Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM25 Gene

protein-coding   GIFtS: 49
GCID: GC11P118401

Transmembrane Protein 25

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 251 2
0610039J01Rik2

External Ids:    HGNC: 258901   Entrez Gene: 848662   Ensembl: ENSG000001495827   OMIM: 6139345   UniProtKB: Q86YD33   

Export aliases for TMEM25 gene to outside databases

Previous GC identifers: GC11P117941 GC11P117907 GC11P114338


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM25 Gene: 
TMEM25 (transmembrane protein 25) is a protein-coding gene. Diseases associated with TMEM25 include breast cancer.

Gene Wiki entry for TMEM25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM25 gene promoter:
         STAT5B   HOXA9B   HOXA9   Sp1   CUTL1   C/EBPalpha   Meis-1b   Chx10   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM25 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

TMEM25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM25 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118401:  view genomic region     (about GC identifiers)

Start:
118,401,756 bp from pter      End:
118,417,995 bp from pter
Size:
16,240 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMM25_HUMAN, Q86YD3 (See protein sequence)
Recommended Name: Transmembrane protein 25 precursor  
Size: 366 amino acids; 39285 Da
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 2: Secreted (Potential)
Subcellular location: Isoform 3: Secreted (Potential)
Secondary accessions: A8K8J4 B0YJA6 B0YJA7 B0YJA9 G5E9U4 Q6UW89 Q86UA7 Q8NBL5 Q96KA6 Q96MW9
Alternative splicing: 5 isoforms:  Q86YD3-1   Q86YD3-2   Q86YD3-3   Q86YD3-4   Q86YD3-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM25: NX_Q86YD3

Explore proteomics data for TMEM25 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YD3

  • TMEM25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM25 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001137506.1  NP_001137507.1  NP_001137508.1  NP_001137509.1  NP_001137510.1  NP_116169.2  

    ENSEMBL proteins: 
     ENSP00000411882   ENSP00000416071   ENSP00000431663   ENSP00000432062   ENSP00000432040  
     ENSP00000346237   ENSP00000433938   ENSP00000433906   ENSP00000433059   ENSP00000278959  
     ENSP00000431548   ENSP00000315635   ENSP00000435446   ENSP00000431205   ENSP00000436746  
     ENSP00000431145   ENSP00000352924   ENSP00000439408  

    Human Recombinant Protein Products for TMEM25: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TMEM25
    OriGene Protein Over-expression Lysate for TMEM25
    OriGene MassSpec for TMEM25 
    OriGene Custom Protein Services for TMEM25
    GenScript Custom Purified and Recombinant Proteins Services for TMEM25
    Novus Biologicals TMEM25 Lysate
    Sino Biological Recombinant Protein for TMEM25
    Sino Biological Cell Lysate for TMEM25 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM25 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    TMEM25 for ontologies           About GeneDecksing



    TMEM25 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM25
    GenScript Custom Superior Antibodies Services for TMEM25
    Novus Biologicals TMEM25 Antibody
    Abcam antibodies for TMEM25
    Cloud-Clone Corp. Antibodies for TMEM25 
    Search ThermoFisher Antibodies for TMEM25
    Search LSBio for Antibodies for TMEM25 

    Assay Products for TMEM25: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM25
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM25
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM25 
    Cloud-Clone Corp. CLIAs for TMEM25


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q86YD3

    ProtoNet protein and cluster: Q86YD3

    UniProtKB/Swiss-Prot: TMM25_HUMAN, Q86YD3
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    TMEM25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TMEM25 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMEM25:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM25 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM25 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM25 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM25
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM25 (see all 38):
    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-128 hsa-miR-218 hsa-miR-372 hsa-miR-93 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidTMEM25 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMEM25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM25

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM25
    Sirion Biotech Customized adenovirus for overexpression of TMEM25

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TMEM25 (see all 30)
    OriGene ORF clones in mouse, rat for TMEM25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TMEM25 (NM_032780)
    Sino Biological Human cDNA Clone for TMEM25
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM25
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM25 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM25 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM25
    Search LifeMap BioReagents cell lines for TMEM25
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM25


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM25

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TMEM25 (Q86YD32, 3 ENSP000003156354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    --XM_292512.32MINT-2877636
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM25 (TMM25)

