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TMEM259 Gene

protein-coding   GIFtS: 42
GCID: GC19M001006

Transmembrane Protein 259

(Previous name: chromosome 19 open reading frame 6)
(Previous symbol: C19orf6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 2591 2 3     ASBABP12
C19orf61 2 3 5     MBRL2
Aspecific BCL2 ARE-Binding Protein 11 2     MEMBRALIN2
membralin1 2     R32184_32
Chromosome 19 Open Reading Frame 61     

External Ids:    HGNC: 170391   Entrez Gene: 913042   Ensembl: ENSG000001820877   OMIM: 6110115   UniProtKB: Q4ZIN33   

Export aliases for TMEM259 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM259 Gene:
TMEM259 (transmembrane protein 259) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM259
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM259 promoter sequence
   Search Chromatin IP Primers for TMEM259

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM259


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TMEM259 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM259 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001006:  view genomic region     (about GC identifiers)

Start:
1,009,647 bp from pter      End:
1,021,141 bp from pter
Size:
11,495 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MBRL_HUMAN, Q4ZIN3 (See protein sequence)
Recommended Name: Membralin  
Size: 620 amino acids; 67889 Da
Sequence caution: Sequence=AAC12681.1; Type=Erroneous gene model prediction;
Secondary accessions: O60392 Q8NF79 Q96H30
Alternative splicing: 2 isoforms:  Q4ZIN3-1   Q4ZIN3-2   

Explore the universe of human proteins at neXtProt for TMEM259: NX_Q4ZIN3

Explore proteomics data for TMEM259 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys280
  • Glycosylation2 at Asn189
  • Modification sites at PhosphoSitePlus

  • See TMEM259 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001028198.1  NP_219488.1  

    ENSEMBL proteins: 
     ENSP00000349087   ENSP00000475704   ENSP00000331423   ENSP00000475219   ENSP00000475672  
     ENSP00000475354   ENSP00000476127   ENSP00000467728  

    TMEM259 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TMEM259
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TMEM259
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    Novus Biologicals TMEM259 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TMEM259 

    TMEM259 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMEM259
    Browse R&D Systems for Antibodies
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    Novus Biologicals TMEM259 Antibodies
    Search for Antibodies for TMEM259 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TMEM259
    LSBio Antibodies in human, mouse, rat for TMEM259

    TMEM259 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM259
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TMEM259 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019144 Membralin

    Graphical View of Domain Structure for InterPro Entry Q4ZIN3

    ProtoNet protein and cluster: Q4ZIN3


    Find genes that share domains with TMEM259           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM259
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM259

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM259
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM259

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM259:
    hsa-mir-590-3p (MIRT016161)

    Block miRNA regulation of human, mouse, rat TMEM259 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM259
    SwitchGear 3'UTR luciferase reporter plasmidTMEM259 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM259
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM259

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM259

    Clone
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    OriGene clones in human, mouse for TMEM259 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TMEM259
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM259
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM259

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM259
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM259 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM259


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MBRL_HUMAN, Q4ZIN3: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Note=Cytoplasmic according to
    PubMed:16084606

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM259           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM259
    Interactions:

        Search GeneGlobe Interaction Network for TMEM259

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for TMEM259 (Q4ZIN33 ENSP000003490874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    ARSEP516903, ENSP000003705264I2D: score=3 STRING: ENSP00000370526
    WIPI2Q9Y4P83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM259 (MBRL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM259 gene (2 alternative transcripts): 
    NM_001033026.1  NM_033420.3  

    Unigene Cluster for TMEM259:

    Transmembrane protein 259
    Hs.515003  [show with all ESTs]
    Unigene Representative Sequence: NM_001033026
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356663(uc021ume.1 uc002lqr.1) ENST00000593068 ENST00000333175(uc002lqs.1)
    ENST00000592618 ENST00000592052 ENST00000587266 ENST00000586285 ENST00000586704
    ENST00000591128 ENST00000587644 ENST00000607316 ENST00000592590 ENST00000586250
    ENST00000589055 ENST00000589831
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM259 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM259
    SwitchGear 3'UTR luciferase reporter plasmidTMEM259 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM259
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM259
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM259 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TMEM259
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM259
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM259
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM259
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM259
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat TMEM259
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM259
      QuantiFast Probe-based Assays in human, mouse, rat TMEM259

    Additional mRNA sequence: 

    AK095756.1 AY140906.1 BC008957.2 DQ005958.1 

    19 DOTS entries:

    DT.100761612  DT.80100861  DT.95371102  DT.99949281  DT.97854265  DT.92448849  DT.97802807  DT.95119520 
    DT.99981513  DT.100788861  DT.100788844  DT.100788858  DT.100059477  DT.95299191  DT.95371095  DT.100757228 
    DT.75105617  DT.95325494  DT.100048590 

