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Aliases for TMEM25 Gene

Aliases for TMEM25 Gene

  • Transmembrane Protein 25 2 3 5
  • 0610039J01Rik 3

External Ids for TMEM25 Gene

Previous GeneCards Identifiers for TMEM25 Gene

  • GC11P117941
  • GC11P117907
  • GC11P118401
  • GC11P114338

Summaries for TMEM25 Gene

GeneCards Summary for TMEM25 Gene

TMEM25 (Transmembrane Protein 25) is a Protein Coding gene.

Gene Wiki entry for TMEM25 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM25 Gene

Genomics for TMEM25 Gene

Regulatory Elements for TMEM25 Gene

Enhancers for TMEM25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM25 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM25 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM25 Gene

Chromosome:
11
Start:
118,531,041 bp from pter
End:
118,547,280 bp from pter
Size:
16,240 bases
Orientation:
Plus strand

Genomic View for TMEM25 Gene

Genes around TMEM25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM25 Gene

Proteins for TMEM25 Gene

  • Protein details for TMEM25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YD3-TMM25_HUMAN
    Recommended name:
    Transmembrane protein 25
    Protein Accession:
    Q86YD3
    Secondary Accessions:
    • A8K8J4
    • B0YJA6
    • B0YJA7
    • B0YJA9
    • G5E9U4
    • Q6UW89
    • Q86UA7
    • Q8NBL5
    • Q96KA6
    • Q96MW9

    Protein attributes for TMEM25 Gene

    Size:
    366 amino acids
    Molecular mass:
    39285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM25 Gene

Proteomics data for TMEM25 Gene at MOPED

Post-translational modifications for TMEM25 Gene

  • Glycosylation at Asn 106, Asn 162, Asn 175, Asn 192, and Asn 205
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM25 Gene

Domains & Families for TMEM25 Gene

Gene Families for TMEM25 Gene

Protein Domains for TMEM25 Gene

Suggested Antigen Peptide Sequences for TMEM25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YD3

UniProtKB/Swiss-Prot:

TMM25_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TMEM25: view

Function for TMEM25 Gene

genes like me logo Genes that share phenotypes with TMEM25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM25

miRNA for TMEM25 Gene

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM25 Gene

Localization for TMEM25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM25 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM25 Gene COMPARTMENTS Subcellular localization image for TMEM25 gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytoskeleton 2
golgi apparatus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM25: view

Pathways & Interactions for TMEM25 Gene

SuperPathways for TMEM25 Gene

No Data Available

Interacting Proteins for TMEM25 Gene

Selected Interacting proteins: Q86YD3-TMM25_HUMAN for TMEM25 Gene via MINT UniProtKB I2D

Gene Ontology (GO) - Biological Process for TMEM25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM25 Gene

Drugs & Compounds for TMEM25 Gene

No Compound Related Data Available

Transcripts for TMEM25 Gene

Unigene Clusters for TMEM25 Gene

Transmembrane protein 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM25 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ·
SP1: - -
SP2: - - - - - - - - - - - - -
SP3: - -
SP4: -
SP5: - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - -
SP15: - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - -
SP19: - - - - - - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - -
SP22: - - -
SP23: - -
SP24: - -
SP25: - - - - - - - - -
SP26: - - -
SP27:
SP28: - - - -
SP29: - - - - - -
SP30: - - -
SP31: - - -

ExUns: 11c · 11d ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8: - - - - - -
SP9: - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - - - - -
SP27: -
SP28:
SP29:
SP30:
SP31:

Relevant External Links for TMEM25 Gene

GeneLoc Exon Structure for
TMEM25
ECgene alternative splicing isoforms for
TMEM25

Expression for TMEM25 Gene

mRNA expression in normal human tissues for TMEM25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TMEM25 Gene Hs.564188

genes like me logo Genes that share expression patterns with TMEM25: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM25 Gene

Orthologs for TMEM25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM25 35
  • 90.59 (n)
  • 93.15 (a)
TMEM25 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM25 35
  • 90.67 (n)
  • 95.34 (a)
TMEM25 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem25 35
  • 87.31 (n)
  • 91.23 (a)
Tmem25 16
Tmem25 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM25 35
  • 99.18 (n)
  • 98.91 (a)
TMEM25 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem25 35
  • 86.94 (n)
  • 90.68 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM25 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM25 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170615 35
  • 51.63 (n)
  • 42.28 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM25 36
  • 30 (a)
OneToOne
Species with no ortholog for TMEM25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM25 Gene

ENSEMBL:
Gene Tree for TMEM25 (if available)
TreeFam:
Gene Tree for TMEM25 (if available)

Paralogs for TMEM25 Gene

No data available for Paralogs for TMEM25 Gene

Variants for TMEM25 Gene

Sequence variations from dbSNP and Humsavar for TMEM25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12289253 - 118,534,353(+) CAGCC(A/C/G)AGGTA reference, missense
VAR_033623 -
rs520331 -- 118,537,299(+) tcgcg(C/T)caatg intron-variant
rs520362 -- 118,537,309(+) gcact(C/T)cagcc intron-variant
rs520439 -- 118,537,340(+) cgtcc(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM25 Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294

Variation tolerance for TMEM25 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.99; 96.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM25 Gene

Disorders for TMEM25 Gene

Relevant External Links for TMEM25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM25

No disorders were found for TMEM25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM25 Gene

Publications for TMEM25 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Identification and characterization of human TMEM25 and mouse Tmem25 genes in silico. (PMID: 15254712) Katoh M. … Katoh M. (Oncol. Rep. 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. TMEM25 is a candidate biomarker methylated and down-regulated in colorectal cancer. (PMID: 23324576) HraA!ovec S. … Ravnik-GlavaA8 M. (Dis. Markers 2013) 3

Products for TMEM25 Gene

Sources for TMEM25 Gene

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