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TMEM255A Gene

protein-coding   GIFtS: 39
GCID: GC0XM119393

Transmembrane Protein 255A

(Previous names: family with sequence similarity 70, member A)
(Previous symbol: FAM70A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 255A1 2
FAM70A1 2 3
Family With Sequence Similarity 70, Member A1 2
Protein FAM70A2 3

External Ids:    HGNC: 260861   Entrez Gene: 550262   Ensembl: ENSG000001253557   UniProtKB: Q5JRV83   

Export aliases for TMEM255A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM255A Gene:
TMEM255A (transmembrane protein 255A) is a protein-coding gene. Diseases associated with TMEM255A include sinusitis, and endotheliitis. An important paralog of this gene is TMEM255B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM255A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM255A promoter sequence
   Search Chromatin IP Primers for TMEM255A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM255A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

TMEM255A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM255A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM119393:  view genomic region     (about GC identifiers)

Start:
119,392,505 bp from pter      End:
119,445,411 bp from pter
Size:
52,907 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T255A_HUMAN, Q5JRV8 (See protein sequence)
Recommended Name: Transmembrane protein 255A  
Size: 349 amino acids; 38449 Da
Secondary accessions: A8K0W9 B1APR4 B3KPI6 E9PAR3 Q86Y72 Q9NWN8
Alternative splicing: 4 isoforms:  Q5JRV8-1   Q5JRV8-2   Q5JRV8-3   Q5JRV8-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for TMEM255A: NX_Q5JRV8

Explore proteomics data for TMEM255A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM255A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001098014.1  NP_001098015.1  NP_060408.3  

    ENSEMBL proteins: 
     ENSP00000310110   ENSP00000360420   ENSP00000360403   ENSP00000428013   ENSP00000405781  

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028014 FAM70

    Graphical View of Domain Structure for InterPro Entry Q5JRV8

    ProtoNet protein and cluster: Q5JRV8

    UniProtKB/Swiss-Prot: T255A_HUMAN, Q5JRV8
    Similarity: Belongs to the TMEM255 family


    TMEM255A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM255A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM255A

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    hsa-mir-103a-3p (MIRT027198), hsa-mir-16-5p (MIRT032067)

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    Search for qRT-PCR Assays for microRNAs that regulate TMEM255A
    SwitchGear 3'UTR luciferase reporter plasmidTMEM255A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM255A

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM255A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T255A_HUMAN, Q5JRV8: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM255A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM255A
    Interactions:

        Search GeneGlobe Interaction Network for TMEM255A

    1 Interacting protein for TMEM255A (Q5JRV83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC1P630003I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM255A (T255A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM255A gene (3 alternative transcripts): 
    NM_001104544.1  NM_001104545.1  NM_017938.3  

    Unigene Cluster for TMEM255A:

    Transmembrane protein 255A
    Hs.437563  [show with all ESTs]
    Unigene Representative Sequence: NM_017938
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309720 ENST00000371369(uc004eso.4 uc004esp.4 uc010nqo.3)
    ENST00000371352 ENST00000519908 ENST00000480821 ENST00000440464
    miRNA
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    Block miRNA regulation of human, mouse, rat TMEM255A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM255A
    SwitchGear 3'UTR luciferase reporter plasmidTMEM255A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM255A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM255A
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM255A
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM255A
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat TMEM255A
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM255A
      QuantiFast Probe-based Assays in human, mouse, rat TMEM255A

    Additional mRNA sequence: 

    AF450484.1 AK000723.1 AK056403.1 AK289684.1 BC047054.1 

    4 DOTS entries:

    DT.424394  DT.95365800  DT.100748085  DT.121320185 

    Selected AceView cDNA sequences (see all 41):

    AI418667 AW139313 F10649 BM549514 F13057 CA390867 AF450484 BQ720601 
    BI091147 AI765030 BF447516 BI550456 AI359370 BU177363 BI458398 AA131443 
    BG205083 BC047054 BQ723016 BQ723190 NM_017938 BU172913 BI670089 CD512287 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM255A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                      -                                       
    SP2:                                      -     -                                 
    SP3:                                            -                                 
    SP4:                                      -     -     -     -                     


    ECgene alternative splicing isoforms for TMEM255A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM255A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM255A Expression
    About this image


    TMEM255A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Gonad
             Primordial germ cell-like cells
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
    TMEM255A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM255A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437563
        Custom PCR Arrays for TMEM255A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM255A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM255A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem255a1 , 5 family with sequence similarity 70, member A5
    transmembrane protein 255A1
    91.21(n)1
    95.42(a)1
      X (22.46 cM)5
    2453861  NM_172930.31  NP_766518.31 
     381965735 
    chicken
    (Gallus gallus)
    Aves TMEM255A6
    transmembrane protein 255A
    85(a)
    1 ↔ 1
    4(16410815-16432452)
    lizard
    (Anolis carolinensis)
    Reptilia TMEM255A6
    transmembrane protein 255A
    80(a)
    1 ↔ 1
    GL343950.1(31703-52971)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem255a1 transmembrane protein 255A 68.79(n)
    71.91(a)
      497005  NM_001011501.1  NP_001011501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem255a1 transmembrane protein 255A 64.46(n)
    66.88(a)
      798934  XM_005173287.1  XP_005173344.1 


    ENSEMBL Gene Tree for TMEM255A (if available)
    TreeFam Gene Tree for TMEM255A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM255A gene
    TMEM255B2  
    1 SIMAP similar gene for TMEM255A using alignment to 2 protein entries:     T255A_HUMAN (see all proteins):
    TMEM255B

    TMEM255A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM255A (see all 771)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59108111,2
    C,F,H--119386544(+) ACTTTA/GTATAA 3 -- ut3115Minor allele frequency- G:0.01NS EA WA NA CSA 972
    rs1846782061,2
    --119386672(+) AAATGA/TGATAA 3 -- ut310--------
    rs2000790171,2
    --119386794(+) TTTGT-/TTAG  
            
    TTAGT
    3 -- ut310--------
    rs1416811521,2
    --119386799(+) TTAGTC/TAGTCA 3 -- ut310--------
    rs2010459211,2
    --119386800(+) TAGTT-/AGTC  
            
    AGTTG
    3 -- ut310--------
    rs1891778471,2
    --119386869(+) AAATCA/GTAGTA 3 -- ut310--------
    rs1996551281,2
    --119386978(+) ACTGT-/TAATAATG 3 -- cds10--------
    rs1822184491,2
    --119387093(+) GCAAAA/GTTGGC 3 -- ut310--------
    rs1435027551,2
    C--119387099(+) TTGGCC/TGGAAA 3 -- ut310--------
    rs1863166241,2
    --119387136(+) GAGAAC/GTGTCT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM255A (119392505 - 119445411 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM255A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM255A
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM255A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TMEM255A:    
    About MalaCards
    sinusitis    endotheliitis


    TMEM255A for disorders           About GeneDecksing


    Export disorders for TMEM255A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM255A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM255A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55026 HGNC: 26086 AceView: FLJ20716 Ensembl:ENSG00000125355 euGenes: HUgn55026
    ECgene: TMEM255A H-InvDB: TMEM255A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM255A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM255A gene:
    Search GeneIP for patents involving TMEM255A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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