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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM260 Gene

protein-coding   GIFtS: 35
GCID: GC14P056956

Transmembrane Protein 260

(Previous name: chromosome 14 open reading frame 101)
(Previous symbol: C14orf101)
  Search for TMEM260
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2601 2
C14orf1011 2 3
Chromosome 14 Open Reading Frame 1011
UPF0679 Protein C14orf1012

External Ids:    HGNC: 201851   Entrez Gene: 549162   Ensembl: ENSG000000702697   UniProtKB: Q9NX783   

Export aliases for TMEM260 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM260 Gene: 
TMEM260 (transmembrane protein 260) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM260
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM260

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM260


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.2

TMEM260 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM260 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P056956:  view genomic region     (about GC identifiers)

Start:
56,955,072 bp from pter      End:
57,117,324 bp from pter
Size:
162,253 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM260_HUMAN, Q9NX78 (See protein sequence)
Recommended Name: Transmembrane protein 260  
Size: 707 amino acids; 79536 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAA91139.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BC045556; Type=Frameshift; Positions=212;
Secondary accessions: A8KAN4 B3KPF5 Q86XE1
Alternative splicing: 2 isoforms:  Q9NX78-1   Q9NX78-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM260: NX_Q9NX78

Explore proteomics data for TMEM260 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NX78

  • TMEM260 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM260 Protein Expression
    REFSEQ proteins: NP_060269.3  
    ENSEMBL proteins: 
     ENSP00000451677   ENSP00000450988   ENSP00000261556   ENSP00000452065   ENSP00000442602  
     ENSP00000452579   ENSP00000452441   ENSP00000451695   ENSP00000441934   ENSP00000438742  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM260 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR021280 DUF2723

    Graphical View of Domain Structure for InterPro Entry Q9NX78

    ProtoNet protein and cluster: Q9NX78

    UniProtKB/Swiss-Prot: TM260_HUMAN, Q9NX78
    Similarity: Belongs to the TMEM260 family


    TMEM260 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM260 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM260

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM260 (TM260)

    Search CenterWatch for drugs/clinical trials and news about TMEM260 / TM260

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM260 gene: 
    NM_017799.3  

    Unigene Cluster for TMEM260:

    Transmembrane protein 260
    Hs.497253  [show with all ESTs]
    Unigene Representative Sequence: NM_017799
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556810 ENST00000556422(uc001xcj.3 uc001xco.3) ENST00000261556(uc001xcl.1 uc001xcm.3 uc001xcn.3 uc010trf.2)
    ENST00000557657(uc001xck.3) ENST00000556975 ENST00000555497 ENST00000557626(uc010aot.1)
    ENST00000539559 ENST00000556079 ENST00000554981 ENST00000556929 ENST00000555905
    ENST00000553335 ENST00000556648 ENST00000555046 ENST00000538838 ENST00000536419

    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TMEM260 
    Primer
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    Additional mRNA sequence: 

    AK000399.1 AK023885.1 AK056291.1 AK293099.1 AK295989.1 AK309920.1 BC045556.1 BC121163.1 
    BC121164.1 BX647387.1 

    15 DOTS entries:

    DT.446082  DT.91882228  DT.101983407  DT.95371829  DT.40304197  DT.75158201  DT.100723425  DT.100817727 
    DT.120763963  DT.100645045  DT.120763971  DT.99987390  DT.120763923  DT.97836960  DT.95081851 

    24/165 AceView cDNA sequences (see all 165):

    AU141383 NM_017799 AI867450 Z38443 AA825545 AW195340 BE047426 AA812777 
    BC008949 N36294 BM727670 AA722891 BG109975 AA749144 AA262505 AI336337 
    AK023885 AA648958 AI573209 AK056291 BC023579 BM680346 AW079969 AA682799 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM260    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                -                 -                                                               
    SP2:                                -                 -           -                                                   
    SP3:                                -           -     -                                                               
    SP4:                                                  -           -                                                   
    SP5:                                                              -                                                   


    ECgene alternative splicing isoforms for TMEM260

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM260 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM260 Expression
    About this image


    See TMEM260 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM260

    SOURCE GeneReport for Unigene cluster: Hs.497253
        SABiosciences Custom PCR Arrays for TMEM260
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM260

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM260 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 6720456H20Rik1 , 5 RIKEN cDNA 6720456H20 gene1, 5 83.74(n)1
    82.93(a)1
      14 (25.06 cM)5
    2189891  NM_172600.31  NP_766188.31 
     484461285 
    chicken
    (Gallus gallus)
    Aves C5H14orf1011 chromosome 5 open reading frame, human C14orf101 72.01(n)
    72.11(a)
      423551  XM_421443.3  XP_421443.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2606
    transmembrane protein 260
    67(a)
    1 ↔ 1
    GL343651.1(19608-118125)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5596501 UPF0679 protein C14orf101 homolog 56.43(n)
    50.08(a)
      559650  XM_683011.4  XP_688103.4 


    ENSEMBL Gene Tree for TMEM260 (if available)
    TreeFam Gene Tree for TMEM260 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM260 gene
    1 SIMAP similar gene for TMEM260 using alignment to 9 protein entries:     TM260_HUMAN (see all proteins):
    C14orf101

    TMEM260 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1618 SNPs in TMEM260 are shown (see all 1618)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846058791,2
    --57044673(+) TCCAGC/GACTGA 1 -- us2k10--------
    rs1458507701,2
    --57044716(+) TCCCCC/TCCAAA 1 -- us2k10--------
    rs1889757871,2
    --57044811(+) ACTCAC/TTGGCA 1 -- us2k10--------
    rs1384507101,2
    --57044821(+) ATGTTC/TTTTCA 1 -- us2k10--------
    rs795554511,2
    C,F--57044860(+) ACTATC/TTATTG 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs1815853471,2
    --57044894(+) CATTTA/CTCAAC 1 -- us2k10--------
    rs732753861,2
    C--57044932(+) TTCTAT/CAGGAC 1 -- us2k14Minor allele frequency- C:0.09WA NA EA 360
    rs1863120981,2
    --57044950(+) TGGATA/GAGGCT 1 -- us2k10--------
    rs567779971,2
    C,F--57044966(+) AGGTCC/TTCTGC 1 -- us2k13Minor allele frequency- T:0.07WA CSA 122
    rs124360471,2
    C,F,H--57045048(+) aaggaT/Gccact 1 -- us2k122Minor allele frequency- G:0.50NS EA NA CSA WA 2338

    HapMap Linkage Disequilibrium report for TMEM260 (56955072 - 57117324 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM260: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM260
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM260

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM260 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM260)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54916 HGNC: 20185 AceView: C14orf101 Ensembl:ENSG00000070269 euGenes: HUgn54916
    ECgene: TMEM260 H-InvDB: TMEM260

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM260 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM260 gene:
    Search GeneIP for patents involving TMEM260

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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