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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM259 Gene

protein-coding   GIFtS: 40
GCID: GC19M001006

Transmembrane Protein 259

(Previous name: chromosome 19 open reading frame 6)
(Previous symbol: C19orf6)
  Search for TMEM259
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2591 2 3     ASBABP12
C19orf61 2 3 5     MBRL2
Aspecific BCL2 ARE-Binding Protein 11 2     MEMBRALIN2
membralin1 2     R32184_32
Chromosome 19 Open Reading Frame 61     

External Ids:    HGNC: 170391   Entrez Gene: 913042   Ensembl: ENSG000001820877   OMIM: 6110115   UniProtKB: Q4ZIN33   

Export aliases for TMEM259 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM259 Gene: 
TMEM259 (transmembrane protein 259) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM259
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM259 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM259

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM259


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TMEM259 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM259 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001006:  view genomic region     (about GC identifiers)

Start:
1,009,647 bp from pter      End:
1,021,141 bp from pter
Size:
11,495 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MBRL_HUMAN, Q4ZIN3 (See protein sequence)
Recommended Name: Membralin  
Size: 620 amino acids; 67889 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Note=Cytoplasmic according to
PubMed:16084606
Sequence caution: Sequence=AAC12681.1; Type=Erroneous gene model prediction;
Secondary accessions: O60392 Q8NF79 Q96H30
Alternative splicing: 2 isoforms:  Q4ZIN3-1   Q4ZIN3-2   

Explore the universe of human proteins at neXtProt for TMEM259: NX_Q4ZIN3

Explore proteomics data for TMEM259 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4ZIN3

  • TMEM259 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM259 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001028198.1  NP_219488.1  

    ENSEMBL proteins: 
     ENSP00000349087   ENSP00000475704   ENSP00000331423   ENSP00000475219   ENSP00000475672  
     ENSP00000475354   ENSP00000476127   ENSP00000467728  

    Human Recombinant Protein Products for TMEM259: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TMEM259
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TMEM259
    GenScript Custom Purified and Recombinant Proteins Services for TMEM259
    Novus Biologicals TMEM259 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral to membrane IEA--

    TMEM259 for ontologies           About GeneDecksing



    TMEM259 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMEM259
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    GenScript Custom Superior Antibodies Services for TMEM259
    Novus Biologicals TMEM259 Antibodies
    Abcam antibodies for TMEM259
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for TMEM259
    Search LSBio for Antibodies for TMEM259 

    Assay Products for TMEM259: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM259
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM259
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019144 Membralin

    Graphical View of Domain Structure for InterPro Entry Q4ZIN3

    ProtoNet protein and cluster: Q4ZIN3


    TMEM259 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM259 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM259

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM259 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM259 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM259
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TMEM259
    SwitchGear 3'UTR luciferase reporter plasmidTMEM259 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMEM259
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM259

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TMEM259
    Sirion Biotech Customized adenovirus for overexpression of TMEM259

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TMEM259 (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TMEM259
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM259
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM259
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM259 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM259 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TMEM259
    Search LifeMap BioReagents cell lines for TMEM259
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM259


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM259

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for TMEM259 (Q4ZIN33 ENSP000003490874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    ARSEP516903, ENSP000003705264I2D: score=3 STRING: ENSP00000370526
    WIPI2Q9Y4P83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM259 (MBRL)

    Search CenterWatch for drugs/clinical trials and news about TMEM259 / MBRL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM259 gene (2 alternative transcripts): 
    NM_001033026.1  NM_033420.3  

    Unigene Cluster for TMEM259:

    Transmembrane protein 259
    Hs.515003  [show with all ESTs]
    Unigene Representative Sequence: NM_001033026
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356663(uc021ume.1 uc002lqr.1) ENST00000593068 ENST00000333175(uc002lqs.1)
    ENST00000592618 ENST00000592052 ENST00000587266 ENST00000586285 ENST00000586704
    ENST00000591128 ENST00000587644 ENST00000607316 ENST00000592590 ENST00000586250
    ENST00000589055 ENST00000589831
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM259
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TMEM259
    SwitchGear 3'UTR luciferase reporter plasmidTMEM259 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMEM259
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM259
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM259 (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for TMEM259
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM259
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM259
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM259 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM259 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM259
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM259
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat TMEM259
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM259
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM259

    Additional mRNA sequence: 

    AK095756.1 AY140906.1 BC008957.2 DQ005958.1 

    19 DOTS entries:

    DT.100761612  DT.80100861  DT.95371102  DT.99949281  DT.97854265  DT.92448849  DT.97802807  DT.95119520 
    DT.99981513  DT.100788861  DT.100788844  DT.100788858  DT.100059477  DT.95299191  DT.95371095  DT.100757228 
    DT.75105617  DT.95325494  DT.100048590 

