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Aliases for TMEM253 Gene

Aliases for TMEM253 Gene

  • Transmembrane Protein 253 2 3 5
  • C14orf176 3 4
  • C14orf95 3 4
  • Chromosome 14 Open Reading Frame 176 2
  • Chromosome 14 Open Reading Frame 95 2
  • Transmembrane Protein C14orf176 3
  • Non-Protein Coding RNA 220 2
  • NCRNA00220 3

External Ids for TMEM253 Gene

Previous HGNC Symbols for TMEM253 Gene

  • NCRNA00220
  • C14orf95
  • C14orf176

Previous GeneCards Identifiers for TMEM253 Gene

  • GC14P021567

Summaries for TMEM253 Gene

GeneCards Summary for TMEM253 Gene

TMEM253 (Transmembrane Protein 253) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM253 Gene

Genomics for TMEM253 Gene

Regulatory Elements for TMEM253 Gene

Promoters for TMEM253 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM253 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM253 Gene

Chromosome:
14
Start:
21,098,937 bp from pter
End:
21,103,724 bp from pter
Size:
4,788 bases
Orientation:
Plus strand

Genomic View for TMEM253 Gene

Genes around TMEM253 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM253 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM253 Gene

Proteins for TMEM253 Gene

  • Protein details for TMEM253 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7T8-TM253_HUMAN
    Recommended name:
    Transmembrane protein 253
    Protein Accession:
    P0C7T8

    Protein attributes for TMEM253 Gene

    Size:
    217 amino acids
    Molecular mass:
    23522 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM253 Gene

Proteomics data for TMEM253 Gene at MOPED

Post-translational modifications for TMEM253 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM253 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM253 Gene

Domains & Families for TMEM253 Gene

Protein Domains for TMEM253 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM253 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM253: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM253 Gene

Function for TMEM253 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM253 Gene

Localization for TMEM253 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM253 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM253 Gene COMPARTMENTS Subcellular localization image for TMEM253 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM253 Gene

Pathways & Interactions for TMEM253 Gene

SuperPathways for TMEM253 Gene

No Data Available

Interacting Proteins for TMEM253 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000451229%0d%0a9606.ENSP00000336799%0d%0a9606.ENSP00000343656%0d%0a
Selected Interacting proteins: ENSP00000451229 for TMEM253 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM253 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM253 Gene

Drugs & Compounds for TMEM253 Gene

No Compound Related Data Available

Transcripts for TMEM253 Gene

mRNA/cDNA for TMEM253 Gene

(10) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM253 Gene

Transmembrane protein 253:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM253 Gene

No ASD Table

Relevant External Links for TMEM253 Gene

GeneLoc Exon Structure for
TMEM253
ECgene alternative splicing isoforms for
TMEM253

Expression for TMEM253 Gene

mRNA expression in normal human tissues for TMEM253 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM253 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.2) and Colon - Transverse (x12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM253 Gene



SOURCE GeneReport for Unigene cluster for TMEM253 Gene Hs.540107

genes like me logo Genes that share expression patterns with TMEM253: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM253 Gene

Orthologs for TMEM253 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM253 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM253 35
  • 99.39 (n)
  • 99.54 (a)
C14H14ORF176 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM253 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM253 36
  • 77 (a)
OneToOne
TMEM253 35
  • 85.19 (n)
  • 82.32 (a)
mouse
(Mus musculus)
Mammalia Tmem253 35
  • 80.57 (n)
  • 73.37 (a)
Tmem253 36
  • 72 (a)
OneToOne
Tmem253 16
rat
(Rattus norvegicus)
Mammalia Tmem253 35
  • 81.24 (n)
  • 73.37 (a)
Species with no ortholog for TMEM253:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM253 Gene

ENSEMBL:
Gene Tree for TMEM253 (if available)
TreeFam:
Gene Tree for TMEM253 (if available)

Paralogs for TMEM253 Gene

No data available for Paralogs for TMEM253 Gene

Variants for TMEM253 Gene

Variation tolerance for TMEM253 Gene

Gene Damage Index Score: 1.58; 30.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM253 Gene

HapMap Linkage Disequilibrium report
TMEM253

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TMEM253 Gene

Disorders for TMEM253 Gene

Relevant External Links for TMEM253

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM253

No disorders were found for TMEM253 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM253 Gene

Publications for TMEM253 Gene

  1. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 67
  2. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3

Products for TMEM253 Gene

Sources for TMEM253 Gene

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