    Search CenterWatch for drugs/clinical trials and news about TMEM25 / TMM25

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM25 gene (6 alternative transcripts): 
    NM_001144034.1  NM_001144035.1  NM_001144036.1  NM_001144037.1  NM_001144038.1  NM_032780.3  

    Unigene Cluster for TMEM25:

    Transmembrane protein 25
    Hs.564188  [show with all ESTs]
    Unigene Representative Sequence: NM_032780
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000411589(uc009zad.3) ENST00000442938(uc001ptl.2 uc001ptm.2)
    ENST00000526941 ENST00000527785 ENST00000525118 ENST00000534181 ENST00000528373
    ENST00000354284 ENST00000529176 ENST00000530423 ENST00000533137 ENST00000533587
    ENST00000529001(uc010ryd.1) ENST00000532762 ENST00000526973 ENST00000354064
    ENST00000533627 ENST00000533102(uc001ptk.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM25
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM25 (see all 38):
    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-128 hsa-miR-218 hsa-miR-372 hsa-miR-93 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidTMEM25 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMEM25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM25
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM25 (see all 30)
    OriGene ORF clones in mouse, rat for TMEM25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TMEM25 (NM_032780)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM25
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM25 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM25 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM25
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM25
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM25
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM25
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM25

    Additional mRNA sequence: 

    AK027305.1 AK056325.1 AK075437.1 AK225415.1 AK292359.1 AK293670.1 AK297255.1 AY358919.1 
    BC036433.1 BC042896.1 BC051841.1 

    24/28 DOTS entries (see all 28):

    DT.100787805  DT.101984160  DT.120717148  DT.100787806  DT.213383  DT.120717270  DT.120717200  DT.100787814 
    DT.95277310  DT.120717134  DT.100787812  DT.91727311  DT.120717178  DT.100787808  DT.100787815  DT.120717204 
    DT.120717342  DT.100787816  DT.120717242  DT.100787807  DT.120717186  DT.95236241  DT.120717188  DT.100787817 

    24/140 AceView cDNA sequences (see all 140):

    BM755926 AL525085 AI655677 BQ575769 BP367382 BP358627 BC042896 BI916135 
    BI826047 AI084891 CR621200 BM757848 CA411976 BM767613 AW613509 BQ001717 
    BI755230 NM_032780 BG819434 AI658541 AU279661 BX460006 CD634287 AK096260 

    GeneLoc Exon Structure

    5/31 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM25 (see all 31)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ·
    SP1:                                                        -                                                     -                                             
    SP2:                    -     -     -                       -     -     -     -     -     -     -     -     -     -                                             
    SP3:                                                        -                                                     -                                             
    SP4:                                                                                                              -                                             
    SP5:                    -     -     -                       -     -     -     -     -     -     -                 -                                             

    ExUns: 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                              
    SP2:              -     -     -     -     -     -                                 
    SP3:              -     -     -     -     -     -                                 
    SP4:              -     -     -     -     -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for TMEM25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTGCCTA
    TMEM25 Expression
    About this image


    See TMEM25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM25

    SOURCE GeneReport for Unigene cluster: Hs.564188
        SABiosciences Custom PCR Arrays for TMEM25
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM25
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM25
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM25
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM25
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM25 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem251 , 5 transmembrane protein 251, 5 87.31(n)1
    91.23(a)1
      9 (24.84 cM)5
    716871  NM_027865.21  NP_082141.11 
     447937765 
    zebrafish
    (Danio rerio)
    Actinopterygii TMEM256
    transmembrane protein 25
    28(a)
    1 ↔ 1
    15(46543800-46545096)


