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Aliases for TMEM256-PLSCR3 Gene

Subcategory (RNA class) for TMEM256-PLSCR3 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for TMEM256-PLSCR3 Gene

  • TMEM256-PLSCR3 Readthrough (NMD Candidate) 2 3 5
  • Ca(2+)-Dependent Phospholipid Scramblase 3 4
  • PL Scramblase 3 4
  • C17orf61-PLSCR3 3
  • PLSCR3 4

External Ids for TMEM256-PLSCR3 Gene

Previous GeneCards Identifiers for TMEM256-PLSCR3 Gene

  • GC17M007296

Summaries for TMEM256-PLSCR3 Gene

Entrez Gene Summary for TMEM256-PLSCR3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring chromosome 17 open reading frame 61 (C17orf61) and phospholipid scramblase 3 (PLSCR3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jan 2011]

GeneCards Summary for TMEM256-PLSCR3 Gene

TMEM256-PLSCR3 (TMEM256-PLSCR3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is PLSCR1.

UniProtKB/Swiss-Prot for TMEM256-PLSCR3 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM256-PLSCR3 Gene

Genomics for TMEM256-PLSCR3 Gene

Regulatory Elements for TMEM256-PLSCR3 Gene

Enhancers for TMEM256-PLSCR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007474 1.6 FANTOM5 ENCODE 11 -76.5 -76459 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F007465 1 Ensembl ENCODE 11.1 -62.9 -62897 2.2 HDAC1 ESRRA ZNF175 BCL11B YY1 HIC1 NCOR1 POLR2A RCOR1 NR2F6 CHRNB1 FGF11 TMEM102 C17orf74 SPEM1 TNFSF12 TNFSF12-TNFSF13 NLGN2 TMEM256 TMEM256-PLSCR3
GH17F007454 1 ENCODE 10.8 -51.9 -51850 2.0 HDGF ATF1 PKNOX1 CREB3L1 ZNF493 ZFP64 SIN3A FEZF1 ETS1 YY1 DVL2 PFAS CNTROB CTC1 LOC105371523 CHRNB1 NLGN2 SNORA48 SNORD10 NEURL4
GH17F007380 0.8 ENCODE 11.7 +23.0 22960 1.4 ELF3 TBP DRAP1 KLF1 SAP130 TAF1 ARID4B TEAD3 ZBTB48 POLR2A CHRNB1 TMEM95 KCTD11 NLGN2 TMEM256 TMEM256-PLSCR3 SPEM1 C17orf74 ACAP1 ENSG00000224647
GH17F007471 0.7 Ensembl 11 -68.0 -67970 0.6 ZNF202 ZFP64 ZBTB11 ZNF140 ZNF266 ZBTB8A ZNF623 ZNF518A ZNF781 ZNF101 PFAS LOC105371523 DVL2 CNTROB CHRNB1 CTC1 NLGN2 SNORD10 SNORA48 CYB5D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM256-PLSCR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM256-PLSCR3 Gene

Chromosome:
17
Start:
7,389,727 bp from pter
End:
7,404,131 bp from pter
Size:
14,405 bases
Orientation:
Minus strand

Genomic View for TMEM256-PLSCR3 Gene

Genes around TMEM256-PLSCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM256-PLSCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM256-PLSCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM256-PLSCR3 Gene

Proteins for TMEM256-PLSCR3 Gene

  • Protein details for TMEM256-PLSCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY6-PLS3_HUMAN
    Recommended name:
    Phospholipid scramblase 3
    Protein Accession:
    Q9NRY6
    Secondary Accessions:
    • A8K252
    • Q567U0
    • Q8NBW6
    • Q96F13

    Protein attributes for TMEM256-PLSCR3 Gene

    Size:
    295 amino acids
    Molecular mass:
    31648 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PDCD6 in a calcium-dependent manner.
    • Interacts with PDCD6 in a calcium-dependent manner.

neXtProt entry for TMEM256-PLSCR3 Gene

Protein Expression for TMEM256-PLSCR3 Gene

Post-translational modifications for TMEM256-PLSCR3 Gene

  • Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM256-PLSCR3 Gene

Domains & Families for TMEM256-PLSCR3 Gene

Protein Domains for TMEM256-PLSCR3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRY6

UniProtKB/Swiss-Prot:

PLS3_HUMAN :
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
  • Belongs to the phospholipid scramblase family.
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with TMEM256-PLSCR3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM256-PLSCR3 Gene

Function for TMEM256-PLSCR3 Gene

Molecular function for TMEM256-PLSCR3 Gene

UniProtKB/Swiss-Prot Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

Gene Ontology (GO) - Molecular Function for TMEM256-PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0017124 SH3 domain binding IEA --
GO:0017128 phospholipid scramblase activity NAS --
GO:0048306 calcium-dependent protein binding IPI --
genes like me logo Genes that share ontologies with TMEM256-PLSCR3: view

