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Aliases for TMEM256 Gene

Aliases for TMEM256 Gene

  • Transmembrane Protein 256 2 3 5
  • C17orf61 3 4
  • Chromosome 17 Open Reading Frame 61 2
  • UPF0451 Protein C17orf61 3

External Ids for TMEM256 Gene

Previous HGNC Symbols for TMEM256 Gene

  • C17orf61

Previous GeneCards Identifiers for TMEM256 Gene

  • GC17M007307

Summaries for TMEM256 Gene

GeneCards Summary for TMEM256 Gene

TMEM256 (Transmembrane Protein 256) is a Protein Coding gene. Diseases associated with TMEM256 include Meckel Syndrome 1. An important paralog of this gene is ENSG00000262481.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM256 Gene

Genomics for TMEM256 Gene

Regulatory Elements for TMEM256 Gene

Enhancers for TMEM256 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007474 1.6 FANTOM5 ENCODE 11 -76.5 -76453 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F007465 1 Ensembl ENCODE 11.1 -62.9 -62891 2.2 HDAC1 ESRRA ZNF175 BCL11B YY1 HIC1 NCOR1 POLR2A RCOR1 NR2F6 CHRNB1 FGF11 TMEM102 C17orf74 SPEM1 TNFSF12 TNFSF12-TNFSF13 NLGN2 TMEM256 TMEM256-PLSCR3
GH17F007454 1 ENCODE 10.8 -51.8 -51844 2.0 HDGF ATF1 PKNOX1 CREB3L1 ZNF493 ZFP64 SIN3A FEZF1 ETS1 YY1 DVL2 PFAS CNTROB CTC1 LOC105371523 CHRNB1 NLGN2 SNORA48 SNORD10 NEURL4
GH17F007380 0.8 ENCODE 11.7 +23.0 22966 1.4 ELF3 TBP DRAP1 KLF1 SAP130 TAF1 ARID4B TEAD3 ZBTB48 POLR2A CHRNB1 TMEM95 KCTD11 NLGN2 TMEM256 TMEM256-PLSCR3 SPEM1 C17orf74 ACAP1 ENSG00000224647
GH17F007401 1.1 ENCODE 7.4 +0.0 12 4.8 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 DVL2 ENSG00000262067 ENSG00000271029 SPEM1 ENSG00000262089 SNORD10 C17orf74 CNTROB CHRNB1 ACAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM256 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM256 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340190 -863 3200 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TMEM256 Gene

Chromosome:
17
Start:
7,402,974 bp from pter
End:
7,404,137 bp from pter
Size:
1,164 bases
Orientation:
Minus strand

Genomic View for TMEM256 Gene

Genes around TMEM256 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM256 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM256 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM256 Gene

Proteins for TMEM256 Gene

  • Protein details for TMEM256 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2U0-TM256_HUMAN
    Recommended name:
    Transmembrane protein 256
    Protein Accession:
    Q8N2U0

    Protein attributes for TMEM256 Gene

    Size:
    113 amino acids
    Molecular mass:
    11742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM256 Gene

Post-translational modifications for TMEM256 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM256 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM256 Gene

Domains & Families for TMEM256 Gene

Protein Domains for TMEM256 Gene

Suggested Antigen Peptide Sequences for TMEM256 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2U0

UniProtKB/Swiss-Prot:

TM256_HUMAN :
  • Belongs to the TMEM256 family.
Family:
  • Belongs to the TMEM256 family.
genes like me logo Genes that share domains with TMEM256: view

No data available for Gene Families for TMEM256 Gene

Function for TMEM256 Gene

Gene Ontology (GO) - Molecular Function for TMEM256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM256: view

Phenotypes for TMEM256 Gene

genes like me logo Genes that share phenotypes with TMEM256: view

Animal Models for TMEM256 Gene

MGI Knock Outs for TMEM256:

Animal Model Products

miRNA for TMEM256 Gene

miRTarBase miRNAs that target TMEM256

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM256 Gene

Localization for TMEM256 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM256 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM256 gene
Compartment Confidence
extracellular 5
mitochondrion 2
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMEM256: view

Pathways & Interactions for TMEM256 Gene

SuperPathways for TMEM256 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM256: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM256 Gene

Transcripts for TMEM256 Gene

mRNA/cDNA for TMEM256 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(267) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM256 Gene

Transmembrane protein 256:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM256 Gene

No ASD Table

Relevant External Links for TMEM256 Gene

GeneLoc Exon Structure for
TMEM256
ECgene alternative splicing isoforms for
TMEM256

Expression for TMEM256 Gene

Protein differential expression in normal tissues from HIPED for TMEM256 Gene

This gene is overexpressed in Urine (37.9) and Nasal epithelium (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM256 Gene



Protein tissue co-expression partners for TMEM256 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM256 Gene:

TMEM256

SOURCE GeneReport for Unigene cluster for TMEM256 Gene:

Hs.730789

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM256 Gene

Orthologs for TMEM256 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM256 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM256 34
  • 99.41 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
TMEM256 34
  • 89.68 (n)
cow
(Bos Taurus)
Mammalia TMEM256 34 35
  • 89.56 (n)
mouse
(Mus musculus)
Mammalia Tmem256 34 16 35
  • 87.07 (n)
rat
(Rattus norvegicus)
Mammalia Tmem256 34
  • 87.07 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem256 34 35
  • 57.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42395 35
  • 23 (a)
ManyToMany
CG4686 35
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y106G6H.8 35
  • 26 (a)
OneToMany
Species where no ortholog for TMEM256 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM256 Gene

ENSEMBL:
Gene Tree for TMEM256 (if available)
TreeFam:
Gene Tree for TMEM256 (if available)

Paralogs for TMEM256 Gene

Paralogs for TMEM256 Gene

Pseudogenes.org Pseudogenes for TMEM256 Gene

genes like me logo Genes that share paralogs with TMEM256: view

Variants for TMEM256 Gene

Sequence variations from dbSNP and Humsavar for TMEM256 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111420183 -- 7,405,483(+) GGGTG(A/G)GGCGC upstream-variant-2KB
rs112006080 -- 7,402,673(+) CTCAA(-/AAT)AATAA intron-variant
rs112166972 -- 7,403,850(+) ACCAA(C/T)TGGAC intron-variant, upstream-variant-2KB
rs112244220 -- 7,403,230(+) CACAG(A/T)AAACA intron-variant
rs112572804 -- 7,405,051(+) CCCCC(A/G)CCCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM256 Gene

Variant ID Type Subtype PubMed ID
nsv952118 CNV deletion 24416366
nsv574322 CNV loss 21841781
nsv523672 CNV loss 19592680
nsv470575 CNV loss 18288195
nsv457659 CNV loss 19166990
esv2662967 CNV deletion 23128226
esv2422288 CNV deletion 17116639
esv1007381 CNV deletion 20482838

Variation tolerance for TMEM256 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM256 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM256

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM256 Gene

Disorders for TMEM256 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM256 Gene - From: DISEASES

Disorder Aliases PubMed IDs
meckel syndrome 1
  • meckel syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM256

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM256
genes like me logo Genes that share disorders with TMEM256: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM256 Gene

Publications for TMEM256 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3 64

Products for TMEM256 Gene

Sources for TMEM256 Gene

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