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TMEM245 Gene

protein-coding   GIFtS: 39
GCID: GC09M111778

Transmembrane Protein 245

(Previous name: chromosome 9 open reading frame 5)
(Previous symbol: C9orf5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 2451 2     CG-22
C9orf51 2 3     CG22
Protein CG-22 3     Transmembrane Protein C9orf52
Chromosome 9 Open Reading Frame 51     

External Ids:    HGNC: 13631   Entrez Gene: 237312   Ensembl: ENSG000001067717   UniProtKB: Q9H3303   

Export aliases for TMEM245 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM245 Gene:
TMEM245 (transmembrane protein 245) is a protein-coding gene. Diseases associated with TMEM245 include malaria, and schizophrenia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM245
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM245 promoter sequence
   Search Chromatin IP Primers for TMEM245

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM245


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31

TMEM245 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM245 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M111778:  view genomic region     (about GC identifiers)

Start:
111,777,415 bp from pter      End:
111,882,225 bp from pter
Size:
104,811 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM245_HUMAN, Q9H330 (See protein sequence)
Recommended Name: Transmembrane protein 245  
Size: 911 amino acids; 100945 Da
Sequence caution: Sequence=CAI39474.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DSW7 Q5JTQ5 Q5SS43 Q6ZME3 Q8NDJ5 Q96CG6
Alternative splicing: 4 isoforms:  Q9H330-1   Q9H330-2   Q9H330-3   Q9H330-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM245: NX_Q9H330

Explore proteomics data for TMEM245 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn210, Asn500, Asn551, Asn575
  • Modification sites at PhosphoSitePlus

  • See TMEM245 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114401.2  
    ENSEMBL proteins: 
     ENSP00000363714   ENSP00000394798   ENSP00000417842  

    TMEM245 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    Search LSBio for Antibodies for TMEM245

    TMEM245 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002549 UPF0118

    Graphical View of Domain Structure for InterPro Entry Q9H330

    ProtoNet protein and cluster: Q9H330

    1 Blocks protein domain: IPB002549 Protein of unknown function UPF0118

    UniProtKB/Swiss-Prot: TM245_HUMAN, Q9H330
    Similarity: Belongs to the UPF0118 (TMEM245) family


    TMEM245 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TMEM245 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM245:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM245
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM245

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM245
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM245

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM245:
    hsa-mir-340-5p (MIRT019650), hsa-mir-183-5p (MIRT047061), hsa-mir-186-5p (MIRT021185), hsa-mir-221-3p (MIRT024168), hsa-mir-222-3p (MIRT046663), hsa-mir-374b-5p (MIRT016078), hsa-mir-106b-5p (MIRT020473), hsa-mir-16-5p (MIRT031582), hsa-mir-21-5p (MIRT030795)

    Block miRNA regulation of human, mouse, rat TMEM245 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM245
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM245

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM245
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM245

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM245


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM245_HUMAN, Q9H330: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS10564813

    TMEM245 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM245
    Interactions:

        Search GeneGlobe Interaction Network for TMEM245

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMEM245 (ENSP000003637144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    TMEM245 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM245 (TM245)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM245 gene (2 alternative transcripts): 
    NM_001099734.1  NM_032012.3  

    Unigene Clusters for TMEM245:

    Transmembrane protein 245
    Hs.308074  [show with all ESTs], Hs.621479
    Unigene Representative Sequences: AF153415, AF086175
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374586(uc022bln.1 uc004bds.4 uc004bdt.4) ENST00000472207
    ENST00000413712 ENST00000491854 ENST00000482868
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM245
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM245
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM245
    Primer
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    Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat TMEM245
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM245
      QuantiFast Probe-based Assays in human, mouse, rat TMEM245

    Additional mRNA sequence: AF086175.1 

    14 DOTS entries:

    DT.99979085  DT.455845  DT.100029113  DT.100804432  DT.99973105  DT.92427143  DT.100804438  DT.121169192 
    DT.91958381  DT.121169199  DT.121169214  DT.121169215  DT.92019780  DT.95271120 

