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TMEM255B Gene

protein-coding   GIFtS: 33
GCID: GC13P114463

Transmembrane Protein 255B

(Previous names: family with sequence similarity 70, member B)
(Previous symbol: FAM70B)
  Search for TMEM255B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 255B1 2
FAM70B1 2 3
Family With Sequence Similarity 70, Member B1 2
Protein FAM70B2 3

External Ids:    HGNC: 282971   Entrez Gene: 3480132   Ensembl: ENSG000001844977   UniProtKB: Q8WV153   

Export aliases for TMEM255B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM255B Gene:
TMEM255B (transmembrane protein 255B) is a protein-coding gene. An important paralog of this gene is TMEM255A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024498.13  NC_018924.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM255B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM255B promoter sequence
   Search Chromatin IP Primers for TMEM255B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM255B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

TMEM255B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM255B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P114463:  view genomic region     (about GC identifiers)

Start:
114,462,216 bp from pter      End:
114,514,926 bp from pter
Size:
52,711 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T255B_HUMAN, Q8WV15 (See protein sequence)
Recommended Name: Transmembrane protein 255B  
Size: 326 amino acids; 34609 Da

Explore the universe of human proteins at neXtProt for TMEM255B: NX_Q8WV15

Explore proteomics data for TMEM255B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM255B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872420.1  
    ENSEMBL proteins: 
     ENSP00000364502   ENSP00000364497  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028014 FAM70

    Graphical View of Domain Structure for InterPro Entry Q8WV15

    ProtoNet protein and cluster: Q8WV15

    UniProtKB/Swiss-Prot: T255B_HUMAN, Q8WV15
    Similarity: Belongs to the TMEM255 family


    TMEM255B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM255B:
     Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tmem255b):
     behavior/neurological 

    TMEM255B for phenotypes           About GeneDecksing

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T255B_HUMAN, Q8WV15: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM255B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM255B
    Interactions:

        Search GeneGlobe Interaction Network for TMEM255B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM255B (T255B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM255B gene: 
    NM_182614.2  

    Unigene Cluster for TMEM255B:

    Transmembrane protein 255B
    Hs.280805  [show with all ESTs]
    Unigene Representative Sequence: AK295653
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375353(uc010tkh.2 uc001vuh.3) ENST00000488362 ENST00000483678
    ENST00000375348 ENST00000498692 ENST00000467169
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    Additional mRNA sequence: 

    AK295653.1 BC018995.2 

    6 DOTS entries:

    DT.97809909  DT.99962926  DT.75158213  DT.205021  DT.70102476  DT.75199380 

    23 AceView cDNA sequences:

    F24453 BE938214 AA974725 BU149172 BI837600 NM_182614 BC018995 AI768413 
    AW451345 AA974579 AW072215 BF568402 AI275139 AA319957 BF000569 BX475662 
    BQ771931 AW196736 BI837539 AI915126 BQ773703 BE767518 BE693338 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM255B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM255B Expression
    About this image

    TMEM255B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM255B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.280805
        Custom PCR Arrays for TMEM255B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM255B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM255B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem255b1 , 5 family with sequence similarity 70, member B5
    transmembrane protein 255B1
    77.85(n)1
    78.46(a)1
      8 (6.00 cM)5
    2724651  NM_001143671.11  NP_001137143.11 
     134354595 
    chicken
    (Gallus gallus)
    Aves FAM70B1 family with sequence similarity 70, member B 67.82(n)
    70(a)
      418738  XM_416937.4  XP_416937.4 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM255B6
    transmembrane protein 255B
    63(a)
    1 ↔ 1
    3(106344205-106417648)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem255b1 transmembrane protein 255B 63.81(n)
    64.44(a)
      100493173  XM_004911801.1  XP_004911858.1 
    zebrafish
    (Danio rerio)
    Actinopterygii TMEM255B6
    transmembrane protein 255B
    38(a)
    1 ↔ 1
    18(39290460-39357922) ENSDARG00000076050


    ENSEMBL Gene Tree for TMEM255B (if available)
    TreeFam Gene Tree for TMEM255B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM255B gene
    TMEM255A2  
    1 SIMAP similar gene for TMEM255B using alignment to 2 protein entries:     T255B_HUMAN (see all proteins):
    TMEM255A

    TMEM255B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM255B (see all 1589)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823896051,2
    Cuntested1114473149(+) ATCACA/G/TGCGGA 1 -- int10--------
    rs614996111,2
    C--114460233(-) TACAC-/ACAT  
            
    GCATG
    1 -- us2k10--------
    rs1392712421,2
    C--114460271(+) TGCACA/GTATAA 1 -- us2k10--------
    rs2009150311,2
    --114460292(+) ATGCA-/TGTG  
            
    TGTAT
    1 -- us2k10--------
    rs96045321,2
    C,F,A--114460296(-) catACA/GCAcat 1 -- us2k16Minor allele frequency- G:0.49NA WA EA 364
    rs1837561531,2
    --114460303(+) TATGTA/GTGTGT 1 -- us2k10--------
    rs1866399251,2
    --114460312(+) GTATGC/TATGTG 1 -- us2k10--------
    rs1437209221,2
    --114460320(+) GTGTGC/TGTGTA 1 -- us2k10--------
    rs569617001,2
    C--114460346(-) ATACA-/CACA  
            
    TGCAT
    1 -- us2k10--------
    rs1507847671,2
    C--114460349(-) CACAT-/ACAC  
            
    ACATG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM255B (114462216 - 114514926 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM255B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM255B
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM255B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM255B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM255B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 348013 HGNC: 28297 AceView: MGC20579 Ensembl:ENSG00000184497 euGenes: HUgn348013
    ECgene: TMEM255B H-InvDB: TMEM255B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM255B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM255B gene:
    Search GeneIP for patents involving TMEM255B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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