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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM255B Gene

protein-coding   GIFtS: 33
GCID: GC13P114463

Transmembrane Protein 255B

(Previous names: family with sequence similarity 70, member B)
(Previous symbol: FAM70B)
  Search for TMEM255B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 255B1 2
FAM70B1 2 3
Family With Sequence Similarity 70, Member B1 2
Protein FAM70B2 3

External Ids:    HGNC: 282971   Entrez Gene: 3480132   Ensembl: ENSG000001844977   UniProtKB: Q8WV153   

Export aliases for TMEM255B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM255B Gene: 
TMEM255B (transmembrane protein 255B) is a protein-coding gene. An important paralog of this gene is TMEM255A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_077627.3  NC_018924.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM255B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM255B promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM255B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM255B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

TMEM255B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM255B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P114463:  view genomic region     (about GC identifiers)

Start:
114,462,216 bp from pter      End:
114,514,926 bp from pter
Size:
52,711 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T255B_HUMAN, Q8WV15 (See protein sequence)
Recommended Name: Transmembrane protein 255B  
Size: 326 amino acids; 34609 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for TMEM255B: NX_Q8WV15

Explore proteomics data for TMEM255B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WV15

  • TMEM255B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM255B Protein Expression
    REFSEQ proteins: NP_872420.1  
    ENSEMBL proteins: 
     ENSP00000364502   ENSP00000364497  

    Human Recombinant Protein Products for TMEM255B: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM255B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8WV15

    UniProtKB/Swiss-Prot: T255B_HUMAN, Q8WV15
    Similarity: Belongs to the TMEM255 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM255B:
     Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tmem255b):
     behavior/neurological 

    TMEM255B for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM255B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM255B (T255B)

    Search CenterWatch for drugs/clinical trials and news about TMEM255B / T255B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for TMEM255B gene: 
    NM_182614.2  

    Unigene Cluster for TMEM255B:

    Transmembrane protein 255B
    Hs.280805  [show with all ESTs]
    Unigene Representative Sequence: AK295653
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375353(uc010tkh.2 uc001vuh.3) ENST00000488362 ENST00000483678
    ENST00000375348 ENST00000498692 ENST00000467169
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM255B

    Additional mRNA sequence: 

    AK295653.1 BC018995.2 

    6 DOTS entries:

    DT.97809909  DT.99962926  DT.75158213  DT.205021  DT.70102476  DT.75199380 

    23 AceView cDNA sequences:

    F24453 BU149172 AA974725 NM_182614 AW451345 BI837600 AI768413 BE938214 
    BC018995 BX475662 BQ771931 AI275139 AA319957 BF000569 BF568402 AW072215 
    AA974579 AI915126 AW196736 BI837539 BQ773703 BE767518 BE693338 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See TMEM255B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM255B

    SOURCE GeneReport for Unigene cluster: Hs.280805
        SABiosciences Custom PCR Arrays for TMEM255B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM255B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM255B gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem255b5
    Fam70b1
    family with sequence similarity 70, member B1, 5 77.85(n)1
    78.46(a)1
      8 (6.00 cM)5
    2724651  NM_001143671.11  NP_001137143.11 
     134354595 
    chicken
    (Gallus gallus)
    Aves FAM70B1 family with sequence similarity 70, member B 70.47(n)
    73.77(a)
      418738  XM_416937.3  XP_416937.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM255B6
    transmembrane protein 255B
    60(a)
    1 ↔ 1
    3(106344205-106417648)
    zebrafish
    (Danio rerio)
    Actinopterygii TMEM255B6
    transmembrane protein 255B
    38(a)
    1 ↔ 1
    18(39290460-39357922)


    ENSEMBL Gene Tree for TMEM255B (if available)
    TreeFam Gene Tree for TMEM255B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM255B gene
    TMEM255A2  
    1 SIMAP similar gene for TMEM255B using alignment to 2 protein entries:     T255B_HUMAN (see all proteins):
    TMEM255A

    TMEM255B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1589 SNPs in TMEM255B are shown (see all 1589)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823896051,2
    Cuntested1114473149(+) ATCACA/G/TGCGGA 1 -- int10--------
    rs614996111,2
    C--114460233(-) TACAC-/ACAT  
            
    GCATG
    1 -- us2k10--------
    rs1392712421,2
    C--114460271(+) TGCACA/GTATAA 1 -- us2k10--------
    rs2009150311,2
    --114460292(+) ATGCA-/TGTG  
            
    TGTAT
    1 -- us2k10--------
    rs96045321,2
    C,F,A--114460296(-) catACA/GCAcat 1 -- us2k16Minor allele frequency- G:0.49NA WA EA 364
    rs1837561531,2
    --114460303(+) TATGTA/GTGTGT 1 -- us2k10--------
    rs1866399251,2
    --114460312(+) GTATGC/TATGTG 1 -- us2k10--------
    rs1437209221,2
    --114460320(+) GTGTGC/TGTGTA 1 -- us2k10--------
    rs569617001,2
    C--114460346(-) ATACA-/CACA  
            
    TGCAT
    1 -- us2k10--------
    rs1507847671,2
    C--114460349(-) CACAT-/ACAC  
            
    ACATG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM255B (114462216 - 114514926 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM255B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM255B
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM255B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM255B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM255B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 348013 HGNC: 28297 AceView: MGC20579 Ensembl:ENSG00000184497 euGenes: HUgn348013
    ECgene: TMEM255B H-InvDB: TMEM255B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM255B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM255B gene:
    Search GeneIP for patents involving TMEM255B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Search for Antibodies for TMEM255B at Abcam
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     Search LifeMap BioReagents cell lines for TMEM255B
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMEM255B
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM255B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM255B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM255B
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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