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Aliases for TMEM245 Gene

Aliases for TMEM245 Gene

  • Transmembrane Protein 245 2 3
  • Protein CG-2 3 4
  • C9orf5 3 4
  • Chromosome 9 Open Reading Frame 5 2
  • Transmembrane Protein C9orf5 3
  • CG-2 3
  • CG2 3

External Ids for TMEM245 Gene

Previous HGNC Symbols for TMEM245 Gene

  • C9orf5

Previous GeneCards Identifiers for TMEM245 Gene

  • GC09M111778

Summaries for TMEM245 Gene

GeneCards Summary for TMEM245 Gene

TMEM245 (Transmembrane Protein 245) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM245 Gene

Genomics for TMEM245 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM245 Gene

Start:
109,015,135 bp from pter
End:
109,119,945 bp from pter
Size:
104,811 bases
Orientation:
Minus strand

Genomic View for TMEM245 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM245 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM245 Gene

No data available for Regulatory Elements for TMEM245 Gene

Proteins for TMEM245 Gene

  • Protein details for TMEM245 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H330-TM245_HUMAN
    Recommended name:
    Transmembrane protein 245
    Protein Accession:
    Q9H330
    Secondary Accessions:
    • B4DSW7
    • Q5JTQ5
    • Q5SS43
    • Q6ZME3
    • Q8NDJ5
    • Q96CG6

    Protein attributes for TMEM245 Gene

    Size:
    911 amino acids
    Molecular mass:
    100945 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI39474.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM245 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM245 Gene

Proteomics data for TMEM245 Gene at MOPED

Post-translational modifications for TMEM245 Gene

  • Glycosylation at Asn210, Asn500, Asn551, and Asn575
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM245 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM245 Gene

Domains for TMEM245 Gene

Protein Domains for TMEM245 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H330

UniProtKB/Swiss-Prot:

TM245_HUMAN :
  • Q9H330
Family:
  • Belongs to the UPF0118 (TMEM245) family.
genes like me logo Genes that share domains with TMEM245: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM245 Gene

Function for TMEM245 Gene

Gene Ontology (GO) - Molecular Function for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM245: view

Phenotypes for TMEM245 Gene

GenomeRNAi human phenotypes for TMEM245:
genes like me logo Genes that share phenotypes with TMEM245: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM245

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM245 Gene

Localization for TMEM245 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM245 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 10564813
genes like me logo Genes that share ontologies with TMEM245: view

No data available for Subcellular locations from COMPARTMENTS for TMEM245 Gene

Pathways for TMEM245 Gene

SuperPathways for TMEM245 Gene

No Data Available

Interacting Proteins for TMEM245 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363714%0d%0a9606.ENSP00000282397%0d%0a9606.ENSP00000371577%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000363714 for TMEM245 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM245 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM245: view

No data available for Pathways by source for TMEM245 Gene

Transcripts for TMEM245 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM245

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM245 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for TMEM245 Gene

GeneLoc Exon Structure for
TMEM245
ECgene alternative splicing isoforms for
TMEM245

Expression for TMEM245 Gene

mRNA expression in normal human tissues for TMEM245 Gene

Protein differential expression in normal tissues for TMEM245 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM245 Gene

SOURCE GeneReport for Unigene cluster for TMEM245 Gene Hs.308074

mRNA Expression by UniProt/SwissProt for TMEM245 Gene

Q9H330-TM245_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TMEM245: view

Expression partners for TMEM245 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM245 Gene

Orthologs for TMEM245 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM245 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM245 35
  • 90 (n)
  • 92.1 (a)
TMEM245 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM245 35
  • 91.22 (n)
  • 93.59 (a)
TMEM245 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem245 35
  • 88.11 (n)
  • 92.49 (a)
Tmem245 16
Tmem245 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM245 35
  • 99.51 (n)
  • 99.32 (a)
TMEM245 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem245 35
  • 87.8 (n)
  • 91.88 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM245 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM245 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H9ORF5 35
  • 77.68 (n)
  • 82.88 (a)
TMEM245 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM245 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem245 35
  • 62.73 (n)
  • 61.81 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14788 35
LOC100000119 35
  • 69.56 (n)
  • 79.67 (a)
tmem245 36
  • 72 (a)
OneToMany
TMEM245 (2 of 2) 36
  • 55 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003409 35
  • 43.21 (n)
  • 31.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2698 35
  • 43.68 (n)
  • 30.64 (a)
CG2698 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M01F1.4 35
  • 47.06 (n)
  • 35.77 (a)
M01F1.4 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for TMEM245:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM245 Gene

ENSEMBL:
Gene Tree for TMEM245 (if available)
TreeFam:
Gene Tree for TMEM245 (if available)

Paralogs for TMEM245 Gene

No data available for Paralogs for TMEM245 Gene

Variants for TMEM245 Gene

Sequence variations from dbSNP and Humsavar for TMEM245 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6825 -- 109,119,647(+) CCGCA(C/T)AGCAC reference, synonymous-codon
rs7340 -- 109,016,949(+) TTTTT(C/T)CCTAT utr-variant-3-prime
rs7581 -- 109,016,967(-) CTTTC(A/G)ACCTC utr-variant-3-prime
rs7776 -- 109,020,251(-) TTCAG(A/C)GTTGG utr-variant-3-prime
rs11705 -- 109,017,018(+) CCCTC(A/T)CAGCC utr-variant-3-prime

Relevant External Links for TMEM245 Gene

HapMap Linkage Disequilibrium report
TMEM245

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM245 Gene

Disorders for TMEM245 Gene

No disorders were found for TMEM245 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM245 Gene

Publications for TMEM245 Gene

  1. Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene. (PMID: 10564813) Chadwick B.P. … Slaugenhaupt S.A. (Gene 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for TMEM245 Gene

Sources for TMEM245 Gene

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