TMEM251 Gene
protein-coding GIFtS: 31
GCID: GC14P093653
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|
transmembrane protein 251(Previous name: chromosome 14 open reading frame 109 )
(Previous symbol: C14orf109)
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Aliases
for TMEM251 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 2511 2 | | C14orf1091 2 3 | | DKFZP564F11231 | | Chromosome 14 Open Reading Frame 1091 | | UPF0694 Transmembrane Protein C14orf1092 |
Export aliases for TMEM251 gene to outside databases |
Summaries
for TMEM251 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM251 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TMEM251
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM251
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM251 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.12 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.12TMEM251 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P093653: view genomic region
(about GC identifiers)
Start:
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93,651,296 bp from pter |
End:
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93,653,434 bp from pter |
Size:
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2,139 bases |
Orientation:
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plus strand |
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Proteins
for TMEM251 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM251_HUMAN, Q8N6I4 (See
protein sequence)Recommended Name: Transmembrane protein 251 Size: 163 amino acids; 18747 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH30119.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: J3KQ65 Q9Y4S5Alternative splicing: 3 isoforms: Q8N6I4-1 Q8N6I4-2 Q8N6I4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM251: NX_Q8N6I4
TMEM251 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092091.1 NP_056491.1
ENSEMBL proteins: ENSP00000283534 ENSP00000388431
Human Recombinant Protein Products for TMEM251:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM251 for ontologies About GeneDecksing
TMEM251 Antibody Products:
Assay Products for TMEM251: |
Protein
Domains /
Families
for TMEM251 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8N6I4 UniProtKB/Swiss-Prot: TM251_HUMAN, Q8N6I4Similarity: Belongs to the TMEM251 family |
Function
for TMEM251 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM251 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM251 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TMEM251 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM251 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM251 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM251 |
|
Pathways & Interactions
for TMEM251 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM251
|
Drugs & Compounds
for TMEM251 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM251
Search CenterWatch for drugs/clinical trials and news about TMEM251 / TM251
|
Transcripts
for TMEM251 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM251 gene (2 alternative transcripts): NM_001098621.1 NM_015676.1 Unigene Cluster for TMEM251: Transmembrane protein 251 Hs.275352 [show with all ESTs]Unigene Representative Sequence: NM_0010986212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283534(uc001ybk.4) ENST00000415050(uc010auo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM251 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM251 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TMEM251 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM251 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM251 |
Additional cDNA sequence: AL080118.1 BC030119.2 7 DOTS entries: DT.100778330 DT.216079 DT.100778328 DT.100707176 DT.100778327 DT.100808943 DT.120754348 24/111 AceView cDNA sequences (see all 111): AI039547 AI222746 N31611 BU623312 AW471054 BQ632077 CA866425 AA825761 AW593257 CA390782 AI342456 AA830907 CA443785 CR599371 H70117 N43016 AI346504 N76399 BM974467 AA314632 T15431 F29295 AA991777 AA374774
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM251 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 |
|---|
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| SP1: | | | | | | | - | | | | - | | - | | | | |
| SP2: | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM251
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Expression
for TMEM251 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TMEM251 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM251
SOURCE GeneReport for Unigene cluster: Hs.275352
SABiosciences Custom PCR Arrays for TMEM251
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM251
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TMEM251 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM251 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM251 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM251 |
Orthologs
for TMEM251 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM251 gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tmem2511 , 5 |
RIKEN cDNA D230037D09 gene5
transmembrane protein 2511 |
90.39(n)1
92.64(a)1 |
|
12 (52.15 cM)5
3203511 NM_177140.31 NP_796114.11
1027437605 |
chicken
(Gallus gallus) |
Aves |
TMEM2511 |
transmembrane protein 251 |
82.82(n)
92.31(a) |
|
423422 NM_001079732.1 NP_001073200.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C14orf1096 |
-- |
87(a) |
1 ↔ 1 |
1(10928309-10928701) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.256002 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.64(n) |
|
BU915937.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb01e082 |
Transcribed sequence with weak similarity to protein more |
76.3(n) |
|
57069303 |
ENSEMBL Gene Tree for TMEM251 (if available)
TreeFam Gene Tree for TMEM251 (if available) |
Paralogs
for TMEM251 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM251 gene
TMEM251 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TMEM251
PGOHUM00000235308
|
Genomic Variants
for TMEM251 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM251 (93651296 - 93653434 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM251: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMEM251 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM251 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM251 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM251) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM251 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM251 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM251 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM251 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM251 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM251 gene:
Search GeneIP for patents involving TMEM251
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM251 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM251 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM251 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM251 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM251 | | OriGene 3'-UTR Clone for TMEM251 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM251 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM251 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM251 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM251 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM251 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM251 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM251 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM251 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM251 |
| |  |  |  |  | | | | |
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 |
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 | | | TMEM251 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM251 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM251 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM251 |
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