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Aliases for TMEM251 Gene

Aliases for TMEM251 Gene

  • Transmembrane Protein 251 2 3
  • C14orf109 3 4
  • UPF0694 Transmembrane Protein C14orf109 3
  • Chromosome 14 Open Reading Frame 109 2

External Ids for TMEM251 Gene

Previous HGNC Symbols for TMEM251 Gene

  • C14orf109

Previous GeneCards Identifiers for TMEM251 Gene

  • GC14P093653

Summaries for TMEM251 Gene

GeneCards Summary for TMEM251 Gene

TMEM251 (Transmembrane Protein 251) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM251 Gene

Genomics for TMEM251 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM251 Gene

Start:
93,184,951 bp from pter
End:
93,187,089 bp from pter
Size:
2,139 bases
Orientation:
Plus strand

Genomic View for TMEM251 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM251 Gene

No data available for Regulatory Elements for TMEM251 Gene

Proteins for TMEM251 Gene

  • Protein details for TMEM251 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6I4-TM251_HUMAN
    Recommended name:
    Transmembrane protein 251
    Protein Accession:
    Q8N6I4
    Secondary Accessions:
    • J3KQ65
    • Q9Y4S5

    Protein attributes for TMEM251 Gene

    Size:
    163 amino acids
    Molecular mass:
    18747 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30119.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM251 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM251 Gene

Proteomics data for TMEM251 Gene at MOPED

Post-translational modifications for TMEM251 Gene

No Post-translational modifications

Other Protein References for TMEM251 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM251 Gene

Domains for TMEM251 Gene

Protein Domains for TMEM251 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N6I4

UniProtKB/Swiss-Prot:

TM251_HUMAN :
  • Q8N6I4
Family:
  • Belongs to the TMEM251 family.
genes like me logo Genes that share domains with TMEM251: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM251 Gene

Function for TMEM251 Gene

Animal Model Products

CRISPR Products

miRNA for TMEM251 Gene

miRTarBase miRNAs that target TMEM251

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM251

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM251 Gene

Localization for TMEM251 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM251 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM251: view

No data available for Subcellular locations from COMPARTMENTS for TMEM251 Gene

Pathways for TMEM251 Gene

SuperPathways for TMEM251 Gene

No Data Available

Interacting Proteins for TMEM251 Gene

Gene Ontology (GO) - Biological Process for TMEM251 Gene

None

No data available for Pathways by source for TMEM251 Gene

Transcripts for TMEM251 Gene

mRNA/cDNA for TMEM251 Gene

(111) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM251 Gene

Transmembrane protein 251:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM251

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM251
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM251 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3
SP1: - - -
SP2: -
SP3:

Relevant External Links for TMEM251 Gene

GeneLoc Exon Structure for
TMEM251
ECgene alternative splicing isoforms for
TMEM251

Expression for TMEM251 Gene

mRNA expression in normal human tissues for TMEM251 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM251 Gene

SOURCE GeneReport for Unigene cluster for TMEM251 Gene Hs.275352

genes like me logo Genes that share expressions with TMEM251: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM251 Gene

Orthologs for TMEM251 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM251 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM251 35
  • 99.8 (n)
  • 99.41 (a)
TMEM251 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM251 35
  • 93.66 (n)
  • 96.32 (a)
TMEM251 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM251 35
  • 94.27 (n)
  • 96.93 (a)
TMEM251 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem251 35
  • 90.39 (n)
  • 92.64 (a)
Tmem251 16
Tmem251 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM251 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM251 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem251 35
  • 90.59 (n)
  • 93.87 (a)
chicken
(Gallus gallus)
Aves TMEM251 35
  • 82.82 (n)
  • 92.31 (a)
TMEM251 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM251 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25600 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4165 35
tmem251 35
  • 78.21 (n)
  • 84.62 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem251 35
  • 69.74 (n)
  • 74.62 (a)
tmem251 36
  • 70 (a)
OneToOne
wufb01e08 35
Species with no ortholog for TMEM251:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM251 Gene

ENSEMBL:
Gene Tree for TMEM251 (if available)
TreeFam:
Gene Tree for TMEM251 (if available)

Paralogs for TMEM251 Gene

Pseudogenes.org Pseudogenes for TMEM251 Gene

genes like me logo Genes that share paralogs with TMEM251: view

No data available for Paralogs for TMEM251 Gene

Variants for TMEM251 Gene

Sequence variations from dbSNP and Humsavar for TMEM251 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10133344 -- 93,187,304(+) TTTTT(G/T)TGGAG downstream-variant-500B
rs74984385 -- 93,187,059(+) CAGAC(A/G)TGATC utr-variant-3-prime
rs77126471 -- 93,187,258(+) AAATT(A/G)TTATT downstream-variant-500B
rs77387017 -- 93,187,312(+) GAGAA(C/T)GGGGT downstream-variant-500B
rs111381620 -- 93,187,439(+) AAAAA(A/T)ATTTT downstream-variant-500B

Relevant External Links for TMEM251 Gene

HapMap Linkage Disequilibrium report
TMEM251

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM251 Gene

Disorders for TMEM251 Gene

No disorders were found for TMEM251 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM251 Gene

Publications for TMEM251 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM251 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TMEM251
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM251
    • Block miRNA regulation of TMEM251 using miScript Target Protectors

    Sources for TMEM251 Gene

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