Subcategory (RNA class) for TMEM256-PLSCR3 Gene
Quality Score for this RNA gene is
Aliases for TMEM256-PLSCR3 Gene
External Ids for TMEM256-PLSCR3 Gene
Previous GeneCards Identifiers for TMEM256-PLSCR3 Gene
This locus represents naturally occurring read-through transcription between the neighboring chromosome 17 open reading frame 61 (C17orf61) and phospholipid scramblase 3 (PLSCR3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jan 2011]
GeneCards Summary for TMEM256-PLSCR3 Gene
TMEM256-PLSCR3 (TMEM256-PLSCR3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is PLSCR1.
UniProtKB/Swiss-Prot for TMEM256-PLSCR3 Gene
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.