Aliases for TMEM246 Gene
Aliases for TMEM246 Gene
External Ids for TMEM246 Gene
- HGNC: 28180
- Entrez Gene: 84302
- Ensembl: ENSG00000165152
- UniProtKB: Q9BRR3
Previous HGNC Symbols for TMEM246 Gene
- C9orf125
Previous GeneCards Identifiers for TMEM246 Gene
- GC09M104236
Summaries for TMEM246 Gene
GeneCards Summary for TMEM246 Gene
TMEM246 (Transmembrane Protein 246) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM246 Gene
Genomics for TMEM246 Gene
Regulatory Elements for TMEM246 Gene
Enhancers for TMEM246 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TMEM246 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TMEM246 Gene
- Chromosome:
- 9
- Start:
- 101,473,158 bp from pter
- End:
- 101,533,537 bp from pter
- Size:
- 60,380 bases
- Orientation:
- Minus strand
Genomic View for TMEM246 Gene
Genes around TMEM246 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.1 by Ensembl
- 9q31.1 by Entrez Gene
- 9q31.1 by HGNC
TMEM246 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM246 Gene
Proteins for TMEM246 Gene
-
Protein details for TMEM246 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BRR3-TM246_HUMAN
- Recommended name:
- Transmembrane protein 246
- Protein Accession:
- Q9BRR3
- Q49AQ4
Protein attributes for TMEM246 Gene
- Size:
- 403 amino acids
- Molecular mass:
- 46588 Da
- Quaternary structure:
- No Data Available
Protein Expression for TMEM246 Gene
Post-translational modifications for TMEM246 Gene
Other Protein References for TMEM246 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TMEM246
- Novus Biologicals Antibodies for TMEM246
- Abcam antibodies for TMEM246
- Search GeneTex for Antibodies for TMEM246
Protein Products
-
OriGene Purified Proteins for TMEM246
- Search Origene for MassSpec and Protein Over-expression Lysates for TMEM246
- Origene Custom Protein Services for TMEM246
- Novus Biologicals proteins for TMEM246
- Search GeneTex for Proteins for TMEM246
Assay Products
No data available for DME Specific Peptides for TMEM246 Gene
Domains & Families for TMEM246 Gene
Suggested Antigen Peptide Sequences for TMEM246 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BRR3- Family:
-
- Belongs to the TMEM246 family.
No data available for Gene Families for TMEM246 Gene
Function for TMEM246 Gene
Phenotypes for TMEM246 Gene
- GenomeRNAi human phenotypes for TMEM246:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased cell number
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM246 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM246 gene
- Search ViGene Biosciences for TMEM246
CRISPR Products
-
OriGene CRISPR knockouts for TMEM246
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM246
- GenScript: Design CRISPR guide RNA sequences for TMEM246
miRNA for TMEM246 Gene
- miRTarBase miRNAs that target TMEM246
-
- hsa-mir-215-5p (MIRT024663)
- hsa-mir-192-5p (MIRT026402)
- hsa-mir-513b-5p (MIRT533722)
- hsa-mir-4695-3p (MIRT533723)
- hsa-mir-6862-3p (MIRT533724)
- hsa-mir-6784-3p (MIRT533725)
- hsa-mir-6511b-3p (MIRT533726)
- hsa-mir-6511a-3p (MIRT533727)
- hsa-mir-4719 (MIRT533728)
- hsa-mir-1285-5p (MIRT533729)
- hsa-mir-3692-3p (MIRT717247)
- hsa-mir-2355-5p (MIRT717248)
- hsa-mir-4436b-5p (MIRT717249)
- hsa-mir-6509-3p (MIRT717250)
- hsa-mir-6754-3p (MIRT717251)
- hsa-mir-412-3p (MIRT717252)
- hsa-mir-6734-3p (MIRT717253)
- hsa-mir-4773 (MIRT717254)
miRNA Products
- Search ViGene Biosciences for TMEM246
Clone Products
- OriGene clones in human for TMEM246
- OriGene ORF clones in human,mouse,rat for TMEM246
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TMEM246
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM246 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM246 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM246 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM246 Gene
Localization for TMEM246 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM246 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 3 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 1 |
| extracellular | 1 |
| lysosome | 1 |
| peroxisome | 1 |
| plasma membrane | 1 |
| vacuole | 1 |
No data available for Gene Ontology (GO) - Cellular Components for TMEM246 Gene
Pathways & Interactions for TMEM246 Gene
More details on SuperPathways for TMEM246
No Data Available
Interacting Proteins for TMEM246 Gene
No data available for Pathways by source and SIGNOR curated interactions for TMEM246 Gene
Transcripts for TMEM246 Gene
mRNA/cDNA for TMEM246 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (99) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM246 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM246