    ENSEMBL Gene Tree for TMEM25 (if available)
    TreeFam Gene Tree for TMEM25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/326 SNPs in TMEM25 are shown (see all 326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115507691,2
    C--118402504(+) GCCTAG/TGCCCG 6 -- ut512Minor allele frequency- T:0.05CSA WA 120
    rs1404303871,2
    C--118402625(+) CTGGGC/TTCCAA 6 -- int10--------
    rs1504061051,2
    C--118402633(+) CAAAGA/CCCCCT 6 -- int10--------
    rs356151201,2
    F--118402720(+) CTACCC/ATAGGT 6 -- int11Minor allele frequency- A:0.50NA 4
    rs359154341,2,4
    C,F--118402869(+) GGTTGG/CGGGGA 11 /C /W mis1 int14Minor allele frequency- C:0.01NA CSA 3874
    rs455587321,2
    C,F--118402962(+) GCAGGC/G/TGGGCC 16 G syn1 int15NS NA CSA EU 5050
    rs1378610341,2
    C,F--118403055(+) GCCTTC/TTCTGG 11 F syn1 int12Minor allele frequency- T:0.00NA EU 5655
    rs1467529191,2
    C,F--118403069(+) CACCAG/TCACCT 11 S I mis1 int12Minor allele frequency- T:0.00NA EU 5659
    rs1383503131,2
    C,F--118403151(+) GCCAAC/TGCCTC 11 N syn1 int11Minor allele frequency- T:0.00NA 4552
    rs79332431,2
    C,F,A,H--118403205(+) GGAGAT/GAGGTT 6 -- int118Minor allele frequency- G:0.12NS EA NA CSA WA 2261

    HapMap Linkage Disequilibrium report for TMEM25 (118401756 - 118417995 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM25:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1319n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM25
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613934    OMIM disorders: --

    2 diseases for TMEM25:    About MalaCards
    breast cancer    


    TMEM25 for disorders           About GeneDecksing


    Export disorders for TMEM25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM25 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TMEM25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. (PubMed id 15254712)1, 3 Katoh M. and Katoh M. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. TMEM25 is a candidate biomarker methylated and down-re gulated in colorectal cancer. (PubMed id 23324576)1 Hrasovec S....Ravnik-Glavac M. (2013)
    8. TMEM25, REPS2 and Meis 1: favourable prognostic and p redictive biomarkers for breast cancer. (PubMed id 19776672)1 Doolan P....O'Driscoll L. (2009)
    9. Broad spectrum identification of SUMO substrates in m elanoma cells. (PubMed id 17549794)1 Ganesan A.K....White M.A. (2007)
    10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84866 HGNC: 25890 AceView: TMEM25 Ensembl:ENSG00000149582 euGenes: HUgn84866
    ECgene: TMEM25 H-InvDB: TMEM25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM25 gene:
    Search GeneIP for patents involving TMEM25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMEM25  
     OriGene qPCR primer pairs and template standards for TMEM25   OriGene Protein Over-expression Lysate for TMEM25  
     OriGene MassSpec something-or-other for TMEM25   OriGene clones in human, mouse for TMEM25  
     OriGene qSTAR qPCR primer pairs in human, mouse for TMEM25   OriGene Purified Protein for TMEM25  
     OriGene ORF clones in mouse, rat for TMEM25   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMEM25   OriGene Custom Protein Services for TMEM25  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM25
     QIAGEN SeqTarget long-range PCR primers for resequencing TMEM25
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM25
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM25
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM25
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM25
     GenScript Custom Purified and Recombinant Proteins Services for TMEM25 GenScript cDNA clones with any tag delivered in your preferred vector for TMEM25
     GenScript Custom Assay Services for TMEM25 GenScript Custom Superior Antibodies Services for TMEM25
     GenScript Custom overexpressing Cell Line Services for TMEM25 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TMEM25 promoter
     Search Chromatin IP Primers for TMEM25
     RT2 qPCR Primer Assay in human, mouse, rat TMEM25
     Search GNC Networks for TMEM25
     SABiosciences Custom PCR Arrays for TMEM25
     Search Tocris compounds for TMEM25 (TMM25)
     Proteins and Antibodies for TMEM25
     Cell Lysates for TMEM25
     cDNA Clones for TMEM25
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMEM25 antibodies
     TMEM25 lysates
     Antibodies for TMEM25
     See all of Abcam's Antibodies, Kits and Proteins for TMEM25
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TMEM25
     Antibodies for TMEM25
     ELISAs for TMEM25
     CLIAs for TMEM25
     Search LifeMap BioReagents cell lines for TMEM25
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM25
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM25
     SwitchGear Promoter luciferase reporter plasmids for TMEM25
     Search ThermoFisher Antibodies for TMEM25
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM25
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM25
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM25
    Customized:
     lentivirus for stable overexpression of TMEM25
     lentivirus expression plasmids for stable overexpression of TMEM25
     adenovirus for overexpression of TMEM25
     Search LSBio for Antibodies for TMEM25
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMEM25 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4