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Aliases for TMEM256 Gene

Aliases for TMEM256 Gene

  • Transmembrane Protein 256 2 3 5
  • C17orf61 3 4
  • Chromosome 17 Open Reading Frame 61 2
  • UPF0451 Protein C17orf61 3

External Ids for TMEM256 Gene

Previous HGNC Symbols for TMEM256 Gene

  • C17orf61

Previous GeneCards Identifiers for TMEM256 Gene

  • GC17M007307

Summaries for TMEM256 Gene

GeneCards Summary for TMEM256 Gene

TMEM256 (Transmembrane Protein 256) is a Protein Coding gene. An important paralog of this gene is ENSG00000262481.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM256 Gene

Genomics for TMEM256 Gene

Regulatory Elements for TMEM256 Gene

Promoters for TMEM256 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM256 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM256 Gene

7,402,974 bp from pter
7,404,137 bp from pter
1,164 bases
Minus strand

Genomic View for TMEM256 Gene

Genes around TMEM256 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM256 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM256 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM256 Gene

Proteins for TMEM256 Gene

  • Protein details for TMEM256 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 256
    Protein Accession:

    Protein attributes for TMEM256 Gene

    113 amino acids
    Molecular mass:
    11742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM256 Gene

Proteomics data for TMEM256 Gene at MOPED

Post-translational modifications for TMEM256 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM256 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM256 Gene

Domains & Families for TMEM256 Gene

Protein Domains for TMEM256 Gene


Suggested Antigen Peptide Sequences for TMEM256 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM256 family.
  • Belongs to the TMEM256 family.
genes like me logo Genes that share domains with TMEM256: view

No data available for Gene Families for TMEM256 Gene

Function for TMEM256 Gene

Phenotypes for TMEM256 Gene

genes like me logo Genes that share phenotypes with TMEM256: view

Animal Models for TMEM256 Gene

MGI Knock Outs for TMEM256:

Animal Model Products

CRISPR Products

miRNA for TMEM256 Gene

miRTarBase miRNAs that target TMEM256

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM256 Gene

Localization for TMEM256 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM256 Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TMEM256 Gene

Pathways & Interactions for TMEM256 Gene

SuperPathways for TMEM256 Gene

No Data Available

Interacting Proteins for TMEM256 Gene

Gene Ontology (GO) - Biological Process for TMEM256 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM256 Gene

Drugs & Compounds for TMEM256 Gene

No Compound Related Data Available

Transcripts for TMEM256 Gene

mRNA/cDNA for TMEM256 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(267) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM256 Gene

Transmembrane protein 256:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM256 Gene

No ASD Table

Relevant External Links for TMEM256 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM256 Gene

Protein differential expression in normal tissues from HIPED for TMEM256 Gene

This gene is overexpressed in Urine (37.9) and Nasal epithelium (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM256 Gene

SOURCE GeneReport for Unigene cluster for TMEM256 Gene Hs.730789

Protein tissue co-expression partners for TMEM256 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM256 Gene

Orthologs for TMEM256 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM256 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM256 35
  • 89.56 (n)
  • 89.9 (a)
TMEM256 36
  • 90 (a)
(Canis familiaris)
Mammalia TMEM256 35
  • 89.68 (n)
  • 91.15 (a)
-- 36
  • 91 (a)
(Mus musculus)
Mammalia Tmem256 35
  • 87.07 (n)
  • 91.84 (a)
Tmem256 16
Tmem256 36
  • 89 (a)
(Pan troglodytes)
Mammalia TMEM256 35
  • 99.41 (n)
  • 99.12 (a)
-- 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem256 35
  • 87.07 (n)
  • 89.8 (a)
(Danio rerio)
Actinopterygii tmem256 35
  • 57.45 (n)
  • 51.06 (a)
tmem256 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42395 36
  • 23 (a)
CG4686 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea Y106G6H.8 36
  • 26 (a)
Species with no ortholog for TMEM256:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM256 Gene

Gene Tree for TMEM256 (if available)
Gene Tree for TMEM256 (if available)

Paralogs for TMEM256 Gene

Paralogs for TMEM256 Gene Pseudogenes for TMEM256 Gene

genes like me logo Genes that share paralogs with TMEM256: view

Variants for TMEM256 Gene

Variation tolerance for TMEM256 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM256 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TMEM256 Gene

Disorders for TMEM256 Gene

Relevant External Links for TMEM256

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM256 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM256 Gene

Publications for TMEM256 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3

Products for TMEM256 Gene

Sources for TMEM256 Gene

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