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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM26 Gene

protein-coding   GIFtS: 43
GCID: GC10M063166

Transmembrane Protein 26

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 261 2

External Ids:    HGNC: 285501   Entrez Gene: 2196232   Ensembl: ENSG000001969327   UniProtKB: Q6ZUK43   

Export aliases for TMEM26 gene to outside databases

Previous GC identifers: GC10M062513 GC10M062842 GC10M057155


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM26 Gene: 
TMEM26 (transmembrane protein 26) is a protein-coding gene. Diseases associated with TMEM26 include alzheimer's disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM26 gene promoter:
         TBP   GATA-3   GATA-2   GATA-1   POU2F1   Ik-2   POU2F1a   HOXA5   MRF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM26 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.2   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q21.3

TMEM26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM26 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M063166:  view genomic region     (about GC identifiers)

Start:
63,166,401 bp from pter      End:
63,213,208 bp from pter
Size:
46,808 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMM26_HUMAN, Q6ZUK4 (See protein sequence)
Recommended Name: Transmembrane protein 26  
Size: 368 amino acids; 41672 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6ZVM0 Q8IVN9
Alternative splicing: 2 isoforms:  Q6ZUK4-1   Q6ZUK4-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TMEM26: NX_Q6ZUK4

Explore proteomics data for TMEM26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZUK4

  • TMEM26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM26 Protein Expression
    REFSEQ proteins: NP_848600.2  
    ENSEMBL proteins: 
     ENSP00000425286   ENSP00000382237   ENSP00000277749   ENSP00000426071   ENSP00000382232  

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    Cloud-Clone Corp. Proteins for TMEM26 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM26 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019169 Transmembrane_26

    Graphical View of Domain Structure for InterPro Entry Q6ZUK4

    ProtoNet protein and cluster: Q6ZUK4


    TMEM26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM26 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM26 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM26


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM26

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM26 (TMM26)

    Search CenterWatch for drugs/clinical trials and news about TMEM26 / TMM26

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM26 gene: 
    NM_178505.6  

    Unigene Cluster for TMEM26:

    Transmembrane protein 26
    Hs.623955  [show with all ESTs]
    Unigene Representative Sequence: CR749606
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503886 ENST00000399298(uc001jlo.2) ENST00000507507(uc001jlp.1)
    ENST00000277749 ENST00000488505(uc001jlq.3) ENST00000399293

    miRNA
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    hsa-miR-579 hsa-miR-4254 hsa-miR-4272 hsa-miR-938 hsa-miR-30d hsa-miR-138-2* hsa-miR-10b* hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    OriGene clones in human, mouse for TMEM26 (see all 8)
    OriGene ORF clones in mouse, rat for TMEM26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM26 (NM_178505)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM26
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM26 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM26 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM26
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM26
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM26
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM26
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM26

    Additional mRNA sequence: 

    AK124367.1 AK125611.1 BC042872.1 CR749606.1 

    4 DOTS entries:

    DT.100747442  DT.75104369  DT.121218172  DT.40301135 

    17 AceView cDNA sequences:

    AK124367 BX280925 AK125611 BQ673717 BC042872 NM_178505 BM926461 BI825526 
    AI982590 AI382316 CR749606 AA330486 AW299470 AW510476 AW749945 R94282 
    BF511237 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM26 expression in normal human tissues (normalized intensities)      TMEM26 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAGTTTC
    TMEM26 Expression
    About this image


    TMEM26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor EN7
     
     Smooth Muscle (Muscoskeletal System)
             Human Bronchial Smooth Muscle Cells (HBSM)   
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Lower Urinary Tract (Urinary System)
             Human Urothelial Cells (HUC)   
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod

    See TMEM26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM26

    SOURCE GeneReport for Unigene cluster: Hs.623955
        SABiosciences Custom PCR Arrays for TMEM26
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM26
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM26
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM26 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem261 , 5 transmembrane protein 261, 5 75.11(n)1
    70.8(a)1
      10 (35.64 cM)5
    3277661  NM_177794.31  NP_808462.21 
     687237465 
    chicken
    (Gallus gallus)
    Aves TMEM261 transmembrane protein 26 69.44(n)
    68.62(a)
      423663  NM_001199598.1  NP_001186527.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM266
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343204.1(3676397-3718001)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123422 Xenopus laevis transcribed sequence with weak similarity more 79.58(n)    BJ068018.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7945071 transmembrane protein 26-like 57.22(n)
    55.05(a)
      794507  XM_001334449.3  XP_001334485.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142381 CG14238 46.87(n)
    38.59(a)
      43195  NM_143223.1  NP_651480.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y119C1B.31 Protein Y119C1B.3 45.22(n)
    35.66(a)
      191027  NM_058985.2  NP_491386.2 


    ENSEMBL Gene Tree for TMEM26 (if available)
    TreeFam Gene Tree for TMEM26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1050 SNPs in TMEM26 are shown (see all 1050)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852663811,2
    --63166064(+) CAGAAA/GATCTT 1 -- ds50010--------
    rs768456761,2
    --63166082(+) CCCCAA/CAGGCT 1 -- ds50010--------
    rs1462887001,2
    --63166320(+) TTAAAC/TTAGAG 1 -- ds50010--------
    rs1897398071,2
    --63166419(+) CACTAA/TTTAAT 1 -- ut310--------
    rs1395251751,2
    --63166485(+) GCAGAG/TAAAAT 1 -- ut310--------
    rs1823460121,2
    --63166549(+) TAAAAC/TATAAG 1 -- ut310--------
    rs1428342221,2
    --63166661(+) AACCCC/TAAATC 1 -- ut310--------
    rs1453925461,2
    C--63166742(+) TCCCC-/TTTTTT 1 -- ut310--------
    rs109947541,2
    C,F,A,H--63166773(+) TTGGTA/GTTTCA 1 -- ut3124Minor allele frequency- G:0.49NS EA NA WA CSA 2351
    rs1999840501,2
    C--63166873(-) TACAGA/GAGAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM26 (63166401 - 63213208 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM26: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM26
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TMEM26:    About MalaCards
    alzheimer's disease    


    TMEM26 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TMEM26
    Human Genome Epidemiology (HuGE) Navigator: TMEM26 (1 document)

    Export disorders for TMEM26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM26 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TMEM26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (2009)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD. (PubMed id 22986903)1 Hansel N.N....Barnes K.C. (2013)
    7. Genetic association with overall survival of taxane-tr eated lung cancer patients - a genome-wide association study in human lymphoblas toid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (2012)
    8. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (2009)
    9. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219623 HGNC: 28550 AceView: TMEM26 Ensembl:ENSG00000196932 euGenes: HUgn219623
    ECgene: TMEM26 H-InvDB: TMEM26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM26 gene:
    Search GeneIP for patents involving TMEM26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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