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Aliases for TMEM26 Gene

Aliases for TMEM26 Gene

  • Transmembrane Protein 26 2 3 5

External Ids for TMEM26 Gene

Previous GeneCards Identifiers for TMEM26 Gene

  • GC10M062513
  • GC10M062842
  • GC10M063166
  • GC10M057155

Summaries for TMEM26 Gene

Entrez Gene Summary for TMEM26 Gene

  • This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TMEM26 Gene

TMEM26 (Transmembrane Protein 26) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM26 Gene

Genomics for TMEM26 Gene

Regulatory Elements for TMEM26 Gene

Enhancers for TMEM26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F061463 1.4 FANTOM5 Ensembl ENCODE 20.6 -11.4 -11403 2.7 CTCF PKNOX1 MAX RAD21 RFX5 FOS NR2F6 ZNF202 ZNF362 ZNF654 TMEM26 ARID5B GC10P061456 GC10M061462
GH10F061829 1.5 FANTOM5 Ensembl ENCODE 13.6 -377.3 -377260 1.7 ATF1 ARNT ZNF48 CBX5 GATA2 NCOA1 MBD2 MEF2D SMARCA4 PBX2 TMEM26 C10orf107 ARID5B ENSG00000233643
GH10F061451 0.9 ENCODE 21 +0.3 315 4.1 PKNOX1 FEZF1 ETS1 RCOR1 CREM EGR2 SP3 JUNB TBX21 NR2F2 TMEM26 TMEM26-AS1
GH10F061475 1 ENCODE 14.9 -22.4 -22353 0.9 PKNOX1 ATF1 FEZF1 ZNF121 FOS TSHZ1 ZNF488 ZNF518A SMARCA4 PBX2 TMEM26 GC10P061456 GC10M061462
GH10F061397 1.1 Ensembl ENCODE 11.6 +55.5 55450 2.0 ZNF2 RAD21 YY1 ZNF143 ZNF391 FOS DEK MIXL1 ZNF654 JUNB TMEM26-AS1 TMEM26 C10orf107 GC10M061433 GC10P061339
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM26 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000355732 549 1800 CTCF ZNF146 PKNOX1 SUZ12 ZMYM3 RAD21 ETS1 ZFHX2 CTBP1 PRDM10

Genomic Location for TMEM26 Gene

61,406,642 bp from pter
61,453,450 bp from pter
46,809 bases
Minus strand

Genomic View for TMEM26 Gene

Genes around TMEM26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM26 Gene

Proteins for TMEM26 Gene

  • Protein details for TMEM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 26
    Protein Accession:
    Secondary Accessions:
    • Q6ZVM0
    • Q8IVN9

    Protein attributes for TMEM26 Gene

    368 amino acids
    Molecular mass:
    41672 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM26 Gene


neXtProt entry for TMEM26 Gene

Post-translational modifications for TMEM26 Gene

  • Glycosylation at Asn 110 and Asn 116
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM26 Gene

No data available for DME Specific Peptides for TMEM26 Gene

Domains & Families for TMEM26 Gene

Protein Domains for TMEM26 Gene


Suggested Antigen Peptide Sequences for TMEM26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM26: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM26 Gene

Function for TMEM26 Gene

genes like me logo Genes that share phenotypes with TMEM26: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM26 Gene

Localization for TMEM26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM26 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM26 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM26: view

Pathways & Interactions for TMEM26 Gene

SuperPathways for TMEM26 Gene

No Data Available

Interacting Proteins for TMEM26 Gene

Gene Ontology (GO) - Biological Process for TMEM26 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM26 Gene

Transcripts for TMEM26 Gene

Unigene Clusters for TMEM26 Gene

Transmembrane protein 26:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM26 Gene

No ASD Table

Relevant External Links for TMEM26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM26 Gene

This gene is overexpressed in Spleen (x11.2) and Breast - Mammary Tissue (x4.7).

Protein differential expression in normal tissues from HIPED for TMEM26 Gene

This gene is overexpressed in Testis (45.9) and Fetal testis (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM26 Gene

Protein tissue co-expression partners for TMEM26 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM26 Gene:


SOURCE GeneReport for Unigene cluster for TMEM26 Gene:

genes like me logo Genes that share expression patterns with TMEM26: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM26 Gene

Orthologs for TMEM26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM26 34 35
  • 98.91 (n)
(Bos Taurus)
Mammalia TMEM26 34 35
  • 85.78 (n)
(Canis familiaris)
Mammalia TMEM26 34 35
  • 85.05 (n)
(Rattus norvegicus)
Mammalia Tmem26 34
  • 75.48 (n)
(Mus musculus)
Mammalia Tmem26 34 16 35
  • 75.02 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM26 35
  • 70 (a)
(Monodelphis domestica)
Mammalia TMEM26 35
  • 60 (a)
(Gallus gallus)
Aves TMEM26 34 35
  • 67.04 (n)
(Anolis carolinensis)
Reptilia TMEM26 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732964 34
  • 63.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12342 34
(Danio rerio)
Actinopterygii LOC794507 34
  • 57.11 (n)
TMEM26 (2 of 3) 35
  • 51 (a)
TMEM26 (3 of 3) 35
  • 49 (a)
tmem26b 35
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14238 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea Y119C1B.3 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for TMEM26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM26 Gene

Gene Tree for TMEM26 (if available)
Gene Tree for TMEM26 (if available)

Paralogs for TMEM26 Gene

No data available for Paralogs for TMEM26 Gene

Variants for TMEM26 Gene

Sequence variations from dbSNP and Humsavar for TMEM26 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10128249 -- 61,438,134(+) TCTCT(A/T)AAAAA intron-variant
rs10509148 -- 61,410,138(+) AATAG(C/T)CACTA nc-transcript-variant, utr-variant-3-prime
rs10509149 -- 61,427,054(+) AATGT(A/G)GTAAT intron-variant
rs10555555 -- 61,451,992(+) ATATA(-/TATA)TATAT intron-variant, upstream-variant-2KB
rs10606887 -- 61,451,987(+) TATTG(-/ATAT)ATATA intron-variant, upstream-variant-2KB

Variation tolerance for TMEM26 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM26 Gene

Disorders for TMEM26 Gene

Relevant External Links for TMEM26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM26 Gene

Publications for TMEM26 Gene

  1. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for TMEM26 Gene

Sources for TMEM26 Gene

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