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Aliases for TMEM25 Gene

Aliases for TMEM25 Gene

  • Transmembrane Protein 25 2 3 5
  • 0610039J01Rik 3

External Ids for TMEM25 Gene

Previous GeneCards Identifiers for TMEM25 Gene

  • GC11P117941
  • GC11P117907
  • GC11P118401
  • GC11P114338

Summaries for TMEM25 Gene

GeneCards Summary for TMEM25 Gene

TMEM25 (Transmembrane Protein 25) is a Protein Coding gene.

Gene Wiki entry for TMEM25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM25 Gene

Genomics for TMEM25 Gene

Regulatory Elements for TMEM25 Gene

Enhancers for TMEM25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G118433 1.9 VISTA Ensembl ENCODE dbSUPER 10.6 -93.0 -92953 8.2 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 IFT46 THY1 CCDC84 LOC101929089 TMEM25 ATP5L ENSG00000254873 HINFP DSCAML1 ARCN1
GH11G118442 1.3 Ensembl ENCODE dbSUPER 10.6 -87.8 -87803 1.1 TBL1XR1 BACH1 BMI1 RELA ZFHX2 GATA3 ARID3A POLR2A EED ETV6 ENSG00000254873 ATP5L LOC101929089 TMEM25 TTC36 KMT2A GC11M118474
GH11G117814 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.3 -713.6 -713639 6.7 HDGF PKNOX1 FOXA2 ARNT ZFP64 WRNIP1 ARID4B SIN3A YBX1 ZNF2 IL10RA DSCAML1 FXYD2 FXYD6-FXYD2 FXYD6 TMPRSS13 CEP164 TMEM25 JAML GC11P117669
GH11G118580 0.5 dbSUPER 10.6 +50.4 50409 1.8 PAF1 PKNOX1 JUN ZBTB33 IFT46 PHLDB1 LOC101929089 TMEM25 TTC36 ENSG00000254873 ATP5L KMT2A ENSG00000255384 LOC101929133
GH11G118587 0.5 dbSUPER 10.4 +57.1 57072 1.2 PKNOX1 GATA3 ZNF24 IFT46 TMEM25 LOC101929089 TTC36 KMT2A ENSG00000255384 HMBS H2AFX C2CD2L DPAGT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM25 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045639 -88 1601 HDGF ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for TMEM25 Gene

Chromosome:
11
Start:
118,531,041 bp from pter
End:
118,547,280 bp from pter
Size:
16,240 bases
Orientation:
Plus strand

Genomic View for TMEM25 Gene

Genes around TMEM25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM25 Gene

Proteins for TMEM25 Gene

  • Protein details for TMEM25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD3-TMM25_HUMAN
    Recommended name:
    Transmembrane protein 25
    Protein Accession:
    Q86YD3
    Secondary Accessions:
    • A8K8J4
    • B0YJA6
    • B0YJA7
    • B0YJA9
    • G5E9U4
    • Q6UW89
    • Q86UA7
    • Q8NBL5
    • Q96KA6
    • Q96MW9

    Protein attributes for TMEM25 Gene

    Size:
    366 amino acids
    Molecular mass:
    39285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM25 Gene

Post-translational modifications for TMEM25 Gene

  • Glycosylation at Asn106, Asn162, Asn175, Asn192, and Asn205
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM25 Gene

Domains & Families for TMEM25 Gene

Gene Families for TMEM25 Gene

Protein Domains for TMEM25 Gene

Suggested Antigen Peptide Sequences for TMEM25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM25: view

No data available for UniProtKB/Swiss-Prot for TMEM25 Gene

Function for TMEM25 Gene

Gene Ontology (GO) - Molecular Function for TMEM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM25: view
genes like me logo Genes that share phenotypes with TMEM25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM25

CRISPR Products

miRNA for TMEM25 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM25 Gene

Localization for TMEM25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM25 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM25 gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytoskeleton 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM25: view

Pathways & Interactions for TMEM25 Gene

SuperPathways for TMEM25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM25 Gene

Drugs & Compounds for TMEM25 Gene

No Compound Related Data Available

Transcripts for TMEM25 Gene

Unigene Clusters for TMEM25 Gene

Transmembrane protein 25:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM25 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ·
SP1: - -
SP2: - - - - - - - - - - - - -
SP3: - -
SP4: -
SP5: - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - -
SP19: - - - - - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - -
SP22: - - -
SP23: - -
SP24: - -
SP25: - - - - - - - - -
SP26: - - -
SP27:
SP28: - - - -
SP29: - - - - - -
SP30: - - -
SP31: - - -

ExUns: 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8: - - - - - -
SP9: - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - - - - -
SP27: -
SP28:
SP29:
SP30:
SP31:

Relevant External Links for TMEM25 Gene

GeneLoc Exon Structure for
TMEM25
ECgene alternative splicing isoforms for
TMEM25

Expression for TMEM25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM25 Gene:

TMEM25

SOURCE GeneReport for Unigene cluster for TMEM25 Gene:

Hs.564188

Evidence on tissue expression from TISSUES for TMEM25 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with TMEM25: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM25 Gene

Orthologs for TMEM25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM25 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia TMEM25 34 35
  • 90.67 (n)
cow
(Bos Taurus)
Mammalia TMEM25 34 35
  • 90.59 (n)
mouse
(Mus musculus)
Mammalia Tmem25 34 16 35
  • 87.31 (n)
rat
(Rattus norvegicus)
Mammalia Tmem25 34
  • 86.94 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM25 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM25 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170615 34
  • 51.63 (n)
zebrafish
(Danio rerio)
Actinopterygii TMEM25 35
  • 30 (a)
OneToOne
Species where no ortholog for TMEM25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM25 Gene

ENSEMBL:
Gene Tree for TMEM25 (if available)
TreeFam:
Gene Tree for TMEM25 (if available)

Paralogs for TMEM25 Gene

No data available for Paralogs for TMEM25 Gene

Variants for TMEM25 Gene

Sequence variations from dbSNP and Humsavar for TMEM25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000109082 -- 118,533,115(+) CCACA(C/G/T)GGTGC intron-variant, nc-transcript-variant, reference, missense
rs1000451566 -- 118,538,111(+) TCCCA(A/C)CAATA intron-variant
rs1001194423 -- 118,543,306(+) CATGT(A/G)TTTAT intron-variant
rs1001520528 -- 118,531,757(+) ACAGG(C/G)CCGCC intron-variant, upstream-variant-2KB
rs1001578541 -- 118,544,165(+) CTTGG(C/G)TGACA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM25 Gene

Variant ID Type Subtype PubMed ID
esv3359887 CNV insertion 20981092
esv3579929 CNV loss 25503493
esv3627872 CNV gain 21293372
nsv1044281 CNV gain 25217958
nsv1122673 CNV deletion 24896259

Variation tolerance for TMEM25 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.99; 96.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM25 Gene

Disorders for TMEM25 Gene

Relevant External Links for TMEM25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM25

No disorders were found for TMEM25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM25 Gene

Publications for TMEM25 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. (PMID: 15254712) Katoh M. … Katoh M. (Oncol. Rep. 2004) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64

Products for TMEM25 Gene

Sources for TMEM25 Gene

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