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Aliases for TMEM25 Gene

Aliases for TMEM25 Gene

  • Transmembrane Protein 25 2 3
  • 0610039J01Rik 3

External Ids for TMEM25 Gene

Summaries for TMEM25 Gene

GeneCards Summary for TMEM25 Gene

TMEM25 (Transmembrane Protein 25) is a Protein Coding gene.

Gene Wiki entry for TMEM25 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM25 Gene

Genomics for TMEM25 Gene

Genomic Location for TMEM25 Gene

Start:
118,531,041 bp from pter
End:
118,547,280 bp from pter
Size:
16,240 bases
Orientation:
Plus strand

Genomic View for TMEM25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM25 Gene

Regulatory Elements for TMEM25 Gene

Proteins for TMEM25 Gene

  • Protein details for TMEM25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD3-TMM25_HUMAN
    Recommended name:
    Transmembrane protein 25
    Protein Accession:
    Q86YD3
    Secondary Accessions:
    • A8K8J4
    • B0YJA6
    • B0YJA7
    • B0YJA9
    • G5E9U4
    • Q6UW89
    • Q86UA7
    • Q8NBL5
    • Q96KA6
    • Q96MW9

    Protein attributes for TMEM25 Gene

    Size:
    366 amino acids
    Molecular mass:
    39285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM25 Gene

Proteomics data for TMEM25 Gene at MOPED

Post-translational modifications for TMEM25 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn106, Asn162, Asn175, Asn192, and Asn205

No data available for DME Specific Peptides for TMEM25 Gene

Domains for TMEM25 Gene

Gene Families for TMEM25 Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

Protein Domains for TMEM25 Gene

Suggested Antigen Peptide Sequences for TMEM25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YD3

UniProtKB/Swiss-Prot:

TMM25_HUMAN
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • Q86YD3
genes like me logo Genes that share domains with TMEM25: view

Function for TMEM25 Gene

Gene Ontology (GO) - Molecular Function for TMEM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM25: view

Phenotypes for TMEM25 Gene

genes like me logo Genes that share phenotypes with TMEM25: view

miRNA for TMEM25 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM25 Gene

Localization for TMEM25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM25 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM25 Gene COMPARTMENTS Subcellular localization image for TMEM25 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM25: view

Pathways for TMEM25 Gene

SuperPathways for TMEM25 Gene

No Data Available

Interacting Proteins for TMEM25 Gene

Gene Ontology (GO) - Biological Process for TMEM25 Gene

None

No data available for Pathways by source for TMEM25 Gene

Transcripts for TMEM25 Gene

Unigene Clusters for TMEM25 Gene

Transmembrane protein 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM25 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ·
SP1: - -
SP2: - - - - - - - - - - - - -
SP3: - -
SP4: -
SP5: - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - -
SP19: - - - - - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - -
SP22: - - -
SP23: - -
SP24: - -
SP25: - - - - - - - - -
SP26: - - -
SP27:
SP28: - - - -
SP29: - - - - - -
SP30: - - -
SP31: - - -

ExUns: 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8: - - - - - -
SP9: - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - - - - -
SP27: -
SP28:
SP29:
SP30:
SP31:

Relevant External Links for TMEM25 Gene

GeneLoc Exon Structure for
TMEM25
ECgene alternative splicing isoforms for
TMEM25

Expression for TMEM25 Gene

mRNA expression in normal human tissues for TMEM25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TMEM25 Gene Hs.564188

genes like me logo Genes that share expressions with TMEM25: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for TMEM25 Gene

Orthologs for TMEM25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM25 35
  • 99.18 (n)
  • 98.91 (a)
TMEM25 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM25 35
  • 90.59 (n)
  • 93.15 (a)
TMEM25 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM25 35
  • 90.67 (n)
  • 95.34 (a)
TMEM25 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem25 35
  • 87.31 (n)
  • 91.23 (a)
Tmem25 16
Tmem25 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM25 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM25 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem25 35
  • 86.94 (n)
  • 90.68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170615 35
  • 51.63 (n)
  • 42.28 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM25 36
  • 30 (a)
OneToOne
Species with no ortholog for TMEM25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM25 Gene

ENSEMBL:
Gene Tree for TMEM25 (if available)
TreeFam:
Gene Tree for TMEM25 (if available)

Paralogs for TMEM25 Gene

No data available for Paralogs for TMEM25 Gene

Variants for TMEM25 Gene

Sequence variations from dbSNP and Humsavar for TMEM25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs478865 -- 118,536,223(-) tgagc(A/C)aaact intron-variant, downstream-variant-500B
rs497586 -- 118,537,115(+) GCGGG(C/T)GGATT intron-variant
rs510218 -- 118,534,937(-) GAGTA(C/T)TGGGG utr-variant-3-prime, intron-variant
rs512849 -- 118,534,628(-) AGGAA(A/C/T)GGGAG utr-variant-3-prime, intron-variant
rs520331 -- 118,537,299(+) tcgcg(C/T)caatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM25 Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294

Relevant External Links for TMEM25 Gene

HapMap Linkage Disequilibrium report
TMEM25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM25 Gene

Disorders for TMEM25 Gene

No disorders were found for TMEM25 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM25 Gene

Publications for TMEM25 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. (PMID: 15254712) Katoh M. … Katoh M. (Oncol. Rep. 2004) 2 3
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM25 Gene

Sources for TMEM25 Gene

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