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Aliases for TMEM259 Gene

Aliases for TMEM259 Gene

  • Transmembrane Protein 259 2 3 4 5
  • Aspecific BCL2 ARE-Binding Protein 1 2 3
  • Membralin 2 3
  • C19orf6 3 4
  • Chromosome 19 Open Reading Frame 6 2
  • R32184_3 3
  • ASBABP1 3
  • MBRL 3

External Ids for TMEM259 Gene

Previous HGNC Symbols for TMEM259 Gene

  • C19orf6

Summaries for TMEM259 Gene

GeneCards Summary for TMEM259 Gene

TMEM259 (Transmembrane Protein 259) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM259 Gene

  • May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.

Additional gene information for TMEM259 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM259 Gene

Genomics for TMEM259 Gene

Regulatory Elements for TMEM259 Gene

Enhancers for TMEM259 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H001382 1.5 ENCODE dbSUPER 99.7 -362.8 -362847 2.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 SF3A2 CIRBP TMEM259 DAZAP1 MUM1 TCF3 LOC100288123 GRIN3B PTBP1 SPPL2B
GH19H000479 1.5 Ensembl ENCODE dbSUPER 86.6 +540.9 540894 0.8 HDGF PKNOX1 ATF1 ARNT ZNF133 ARID4B SIN3A YBX1 ZNF2 TCF12 DAZAP1 TMEM259 PTBP1 ENSG00000267317 MIER2 GRIN3B MED16 RPS15 CIRBP CNN2
GH19H001202 1.7 Ensembl ENCODE dbSUPER 76.4 -185.6 -185578 8 ZFP64 FEZF1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D ZNF610 CIRBP TMEM259 DAZAP1 LOC100288123 TCF3 PTBP1 GRIN3B POLRMT MIER2 DOT1L
GH19H001236 1.9 FANTOM5 ENCODE dbSUPER 65.2 -235.7 -235680 41.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZC3H11A SF3A2 TCF3 LOC100288123 MIER2 CIRBP TMEM259 DAZAP1 PTBP1 C19orf24 MUM1
GH19H001019 1.5 ENCODE dbSUPER 76.9 0.0 -29 4.4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 ZC3H11A MEF2D DAZAP1 TMEM259 LOC100288123 TCF3 GRIN3B MIER2 PTBP1 MED16 CIRBP ENSG00000267317
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM259 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM259 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105600 279 1801 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 ZC3H11A

Genomic Locations for TMEM259 Gene

Genomic Locations for TMEM259 Gene
11,532 bases
Minus strand

Genomic View for TMEM259 Gene

Genes around TMEM259 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM259 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM259 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM259 Gene

Proteins for TMEM259 Gene

  • Protein details for TMEM259 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O60392
    • Q8NF79
    • Q96H30

    Protein attributes for TMEM259 Gene

    620 amino acids
    Molecular mass:
    67889 Da
    Quaternary structure:
    • Interacts with ERLIN2.
    • Sequence=AAC12681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM259 Gene


neXtProt entry for TMEM259 Gene

Post-translational modifications for TMEM259 Gene

No data available for DME Specific Peptides for TMEM259 Gene

Domains & Families for TMEM259 Gene

Gene Families for TMEM259 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM259 Gene


Suggested Antigen Peptide Sequences for TMEM259 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the membralin family.
  • Belongs to the membralin family.
genes like me logo Genes that share domains with TMEM259: view

Function for TMEM259 Gene

Molecular function for TMEM259 Gene

UniProtKB/Swiss-Prot Function:
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.

Phenotypes From GWAS Catalog for TMEM259 Gene

genes like me logo Genes that share phenotypes with TMEM259: view

Animal Model Products

CRISPR Products

miRNA for TMEM259 Gene

miRTarBase miRNAs that target TMEM259

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM259 Gene

Localization for TMEM259 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM259 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM259 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM259 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM259: view

Pathways & Interactions for TMEM259 Gene

SuperPathways for TMEM259 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM259 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress IEA --
GO:1901215 negative regulation of neuron death IEA --
GO:1904294 positive regulation of ERAD pathway IEA --
genes like me logo Genes that share ontologies with TMEM259: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM259 Gene

Drugs & Compounds for TMEM259 Gene

No Compound Related Data Available

Transcripts for TMEM259 Gene

Unigene Clusters for TMEM259 Gene

Transmembrane protein 259:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM259 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for TMEM259 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM259 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM259 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM259 Gene

This gene is overexpressed in Urine (36.8) and Pancreas (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM259 Gene

Protein tissue co-expression partners for TMEM259 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM259 Gene:


SOURCE GeneReport for Unigene cluster for TMEM259 Gene:


Evidence on tissue expression from TISSUES for TMEM259 Gene

  • Liver(4.4)
  • Muscle(4.4)
  • Spleen(4.4)
  • Nervous system(3.8)
  • Lung(2.7)
  • Kidney(2.6)
  • Intestine(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with TMEM259: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM259 Gene

Orthologs for TMEM259 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM259 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM259 34
  • 97 (a)
C19H19orf6 33
  • 96.95 (n)
(Canis familiaris)
Mammalia TMEM259 34
  • 89 (a)
C20H19orf6 33
  • 86.43 (n)
(Bos Taurus)
Mammalia TMEM259 33 34
  • 86.58 (n)
(Rattus norvegicus)
Mammalia Mbrl 33
  • 84.93 (n)
(Mus musculus)
Mammalia Tmem259 33 16 34
  • 84.5 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM259 34
  • 74 (a)
(Monodelphis domestica)
Mammalia TMEM259 34
  • 71 (a)
(Gallus gallus)
Aves C19ORF6 33
  • 74.07 (n)
TMEM259 34
  • 72 (a)
(Anolis carolinensis)
Reptilia TMEM259 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem259 33
  • 70.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14528 33
(Danio rerio)
Actinopterygii tmem259 33 34
  • 71.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8405 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea Y59C2A.2 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for TMEM259 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM259 Gene

Gene Tree for TMEM259 (if available)
Gene Tree for TMEM259 (if available)

Paralogs for TMEM259 Gene

No data available for Paralogs for TMEM259 Gene

Variants for TMEM259 Gene

Sequence variations from dbSNP and Humsavar for TMEM259 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000026779 -- 1,016,156(+) CGCCA(A/G)GCATT intron-variant
rs1000078217 -- 1,010,539(+) GAGGC(C/G)CTCAG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1000481993 -- 1,009,991(+) CACCC(C/G)AAGCC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000726421 -- 1,022,781(+) AATGA(C/T)ACATA upstream-variant-2KB
rs1000906907 -- 1,021,138(+) CGGCG(C/T)TGCTG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM259 Gene

Variant ID Type Subtype PubMed ID
nsv9662 CNV gain 18304495
nsv953938 CNV deletion 24416366
nsv833704 CNV gain 17160897
nsv828360 CNV loss 20364138
nsv578189 CNV loss 21841781
nsv578188 CNV loss 21841781
nsv469845 CNV loss 16826518
nsv1160555 CNV deletion 26073780
esv3643385 CNV gain 21293372
esv3643384 CNV loss 21293372
esv3643383 CNV gain 21293372
esv2758743 CNV gain+loss 17122850
dgv135n111 CNV deletion 26073780

Variation tolerance for TMEM259 Gene

Gene Damage Index Score: 3.61; 56.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM259 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM259 Gene

Disorders for TMEM259 Gene

Relevant External Links for TMEM259

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM259 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM259 Gene

Publications for TMEM259 Gene

  1. Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma. (PMID: 16084606) Chen YC … Shih IeM (Biochimica et biophysica acta 2005) 2 3 4 22 60
  2. Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. (PMID: 12638133) Andersson O … von Euler G (Brain research. Gene expression patterns 2002) 2 3 4 22 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TMEM259 Gene

Sources for TMEM259 Gene

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