    Selected AceView cDNA sequences (see all 474):

    AA358036 BM505508 CA393820 BP360669 BM504693 AI870957 BF433314 AA335577 
    CK820104 AL556162 AA331786 AI421746 AW026344 BQ130458 AA813361 BF971205 
    BQ011505 AA455435 AL833960 AI379308 BU196024 BQ719910 AI338793 AI401240 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM245 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                                                                                        -     -                 -                     
    SP2:                                                        -                                               -     -                 -                     
    SP3:                                                        -                                                                                             
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                -                     


    ECgene alternative splicing isoforms for TMEM245

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM245 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAAGGCAC
    TMEM245 Expression
    About this image

    TMEM245 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM245 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.308074 Hs.621479

    UniProtKB/Swiss-Prot: TM245_HUMAN, Q9H330
    Tissue specificity: Widely expressed

        Custom PCR Arrays for TMEM245
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM245

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM245 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2451 , 5 RIKEN cDNA D730040F13 gene5
    transmembrane protein 2451
    88.11(n)1
    92.49(a)1
      4 (31.66 cM)5
    2424741  NM_175518.51  NP_780727.31 
     568669235 
    chicken
    (Gallus gallus)
    Aves C2H9ORF51 chromosome 2 open reading frame, human C9orf5 77.68(n)
    82.88(a)
      420957  XM_419042.4  XP_419042.4 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2456
    transmembrane protein 245
    75(a)
    1 ↔ 1
    6(57422084-57488332)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem2451 transmembrane protein 245 62.73(n)
    61.81(a)
      100124972  NM_001102907.1  NP_001096377.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147882 Transcribed sequence with moderate similarity to protein more 80.8(n)    BM140903.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG26981 CG2698 43.68(n)
    30.64(a)
      40945  NM_001260047.1  NP_001246976.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M01F1.41 M01F1.4 47.06(n)
    35.77(a)
      175457  NM_001027516.1  NP_001022687.1 


    ENSEMBL Gene Tree for TMEM245 (if available)
    TreeFam Gene Tree for TMEM245 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM245 (see all 2199)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs92991681,2
    C--81482311(+) GGGGG-/G/G   
       G
    /GGG
    AAGCT
    1 -- us2k1 tfbs3 trp31NA 2
    rs1923234851,2
    --111777985(+) GAATAC/TCACCA 1 -- ut310--------
    rs70412811,2
    C,F--111778015(+) AGAGCC/ACCCCC 1 -- ut31 ese35Minor allele frequency- A:0.16NA CSA WA 244
    rs1840917691,2
    --111778028(+) CTGTAC/TAATAA 1 -- ut310--------
    rs1430759841,2
    C--111778432(+) GGGAGC/TGCAGT 1 -- ut310--------
    rs1482020821,2
    --111778436(+) GTGCAA/GTCTAA 1 -- ut310--------
    rs1411375081,2
    --111778458(+) GTTTGC/TCCCCT 1 -- ut310--------
    rs1874875851,2
    --111778476(+) ATTCAC/TAATGT 1 -- ut310--------
    rs1507109771,2
    --111778492(+) AGCATA/GTTCAA 1 -- ut310--------
    rs762362521,2
    C--111778675(+) AAAGGA/GAAGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM245 (111777415 - 111882225 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM245: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM245
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM245

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TMEM245:    
    About MalaCards
    malaria    schizophrenia


    TMEM245 for disorders           About GeneDecksing


    Export disorders for TMEM245 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM245 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with TMEM245)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene. (PubMed id 10564813)1, 2, 3 Chadwick B.P.... Slaugenhaupt S.A. (Gene 1999)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. (PubMed id 23382809)1 Xu C....Wang K. (PLoS ONE 2013)
    6. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)1 Luciano M....Deary I.J. (Biol Psychol 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23731 HGNC: 1363 AceView: C9orf5 Ensembl:ENSG00000106771 euGenes: HUgn23731
    ECgene: TMEM245 H-InvDB: TMEM245

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM245 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM245 gene:
    Search GeneIP for patents involving TMEM245

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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