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Aliases for TMEM255B Gene

Aliases for TMEM255B Gene

  • Transmembrane Protein 255B 2 3 5
  • Family With Sequence Similarity 70, Member B 2 3
  • Protein FAM70B 3 4
  • FAM70B 3 4

External Ids for TMEM255B Gene

Previous HGNC Symbols for TMEM255B Gene

  • FAM70B

Previous GeneCards Identifiers for TMEM255B Gene

  • GC13P114463

Summaries for TMEM255B Gene

GeneCards Summary for TMEM255B Gene

TMEM255B (Transmembrane Protein 255B) is a Protein Coding gene. An important paralog of this gene is TMEM255A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM255B Gene

Genomics for TMEM255B Gene

Regulatory Elements for TMEM255B Gene

Enhancers for TMEM255B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F113816 1.3 FANTOM5 ENCODE 49.9 +58.7 58744 2.8 KLF17 ZNF2 RAD21 GLIS2 ZNF366 ZNF263 ZNF654 CEBPB REST ZEB2 TMEM255B GAS6-AS1 ADPRHL1 LOC105370380 GAS6
GH13F113801 1.1 Ensembl ENCODE 46.7 +42.9 42899 1.7 CTCF GABPB1 NR3C1 RAD21 ZBTB20 GABPA TMEM255B TMCO3 GAS6-AS1
GH13F113758 0.9 FANTOM5 ENCODE 46.2 +0.5 470 2.6 INSM2 ZNF76 ZNF48 ZNF2 GLIS2 ZNF366 SCRT2 EGR2 ZNF280D SP3 TMEM255B UPF3A GAS6-AS1
GH13F113772 0.6 FANTOM5 45.7 +12.9 12938 0.2 GATA3 ATF3 JUN ZNF140 FOS TMEM255B CHAMP1 GAS6-AS1
GH13F113784 0.4 ENCODE 44.2 +25.8 25835 1.2 ZNF316 JUN MAFK TMEM255B GRK1 GAS6-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM255B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM255B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000521022 390 2001 INSM2 ZNF76 ZNF48 ZNF2 GLIS2 ZNF366 SCRT2 EGR2 ZNF280D SP3

Genomic Location for TMEM255B Gene

Chromosome:
13
Start:
113,759,210 bp from pter
End:
113,816,995 bp from pter
Size:
57,786 bases
Orientation:
Plus strand

Genomic View for TMEM255B Gene

Genes around TMEM255B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM255B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM255B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM255B Gene

Proteins for TMEM255B Gene

  • Protein details for TMEM255B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV15-T255B_HUMAN
    Recommended name:
    Transmembrane protein 255B
    Protein Accession:
    Q8WV15

    Protein attributes for TMEM255B Gene

    Size:
    326 amino acids
    Molecular mass:
    34609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM255B Gene

Post-translational modifications for TMEM255B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM255B Gene

No data available for DME Specific Peptides for TMEM255B Gene

Domains & Families for TMEM255B Gene

Protein Domains for TMEM255B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM255B Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV15

UniProtKB/Swiss-Prot:

T255B_HUMAN :
  • Belongs to the TMEM255 family.
Family:
  • Belongs to the TMEM255 family.
genes like me logo Genes that share domains with TMEM255B: view

No data available for Gene Families for TMEM255B Gene

Function for TMEM255B Gene

Phenotypes for TMEM255B Gene

genes like me logo Genes that share phenotypes with TMEM255B: view

Animal Models for TMEM255B Gene

MGI Knock Outs for TMEM255B:

Animal Model Products

miRNA for TMEM255B Gene

miRTarBase miRNAs that target TMEM255B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM255B Gene

Localization for TMEM255B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM255B Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM255B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM255B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM255B Gene

Pathways & Interactions for TMEM255B Gene

SuperPathways for TMEM255B Gene

No Data Available

Interacting Proteins for TMEM255B Gene

Selected Interacting proteins: Q8WV15-T255B_HUMAN for TMEM255B Gene via IID

Gene Ontology (GO) - Biological Process for TMEM255B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM255B Gene

Transcripts for TMEM255B Gene

Unigene Clusters for TMEM255B Gene

Transmembrane protein 255B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM255B Gene

No ASD Table

Relevant External Links for TMEM255B Gene

GeneLoc Exon Structure for
TMEM255B
ECgene alternative splicing isoforms for
TMEM255B

Expression for TMEM255B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM255B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM255B Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM255B Gene:

TMEM255B

SOURCE GeneReport for Unigene cluster for TMEM255B Gene:

Hs.280805
genes like me logo Genes that share expression patterns with TMEM255B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM255B Gene

Orthologs for TMEM255B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM255B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM70B 34
  • 98.92 (n)
mouse
(Mus musculus)
Mammalia Tmem255b 34 16 35
  • 77.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM255B 35
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM255B 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM255B 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM255B 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM70B 34
  • 67.82 (n)
TMEM255B 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM255B 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem255b 34
  • 63.81 (n)
zebrafish
(Danio rerio)
Actinopterygii TMEM255B 35
  • 38 (a)
OneToOne
Species where no ortholog for TMEM255B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM255B Gene

ENSEMBL:
Gene Tree for TMEM255B (if available)
TreeFam:
Gene Tree for TMEM255B (if available)

