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Aliases for TMEM259 Gene

Aliases for TMEM259 Gene

  • Transmembrane Protein 259 2 3 4
  • C19orf6 3 4 6
  • Aspecific BCL2 ARE-Binding Protein 1 2 3
  • Chromosome 19 Open Reading Frame 6 2
  • Membralin 2
  • MEMBRALIN 3
  • R32184_3 3
  • ASBABP1 3
  • MBRL 3

External Ids for TMEM259 Gene

Previous HGNC Symbols for TMEM259 Gene

  • C19orf6

Summaries for TMEM259 Gene

GeneCards Summary for TMEM259 Gene

TMEM259 (Transmembrane Protein 259) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM259 Gene

Genomics for TMEM259 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM259 Gene

Start:
1,009,648 bp from pter
End:
1,021,179 bp from pter
Size:
11,532 bases
Orientation:
Minus strand

Genomic View for TMEM259 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM259 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM259 Gene

No data available for Regulatory Elements for TMEM259 Gene

Proteins for TMEM259 Gene

  • Protein details for TMEM259 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ZIN3-MBRL_HUMAN
    Recommended name:
    Membralin
    Protein Accession:
    Q4ZIN3
    Secondary Accessions:
    • O60392
    • Q8NF79
    • Q96H30

    Protein attributes for TMEM259 Gene

    Size:
    620 amino acids
    Molecular mass:
    67889 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC12681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM259 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM259 Gene

Proteomics data for TMEM259 Gene at MOPED

Post-translational modifications for TMEM259 Gene

Other Protein References for TMEM259 Gene

No data available for DME Specific Peptides for TMEM259 Gene

Domains for TMEM259 Gene

Protein Domains for TMEM259 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM259: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM259 Gene

Function for TMEM259 Gene

Animal Model Products

miRNA for TMEM259 Gene

miRTarBase miRNAs that target TMEM259

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM259 Gene

Localization for TMEM259 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM259 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic according to PubMed:16084606.

Gene Ontology (GO) - Cellular Components for TMEM259 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM259: view

No data available for Subcellular locations from COMPARTMENTS for TMEM259 Gene

Pathways for TMEM259 Gene

SuperPathways for TMEM259 Gene

No Data Available

Interacting Proteins for TMEM259 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349087%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000331288%0d%0a
Selected Interacting proteins: ENSP00000349087 Q4ZIN3-MBRL_HUMAN for TMEM259 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM259 Gene

None

No data available for Pathways by source for TMEM259 Gene

Transcripts for TMEM259 Gene

Unigene Clusters for TMEM259 Gene

Transmembrane protein 259:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM259

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM259 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - -
SP8:
SP9: -
SP10:

Relevant External Links for TMEM259 Gene

GeneLoc Exon Structure for
TMEM259
ECgene alternative splicing isoforms for
TMEM259

Expression for TMEM259 Gene

mRNA expression in normal human tissues for TMEM259 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TMEM259 Gene

This gene is overexpressed in Urine (36.8) and Pancreas (15.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM259 Gene

SOURCE GeneReport for Unigene cluster for TMEM259 Gene Hs.515003

genes like me logo Genes that share expressions with TMEM259: view

Expression partners for TMEM259 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM259 Gene

Orthologs for TMEM259 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM259 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM259 35
  • 86.58 (n)
  • 87.87 (a)
TMEM259 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf6 35
  • 86.43 (n)
  • 88.51 (a)
TMEM259 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem259 35
  • 84.5 (n)
  • 88.38 (a)
10 16
Tmem259 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf6 35
  • 96.95 (n)
  • 95.58 (a)
TMEM259 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mbrl 35
  • 84.93 (n)
  • 89.08 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM259 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM259 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves C19ORF6 35
  • 74.07 (n)
  • 77.95 (a)
TMEM259 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM259 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem259 35
  • 70.82 (n)
  • 81.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14528 35
zebrafish
(Danio rerio)
Actinopterygii tmem259 35
  • 71.41 (n)
  • 77 (a)
tmem259 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8405 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y59C2A.2 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for TMEM259:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM259 Gene

ENSEMBL:
Gene Tree for TMEM259 (if available)
TreeFam:
Gene Tree for TMEM259 (if available)

Paralogs for TMEM259 Gene

No data available for Paralogs for TMEM259 Gene

Variants for TMEM259 Gene

Sequence variations from dbSNP and Humsavar for TMEM259 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7145 -- 1,012,121(-) GGCTA(C/T)GATGA reference, synonymous-codon, nc-transcript-variant
rs7146 -- 1,014,399(-) GAGCA(C/T)GTGCG synonymous-codon, reference, upstream-variant-2KB, nc-transcript-variant
rs737692 -- 1,017,783(+) ACACA(C/G)AAGCC intron-variant
rs739884 -- 1,018,319(-) GGTGG(C/T)TTTAG intron-variant
rs970100 -- 1,012,612(+) CCCAC(A/C)CACGT intron-variant

Relevant External Links for TMEM259 Gene

HapMap Linkage Disequilibrium report
TMEM259

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM259 Gene

Disorders for TMEM259 Gene

No disorders were found for TMEM259 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM259 Gene

Publications for TMEM259 Gene

  1. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. (PMID: 12638133) Andersson O. … von Euler G. (Gene Expr. Patterns 2002) 2 3 4 23
  2. Identification and characterization of membralin, a novel tumor- associated gene, in ovarian carcinoma. (PMID: 16084606) Chen Y.-C. … Shih I.-M. (Biochim. Biophys. Acta 2005) 2 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM259 Gene

Sources for TMEM259 Gene

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