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Aliases for TMEM251 Gene

Aliases for TMEM251 Gene

  • Transmembrane Protein 251 2 3 5
  • C14orf109 3 4
  • UPF0694 Transmembrane Protein C14orf109 3
  • Chromosome 14 Open Reading Frame 109 2

External Ids for TMEM251 Gene

Previous HGNC Symbols for TMEM251 Gene

  • C14orf109

Previous GeneCards Identifiers for TMEM251 Gene

  • GC14P093653

Summaries for TMEM251 Gene

GeneCards Summary for TMEM251 Gene

TMEM251 (Transmembrane Protein 251) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM251 Gene

Genomics for TMEM251 Gene

Regulatory Elements for TMEM251 Gene

Enhancers for TMEM251 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G092846 1.5 FANTOM5 Ensembl ENCODE 35.8 -337.9 -337851 1.4 HDAC1 ATF1 ZSCAN4 TCF12 GATA2 EGR1 FOS RELB IKZF2 CREM TMEM251 CHGA UNC79 RIN3 MOAP1 BTBD7 GON7 GC14P092878 GC14P092879 GC14P092880
GH14G092723 1.5 FANTOM5 Ensembl ENCODE 26.7 -459.6 -459611 3.9 HDAC1 ATF1 THRB RARA FOS SMARCA5 HMG20B ZNF280D CEBPB ZEB2 TMEM251 SLC24A4 RIN3 MOAP1 GON7 LGMN GC14P092700
GH14G093098 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -81.3 -81331 10.1 PKNOX1 FOXA2 RAD21 ZNF121 SCRT2 ZNF143 IKZF2 EGR2 ZNF263 CEBPB ITPK1 TMEM251 ITPK1-AS1 MOAP1 UNC79 GC14P093068
GH14G092866 0.9 FANTOM5 23.4 -318.5 -318511 0.3 TBP FUS SIN3A ZSCAN9 ZNF48 YY1 SLC30A9 GLIS2 BCLAF1 SMAD5 TMEM251 UNC79 MOAP1 RIN3 GON7 BTBD7 PIR36925 GC14P092880 GC14P092879 GC14P092878
GH14G093006 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -176.5 -176473 4.6 HDAC1 PKNOX1 ATF1 FOXA2 INSM2 ARID4B SIN3A KLF17 FEZF1 THRB ITPK1 MOAP1 TMEM251 RIN3 UNC79 ITPK1-AS1 GC14P093068 PIR52280
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM251 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM251 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072391 149 1801 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF207

Genomic Location for TMEM251 Gene

Chromosome:
14
Start:
93,184,951 bp from pter
End:
93,187,089 bp from pter
Size:
2,139 bases
Orientation:
Plus strand

Genomic View for TMEM251 Gene

Genes around TMEM251 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM251 Gene

Proteins for TMEM251 Gene

  • Protein details for TMEM251 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6I4-TM251_HUMAN
    Recommended name:
    Transmembrane protein 251
    Protein Accession:
    Q8N6I4
    Secondary Accessions:
    • J3KQ65
    • Q9Y4S5

    Protein attributes for TMEM251 Gene

    Size:
    163 amino acids
    Molecular mass:
    18747 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30119.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM251 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM251 Gene

Post-translational modifications for TMEM251 Gene

No Post-translational modifications

Other Protein References for TMEM251 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM251 Gene

Domains & Families for TMEM251 Gene

Protein Domains for TMEM251 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM251 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6I4

UniProtKB/Swiss-Prot:

TM251_HUMAN :
  • Belongs to the TMEM251 family.
Family:
  • Belongs to the TMEM251 family.
genes like me logo Genes that share domains with TMEM251: view

No data available for Gene Families for TMEM251 Gene

Function for TMEM251 Gene

Phenotypes for TMEM251 Gene

GenomeRNAi human phenotypes for TMEM251:
genes like me logo Genes that share phenotypes with TMEM251: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM251 Gene

Localization for TMEM251 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM251 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM251 gene
Compartment Confidence
plasma membrane 2
golgi apparatus 2
extracellular 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM251: view

Pathways & Interactions for TMEM251 Gene

SuperPathways for TMEM251 Gene

No Data Available

Interacting Proteins for TMEM251 Gene

Gene Ontology (GO) - Biological Process for TMEM251 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM251 Gene

Drugs & Compounds for TMEM251 Gene

No Compound Related Data Available

Transcripts for TMEM251 Gene

mRNA/cDNA for TMEM251 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM251 Gene

Transmembrane protein 251:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM251 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3
SP1: - - -
SP2: -
SP3:

Relevant External Links for TMEM251 Gene

GeneLoc Exon Structure for
TMEM251
ECgene alternative splicing isoforms for
TMEM251

Expression for TMEM251 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM251 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM251 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM251 Gene:

TMEM251

SOURCE GeneReport for Unigene cluster for TMEM251 Gene:

Hs.275352

Evidence on tissue expression from TISSUES for TMEM251 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM251: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM251 Gene

Orthologs for TMEM251 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM251 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM251 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia TMEM251 34 35
  • 94.27 (n)
cow
(Bos Taurus)
Mammalia TMEM251 34 35
  • 93.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM251 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM251 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem251 34
  • 90.59 (n)
mouse
(Mus musculus)
Mammalia Tmem251 34 16 35
  • 90.39 (n)
chicken
(Gallus gallus)
Aves TMEM251 34 35
  • 82.82 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM251 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem251 34
  • 78.21 (n)
Str.4165 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25600 34
zebrafish
(Danio rerio)
Actinopterygii tmem251 34 35
  • 69.74 (n)
wufb01e08 34
Species where no ortholog for TMEM251 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM251 Gene

ENSEMBL:
Gene Tree for TMEM251 (if available)
TreeFam:
Gene Tree for TMEM251 (if available)

Paralogs for TMEM251 Gene

Pseudogenes.org Pseudogenes for TMEM251 Gene

genes like me logo Genes that share paralogs with TMEM251: view

No data available for Paralogs for TMEM251 Gene

Variants for TMEM251 Gene

Sequence variations from dbSNP and Humsavar for TMEM251 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000116037 -- 93,185,023(+) CCACG(C/G)GACAG upstream-variant-2KB, utr-variant-5-prime
rs1001228668 -- 93,187,353(+) TCCTG(A/G)GCTCA downstream-variant-500B
rs1001434329 -- 93,183,483(+) TAGAT(A/G)TTTGA upstream-variant-2KB, reference, missense
rs1001484907 -- 93,183,908(+) CCTCT(C/T)CCGCT upstream-variant-2KB, reference, missense
rs1004292159 -- 93,187,544(+) GTTAA(A/G)TGTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM251 Gene

Variant ID Type Subtype PubMed ID
esv2749028 CNV deletion 23290073
esv3635357 CNV gain 21293372
nsv827029 CNV gain 20364138
nsv827032 CNV gain 20364138

Variation tolerance for TMEM251 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM251 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM251

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM251 Gene

Disorders for TMEM251 Gene

Relevant External Links for TMEM251

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM251

No disorders were found for TMEM251 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM251 Gene

Publications for TMEM251 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM251 Gene

Sources for TMEM251 Gene

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