Paralogs for TMEM255B Gene

Paralogs for TMEM255B Gene

(1) SIMAP similar genes for TMEM255B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM255B: view

Variants for TMEM255B Gene

Sequence variations from dbSNP and Humsavar for TMEM255B Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10654445 -- 113,808,802(-) AGTAA(-/C/CC)CCCCC intron-variant
rs111068253 -- 113,774,733(-) GTGTC(A/G)TGTGT intron-variant
rs111164479 -- 113,796,287(-) GAGGC(A/G)TGTGC intron-variant
rs111173928 -- 113,795,996(-) GTGTG(C/G)TGTGT intron-variant
rs111173929 -- 113,795,987(-) GTGCT(C/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM255B Gene

Variant ID Type Subtype PubMed ID
dgv1045n106 CNV deletion 24896259
dgv1136e59 CNV duplication 20981092
dgv3450n54 CNV gain 21841781
dgv3451n54 CNV loss 21841781
dgv3452n54 CNV loss 21841781
dgv3453n54 CNV loss 21841781
dgv3454n54 CNV loss 21841781
dgv3455n54 CNV loss 21841781
dgv3456n54 CNV loss 21841781
dgv3457n54 CNV loss 21841781
dgv383e199 CNV deletion 23128226
esv1010112 CNV deletion 20482838
esv1010361 CNV insertion 20482838
esv1427020 CNV insertion 17803354
esv1553413 CNV deletion 17803354
esv1615276 CNV insertion 17803354
esv1683520 CNV insertion 17803354
esv24756 CNV gain+loss 19812545
esv2667518 CNV deletion 23128226
esv2741496 CNV deletion 23290073
esv2748366 CNV deletion 23290073
esv2748367 CNV deletion 23290073
esv2748368 CNV deletion 23290073
esv2748369 CNV deletion 23290073
esv2748370 CNV deletion 23290073
esv2748371 CNV deletion 23290073
esv2748372 CNV deletion 23290073
esv2748373 CNV deletion 23290073
esv2748374 CNV deletion 23290073
esv2748376 CNV deletion 23290073
esv2748377 CNV deletion 23290073
esv2748378 CNV deletion 23290073
esv2748379 CNV deletion 23290073
esv2748380 CNV deletion 23290073
esv2748381 CNV deletion 23290073
esv2748382 CNV deletion 23290073
esv2748383 CNV deletion 23290073
esv2748384 CNV deletion 23290073
esv2748385 CNV deletion 23290073
esv2748387 CNV deletion 23290073
esv2748388 CNV deletion 23290073
esv2748389 CNV deletion 23290073
esv2748390 CNV deletion 23290073
esv2748391 CNV deletion 23290073
esv28810 CNV gain+loss 19812545
esv3247052 CNV deletion 24192839
esv3551168 CNV deletion 23714750
esv3551170 CNV deletion 23714750
esv3582860 CNV gain 25503493
esv3633615 CNV gain 21293372
esv3633618 CNV gain 21293372
esv3633619 CNV gain 21293372
esv3633620 CNV loss 21293372
esv3633621 CNV loss 21293372
esv3633622 CNV gain 21293372
nsv1043348 CNV gain 25217958
nsv1112641 CNV deletion 24896259
nsv1119439 CNV insertion 24896259
nsv1127368 CNV deletion 24896259
nsv1145755 CNV insertion 26484159
nsv1148077 CNV deletion 26484159
nsv1148215 CNV deletion 26484159
nsv472041 CNV novel sequence insertion 20440878
nsv473373 CNV novel sequence insertion 20440878
nsv473411 CNV novel sequence insertion 20440878
nsv474005 CNV novel sequence insertion 20440878
nsv474092 CNV novel sequence insertion 20440878
nsv474739 CNV novel sequence insertion 20440878
nsv475949 CNV novel sequence insertion 20440878
nsv479168 CNV novel sequence insertion 20440878
nsv479170 CNV novel sequence insertion 20440878
nsv479303 CNV novel sequence insertion 20440878
nsv480702 CNV novel sequence insertion 20440878
nsv480977 CNV novel sequence insertion 20440878
nsv481630 CNV novel sequence insertion 20440878
nsv511528 CNV loss 21212237
nsv512344 CNV loss 21212237
nsv563388 CNV loss 21841781
nsv563390 CNV loss 21841781
nsv563396 CNV loss 21841781
nsv563397 CNV loss 21841781
nsv563406 CNV loss 21841781
nsv563427 CNV loss 21841781
nsv64170 CNV insertion 16902084
nsv64295 CNV insertion 16902084
nsv821397 CNV deletion 20802225
nsv826836 CNV loss 20364138
nsv826837 CNV loss 20364138
nsv826838 CNV loss 20364138
nsv832727 CNV loss 17160897
nsv951931 CNV deletion 24416366
nsv951932 CNV deletion 24416366
nsv951933 CNV deletion 24416366

Variation tolerance for TMEM255B Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM255B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM255B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM255B Gene

Disorders for TMEM255B Gene

Relevant External Links for TMEM255B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM255B

No disorders were found for TMEM255B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM255B Gene

Publications for TMEM255B Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64

Products for TMEM255B Gene

Sources for TMEM255B Gene

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