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM261
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM261_HUMAN, Q96GE9: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM261           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM261
Interactions:

    Search GeneGlobe Interaction Network for TMEM261

1 Interacting protein for TMEM261 (Q96GE93) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MEF2CQ064133I2D: score=2 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM261 (TM261)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM261 gene: 
NM_033428.1  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000358227(uc022bdi.1 uc003zki.3 uc003zkj.3) ENST00000484082
ENST00000469050
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Selected AceView cDNA sequences (see all 272):

AI284226 AA043623 AI889603 AA147187 AA481335 CA438622 BI822915 CF130658 
CB122762 AA386074 BM852809 AI873460 N46038 N91000 BM928651 AI199865 
AA779250 AA625434 AA700697 AL137489 AA846751 AA442111 BI822295 AA043284 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM261    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d
SP1:                                      -                           
SP2:                          -     -     -                           
SP3:                                -     -                           
SP4:                                                                  
SP5:                    -     -     -     -                           


ECgene alternative splicing isoforms for TMEM261

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM261 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TMEM261 Expression
About this image

TMEM261 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM261 Protein Expression
    Custom PCR Arrays for TMEM261
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM261

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TMEM261 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 3110001D03Rik5
Tmem2611
RIKEN cDNA 3110001D03 gene5
transmembrane protein 2611
71.49(n)1
65.79(a)1
  4 (36.66 cM)5
669281  NM_025849.31  NP_080125.11 
 752773545 
zebrafish
(Danio rerio)
Actinopterygii TMEM2616
transmembrane protein 261
36(a)
1 ↔ 1
10(27633907-27634975) ENSDARG00000092787


ENSEMBL Gene Tree for TMEM261 (if available)
TreeFam Gene Tree for TMEM261 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMEM261 gene

Find genes that share paralogs with TMEM261           About GenesLikeMe


1 Pseudogenes.org Pseudogene for TMEM261
PGOHUM00000246678


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM261 (see all 197)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3750630311,2
C--7791971(+) GTCTC-/TTGTCTC 1 -- ds50010--------
rs1890019761,2
--7792036(+) AAAGGA/GATTCT 1 -- ds50010--------
rs1816544421,2
--7792055(+) TAAATC/TATAAT 1 -- ds50010--------
rs1158544631,2
C,F--7792060(+) CATAAT/CTAAGC 1 -- ds50011Minor allele frequency- C:0.05WA 118
rs1428333301,2
--7792079(+) TTACAC/TGACTG 1 -- ds50010--------
rs1842670591,2
--7792097(+) ATCCAC/TTGATT 1 -- ds50010--------
rs1900003991,2
--7792140(+) AGCTTC/TAACAA 1 -- ds50010--------
rs109765801,2
C,F,H--7792183(+) TCTGTA/GTTGAA 1 -- ds500122Minor allele frequency- G:0.30NS EA NA CSA WA 2347
rs29906001,2
C,F,O,A,H--7792275(+) AGCACT/GGGCAG 1 -- ds500121Minor allele frequency- G:0.26NA NS EA WA 2466
rs109765811,2
--7792334(+) ACAAAC/TGCAGA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TMEM261 (7796490 - 7888380 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMEM261: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TMEM261
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM261

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM261 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM261)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and functional analysis of 9p24 amplified genes in human breast cancer. (PubMed id 21666724)1, 3 Wu J....Yang Z.Q. (Oncogene 2012)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (Carcinogenesis 2012)
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  6. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (Gut 2009)
  7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  8. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1 Lehner B. and Sanderson C.M. (Genome Res. 2004)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 90871 HGNC: 30536 AceView: C9orf123 Ensembl:ENSG00000137038 euGenes: HUgn90871
ECgene: TMEM261 H-InvDB: TMEM261

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM261 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM261 gene:
Search GeneIP for patents involving TMEM261

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 SwitchGear 3'UTR luciferase reporter plasmids for TMEM261
 Browse SwitchGear Promoter luciferase reporter plasmids for TMEM261
 Search ThermoFisher Antibodies for TMEM261
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM261
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM261
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM261
 LSBio Antibodies in human, mouse, rat for TMEM261
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for TMEM261
  Search eBioscience for proteins for TMEM261
  Search eBioscience for elisas for TMEM261
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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