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Aliases for TMEM245 Gene

Aliases for TMEM245 Gene

  • Transmembrane Protein 245 2 3 5
  • Protein CG-2 3 4
  • C9orf5 3 4
  • Chromosome 9 Open Reading Frame 5 2
  • Transmembrane Protein C9orf5 3
  • CG-2 3
  • CG2 3

External Ids for TMEM245 Gene

Previous HGNC Symbols for TMEM245 Gene

  • C9orf5

Previous GeneCards Identifiers for TMEM245 Gene

  • GC09M111778

Summaries for TMEM245 Gene

GeneCards Summary for TMEM245 Gene

TMEM245 (Transmembrane Protein 245) is a Protein Coding gene. Diseases associated with TMEM245 include Spermatocele.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM245 Gene

Genomics for TMEM245 Gene

Regulatory Elements for TMEM245 Gene

Enhancers for TMEM245 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G109096 1.5 Ensembl ENCODE dbSUPER 23.6 +20.0 20048 6.5 HDGF PKNOX1 FOXA2 ARNT ARID4B FEZF1 YY1 GATA2 FOS ZNF548 ELP1 CTNNAL1 FRRS1L TMEM245 FAM206A MIR32 ENSG00000199331 GC09M109081
GH09G109113 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +2.4 2440 9.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 FRRS1L ELP1 CTNNAL1 TMEM245 MIR32 ENSG00000199331 FAM206A GC09M109081
GH09G109010 1.1 ENCODE 20.4 +107.1 107137 5.4 HDGF PKNOX1 FOXA2 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FRRS1L ELP1 CTNNAL1 TMEM245 ENSG00000199331 MIR32 GC09M109014 PIR44811
GH09G109128 1.4 ENCODE dbSUPER 12.5 -11.9 -11895 6.0 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 CTNNAL1 FRRS1L TMEM245 MIR32 ENSG00000199331 RNU6-984P EPB41L4B GC09M109131
GH09G109091 0.6 dbSUPER 23.6 +27.1 27141 2.5 ZNF766 ZNF366 ZNF512 CEBPB JUNB CEBPG CTNNAL1 TMEM245 FAM206A ELP1 MIR32 ENSG00000199331 GC09M109081
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM245 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM245 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000239516 545 2001 PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2

Genomic Location for TMEM245 Gene

Chromosome:
9
Start:
109,015,135 bp from pter
End:
109,119,945 bp from pter
Size:
104,811 bases
Orientation:
Minus strand

Genomic View for TMEM245 Gene

Genes around TMEM245 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM245 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM245 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM245 Gene

Proteins for TMEM245 Gene

  • Protein details for TMEM245 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H330-TM245_HUMAN
    Recommended name:
    Transmembrane protein 245
    Protein Accession:
    Q9H330
    Secondary Accessions:
    • B4DSW7
    • Q5JTQ5
    • Q5SS43
    • Q6ZME3
    • Q8NDJ5
    • Q96CG6

    Protein attributes for TMEM245 Gene

    Size:
    911 amino acids
    Molecular mass:
    100945 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI39474.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM245 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM245 Gene

Post-translational modifications for TMEM245 Gene

  • Glycosylation at Asn210, posLast=500500, posLast=551551, and posLast=575575
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM245 Gene

Domains & Families for TMEM245 Gene

Protein Domains for TMEM245 Gene

Suggested Antigen Peptide Sequences for TMEM245 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H330

UniProtKB/Swiss-Prot:

TM245_HUMAN :
  • Belongs to the UPF0118 (TMEM245) family.
Family:
  • Belongs to the UPF0118 (TMEM245) family.
genes like me logo Genes that share domains with TMEM245: view

No data available for Gene Families for TMEM245 Gene

Function for TMEM245 Gene

Gene Ontology (GO) - Molecular Function for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM245: view
genes like me logo Genes that share phenotypes with TMEM245: view

Animal Model Products

CRISPR Products

miRNA for TMEM245 Gene

miRTarBase miRNAs that target TMEM245

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM245 Gene

Localization for TMEM245 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM245 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM245 gene
Compartment Confidence
plasma membrane 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 10564813
genes like me logo Genes that share ontologies with TMEM245: view

Pathways & Interactions for TMEM245 Gene

SuperPathways for TMEM245 Gene

No Data Available

Interacting Proteins for TMEM245 Gene

Gene Ontology (GO) - Biological Process for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM245: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM245 Gene

Transcripts for TMEM245 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM245 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for TMEM245 Gene

GeneLoc Exon Structure for
TMEM245
ECgene alternative splicing isoforms for
TMEM245

Expression for TMEM245 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM245 Gene

Protein differential expression in normal tissues from HIPED for TMEM245 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM245 Gene



Protein tissue co-expression partners for TMEM245 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM245 Gene:

TMEM245

SOURCE GeneReport for Unigene cluster for TMEM245 Gene:

Hs.308074

mRNA Expression by UniProt/SwissProt for TMEM245 Gene:

Q9H330-TM245_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TMEM245 Gene

  • Eye(4.4)
  • Liver(4.3)
  • Blood(4.1)
  • Nervous system(3.8)
  • Lung(3.6)
  • Kidney(3.3)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with TMEM245: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM245 Gene

Orthologs for TMEM245 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM245 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM245 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia TMEM245 34 35
  • 91.22 (n)
cow
(Bos Taurus)
Mammalia TMEM245 34 35
  • 90 (n)
mouse
(Mus musculus)
Mammalia Tmem245 34 16 35
  • 88.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM245 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem245 34
  • 87.8 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM245 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H9ORF5 34
  • 77.68 (n)
TMEM245 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM245 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem245 34
  • 62.73 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem245 35
  • 72 (a)
OneToMany
LOC100000119 34
  • 69.56 (n)
TMEM245 (2 of 2) 35
  • 55 (a)
OneToMany
Dr.14788 34
fruit fly
(Drosophila melanogaster)
Insecta CG2698 34 35
  • 43.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003409 34
  • 43.21 (n)
worm
(Caenorhabditis elegans)
Secernentea M01F1.4 34 35
  • 47.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for TMEM245 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM245 Gene

ENSEMBL:
Gene Tree for TMEM245 (if available)
TreeFam:
Gene Tree for TMEM245 (if available)

Paralogs for TMEM245 Gene

No data available for Paralogs for TMEM245 Gene

Variants for TMEM245 Gene

Sequence variations from dbSNP and Humsavar for TMEM245 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000033953 -- 109,105,341(+) CAAAA(A/G)GTGGA intron-variant
rs1000040236 -- 109,069,200(+) GATTG(A/T)GTGCC intron-variant
rs1000067186 -- 109,038,451(+) CACCA(C/T)CAAAA intron-variant
rs1000087730 -- 109,118,031(+) TCTGG(A/G)CCTGT intron-variant
rs1000107800 -- 109,093,202(+) TGAAT(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM245 Gene

Variant ID Type Subtype PubMed ID
esv3621428 CNV loss 21293372
nsv473073 CNV novel sequence insertion 20440878
nsv507526 OTHER sequence alteration 20534489
nsv615148 CNV loss 21841781

Variation tolerance for TMEM245 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.89; 89.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM245 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM245

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM245 Gene

Disorders for TMEM245 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM245 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spermatocele
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM245

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM245
genes like me logo Genes that share disorders with TMEM245: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM245 Gene

Publications for TMEM245 Gene

  1. Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene. (PMID: 10564813) Chadwick B.P. … Slaugenhaupt S.A. (Gene 1999) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TMEM245 Gene

Sources for TMEM245 Gene

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