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Aliases for TMEM258 Gene

Aliases for TMEM258 Gene

  • Transmembrane Protein 258 2 3
  • C11orf10 3 4
  • UPF0197 Transmembrane Protein C11orf10 3
  • Chromosome 11 Open Reading Frame 10 2

External Ids for TMEM258 Gene

Previous HGNC Symbols for TMEM258 Gene

  • C11orf10

Previous GeneCards Identifiers for TMEM258 Gene

  • GC11M061557

Summaries for TMEM258 Gene

GeneCards Summary for TMEM258 Gene

TMEM258 (Transmembrane Protein 258) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM258 Gene

Genomics for TMEM258 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM258 Gene

Chromosome:
11
Start:
61,768,501 bp from pter
End:
61,792,802 bp from pter
Size:
24,302 bases
Orientation:
Minus strand

Genomic View for TMEM258 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM258 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM258 Gene

No data available for Regulatory Elements for TMEM258 Gene

Proteins for TMEM258 Gene

  • Protein details for TMEM258 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61165-TM258_HUMAN
    Recommended name:
    Transmembrane protein 258
    Protein Accession:
    P61165
    Secondary Accessions:
    • A8K6L8
    • Q9D953
    • Q9Y2Q7

    Protein attributes for TMEM258 Gene

    Size:
    79 amino acids
    Molecular mass:
    9079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM258 Gene

Proteomics data for TMEM258 Gene at MOPED

Post-translational modifications for TMEM258 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM258 Gene

No data available for DME Specific Peptides for TMEM258 Gene

Domains & Families for TMEM258 Gene

Protein Domains for TMEM258 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM258 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61165

UniProtKB/Swiss-Prot:

TM258_HUMAN :
  • Belongs to the TMEM258 family.
Family:
  • Belongs to the TMEM258 family.
genes like me logo Genes that share domains with TMEM258: view

No data available for Gene Families for TMEM258 Gene

Function for TMEM258 Gene

Phenotypes for TMEM258 Gene

GenomeRNAi human phenotypes for TMEM258:
genes like me logo Genes that share phenotypes with TMEM258: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM258

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM258 Gene

Localization for TMEM258 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM258 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM258 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM258: view

No data available for Subcellular locations from COMPARTMENTS for TMEM258 Gene

Pathways & Interactions for TMEM258 Gene

SuperPathways for TMEM258 Gene

No Data Available

Interacting Proteins for TMEM258 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000257262%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000257262 for TMEM258 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMEM258 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM258 Gene

Drugs & Compounds for TMEM258 Gene

No Compound Related Data Available

Transcripts for TMEM258 Gene

mRNA/cDNA for TMEM258 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM258 Gene

Transmembrane protein 258:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM258

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM258 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b
SP1: - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TMEM258 Gene

GeneLoc Exon Structure for
TMEM258
ECgene alternative splicing isoforms for
TMEM258

Expression for TMEM258 Gene

mRNA expression in normal human tissues for TMEM258 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM258 Gene

This gene is overexpressed in Pancreas (18.9) and Gallbladder (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM258 Gene



SOURCE GeneReport for Unigene cluster for TMEM258 Gene Hs.437779

genes like me logo Genes that share expression patterns with TMEM258: view

Protein tissue co-expression partners for TMEM258 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM258 Gene

Orthologs for TMEM258 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM258 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM258 35
  • 90.3 (n)
  • 98.73 (a)
TMEM258 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM258 35
  • 94.94 (n)
  • 100 (a)
-- 36
  • 99 (a)
OneToMany
C11ORF10 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem258 35
  • 91.98 (n)
  • 100 (a)
Tmem258 16
Tmem258 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf10 35
  • 99.16 (n)
  • 100 (a)
TMEM258 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM258 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM258 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H11ORF10 35
  • 85.65 (n)
  • 100 (a)
TMEM258 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM258 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6254 35
tmem258 35
  • 81.01 (n)
  • 98.73 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
tmem258 35
  • 77.64 (n)
  • 92.41 (a)
tmem258 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005935 35
  • 63.2 (n)
  • 70.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9669 35
  • 61.4 (n)
  • 67.11 (a)
CG9669 36
  • 65 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y57E12AM.1 36
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8385 36
  • 65 (a)
OneToOne
Species with no ortholog for TMEM258:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM258 Gene

ENSEMBL:
Gene Tree for TMEM258 (if available)
TreeFam:
Gene Tree for TMEM258 (if available)

Paralogs for TMEM258 Gene

Pseudogenes.org Pseudogenes for TMEM258 Gene

genes like me logo Genes that share paralogs with TMEM258: view

No data available for Paralogs for TMEM258 Gene

Variants for TMEM258 Gene

Sequence variations from dbSNP and Humsavar for TMEM258 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs102274 -- 61,790,354(-) GGGCT(A/G)GTGAT intron-variant
rs102275 -- 61,790,331(-) GTTAT(A/G)GCCTT intron-variant
rs381845 -- 61,789,425(-) TGAAA(A/G)GGGGT intron-variant
rs395346 -- 61,789,370(+) TCCTA(C/G)TGGCC intron-variant
rs437754 -- 61,790,044(+) TCAGA(A/G)CAGCC intron-variant

Variation tolerance for TMEM258 Gene

Residual Variation Intolerance Score: 57.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM258 Gene

HapMap Linkage Disequilibrium report
TMEM258

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM258 Gene

Disorders for TMEM258 Gene

Relevant External Links for TMEM258

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM258
genes like me logo Genes that share disorders with TMEM258: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM258 Gene

Publications for TMEM258 Gene

  1. Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus. (PMID: 12427278) Adachi N. … Lieber M.R. (OMICS 2002) 2 67
  2. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 67
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 67
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 67
  5. The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. (PMID: 23813974) Bochenek G. … Schaefer A.S. (Hum. Mol. Genet. 2013) 67

Products for TMEM258 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TMEM258
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM258
    • Block miRNA regulation of TMEM258 using miScript Target Protectors

    Sources for TMEM258 Gene

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