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Aliases for TMEM249 Gene

Aliases for TMEM249 Gene

  • Transmembrane Protein 249 2 3 5
  • C8ORFK29 3 4
  • Putative Transmembrane Protein C8orfK29 3

External Ids for TMEM249 Gene

Previous GeneCards Identifiers for TMEM249 Gene

  • GC08M145577

Summaries for TMEM249 Gene

GeneCards Summary for TMEM249 Gene

TMEM249 (Transmembrane Protein 249) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM249 Gene

Genomics for TMEM249 Gene

Regulatory Elements for TMEM249 Gene

Enhancers for TMEM249 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G143634 1.1 ENCODE 5.6 +719.5 719496 2.9 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 NAPRT MAF1 TOP1MT TMEM249 OPLAH SLC39A4 ZNF623 LOC105375799
GH08G144720 0.4 ENCODE 5.5 -365.2 -365233 1.2 CTCF L3MBTL2 RPL8 ARHGAP39 ZNF517 ZNF7 TMEM249 ZNF252P-AS1 PIR37450 ZNF251
GH08G144353 1.3 Ensembl ENCODE 0.7 -0.9 -904 6.7 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 CPSF1 VPS28 TONSL TMEM249 FBXL6 ENSG00000271698
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM249 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM249 Gene

Chromosome:
8
Start:
144,352,219 bp from pter
End:
144,355,609 bp from pter
Size:
3,391 bases
Orientation:
Minus strand

Genomic View for TMEM249 Gene

Genes around TMEM249 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM249 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM249 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM249 Gene

Proteins for TMEM249 Gene

  • Protein details for TMEM249 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2WGJ8-TM249_HUMAN
    Recommended name:
    Transmembrane protein 249
    Protein Accession:
    Q2WGJ8

    Protein attributes for TMEM249 Gene

    Size:
    235 amino acids
    Molecular mass:
    27046 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM249 Gene

Post-translational modifications for TMEM249 Gene

  • Glycosylation at posLast=3838 and Asn115

Other Protein References for TMEM249 Gene

No data available for DME Specific Peptides for TMEM249 Gene

Domains & Families for TMEM249 Gene

Protein Domains for TMEM249 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM249: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM249 Gene

Function for TMEM249 Gene

Phenotypes for TMEM249 Gene

GenomeRNAi human phenotypes for TMEM249:
genes like me logo Genes that share phenotypes with TMEM249: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM249 Gene

Localization for TMEM249 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM249 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM249 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM249 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM249: view

Pathways & Interactions for TMEM249 Gene

SuperPathways for TMEM249 Gene

No Data Available

Interacting Proteins for TMEM249 Gene

Gene Ontology (GO) - Biological Process for TMEM249 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM249 Gene

Drugs & Compounds for TMEM249 Gene

No Compound Related Data Available

Transcripts for TMEM249 Gene

Unigene Clusters for TMEM249 Gene

Transmembrane protein 249:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM249 Gene

No ASD Table

Relevant External Links for TMEM249 Gene

GeneLoc Exon Structure for
TMEM249
ECgene alternative splicing isoforms for
TMEM249

Expression for TMEM249 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM249 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM249 Gene:

TMEM249

SOURCE GeneReport for Unigene cluster for TMEM249 Gene:

Hs.122231

Evidence on tissue expression from TISSUES for TMEM249 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TMEM249: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM249 Gene

Orthologs for TMEM249 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM249 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM249 34
  • 98.21 (n)
cow
(Bos Taurus)
Mammalia TMEM249 34
  • 85.42 (n)
dog
(Canis familiaris)
Mammalia TMEM249 34
  • 81.83 (n)
mouse
(Mus musculus)
Mammalia Gm8140 34
  • 75.77 (n)
Tmem249 16
rat
(Rattus norvegicus)
Mammalia Tmem249 34
  • 73.3 (n)
Species where no ortholog for TMEM249 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM249 Gene

ENSEMBL:
Gene Tree for TMEM249 (if available)
TreeFam:
Gene Tree for TMEM249 (if available)

Paralogs for TMEM249 Gene

No data available for Paralogs for TMEM249 Gene

Variants for TMEM249 Gene

Sequence variations from dbSNP and Humsavar for TMEM249 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000629880 -- 144,353,496(+) GTTTC(C/T)GGGCG nc-transcript-variant, reference, synonymous-codon, missense
rs1000980824 -- 144,353,168(+) AGTGC(A/G)CAACA downstream-variant-500B
rs1001646326 -- 144,355,357(+) TGGGC(C/T)GGCTG downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1002706581 -- 144,354,425(+) CGCGC(A/G)GGGCT intron-variant
rs1004043581 -- 144,353,968(+) TGAGC(G/T)CCAGG nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM249 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
esv2664345 CNV deletion 23128226
esv2759652 CNV gain+loss 17122850
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612931 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for TMEM249 Gene

Gene Damage Index Score: 1.58; 30.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM249 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM249

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM249 Gene

Disorders for TMEM249 Gene

Relevant External Links for TMEM249

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM249

No disorders were found for TMEM249 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM249 Gene

Publications for TMEM249 Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM249 Gene

Sources for TMEM249 Gene

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