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Aliases for TMEM254 Gene

Aliases for TMEM254 Gene

  • Transmembrane Protein 254 2 3 5
  • C10orf57 3 4
  • Chromosome 10 Open Reading Frame 57 2
  • Transmembrane Protein C10orf57 3
  • BA369J21.6 3

External Ids for TMEM254 Gene

Previous HGNC Symbols for TMEM254 Gene

  • C10orf57

Previous GeneCards Identifiers for TMEM254 Gene

  • GC10P081838

Summaries for TMEM254 Gene

GeneCards Summary for TMEM254 Gene

TMEM254 (Transmembrane Protein 254) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM254 Gene

Genomics for TMEM254 Gene

Regulatory Elements for TMEM254 Gene

Enhancers for TMEM254 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F080103 1.1 FANTOM5 Ensembl ENCODE 18.5 +26.4 26436 3.5 RFX1 RFX3 FOXP2 MAFK NR2F2 TMEM254-AS1 TMEM254 SFTPD PIR41694 ENSG00000279399
GH10F080077 1 ENCODE 13.2 +0.3 258 2.6 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1 ZNF121 GLIS2 TMEM254-AS1 PGGT1BP2 NPAP1P2 ZNF519P1 ENSG00000235858 LOC105378386 TMEM254 LINC00857 ANXA11
GH10F080109 1 Ensembl ENCODE 11.5 +31.9 31932 1.5 SOX13 ZNF48 TEAD3 GATA3 NR2F6 MAFK MIXL1 SOX5 GATAD2A NFIA TMEM254-AS1 TMEM254 SFTPD PIR41694 RPL22P18
GH10F080100 0.6 ENCODE 12.7 +22.3 22326 1.3 GATA3 PKNOX1 CTBP1 ZHX2 DPF2 TMEM254-AS1 MBL1P TMEM254 ANXA11 LINC00857 SFTPD ENSG00000279399 PIR41694
GH10F080662 1.1 Ensembl ENCODE 4.9 +584.2 584187 1.1 BCOR CTCF HDAC1 ARNT RAD21 GATA3 CTBP1 GATA2 EED ZNF143 TMEM254 LOC105378386 GC10M080717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM254 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM254 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005559 354 2001 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1 ZNF121 GLIS2

Genomic Location for TMEM254 Gene

Chromosome:
10
Start:
80,078,646 bp from pter
End:
80,092,557 bp from pter
Size:
13,912 bases
Orientation:
Plus strand

Genomic View for TMEM254 Gene

Genes around TMEM254 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM254 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM254 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM254 Gene

Proteins for TMEM254 Gene

  • Protein details for TMEM254 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBM7-TM254_HUMAN
    Recommended name:
    Transmembrane protein 254
    Protein Accession:
    Q8TBM7
    Secondary Accessions:
    • D3DWC8
    • Q53HP4
    • Q5JTC0
    • Q5JTC1
    • Q6IA45
    • Q9H8S6

    Protein attributes for TMEM254 Gene

    Size:
    123 amino acids
    Molecular mass:
    14243 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM254 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM254 Gene

Post-translational modifications for TMEM254 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM254 Gene

Domains & Families for TMEM254 Gene

Protein Domains for TMEM254 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM254 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM254: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM254 Gene

Function for TMEM254 Gene

genes like me logo Genes that share phenotypes with TMEM254: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM254 Gene

Localization for TMEM254 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM254 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM254 gene
Compartment Confidence
extracellular 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM254: view

Pathways & Interactions for TMEM254 Gene

SuperPathways for TMEM254 Gene

No Data Available

Interacting Proteins for TMEM254 Gene

Gene Ontology (GO) - Biological Process for TMEM254 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM254 Gene

Transcripts for TMEM254 Gene

Unigene Clusters for TMEM254 Gene

Transmembrane protein 254:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM254 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9:
SP10: -

Relevant External Links for TMEM254 Gene

GeneLoc Exon Structure for
TMEM254
ECgene alternative splicing isoforms for
TMEM254

Expression for TMEM254 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM254 Gene

Protein differential expression in normal tissues from HIPED for TMEM254 Gene

This gene is overexpressed in Pancreas (13.6), Retina (11.5), CD8 Tcells (9.3), Liver (7.3), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM254 Gene



Protein tissue co-expression partners for TMEM254 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM254 Gene:

TMEM254

SOURCE GeneReport for Unigene cluster for TMEM254 Gene:

Hs.169982
genes like me logo Genes that share expression patterns with TMEM254: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM254 Gene

Orthologs for TMEM254 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM254 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM254 35
  • 100 (a)
OneToOne
C10H10orf57 34
  • 99.46 (n)
rat
(Rattus norvegicus)
Mammalia Fam213a 34
  • 83.74 (n)
cow
(Bos Taurus)
Mammalia TMEM254 34 35
  • 79.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM254 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM254 35
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem254a 35
  • 64 (a)
OneToMany
Tmem254b 35
  • 64 (a)
OneToMany
Tmem254c 35
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM254 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF57 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam213a 34
  • 59.84 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:64043 34
  • 59.29 (n)
TMEM254 35
  • 47 (a)
OneToOne
Species where no ortholog for TMEM254 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM254 Gene

ENSEMBL:
Gene Tree for TMEM254 (if available)
TreeFam:
Gene Tree for TMEM254 (if available)

Paralogs for TMEM254 Gene

genes like me logo Genes that share paralogs with TMEM254: view

No data available for Paralogs for TMEM254 Gene

Variants for TMEM254 Gene

Sequence variations from dbSNP and Humsavar for TMEM254 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10430639 -- 80,080,364(+) AGCTG(A/G)CAGAA intron-variant, upstream-variant-2KB
rs10430708 -- 80,078,315(+) ATTCA(C/T)TCATT intron-variant, upstream-variant-2KB
rs1046707 -- 80,091,364(+) CACTT(C/T)CACTA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1058215 -- 80,088,125(+) GTCTT(C/T)ACTGA intron-variant
rs1058216 -- 80,088,331(+) ATTCT(A/G)TGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM254 Gene

Variant ID Type Subtype PubMed ID
nsv819306 CNV loss 19587683
nsv551635 CNV loss 21841781
nsv1141879 OTHER inversion 24896259
esv3623943 CNV gain 21293372
esv3623942 CNV loss 21293372
esv3623941 CNV gain 21293372
esv3623940 CNV loss 21293372
esv3623939 CNV loss 21293372
dgv941n100 CNV gain 25217958

Variation tolerance for TMEM254 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM254 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM254

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM254 Gene

Disorders for TMEM254 Gene

Relevant External Links for TMEM254

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM254

No disorders were found for TMEM254 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM254 Gene

Publications for TMEM254 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (PMID: 23144326) Kim D.K. … Silverman E.K. (Am. J. Respir. Crit. Care Med. 2012) 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for TMEM254 Gene

Sources for TMEM254 Gene

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