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Aliases for TMEM257 Gene

Aliases for TMEM257 Gene

  • Transmembrane Protein 257 2 3 5
  • CXorf1 3 4
  • Chromosome X Open Reading Frame 1 2

External Ids for TMEM257 Gene

Previous HGNC Symbols for TMEM257 Gene

  • CXorf1

Previous GeneCards Identifiers for TMEM257 Gene

  • GC0XP144909

Summaries for TMEM257 Gene

Entrez Gene Summary for TMEM257 Gene

  • This intronless gene is expressed in the hippocampus and maps close to a candidate region for several X-linked mental retardation (XLMR) syndromes. It is conserved in primates, cow, and horse, but not found in mouse and rat. The exact function of this gene is not known, but on the basis of its physical location and expression pattern, it is proposed to have an important function in the brain. [provided by RefSeq, Jan 2010]

GeneCards Summary for TMEM257 Gene

TMEM257 (Transmembrane Protein 257) is a Protein Coding gene. Diseases associated with TMEM257 include Reading Disorder.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM257 Gene

Genomics for TMEM257 Gene

Regulatory Elements for TMEM257 Gene

Enhancers for TMEM257 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG145842 0.4 ENCODE 0.4 +15.9 15863 1.2 RBBP5 SLITRK2 TMEM257 MIR892C
GH0XG145848 0.3 FANTOM5 0.3 +21.1 21098 0.0 SLITRK2 TMEM257 MIR892C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM257 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM257 Gene

145,827,410 bp from pter
145,829,856 bp from pter
2,447 bases
Plus strand

Genomic View for TMEM257 Gene

Genes around TMEM257 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM257 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM257 Gene

Proteins for TMEM257 Gene

  • Protein details for TMEM257 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 257
    Protein Accession:
    Secondary Accessions:
    • Q14CW0

    Protein attributes for TMEM257 Gene

    111 amino acids
    Molecular mass:
    13452 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM257 Gene

Post-translational modifications for TMEM257 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM257 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM257 Gene

Domains & Families for TMEM257 Gene

Protein Domains for TMEM257 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM257: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM257 Gene

Function for TMEM257 Gene

Gene Ontology (GO) - Molecular Function for TMEM257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM257: view
genes like me logo Genes that share phenotypes with TMEM257: view

Animal Model Products

CRISPR Products

miRNA for TMEM257 Gene

miRTarBase miRNAs that target TMEM257

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM257 Gene

Localization for TMEM257 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM257 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM257 gene
Compartment Confidence
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM257: view

Pathways & Interactions for TMEM257 Gene

SuperPathways for TMEM257 Gene

No Data Available

Interacting Proteins for TMEM257 Gene

Gene Ontology (GO) - Biological Process for TMEM257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM257: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM257 Gene

Drugs & Compounds for TMEM257 Gene

No Compound Related Data Available

Transcripts for TMEM257 Gene

mRNA/cDNA for TMEM257 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM257 Gene

Transmembrane protein 257:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM257 Gene

No ASD Table

Relevant External Links for TMEM257 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM257 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM257 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM257 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x6.1), Brain - Nucleus accumbens (basal ganglia) (x5.9), Brain - Putamen (basal ganglia) (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Cortex (x4.8), and Brain - Frontal Cortex (BA9) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of TMEM257 Gene:


SOURCE GeneReport for Unigene cluster for TMEM257 Gene:


mRNA Expression by UniProt/SwissProt for TMEM257 Gene:

Tissue specificity: Brain. In the hippocampus it is mainly localized in the granular-cell layer of the dentate gyrus and in the CA2-CA3 subfields of Ammons horn.

Evidence on tissue expression from TISSUES for TMEM257 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TMEM257: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM257 Gene

Orthologs for TMEM257 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM257 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM257 34 35
  • 99.7 (n)
(Bos Taurus)
Mammalia TMEM257 34
  • 84.42 (n)
(Canis familiaris)
Mammalia TMEM257 34
  • 80.19 (n)
Species where no ortholog for TMEM257 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM257 Gene

Gene Tree for TMEM257 (if available)
Gene Tree for TMEM257 (if available)

Paralogs for TMEM257 Gene

No data available for Paralogs for TMEM257 Gene

Variants for TMEM257 Gene

Sequence variations from dbSNP and Humsavar for TMEM257 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1002869356 -- 145,826,960(+) GTGTG(C/T)ATATA upstream-variant-2KB, utr-variant-3-prime
rs1005332798 -- 145,825,466(+) GTTAC(C/T)GAGTA upstream-variant-2KB, utr-variant-3-prime
rs1005629705 -- 145,825,902(+) ACATG(G/T)TGAGT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1006216314 -- 145,828,376(+) CATTT(A/T)GATTC utr-variant-3-prime
rs1006338948 -- 145,827,729(+) TTGAA(A/C)CTTTA reference, missense, utr-variant-3-prime

Variation tolerance for TMEM257 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM257 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM257 Gene

Disorders for TMEM257 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM257 Gene - From: DISEASES

Disorder Aliases PubMed IDs
reading disorder
  • dyslexia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM257

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM257: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM257 Gene

Publications for TMEM257 Gene

  1. Identification of CXorf1, a novel intronless gene in Xq27.3 expressed in human hippocampus. (PMID: 9881668) Redolfi E. … Zucchi I. (DNA Cell Biol. 1998) 2 3 4 22 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM257 Gene

Sources for TMEM257 Gene

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