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM246
- GenScript: Design CRISPR guide RNA sequences for TMEM246
miRNA Products
- Search ViGene Biosciences for TMEM246
Clone Products
- OriGene clones in human for TMEM246
- OriGene ORF clones in human,mouse,rat for TMEM246
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TMEM246
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Expression for TMEM246 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Liver Bud
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Adipose (Muscoskeletal System)
This gene is overexpressed in Serum (65.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM246 Gene
SOURCE GeneReport for Unigene cluster for TMEM246 Gene Hs.655738
Primer Products
-
OriGene qPCR primer pairs and template standards for TMEM246
-
OriGene qPCR primer pairs for TMEM246
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM246 Gene
Orthologs for TMEM246 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TMEM246 35 |
|
||
| TMEM246 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TMEM246 35 |
|
||
| TMEM246 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Tmem246 35 |
|
||
| Tmem246 16 |
|
||||
| Tmem246 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM246 35 |
|
||
| TMEM246 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Tmem246 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM246 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C9ORF125 35 |
|
||
| TMEM246 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TMEM246 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem246 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmem246 35 |
|
||
| tmem246 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | F35C11.4 36 |
|
OneToOne |
- Species with no ortholog for TMEM246:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TMEM246 Gene
(1) SIMAP similar genes for TMEM246 Gene using alignment to 1 proteins:
No data available for Paralogs for TMEM246 Gene
Variants for TMEM246 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1113384 | -- | 101,488,361(+) | ATTCC(G/T)AAATT | upstream-variant-2KB | |
| rs1124148 | -- | 101,488,415(+) | TGGCT(C/T)AGTGC | upstream-variant-2KB | |
| rs113016275 | -- | 101,488,852(+) | AGAAA(A/G)TTCTA | upstream-variant-2KB | |
| rs1929482 | -- | 101,484,497(+) | cgtgt(C/T)ataaa | intron-variant | |
| rs1929483 | -- | 101,484,984(+) | CATAA(C/T)TAAGC | intron-variant |
Residual Variation Intolerance Score:
35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.07;
37.93% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMEM246 Gene
Disorders for TMEM246 Gene
Relevant External Links for TMEM246
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TMEM246
No disorders were found for TMEM246 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM246 Gene
Publications for TMEM246 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci. (PMID: 25352737) Ritchie M.D. … McCarty C.A. (Mol. Vis. 2014) 3
Products for TMEM246 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TMEM246
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TMEM246
- Search Origene for MassSpec and Protein Over-expression Lysates for TMEM246
- Origene Custom Protein Services for TMEM246
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for TMEM246
- Browse OriGene Inhibitory RNA Products For TMEM246
- OriGene qPCR primer pairs for TMEM246
- OriGene qPCR primer pairs and template standards for TMEM246
- OriGene CRISPR knockouts for TMEM246
- OriGene clones in human for TMEM246
- OriGene ORF clones in human,mouse,rat for TMEM246
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TMEM246
- GenScript Custom Assay Services for TMEM246
- GenScript Custom overexpressing Cell Line Services for TMEM246
- GenScript: Design CRISPR guide RNA sequences for TMEM246
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TMEM246
- Novus Biologicals Antibodies for TMEM246
- Novus Biologicals proteins for TMEM246
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for TMEM246 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM246 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM246 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM246 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM246 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM246 gene
- Search ViGene Biosciences for TMEM246
- Search ViGene Biosciences for TMEM246
Sources for TMEM246 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon