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Aliases for TMEM259 Gene

Aliases for TMEM259 Gene

  • Transmembrane Protein 259 2 3 4 5
  • Aspecific BCL2 ARE-Binding Protein 1 2 3
  • C19orf6 3 4
  • Chromosome 19 Open Reading Frame 6 2
  • Membralin 2
  • MEMBRALIN 3
  • R32184_3 3
  • ASBABP1 3
  • MBRL 3

External Ids for TMEM259 Gene

Previous HGNC Symbols for TMEM259 Gene

  • C19orf6

Summaries for TMEM259 Gene

GeneCards Summary for TMEM259 Gene

TMEM259 (Transmembrane Protein 259) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM259 Gene

  • May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM259 Gene

Genomics for TMEM259 Gene

Regulatory Elements for TMEM259 Gene

Enhancers for TMEM259 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM259 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM259 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM259 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM259 Gene

Chromosome:
19
Start:
1,009,648 bp from pter
End:
1,021,179 bp from pter
Size:
11,532 bases
Orientation:
Minus strand

Genomic View for TMEM259 Gene

Genes around TMEM259 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM259 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM259 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM259 Gene

Proteins for TMEM259 Gene

  • Protein details for TMEM259 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ZIN3-MBRL_HUMAN
    Recommended name:
    Membralin
    Protein Accession:
    Q4ZIN3
    Secondary Accessions:
    • O60392
    • Q8NF79
    • Q96H30

    Protein attributes for TMEM259 Gene

    Size:
    620 amino acids
    Molecular mass:
    67889 Da
    Quaternary structure:
    • Interacts with ERLIN2.
    SequenceCaution:
    • Sequence=AAC12681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM259 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM259 Gene

Proteomics data for TMEM259 Gene at MOPED

Post-translational modifications for TMEM259 Gene

Other Protein References for TMEM259 Gene

No data available for DME Specific Peptides for TMEM259 Gene

Domains & Families for TMEM259 Gene

Protein Domains for TMEM259 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM259 Gene

Graphical View of Domain Structure for InterPro Entry

Q4ZIN3

UniProtKB/Swiss-Prot:

MBRL_HUMAN :
  • Belongs to the membralin family.
Family:
  • Belongs to the membralin family.
genes like me logo Genes that share domains with TMEM259: view

No data available for Gene Families for TMEM259 Gene

Function for TMEM259 Gene

Molecular function for TMEM259 Gene

UniProtKB/Swiss-Prot Function:
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.
genes like me logo Genes that share phenotypes with TMEM259: view

Animal Model Products

miRNA for TMEM259 Gene

miRTarBase miRNAs that target TMEM259

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM259 Gene

Localization for TMEM259 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM259 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM259 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with TMEM259: view

No data available for Subcellular locations from COMPARTMENTS for TMEM259 Gene

Pathways & Interactions for TMEM259 Gene

SuperPathways for TMEM259 Gene

No Data Available

Interacting Proteins for TMEM259 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349087%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000331288%0d%0a
Selected Interacting proteins: ENSP00000349087 Q4ZIN3-MBRL_HUMAN for TMEM259 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM259 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IEA --
genes like me logo Genes that share ontologies with TMEM259: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM259 Gene

Drugs & Compounds for TMEM259 Gene

No Compound Related Data Available

Transcripts for TMEM259 Gene

Unigene Clusters for TMEM259 Gene

Transmembrane protein 259:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM259 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - -
SP8:
SP9: -
SP10:

Relevant External Links for TMEM259 Gene

GeneLoc Exon Structure for
TMEM259
ECgene alternative splicing isoforms for
TMEM259

Expression for TMEM259 Gene

mRNA expression in normal human tissues for TMEM259 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM259 Gene

This gene is overexpressed in Urine (36.8) and Pancreas (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM259 Gene



SOURCE GeneReport for Unigene cluster for TMEM259 Gene Hs.515003

genes like me logo Genes that share expression patterns with TMEM259: view

Protein tissue co-expression partners for TMEM259 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM259 Gene

Orthologs for TMEM259 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM259 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM259 35
  • 86.58 (n)
  • 87.87 (a)
TMEM259 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf6 35
  • 86.43 (n)
  • 88.51 (a)
TMEM259 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem259 35
  • 84.5 (n)
  • 88.38 (a)
Tmem259 16
Tmem259 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf6 35
  • 96.95 (n)
  • 95.58 (a)
TMEM259 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mbrl 35
  • 84.93 (n)
  • 89.08 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM259 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM259 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves C19ORF6 35
  • 74.07 (n)
  • 77.95 (a)
TMEM259 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM259 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem259 35
  • 70.82 (n)
  • 81.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14528 35
zebrafish
(Danio rerio)
Actinopterygii tmem259 35
  • 71.41 (n)
  • 77 (a)
tmem259 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8405 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y59C2A.2 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for TMEM259:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM259 Gene

ENSEMBL:
Gene Tree for TMEM259 (if available)
TreeFam:
Gene Tree for TMEM259 (if available)

Paralogs for TMEM259 Gene

No data available for Paralogs for TMEM259 Gene

Variants for TMEM259 Gene

Sequence variations from dbSNP and Humsavar for TMEM259 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7258158 -- 1,013,382(+) AGCCC(A/C/G)GGCTG intron-variant
rs12976056 -- 1,022,160(+) aagtg(A/C)tggga upstream-variant-2KB
rs12978770 -- 1,015,996(+) TGGGG(C/T)GAGCC intron-variant
rs8100391 -- 1,010,974(+) CACCC(A/G)GGACC intron-variant
rs12980446 -- 1,022,158(+) caaag(G/T)gctgg upstream-variant-2KB

Variation tolerance for TMEM259 Gene

Gene Damage Index Score: 3.61; 56.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMEM259 Gene

Disorders for TMEM259 Gene

Relevant External Links for TMEM259

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM259

No disorders were found for TMEM259 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM259 Gene

Publications for TMEM259 Gene

  1. Identification and characterization of membralin, a novel tumor- associated gene, in ovarian carcinoma. (PMID: 16084606) Chen Y.-C. … Shih I.-M. (Biochim. Biophys. Acta 2005) 2 3 4 23 67
  2. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. (PMID: 12638133) Andersson O. … von Euler G. (Gene Expr. Patterns 2002) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PMID: 23798571) Roy S.J. … Parent J.L. (Mol. Endocrinol. 2013) 3
  5. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 3

Products for TMEM259 Gene

Sources for TMEM259 Gene

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