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Aliases for TMEM260 Gene

Aliases for TMEM260 Gene

  • Transmembrane Protein 260 2 3
  • C14orf101 3 4
  • Chromosome 14 Open Reading Frame 101 2
  • UPF0679 Protein C14orf101 3

External Ids for TMEM260 Gene

Previous HGNC Symbols for TMEM260 Gene

  • C14orf101

Previous GeneCards Identifiers for TMEM260 Gene

  • GC14P056956

Summaries for TMEM260 Gene

GeneCards Summary for TMEM260 Gene

TMEM260 (Transmembrane Protein 260) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM260 Gene

Genomics for TMEM260 Gene

Genomic Location for TMEM260 Gene

Chromosome:
14
Start:
56,488,354 bp from pter
End:
56,651,884 bp from pter
Size:
163,531 bases
Orientation:
Plus strand

Genomic View for TMEM260 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM260 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM260 Gene

No data available for Regulatory Elements for TMEM260 Gene

Proteins for TMEM260 Gene

  • Protein details for TMEM260 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX78-TM260_HUMAN
    Recommended name:
    Transmembrane protein 260
    Protein Accession:
    Q9NX78
    Secondary Accessions:
    • A8KAN4
    • B3KPF5
    • Q86XE1

    Protein attributes for TMEM260 Gene

    Size:
    707 amino acids
    Molecular mass:
    79536 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91139.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BC045556; Type=Frameshift; Positions=212; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM260 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM260 Gene

Proteomics data for TMEM260 Gene at MOPED

Post-translational modifications for TMEM260 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM260 Gene

Domains & Families for TMEM260 Gene

Protein Domains for TMEM260 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM260 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NX78

UniProtKB/Swiss-Prot:

TM260_HUMAN :
  • Belongs to the TMEM260 family.
Family:
  • Belongs to the TMEM260 family.
genes like me logo Genes that share domains with TMEM260: view

No data available for Gene Families for TMEM260 Gene

Function for TMEM260 Gene

Phenotypes for TMEM260 Gene

GenomeRNAi human phenotypes for TMEM260:
genes like me logo Genes that share phenotypes with TMEM260: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM260

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM260 Gene

Localization for TMEM260 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM260 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM260: view

No data available for Subcellular locations from COMPARTMENTS for TMEM260 Gene

Pathways & Interactions for TMEM260 Gene

SuperPathways for TMEM260 Gene

No Data Available

Interacting Proteins for TMEM260 Gene

Gene Ontology (GO) - Biological Process for TMEM260 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM260 Gene

Drugs & Compounds for TMEM260 Gene

No Compound Related Data Available

Transcripts for TMEM260 Gene

Unigene Clusters for TMEM260 Gene

Transmembrane protein 260:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM260

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM260 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for TMEM260 Gene

GeneLoc Exon Structure for
TMEM260
ECgene alternative splicing isoforms for
TMEM260

Expression for TMEM260 Gene

mRNA expression in normal human tissues for TMEM260 Gene

Protein differential expression in normal tissues from HIPED for TMEM260 Gene

This gene is overexpressed in Cervix (58.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM260 Gene



SOURCE GeneReport for Unigene cluster for TMEM260 Gene Hs.497253

genes like me logo Genes that share expression patterns with TMEM260: view

Protein tissue co-expression partners for TMEM260 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM260 Gene

Orthologs for TMEM260 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM260 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM260 35
  • 90.49 (n)
  • 90.35 (a)
TMEM260 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM260 35
  • 91.04 (n)
  • 90.52 (a)
TMEM260 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem260 35
  • 83.74 (n)
  • 82.93 (a)
6720456H20Rik 16
Tmem260 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM260 35
  • 99.29 (n)
  • 99.29 (a)
C14H14ORF101 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem260 35
  • 82.88 (n)
  • 83.64 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM260 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM260 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF101 35
  • 72.21 (n)
  • 72.31 (a)
TMEM260 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM260 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem260 35
  • 67.62 (n)
  • 64.5 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559650 35
  • 56.66 (n)
  • 50.46 (a)
tmem260 36
  • 49 (a)
OneToOne
Species with no ortholog for TMEM260:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM260 Gene

ENSEMBL:
Gene Tree for TMEM260 (if available)
TreeFam:
Gene Tree for TMEM260 (if available)

Paralogs for TMEM260 Gene

(1) SIMAP similar genes for TMEM260 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TMEM260: view

No data available for Paralogs for TMEM260 Gene

Variants for TMEM260 Gene

Sequence variations from dbSNP and Humsavar for TMEM260 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2610 -- 56,650,761(-) TAAAC(A/T)TAAAA utr-variant-3-prime
rs990637 -- 56,645,777(-) GTAAA(G/T)GCTGT intron-variant
rs1023079 -- 56,650,363(-) CATCC(A/G)CTTCT utr-variant-3-prime
rs1041315 -- 56,622,879(-) TATAA(A/C)TGCAA intron-variant
rs1046465 -- 56,648,029(+) GGTGA(A/T)ATTTT utr-variant-3-prime, intron-variant, nc-transcript-variant

Variation tolerance for TMEM260 Gene

Residual Variation Intolerance Score: 66.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM260 Gene

HapMap Linkage Disequilibrium report
TMEM260
Human Gene Mutation Database (HGMD)
TMEM260

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM260 Gene

Disorders for TMEM260 Gene

Relevant External Links for TMEM260

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM260
genes like me logo Genes that share disorders with TMEM260: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM260 Gene

Publications for TMEM260 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A polymorphism at the microRNA binding site in the 3' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival. (PMID: 24831772) Yang B. … Guo Z. (Cancer Genet 2014) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 67

Products for TMEM260 Gene

Sources for TMEM260 Gene

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