    Selected AceView cDNA sequences (see all 548):

    BM754954 AW207296 AI144320 BE257824 AI498510 CK823508 AI057476 AI572448 
    BE258514 AW583230 AI476664 BM849400 BU543579 AI086031 BQ706909 BM756440 
    AW026983 BM856181 AA488758 BM761930 BI257990 AW071974 NM_033420 BM920433 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM259 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
    SP1:              -                                   -     -                                               -     -                 -                     
    SP2:              -                                   -     -                                               -     -     -     -     -                     
    SP3:                                                                                                        -     -     -     -                           
    SP4:                                                                                      -                 -     -                 -                     
    SP5:                                                                                      -                                                               


    ECgene alternative splicing isoforms for TMEM259

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM259 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM259 Expression
    About this image


    TMEM259 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    TMEM259 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM259 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515003
        Custom PCR Arrays for TMEM259
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM259
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    QuantiTect SYBR Green Assays in human, mouse, rat TMEM259
    QuantiFast Probe-based Assays in human, mouse, rat TMEM259
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM259

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM259 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 105
    Tmem2591
    transmembrane protein 2591 84.5(n)1
    88.38(a)1
      N/A5
    2161571  NM_001003949.31  NP_001003949.21 
    chicken
    (Gallus gallus)
    Aves C19ORF61 chromosome 28 open reading frame, human C19orf6 74.07(n)
    77.95(a)
      420101  XM_418222.4  XP_418222.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2596
    transmembrane protein 259
    96(a)
    1 ↔ 1
    AAWZ02040297(722-7119)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145282 Xenopus laevis transcribed sequence with strong similarity more 81.29(n)    BU909397.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem2591 transmembrane protein 259 71.41(n)
    77(a)
      571445  XM_695035.6  XP_700127.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84056
    --
    27(a)
    1 ↔ 1
    2R(11935177-11946972)
    worm
    (Caenorhabditis elegans)
    Secernentea Y59C2A.26
    Protein Y59C2A.2 (Y59C2A.2) mRNA, complete cds
    35(a)
    1 ↔ 1
    II(2199143-2204139) WBGene00021985


    ENSEMBL Gene Tree for TMEM259 (if available)
    TreeFam Gene Tree for TMEM259 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM259 (see all 445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423625851,2
    C--1010281(+) CCTCCC/GCCACC 2 -- ut310--------
    rs778689011,2
    C--1010396(+) GGCCGG/CGCTAG 3 /P /A ut31 mis12Minor allele frequency- C:0.03CSA NA 122
    rs621311621,2
    C--1010406(+) GGCCCG/ACCTAC 3 /G ut31 syn13Minor allele frequency- A:0.13NA WA 240
    rs1512654541,2
    C--1010432(+) AGTTGC/TGTCAG 3 T A ut31 mis10--------
    rs1859645451,2
    --1010522(+) ACGCCA/GCTCCA 3 R W ut31 mis10--------
    rs1998570131,2
    --1010547(+) AGGCCA/GGACAG 3 S ut31 syn10--------
    rs115403621,2
    C--1010673(-) AGTCCC/TGGGCC 3 P ut31 syn10--------
    rs22401591,2
    C,A,H--1010691(+) GCCCCG/AGGCGA 3 /P ut31 syn15Minor allele frequency- A:0.45NA WA EA 362
    rs1830611181,2
    --1010701(+) AGACGA/GGGCCC 3 P L ut31 mis10--------
    rs104017381,2
    C,F,H--1010755(+) CGCCCG/AAGTTG 3 /S /L ut31 mis1 ese33Minor allele frequency- A:0.00NS NA 386

    HapMap Linkage Disequilibrium report for TMEM259 (1009647 - 1021141 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM259: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM259
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM259

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611011    OMIM disorders: --


    Find genes that share disorders with TMEM259           About GenesLikeMe


    Export disorders for TMEM259 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM259 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TMEM259)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of membralin, a novel tumor- associated gene, in ovarian carcinoma. (PubMed id 16084606)1, 2, 3, 9 Chen Y.-C.... Shih I.-M. (Biochim. Biophys. Acta 2005)
    2. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. (PubMed id 12638133)1, 2, 3, 9 Andersson O. and von Euler G. (Gene Expr. Patterns 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91304 HGNC: 17039 AceView: C19orf6 Ensembl:ENSG00000182087 euGenes: HUgn91304
    ECgene: TMEM259 H-InvDB: TMEM259

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM259 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TMEM259 gene:
    Search GeneIP for patents involving TMEM259

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of TMEM259
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM259
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     Search Addgene for plasmids for TMEM259
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      eBioscience FlowRNA Probe Sets
           
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