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Aliases for TMEM246 Gene

Aliases for TMEM246 Gene

  • Transmembrane Protein 246 2 3
  • C9orf125 3 4
  • Chromosome 9 Open Reading Frame 125 2
  • Transmembrane Protein C9orf125 3

External Ids for TMEM246 Gene

Previous Symbols for TMEM246 Gene

  • C9orf125

Summaries for TMEM246 Gene

GeneCards Summary for TMEM246 Gene

TMEM246 (Transmembrane Protein 246) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM246 Gene

Genomics for TMEM246 Gene

Genomic Location for TMEM246 Gene

Start:
101,473,160 bp from pter
End:
101,533,537 bp from pter
Size:
60,378 bases
Orientation:
Minus strand

Genomic View for TMEM246 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM246 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM246 Gene

No data available for Regulatory Elements for TMEM246 Gene

Proteins for TMEM246 Gene

  • Protein details for TMEM246 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRR3-TM246_HUMAN
    Recommended name:
    Transmembrane protein 246
    Protein Accession:
    Q9BRR3
    Secondary Accessions:
    • Q49AQ4

    Protein attributes for TMEM246 Gene

    Size:
    403 amino acids
    Molecular mass:
    46588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM246 Gene

Proteomics data for TMEM246 Gene at MOPED

Post-translational modifications for TMEM246 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM246 Gene

No data available for DME Specific Peptides for TMEM246 Gene

Domains for TMEM246 Gene

Protein Domains for TMEM246 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM246_HUMAN
Family:
  • Belongs to the TMEM246 family.:
    • Q9BRR3
genes like me logo Genes that share domains with TMEM246: view

No data available for Gene Families for TMEM246 Gene

Function for TMEM246 Gene

Phenotypes for TMEM246 Gene

GenomeRNAi human phenotypes for TMEM246:
genes like me logo Genes that share phenotypes with TMEM246: view

miRNA for TMEM246 Gene

miRTarBase miRNAs that target TMEM246

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM246 Gene

Localization for TMEM246 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM246 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM246 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM246: view

Pathways for TMEM246 Gene

SuperPathways for TMEM246 Gene

No Data Available

Interacting Proteins for TMEM246 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363980%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000309096%0d%0a9606.ENSP00000305595%0d%0a
Selected Interacting proteins: ENSP00000363980 for TMEM246 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM246 Gene

None

No data available for Pathways by source for TMEM246 Gene

Transcripts for TMEM246 Gene

Unigene Clusters for TMEM246 Gene

Transmembrane protein 246:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM246 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for TMEM246 Gene

GeneLoc Exon Structure for
TMEM246
ECgene alternative splicing isoforms for
TMEM246

Expression for TMEM246 Gene

mRNA expression in normal human tissues for TMEM246 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM246 Gene

SOURCE GeneReport for Unigene cluster for TMEM246 Gene Hs.655738

genes like me logo Genes that share expressions with TMEM246: view

Orthologs for TMEM246 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM246 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM246 36
  • 99.6 (n)
  • 100 (a)
TMEM246 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM246 36
  • 91.56 (n)
  • 99.5 (a)
TMEM246 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM246 36
  • 89.74 (n)
  • 97.27 (a)
TMEM246 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem246 36
  • 88.17 (n)
  • 98.26 (a)
Tmem246 16
Tmem246 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM246 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem246 36
  • 88.5 (n)
  • 98.26 (a)
chicken
(Gallus gallus)
Aves C9ORF125 36
  • 67.54 (n)
  • 65.79 (a)
TMEM246 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM246 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem246 36
  • 55.02 (n)
  • 51.04 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem246 36
  • 48.93 (n)
  • 43.85 (a)
tmem246 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F35C11.4 37
  • 27 (a)
OneToOne
Species with no ortholog for TMEM246:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM246 Gene

ENSEMBL:
Gene Tree for TMEM246 (if available)
TreeFam:
Gene Tree for TMEM246 (if available)

Paralogs for TMEM246 Gene

Selected SIMAP similar genes for TMEM246 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM246: view

No data available for Paralogs for TMEM246 Gene

Variants for TMEM246 Gene

Sequence variations from dbSNP and Humsavar for TMEM246 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1113384 -- 101,488,361(+) ATTCC(G/T)AAATT upstream-variant-2KB
rs1124148 -- 101,488,415(+) TGGCT(C/T)AGTGC upstream-variant-2KB
rs1888724 -- 101,486,467(+) CGAAC(A/C)TAAGG intron-variant, upstream-variant-2KB
rs1929482 -- 101,484,497(+) cgtgt(C/T)ataaa intron-variant
rs1929483 -- 101,484,984(+) CATAA(C/T)TAAGC intron-variant

Relevant External Links for TMEM246 Gene

HapMap Linkage Disequilibrium report
TMEM246

No data available for Structural Variations from Database of Genomic Variants (DGV) for TMEM246 Gene

Disorders for TMEM246 Gene

No disorders were found for TMEM246 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM246 Gene

Publications for TMEM246 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TMEM246 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TMEM246
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM246
    • Block miRNA regulation of TMEM246 using miScript Target Protectors

    Sources for TMEM246 Gene

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