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Aliases for TMEM256-PLSCR3 Gene

Subcategory (RNA class) for TMEM256-PLSCR3 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for TMEM256-PLSCR3 Gene

  • TMEM256-PLSCR3 Readthrough (NMD Candidate) 2 3
  • Ca(2+)-Dependent Phospholipid Scramblase 3 4
  • PL Scramblase 3 4
  • C17orf61-PLSCR3 3
  • PLSCR3 4

External Ids for TMEM256-PLSCR3 Gene

Previous GeneCards Identifiers for TMEM256-PLSCR3 Gene

  • GC17M007296

Summaries for TMEM256-PLSCR3 Gene

Entrez Gene Summary for TMEM256-PLSCR3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring chromosome 17 open reading frame 61 (C17orf61) and phospholipid scramblase 3 (PLSCR3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jan 2011]

GeneCards Summary for TMEM256-PLSCR3 Gene

TMEM256-PLSCR3 (TMEM256-PLSCR3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. An important paralog of this gene is PLSCR4.

UniProtKB/Swiss-Prot for TMEM256-PLSCR3 Gene

  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM256-PLSCR3 Gene

Genomics for TMEM256-PLSCR3 Gene

Genomic Location for TMEM256-PLSCR3 Gene

Start:
7,389,727 bp from pter
End:
7,404,131 bp from pter
Size:
14,405 bases
Orientation:
Minus strand

Genomic View for TMEM256-PLSCR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM256-PLSCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM256-PLSCR3 Gene

No data available for Regulatory Elements for TMEM256-PLSCR3 Gene

Proteins for TMEM256-PLSCR3 Gene

  • Protein details for TMEM256-PLSCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY6-PLS3_HUMAN
    Recommended name:
    Phospholipid scramblase 3
    Protein Accession:
    Q9NRY6
    Secondary Accessions:
    • A8K252
    • Q567U0
    • Q8NBW6
    • Q96F13

    Protein attributes for TMEM256-PLSCR3 Gene

    Size:
    295 amino acids
    Molecular mass:
    31648 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with PDCD6 in a calcium-dependent manner.

neXtProt entry for TMEM256-PLSCR3 Gene

Proteomics data for TMEM256-PLSCR3 Gene at MOPED

Protein Expression for TMEM256-PLSCR3 Gene

Post-translational modifications for TMEM256-PLSCR3 Gene

  • Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM256-PLSCR3 Gene

Domains for TMEM256-PLSCR3 Gene

Protein Domains for TMEM256-PLSCR3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRY6

UniProtKB/Swiss-Prot:

PLS3_HUMAN :
  • Q9NRY6
Domain:
  • The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Family:
  • Belongs to the phospholipid scramblase family.
genes like me logo Genes that share domains with TMEM256-PLSCR3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM256-PLSCR3 Gene

Function for TMEM256-PLSCR3 Gene

Molecular function for TMEM256-PLSCR3 Gene

UniProtKB/Swiss-Prot Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

Gene Ontology (GO) - Molecular Function for TMEM256-PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
GO:0017124 SH3 domain binding --
GO:0017128 phospholipid scramblase activity --
GO:0048306 calcium-dependent protein binding --
genes like me logo Genes that share ontologies with TMEM256-PLSCR3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM256-PLSCR3 Gene

Localization for TMEM256-PLSCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM256-PLSCR3 Gene

Mitochondrion membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM256-PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005886 plasma membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TMEM256-PLSCR3: view

No data available for Subcellular locations from COMPARTMENTS for TMEM256-PLSCR3 Gene

Pathways for TMEM256-PLSCR3 Gene

SuperPathways for TMEM256-PLSCR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM256-PLSCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0017121 phospholipid scrambling --
GO:0042593 glucose homeostasis --
GO:0042632 cholesterol homeostasis --
GO:0071222 cellular response to lipopolysaccharide --
genes like me logo Genes that share ontologies with TMEM256-PLSCR3: view

No data available for Pathways by source for TMEM256-PLSCR3 Gene

Transcripts for TMEM256-PLSCR3 Gene

mRNA/cDNA for TMEM256-PLSCR3 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM256-PLSCR3 Gene

No ASD Table

Relevant External Links for TMEM256-PLSCR3 Gene

GeneLoc Exon Structure for
TMEM256-PLSCR3
ECgene alternative splicing isoforms for
TMEM256-PLSCR3

Expression for TMEM256-PLSCR3 Gene

mRNA expression in normal human tissues for TMEM256-PLSCR3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM256-PLSCR3 Gene

mRNA Expression by UniProt/SwissProt for TMEM256-PLSCR3 Gene

Q9NRY6-PLS3_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver
genes like me logo Genes that share expressions with TMEM256-PLSCR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM256-PLSCR3 Gene

Orthologs for TMEM256-PLSCR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM256-PLSCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM256-PLSCR3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLSCR3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM256-PLSCR3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plscr3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM256-PLSCR3 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM256-PLSCR3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM256-PLSCR3 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR848032.2 36
  • 23 (a)
OneToMany
plscr3a 36
  • 48 (a)
OneToMany
plscr3b 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scramb1 36
  • 32 (a)
ManyToMany
scramb2 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea scrm-3 36
  • 34 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2436 36
  • 53 (a)
OneToMany
Species with no ortholog for TMEM256-PLSCR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM256-PLSCR3 Gene

ENSEMBL:
Gene Tree for TMEM256-PLSCR3 (if available)
TreeFam:
Gene Tree for TMEM256-PLSCR3 (if available)

Paralogs for TMEM256-PLSCR3 Gene

Paralogs for TMEM256-PLSCR3 Gene

Selected SIMAP similar genes for TMEM256-PLSCR3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM256-PLSCR3: view

Variants for TMEM256-PLSCR3 Gene

Sequence variations from dbSNP and Humsavar for TMEM256-PLSCR3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8071437 -- 7,400,226(+) cagga(A/G)aattg intron-variant
rs8075788 -- 7,401,074(+) acagg(C/T)gtgag intron-variant
rs8077761 -- 7,398,275(+) ctgta(A/G)tccca intron-variant
rs9901523 -- 7,397,874(+) gagct(C/G)tagct intron-variant
rs9903883 -- 7,402,027(+) GCCTT(C/G)CCTTA intron-variant

Relevant External Links for TMEM256-PLSCR3 Gene

HapMap Linkage Disequilibrium report
TMEM256-PLSCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM256-PLSCR3 Gene

Disorders for TMEM256-PLSCR3 Gene

No disorders were found for TMEM256-PLSCR3 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM256-PLSCR3 Gene

Publications for TMEM256-PLSCR3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  3. Identification of three new members of the phospholipid scramblase gene family. (PMID: 10930526) Wiedmer T. … Sims P.J. (Biochim. Biophys. Acta 2000) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for TMEM256-PLSCR3 Gene

Sources for TMEM256-PLSCR3 Gene

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