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Aliases for TMEM257 Gene

Aliases for TMEM257 Gene

  • Transmembrane Protein 257 2 3
  • CXorf1 3 4 6
  • Chromosome X Open Reading Frame 1 2

External Ids for TMEM257 Gene

Previous HGNC Symbols for TMEM257 Gene

  • CXorf1

Previous GeneCards Identifiers for TMEM257 Gene

  • GC0XP144909

Summaries for TMEM257 Gene

Entrez Gene Summary for TMEM257 Gene

  • This intronless gene is expressed in the hippocampus and maps close to a candidate region for several X-linked mental retardation (XLMR) syndromes. It is conserved in primates, cow, and horse, but not found in mouse and rat. The exact function of this gene is not known, but on the basis of its physical location and expression pattern, it is proposed to have an important function in the brain. [provided by RefSeq, Jan 2010]

GeneCards Summary for TMEM257 Gene

TMEM257 (Transmembrane Protein 257) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM257 Gene

Genomics for TMEM257 Gene

Genomic Location for TMEM257 Gene

145,827,410 bp from pter
145,829,856 bp from pter
2,447 bases
Plus strand

Genomic View for TMEM257 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM257 Gene

No data available for Regulatory Elements for TMEM257 Gene

Proteins for TMEM257 Gene

  • Protein details for TMEM257 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 257
    Protein Accession:
    Secondary Accessions:
    • Q14CW0

    Protein attributes for TMEM257 Gene

    111 amino acids
    Molecular mass:
    13452 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM257 Gene

Proteomics data for TMEM257 Gene at MOPED

Post-translational modifications for TMEM257 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM257 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM257 Gene

Domains for TMEM257 Gene

Protein Domains for TMEM257 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM257: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM257 Gene

Function for TMEM257 Gene

Gene Ontology (GO) - Molecular Function for TMEM257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM257: view

Animal Model Products

CRISPR Products

miRNA for TMEM257 Gene

miRTarBase miRNAs that target TMEM257

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM257

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM257 Gene

Localization for TMEM257 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM257 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM257: view

No data available for Subcellular locations from COMPARTMENTS for TMEM257 Gene

Pathways for TMEM257 Gene

SuperPathways for TMEM257 Gene

No Data Available

Interacting Proteins for TMEM257 Gene

Gene Ontology (GO) - Biological Process for TMEM257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM257: view

No data available for Pathways by source for TMEM257 Gene

Transcripts for TMEM257 Gene

mRNA/cDNA for TMEM257 Gene

(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM257 Gene

Transmembrane protein 257:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM257

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM257 Gene

No ASD Table

Relevant External Links for TMEM257 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM257 Gene

mRNA expression in normal human tissues for TMEM257 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM257 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (6.1), Brain - Nucleus accumbens (basal ganglia) (5.9), Brain - Putamen (basal ganglia) (5.6), Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Cortex (4.8), and Brain - Frontal Cortex (BA9) (4.6).

SOURCE GeneReport for Unigene cluster for TMEM257 Gene Hs.106688

mRNA Expression by UniProt/SwissProt for TMEM257 Gene

Tissue specificity: Brain. In the hippocampus it is mainly localized in the granular-cell layer of the dentate gyrus and in the CA2-CA3 subfields of Ammons horn.
genes like me logo Genes that share expressions with TMEM257: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for TMEM257 Gene

Orthologs for TMEM257 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM257 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM257 35
  • 84.42 (n)
  • 70.75 (a)
(Canis familiaris)
Mammalia TMEM257 35
  • 80.19 (n)
  • 67.92 (a)
(Pan troglodytes)
Mammalia TMEM257 35
  • 99.7 (n)
  • 99.1 (a)
TMEM257 36
  • 99 (a)
Species with no ortholog for TMEM257:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM257 Gene

Gene Tree for TMEM257 (if available)
Gene Tree for TMEM257 (if available)

Paralogs for TMEM257 Gene

No data available for Paralogs for TMEM257 Gene

Variants for TMEM257 Gene

Sequence variations from dbSNP and Humsavar for TMEM257 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2474402 -- 145,829,418(+) GTTTG(C/T)TGGTG utr-variant-3-prime
rs2748590 -- 145,828,595(+) CACCC(C/G)CTACT utr-variant-3-prime
rs3048401 -- 145,830,001(+) AACAA(-/TGAA)CACTT downstream-variant-500B
rs3752359 - 145,827,783(+) TAGCA(G/T)CCCCA missense, reference
rs4306044 -- 145,830,322(+) CACCA(A/G)AGCCA downstream-variant-500B

Relevant External Links for TMEM257 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM257 Gene

Disorders for TMEM257 Gene

No disorders were found for TMEM257 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM257 Gene

Publications for TMEM257 Gene

  1. Identification of CXorf1, a novel intronless gene in Xq27.3 expressed in human hippocampus. (PMID: 9881668) Redolfi E. … Zucchi I. (DNA Cell Biol. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 3

Products for TMEM257 Gene

Sources for TMEM257 Gene

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