Phenotypes for TMEM256-PLSCR3 Gene

genes like me logo Genes that share phenotypes with TMEM256-PLSCR3: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM256-PLSCR3 Gene

Localization for TMEM256-PLSCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM256-PLSCR3 Gene

Mitochondrion membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM256-PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane NAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with TMEM256-PLSCR3: view

No data available for Subcellular locations from COMPARTMENTS for TMEM256-PLSCR3 Gene

Pathways & Interactions for TMEM256-PLSCR3 Gene

SuperPathways for TMEM256-PLSCR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM256-PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0017121 phospholipid scrambling NAS --
GO:0042593 glucose homeostasis IEA --
GO:0042632 cholesterol homeostasis IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with TMEM256-PLSCR3: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM256-PLSCR3 Gene

Transcripts for TMEM256-PLSCR3 Gene

mRNA/cDNA for TMEM256-PLSCR3 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM256-PLSCR3 Gene

No ASD Table

Relevant External Links for TMEM256-PLSCR3 Gene

GeneLoc Exon Structure for
TMEM256-PLSCR3
ECgene alternative splicing isoforms for
TMEM256-PLSCR3

Expression for TMEM256-PLSCR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM256-PLSCR3 Gene

Protein differential expression in normal tissues from HIPED for TMEM256-PLSCR3 Gene

This gene is overexpressed in Bone (13.8) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM256-PLSCR3 Gene



Protein tissue co-expression partners for TMEM256-PLSCR3 Gene

mRNA Expression by UniProt/SwissProt for TMEM256-PLSCR3 Gene:

Q9NRY6-PLS3_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver.
genes like me logo Genes that share expression patterns with TMEM256-PLSCR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM256-PLSCR3 Gene

Orthologs for TMEM256-PLSCR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM256-PLSCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM256-PLSCR3 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plscr3 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLSCR3 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM256-PLSCR3 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM256-PLSCR3 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM256-PLSCR3 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM256-PLSCR3 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plscr3a 35
  • 48 (a)
OneToMany
plscr3b 35
  • 45 (a)
OneToMany
CR848032.2 35
  • 23 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scramb2 35
  • 40 (a)
ManyToMany
scramb1 35
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea scrm-3 35
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2436 35
  • 53 (a)
OneToMany
Species where no ortholog for TMEM256-PLSCR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM256-PLSCR3 Gene

ENSEMBL:
Gene Tree for TMEM256-PLSCR3 (if available)
TreeFam:
Gene Tree for TMEM256-PLSCR3 (if available)

Paralogs for TMEM256-PLSCR3 Gene

Paralogs for TMEM256-PLSCR3 Gene

(4) SIMAP similar genes for TMEM256-PLSCR3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM256-PLSCR3: view

Variants for TMEM256-PLSCR3 Gene

Sequence variations from dbSNP and Humsavar for TMEM256-PLSCR3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1113978 -- 7,390,919(-) CATTA(A/G)AGGGG intron-variant
rs111420183 -- 7,405,483(+) GGGTG(A/G)GGCGC upstream-variant-2KB
rs111545310 -- 7,396,775(+) TGTTT(A/G)TTGAG intron-variant, upstream-variant-2KB
rs112006080 -- 7,402,673(+) CTCAA(-/AAT)AATAA intron-variant
rs112043618 -- 7,397,620(+) GTGCA(A/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM256-PLSCR3 Gene

Variant ID Type Subtype PubMed ID
nsv952118 CNV deletion 24416366
nsv574322 CNV loss 21841781
nsv523672 CNV loss 19592680
nsv470575 CNV loss 18288195
nsv457659 CNV loss 19166990
nsv1116185 CNV deletion 24896259
esv2662967 CNV deletion 23128226
esv2422288 CNV deletion 17116639
esv1007381 CNV deletion 20482838

Variation tolerance for TMEM256-PLSCR3 Gene

Gene Damage Index Score: 0.66; 14.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM256-PLSCR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM256-PLSCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM256-PLSCR3 Gene

Disorders for TMEM256-PLSCR3 Gene

Relevant External Links for TMEM256-PLSCR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM256-PLSCR3

No disorders were found for TMEM256-PLSCR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM256-PLSCR3 Gene

Publications for TMEM256-PLSCR3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  3. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H. … Maki M. (J. Biol. Chem. 2008) 4 64
  4. Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid. (PMID: 17226776) He Y. … Lee R.M. (J. Cell. Biochem. 2007) 4 64
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for TMEM256-PLSCR3 Gene

Sources for TMEM256-PLSCR3 Gene

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