    24/548 AceView cDNA sequences (see all 548):

    CK904886 BI910133 BI761938 CR592871 BE257824 AI498510 CK823508 AI057476 
    AI572448 BE258514 AI122704 AI869531 BM846141 BM682257 BQ895919 AW136424 
    AI144320 AI197882 BQ646386 BC008957 BM754954 BM784193 BQ649265 AL555481 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM259 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
    SP1:              -                                   -     -                                               -     -                 -                     
    SP2:              -                                   -     -                                               -     -     -     -     -                     
    SP3:                                                                                                        -     -     -     -                           
    SP4:                                                                                      -                 -     -                 -                     
    SP5:                                                                                      -                                                               


    ECgene alternative splicing isoforms for TMEM259

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM259 expression in normal human tissues (normalized intensities)      TMEM259 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM259 Expression
    About this image


    TMEM259 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus

    See TMEM259 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM259

    SOURCE GeneReport for Unigene cluster: Hs.515003
        SABiosciences Custom PCR Arrays for TMEM259
    Primer
    Products:
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM259
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM259
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM259

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM259 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 105
    ORF611
    open reading frame 611 85.19(n)1
    89.24(a)1
      N/A5
    2161571  NM_001003949.31  NP_001003949.21 
    chicken
    (Gallus gallus)
    Aves C28H19orf61 chromosome 28 open reading frame, human C19orf6 73.86(n)
    76.91(a)
      420101  XM_418222.3  XP_418222.2 
    lizard
    (Anolis carolinensis)
    Reptilia C19ORF66
    Uncharacterized protein
    96(a)
    1 ↔ 1
    AAWZ02040297(722-7119)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145282 Xenopus laevis transcribed sequence with strong similarity more 81.29(n)    BU909397.1 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71549601 im:7154960 68.85(n)
    72.34(a)
      571445  XM_695035.5  XP_700127.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84051 CG8405 58.06(n)
    53.01(a)
      36772  NM_166137.1  NP_725521.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y59C2A.21 Protein Y59C2A.2 52.67(n)
    47.47(a)
      173576  NM_061811.3  NP_494212.2 


    ENSEMBL Gene Tree for TMEM259 (if available)
    TreeFam Gene Tree for TMEM259 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/445 SNPs in TMEM259 are shown (see all 445)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423625851,2
    C--1010281(+) CCTCCC/GCCACC 2 -- ut310--------
    rs778689011,2
    C--1010396(+) GGCCGG/CGCTAG 3 /P /A ut31 mis12Minor allele frequency- C:0.03CSA NA 122
    rs621311621,2
    C--1010406(+) GGCCCG/ACCTAC 3 /G ut31 syn13Minor allele frequency- A:0.13NA WA 240
    rs1512654541,2
    C--1010432(+) AGTTGC/TGTCAG 3 T A ut31 mis10--------
    rs1859645451,2
    --1010522(+) ACGCCA/GCTCCA 3 R W ut31 mis10--------
    rs1998570131,2
    --1010547(+) AGGCCA/GGACAG 3 S ut31 syn10--------
    rs115403621,2
    C--1010673(-) AGTCCC/TGGGCC 3 P ut31 syn10--------
    rs22401591,2
    C,A,H--1010691(+) GCCCCG/AGGCGA 3 /P ut31 syn15Minor allele frequency- A:0.45NA WA EA 362
    rs1830611181,2
    --1010701(+) AGACGA/GGGCCC 3 P L ut31 mis10--------
    rs104017381,2
    C,F,H--1010755(+) CGCCCG/AAGTTG 3 /S /L ut31 mis1 ese33Minor allele frequency- A:0.00NS NA 386

    HapMap Linkage Disequilibrium report for TMEM259 (1009647 - 1021141 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM259: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM259
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM259

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMEM259 for disorders           About MalaCards
    OMIM gene information: 611011    OMIM disorders: --


    TMEM259 for disorders           About GeneDecksing


    Export disorders for TMEM259 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM259 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TMEM259)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of membralin, a novel tumor- associated gene, in ovarian carcinoma. (PubMed id 16084606)1, 2, 3, 9 Chen Y.-C.... Shih I.-M. (2005)
    2. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. (PubMed id 12638133)1, 2, 3, 9 Andersson O. and von Euler G. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    7. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91304 HGNC: 17039 AceView: C19orf6 Ensembl:ENSG00000182087 euGenes: HUgn91304
    ECgene: TMEM259 H-InvDB: TMEM259

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM259 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM259 gene:
    Search GeneIP for patents involving TMEM259

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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