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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM256 Gene

protein-coding   GIFtS: 32
GCID: GC17M007307

Transmembrane Protein 256

(Previous name: chromosome 17 open reading frame 61)
(Previous symbol: C17orf61)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2561 2
C17orf611 2 3
Chromosome 17 Open Reading Frame 611
UPF0451 Protein C17orf612

External Ids:    HGNC: 286181   Entrez Gene: 2548632   Ensembl: ENSG000002055447   UniProtKB: Q8N2U03   

Export aliases for TMEM256 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM256 Gene: 
TMEM256 (transmembrane protein 256) is a protein-coding gene. Diseases associated with TMEM256 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. An important paralog of this gene is ENSG00000262481.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM256
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM256

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM256


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TMEM256 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM256 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007307:  view genomic region     (about GC identifiers)

Start:
7,306,293 bp from pter      End:
7,307,456 bp from pter
Size:
1,164 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM256_HUMAN, Q8N2U0 (See protein sequence)
Recommended Name: Transmembrane protein 256 precursor  
Size: 113 amino acids; 11742 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for TMEM256: NX_Q8N2U0

Explore proteomics data for TMEM256 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N2U0

  • TMEM256 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM256 Protein Expression
    REFSEQ proteins: NP_689979.1  
    ENSEMBL proteins: 
     ENSP00000301939   ENSP00000468314  

    Human Recombinant Protein Products for TMEM256: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM256 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006696 DUF423

    Graphical View of Domain Structure for InterPro Entry Q8N2U0

    ProtoNet protein and cluster: Q8N2U0

    1 Blocks protein domain: IPB006696 Protein of unknown function DUF423

    UniProtKB/Swiss-Prot: TM256_HUMAN, Q8N2U0
    Similarity: Belongs to the TMEM256 family


    TMEM256 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM256 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM256

    4 Interacting proteins for TMEM256 (Q8N2U03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM203AQ9BTY73I2D: score=3 
    GET4Q7L5D63I2D: score=3 
    FAM45AQ8TCE63I2D: score=1 
    --Q96BK83I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM256 (TM256)

    Search CenterWatch for drugs/clinical trials and news about TMEM256 / TM256

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM256 gene: 
    NM_152766.3  

    Unigene Cluster for TMEM256:

    Transmembrane protein 256
    Hs.730789  [show with all ESTs]
    Unigene Representative Sequence: BG035464
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302422(uc002ggs.3) ENST00000575427 ENST00000576017
    miRNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM256
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM256

    Additional mRNA sequence: BC030270.2 

    10 DOTS entries:

    DT.100022868  DT.100045904  DT.95146663  DT.95320862  DT.109741  DT.95158823  DT.75145079  DT.120936155 
    DT.120936184  DT.311656 

    24/267 AceView cDNA sequences (see all 267):

    BE349577 BP350568 BM672180 CA413589 BF589809 NM_152766 BM685125 AI866899 
    BP351210 AI469898 BU153222 BG122341 AI015659 CR597400 BM700810 BM509910 
    AA641443 BE792564 AF159442 NM_020360 AA634048 BQ069307 CR622721 AI222560 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See TMEM256 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM256

    SOURCE GeneReport for Unigene cluster: Hs.730789
        SABiosciences Custom PCR Arrays for TMEM256
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM256

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM256 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2565
    1810027O10Rik1
    RIKEN cDNA 1810027O10 gene1, 5 87.8(n)1
    90.18(a)1
      11 (42.89 cM)5
    691861  NM_026982.11  NP_081258.11 
     698385145 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1102561 zgc:110256 59.02(n)
    52.29(a)
      550283  NM_001017620.1  NP_001017620.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423951 CG42395 48.67(n)
    37.17(a)
      7354436  NM_001144710.1  NP_001138182.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y106G6H.81 Protein Y106G6H.8 46.47(n)
    39.42(a)
      190926  NM_060332.3  NP_492733.2 


    ENSEMBL Gene Tree for TMEM256 (if available)
    TreeFam Gene Tree for TMEM256 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM256 gene
    ENSG000002624812  

    TMEM256 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMEM256
    PGOHUM00000238517 PGOHUM00000241116


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM256
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM256

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for TMEM256:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    gastric cancer


    TMEM256 for disorders           About GeneDecksing


    Export disorders for TMEM256 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM256 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM256)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. Identification of VKORC1 interaction partners by spli t-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 254863 HGNC: 28618 AceView: PLSCR3andMGC40107 Ensembl:ENSG00000205544 euGenes: HUgn254863
    ECgene: TMEM256 H-InvDB: TMEM256

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM256 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM256 gene:
    Search GeneIP for patents involving TMEM256

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse SwitchGear Promoter luciferase reporter plasmids for TMEM256
     Search ThermoFisher Antibodies for TMEM256
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM256
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM256
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM256
    Customized:
     lentivirus for stable overexpression of TMEM256
     lentivirus expression plasmids for stable overexpression of TMEM256
     adenovirus for overexpression of TMEM256
     Search LSBio for Antibodies for TMEM256
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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