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Aliases for TMEM26 Gene

Aliases for TMEM26 Gene

  • Transmembrane Protein 26 2 3 5

External Ids for TMEM26 Gene

Previous GeneCards Identifiers for TMEM26 Gene

  • GC10M062513
  • GC10M062842
  • GC10M063166
  • GC10M057155

Summaries for TMEM26 Gene

Entrez Gene Summary for TMEM26 Gene

  • This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TMEM26 Gene

TMEM26 (Transmembrane Protein 26) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM26 Gene

Genomics for TMEM26 Gene

Regulatory Elements for TMEM26 Gene

Promoters for TMEM26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM26 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM26 Gene

Chromosome:
10
Start:
61,406,642 bp from pter
End:
61,453,450 bp from pter
Size:
46,809 bases
Orientation:
Minus strand

Genomic View for TMEM26 Gene

Genes around TMEM26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM26 Gene

Proteins for TMEM26 Gene

  • Protein details for TMEM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUK4-TMM26_HUMAN
    Recommended name:
    Transmembrane protein 26
    Protein Accession:
    Q6ZUK4
    Secondary Accessions:
    • Q6ZVM0
    • Q8IVN9

    Protein attributes for TMEM26 Gene

    Size:
    368 amino acids
    Molecular mass:
    41672 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM26 Gene

Proteomics data for TMEM26 Gene at MOPED

Post-translational modifications for TMEM26 Gene

  • Glycosylation at Asn 110 and Asn 116
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM26 Gene

No data available for DME Specific Peptides for TMEM26 Gene

Domains & Families for TMEM26 Gene

Protein Domains for TMEM26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM26: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM26 Gene

Function for TMEM26 Gene

Phenotypes for TMEM26 Gene

genes like me logo Genes that share phenotypes with TMEM26: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM26 Gene

Localization for TMEM26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM26 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM26 Gene COMPARTMENTS Subcellular localization image for TMEM26 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM26 Gene

Pathways & Interactions for TMEM26 Gene

SuperPathways for TMEM26 Gene

No Data Available

Interacting Proteins for TMEM26 Gene

Gene Ontology (GO) - Biological Process for TMEM26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM26 Gene

Drugs & Compounds for TMEM26 Gene

No Compound Related Data Available

Transcripts for TMEM26 Gene

mRNA/cDNA for TMEM26 Gene

Unigene Clusters for TMEM26 Gene

Transmembrane protein 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM26 Gene

No ASD Table

Relevant External Links for TMEM26 Gene

GeneLoc Exon Structure for
TMEM26
ECgene alternative splicing isoforms for
TMEM26

Expression for TMEM26 Gene

mRNA expression in normal human tissues for TMEM26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM26 Gene

This gene is overexpressed in Spleen (x11.2) and Breast - Mammary Tissue (x4.7).

Protein differential expression in normal tissues from HIPED for TMEM26 Gene

This gene is overexpressed in Testis (45.9) and Fetal testis (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM26 Gene



SOURCE GeneReport for Unigene cluster for TMEM26 Gene Hs.623955

genes like me logo Genes that share expression patterns with TMEM26: view

Protein tissue co-expression partners for TMEM26 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM26 Gene

Orthologs for TMEM26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM26 35
  • 85.78 (n)
  • 87.23 (a)
TMEM26 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM26 35
  • 85.05 (n)
  • 80.71 (a)
TMEM26 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem26 35
  • 75.02 (n)
  • 70.8 (a)
Tmem26 16
Tmem26 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM26 35
  • 98.91 (n)
  • 98.64 (a)
TMEM26 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem26 35
  • 75.48 (n)
  • 71.35 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM26 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM26 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM26 35
  • 67.04 (n)
  • 63.61 (a)
TMEM26 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM26 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732964 35
  • 63.88 (n)
  • 66.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12342 35
zebrafish
(Danio rerio)
Actinopterygii LOC794507 35
  • 57.11 (n)
  • 55.05 (a)
TMEM26 (2 of 3) 36
  • 51 (a)
OneToMany
TMEM26 (3 of 3) 36
  • 49 (a)
OneToMany
tmem26b 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14238 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y119C1B.3 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for TMEM26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM26 Gene

ENSEMBL:
Gene Tree for TMEM26 (if available)
TreeFam:
Gene Tree for TMEM26 (if available)

Paralogs for TMEM26 Gene

No data available for Paralogs for TMEM26 Gene

Variants for TMEM26 Gene

Sequence variations from dbSNP and Humsavar for TMEM26 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1879467 -- 61,415,328(+) TAAGG(A/T)CTAAA intron-variant
rs1879468 -- 61,415,799(+) TAAAG(C/T)TTCTT intron-variant
rs1907217 -- 61,413,208(-) GTTCC(A/G)TCAGT intron-variant, downstream-variant-500B
rs1915431 -- 61,413,181(+) GGTTT(A/G/T)CAGGA intron-variant, downstream-variant-500B
rs1915432 -- 61,418,557(+) ttgat(C/T)caagt intron-variant

Variation tolerance for TMEM26 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM26 Gene

HapMap Linkage Disequilibrium report
TMEM26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM26 Gene

Disorders for TMEM26 Gene

Relevant External Links for TMEM26

Genetic Association Database (GAD)
TMEM26
Human Genome Epidemiology (HuGE) Navigator
TMEM26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM26

No disorders were found for TMEM26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM26 Gene

Publications for TMEM26 Gene

  1. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes. (PMID: 25534037) Okla M. … Chung S. (Lipids 2015) 3
  4. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3
  5. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD. (PMID: 22986903) Hansel N.N. … Barnes K.C. (Hum. Genet. 2013) 3

Products for TMEM26 Gene

Sources for TMEM26 Gene

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