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Aliases for TMEM255A Gene

Aliases for TMEM255A Gene

  • Transmembrane Protein 255A 2 3 5
  • Family With Sequence Similarity 70, Member A 2 3
  • Protein FAM70A 3 4
  • FAM70A 3 4

External Ids for TMEM255A Gene

Previous HGNC Symbols for TMEM255A Gene

  • FAM70A

Previous GeneCards Identifiers for TMEM255A Gene

  • GC0XM119393

Summaries for TMEM255A Gene

GeneCards Summary for TMEM255A Gene

TMEM255A (Transmembrane Protein 255A) is a Protein Coding gene. An important paralog of this gene is TMEM255B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM255A Gene

Genomics for TMEM255A Gene

Regulatory Elements for TMEM255A Gene

Enhancers for TMEM255A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG120456 1.1 Ensembl ENCODE 32.6 -146.7 -146674 2.8 PKNOX1 ESRRA ATF1 JUN INSM2 FEZF1 ZNF366 ZSCAN5C SCRT2 ZNF600 TMEM255A LAMP2 ATP1B4
GH0XG120418 0.5 ENCODE 34.2 -108.2 -108216 1.9 PKNOX1 GATA3 RFX1 CTBP1 TMEM255A LAMP2 ATP1B4
GH0XG120302 1.2 Ensembl ENCODE dbSUPER 10.2 +8.7 8718 1.6 USF1 EBF1 ZIC2 ZNF316 POLR2A MAFK RFX1 NR2F1 BHLHE40 USF2 TMEM255A ENSG00000232042
GH0XG120286 0.8 ENCODE 13.2 +24.1 24113 2.0 SOX13 TBP TFAP4 SAP130 EBF1 RARA RELA NCOR1 NR2F6 RELB TMEM255A NKAPP1 C1GALT1C1 ENSG00000232042
GH0XG119674 2 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +626.9 626853 20.2 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A FEZF1 YY1 NKAPP1 SEPT6 NKRF UPF3B MIR766 CXorf56 NKAP SLC25A5-AS1 PGRMC1 TMEM255A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM255A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM255A Gene

Chromosome:
X
Start:
120,251,002 bp from pter
End:
120,311,556 bp from pter
Size:
60,555 bases
Orientation:
Minus strand

Genomic View for TMEM255A Gene

Genes around TMEM255A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM255A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM255A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM255A Gene

Proteins for TMEM255A Gene

  • Protein details for TMEM255A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JRV8-T255A_HUMAN
    Recommended name:
    Transmembrane protein 255A
    Protein Accession:
    Q5JRV8
    Secondary Accessions:
    • A8K0W9
    • B1APR4
    • B3KPI6
    • E9PAR3
    • Q86Y72
    • Q9NWN8

    Protein attributes for TMEM255A Gene

    Size:
    349 amino acids
    Molecular mass:
    38449 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM255A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM255A Gene

Post-translational modifications for TMEM255A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM255A Gene

No data available for DME Specific Peptides for TMEM255A Gene

Domains & Families for TMEM255A Gene

Protein Domains for TMEM255A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM255A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JRV8

UniProtKB/Swiss-Prot:

T255A_HUMAN :
  • Belongs to the TMEM255 family.
Family:
  • Belongs to the TMEM255 family.
genes like me logo Genes that share domains with TMEM255A: view

No data available for Gene Families for TMEM255A Gene

Function for TMEM255A Gene

Phenotypes for TMEM255A Gene

genes like me logo Genes that share phenotypes with TMEM255A: view

Animal Model Products

CRISPR Products

miRNA for TMEM255A Gene

miRTarBase miRNAs that target TMEM255A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM255A Gene

Localization for TMEM255A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM255A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM255A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM255A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM255A: view

Pathways & Interactions for TMEM255A Gene

SuperPathways for TMEM255A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM255A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM255A Gene

Drugs & Compounds for TMEM255A Gene

No Compound Related Data Available

Transcripts for TMEM255A Gene

Unigene Clusters for TMEM255A Gene

Transmembrane protein 255A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM255A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: -
SP4: - - - -

Relevant External Links for TMEM255A Gene

GeneLoc Exon Structure for
TMEM255A
ECgene alternative splicing isoforms for
TMEM255A

Expression for TMEM255A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM255A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM255A Gene

This gene is overexpressed in Brain - Hypothalamus (x8.6) and Brain - Substantia nigra (x6.0).

Protein differential expression in normal tissues from HIPED for TMEM255A Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM255A Gene



Protein tissue co-expression partners for TMEM255A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM255A Gene:

TMEM255A

SOURCE GeneReport for Unigene cluster for TMEM255A Gene:

Hs.437563

Evidence on tissue expression from TISSUES for TMEM255A Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with TMEM255A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM255A Gene

Orthologs for TMEM255A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM255A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMEM255A 35
  • 98 (a)
OneToOne
FAM70A 34
  • 93.79 (n)
cow
(Bos Taurus)
Mammalia MGC142908 35
  • 98 (a)
OneToOne
FAM70A 34
  • 94.46 (n)
rat
(Rattus norvegicus)
Mammalia Tmem255a 34
  • 91.31 (n)
mouse
(Mus musculus)
Mammalia Tmem255a 34 16 35
  • 91.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM255A 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM255A 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM255A 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM255A 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem255a 34
  • 68.79 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem255a 34
  • 64.46 (n)
TMEM255A 35
  • 62 (a)
OneToOne
Species where no ortholog for TMEM255A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM255A Gene

ENSEMBL:
Gene Tree for TMEM255A (if available)
TreeFam:
Gene Tree for TMEM255A (if available)

Paralogs for TMEM255A Gene

Paralogs for TMEM255A Gene

(1) SIMAP similar genes for TMEM255A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM255A: view

Variants for TMEM255A Gene

Sequence variations from dbSNP and Humsavar for TMEM255A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1057518570 Uncertain significance 120,253,452(+) ACATT(C/G)AGTAC intron-variant, reference, missense
rs1000053298 -- 120,272,345(+) GGGTA(C/T)GGGAA intron-variant
rs1000278739 -- 120,252,114(+) TTAGA(C/T)TTTTT intron-variant
rs1000415724 -- 120,252,665(+) TCATG(A/G)TAGTG intron-variant
rs1000518018 -- 120,266,332(+) CTGAC(A/C)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM255A Gene

Variant ID Type Subtype PubMed ID
esv2758889 CNV loss 17122850
esv3574434 CNV loss 25503493

Variation tolerance for TMEM255A Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM255A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM255A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM255A Gene

Disorders for TMEM255A Gene

Relevant External Links for TMEM255A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM255A

No disorders were found for TMEM255A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM255A Gene

Publications for TMEM255A Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TMEM255A Gene

Sources for TMEM255A Gene

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