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Aliases for TMEM248 Gene

Aliases for TMEM248 Gene

  • Transmembrane Protein 248 2 3
  • C7orf42 3 4
  • Chromosome 7 Open Reading Frame 42 2
  • UPF0458 Protein C7orf42 3

External Ids for TMEM248 Gene

Previous HGNC Symbols for TMEM248 Gene

  • C7orf42

Previous GeneCards Identifiers for TMEM248 Gene

  • GC07P066389
  • GC07P066393
  • GC07P066400
  • GC07P066411

Summaries for TMEM248 Gene

GeneCards Summary for TMEM248 Gene

TMEM248 (Transmembrane Protein 248) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM248 Gene

Genomics for TMEM248 Gene

Genomic Location for TMEM248 Gene

Start:
66,921,216 bp from pter
End:
66,958,551 bp from pter
Size:
37,336 bases
Orientation:
Plus strand

Genomic View for TMEM248 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM248 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM248 Gene

No data available for Regulatory Elements for TMEM248 Gene

Proteins for TMEM248 Gene

  • Protein details for TMEM248 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWD8-TM248_HUMAN
    Recommended name:
    Transmembrane protein 248
    Protein Accession:
    Q9NWD8
    Secondary Accessions:
    • Q53H07
    • Q96FR2

    Protein attributes for TMEM248 Gene

    Size:
    314 amino acids
    Molecular mass:
    35052 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM248 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM248 Gene

Proteomics data for TMEM248 Gene at MOPED

Post-translational modifications for TMEM248 Gene

  • Ubiquitination at Lys76, Lys228, and Lys308
  • Glycosylation at Asn132
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM248 Gene

No data available for DME Specific Peptides for TMEM248 Gene

Domains for TMEM248 Gene

Protein Domains for TMEM248 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NWD8

UniProtKB/Swiss-Prot:

TM248_HUMAN :
  • Q9NWD8
Family:
  • Belongs to the TMEM248 family.
genes like me logo Genes that share domains with TMEM248: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM248 Gene

Function for TMEM248 Gene

Gene Ontology (GO) - Molecular Function for TMEM248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM248: view

Phenotypes for TMEM248 Gene

GenomeRNAi human phenotypes for TMEM248:
genes like me logo Genes that share phenotypes with TMEM248: view

Animal Model Products

CRISPR Products

miRNA for TMEM248 Gene

miRTarBase miRNAs that target TMEM248

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM248

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM248 Gene

Localization for TMEM248 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM248 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM248 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM248: view

No data available for Subcellular locations from COMPARTMENTS for TMEM248 Gene

Pathways for TMEM248 Gene

SuperPathways for TMEM248 Gene

No Data Available

Interacting Proteins for TMEM248 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340668%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000316130%0d%0a
Selected Interacting proteins: ENSP00000340668 Q9NWD8-TM248_HUMAN for TMEM248 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for TMEM248 Gene

None

No data available for Pathways by source for TMEM248 Gene

Transcripts for TMEM248 Gene

Unigene Clusters for TMEM248 Gene

Transmembrane protein 248:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM248

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM248 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for TMEM248 Gene

GeneLoc Exon Structure for
TMEM248
ECgene alternative splicing isoforms for
TMEM248

Expression for TMEM248 Gene

mRNA expression in normal human tissues for TMEM248 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM248 Gene

SOURCE GeneReport for Unigene cluster for TMEM248 Gene Hs.488478

genes like me logo Genes that share expressions with TMEM248: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM248 Gene

Orthologs for TMEM248 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM248 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM248 35
  • 99.79 (n)
  • 100 (a)
TMEM248 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM248 35
  • 88.75 (n)
  • 95.86 (a)
TMEM248 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7ORF42 36
  • 98 (a)
OneToOne
TMEM248 35
  • 92.46 (n)
  • 97.77 (a)
mouse
(Mus musculus)
Mammalia Tmem248 35
  • 86.73 (n)
  • 94.59 (a)
Tmem248 16
Tmem248 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM248 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem248 35
  • 86.2 (n)
  • 95.22 (a)
chicken
(Gallus gallus)
Aves C19H7ORF42 35
  • 81.1 (n)
  • 90.45 (a)
TMEM248 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM248 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64441 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.371 35
tmem248 35
  • 74.38 (n)
  • 85.21 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem248 35
  • 73.25 (n)
  • 80.26 (a)
tmem248 36
  • 79 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3210 36
  • 24 (a)
OneToOne
Species with no ortholog for TMEM248:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM248 Gene

ENSEMBL:
Gene Tree for TMEM248 (if available)
TreeFam:
Gene Tree for TMEM248 (if available)

Paralogs for TMEM248 Gene

Selected SIMAP similar genes for TMEM248 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TMEM248 Gene

genes like me logo Genes that share paralogs with TMEM248: view

No data available for Paralogs for TMEM248 Gene

Variants for TMEM248 Gene

Sequence variations from dbSNP and Humsavar for TMEM248 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs869249 -- 66,922,498(+) ATTGA(C/T)CCTAA intron-variant
rs1404980 -- 66,956,001(+) TGTGT(C/T)TGTGG utr-variant-3-prime
rs1589887 -- 66,950,149(+) TCAAC(A/T)TGGGA intron-variant
rs2293350 -- 66,921,348(+) GTGCC(G/T)AGCGG utr-variant-5-prime, upstream-variant-2KB
rs2293351 -- 66,921,904(+) TGTTC(C/T)CTGTG intron-variant, upstream-variant-2KB

Relevant External Links for TMEM248 Gene

HapMap Linkage Disequilibrium report
TMEM248

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM248 Gene

Disorders for TMEM248 Gene

No disorders were found for TMEM248 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM248 Gene

Publications for TMEM248 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM248 Gene

  • antibodies-online peptides for TMEM248
  • antibodies-online antibodies for TMEM248
  • antibodies-online kits for TMEM248

Sources for TMEM248 Gene

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