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Aliases for TMEM244 Gene

Aliases for TMEM244 Gene

  • Transmembrane Protein 244 2 3 5
  • C6orf191 3 4
  • Putative Transmembrane Protein C6orf191 3
  • Chromosome 6 Open Reading Frame 191 2
  • BA174C7.4 3

External Ids for TMEM244 Gene

Previous HGNC Symbols for TMEM244 Gene

  • C6orf191

Previous GeneCards Identifiers for TMEM244 Gene

  • GC06M130152

Summaries for TMEM244 Gene

GeneCards Summary for TMEM244 Gene

TMEM244 (Transmembrane Protein 244) is a Protein Coding gene. Diseases associated with TMEM244 include Sezary's Disease.

Additional gene information for TMEM244 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM244 Gene

Genomics for TMEM244 Gene

Regulatory Elements for TMEM244 Gene

Enhancers for TMEM244 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H129889 0.9 Ensembl ENCODE 11.3 -28.5 -28547 2 L3MBTL2 JUN ZNF592 FOSL1 JUND POLR2A CREB1 NFE2 FOS MGA TMEM244 L3MBTL3 RPL5P21
GH06H129853 0.9 ENCODE 7.8 +7.1 7097 1 HDAC1 PKNOX1 TBL1XR1 INSM2 FEZF1 CHAMP1 TCF12 ZNF766 GATA2 ZNF366 TMEM244 GC06P129854 LOC105377999
GH06H129894 0.8 Ensembl ENCODE 5.6 -33.7 -33720 1 ZNF316 JUND IKZF1 IKZF2 MAFK SPI1 L3MBTL3 TMEM244
GH06H129875 0.7 Ensembl 6.3 -14.6 -14554 0 SMARCA5 BACH1 JUNB BMI1 ELF1 DPF2 BATF BCL11A ZNF24 ATF7 TMEM244 L3MBTL3
GH06H129891 0.3 FANTOM5 11.2 -30.4 -30390 0 TMEM244 L3MBTL3 RPL5P21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM244 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM244 Gene

Chromosome:
6
Start:
129,831,244 bp from pter
End:
129,861,547 bp from pter
Size:
30,304 bases
Orientation:
Minus strand

Genomic View for TMEM244 Gene

Genes around TMEM244 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM244 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM244 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM244 Gene

Proteins for TMEM244 Gene

  • Protein details for TMEM244 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVB8-TM244_HUMAN
    Recommended name:
    Transmembrane protein 244
    Protein Accession:
    Q5VVB8

    Protein attributes for TMEM244 Gene

    Size:
    128 amino acids
    Molecular mass:
    14657 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM244 Gene

Post-translational modifications for TMEM244 Gene

No Post-translational modifications

Other Protein References for TMEM244 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM244 Gene

Domains & Families for TMEM244 Gene

Gene Families for TMEM244 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM244 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM244 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM244: view

No data available for UniProtKB/Swiss-Prot for TMEM244 Gene

Function for TMEM244 Gene

Phenotypes From GWAS Catalog for TMEM244 Gene

Phenotypes for TMEM244 Gene

genes like me logo Genes that share phenotypes with TMEM244: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM244
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM244 Gene

Localization for TMEM244 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM244 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM244 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM244 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM244: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM244 Gene

Pathways & Interactions for TMEM244 Gene

SuperPathways for TMEM244 Gene

No Data Available

Interacting Proteins for TMEM244 Gene

Gene Ontology (GO) - Biological Process for TMEM244 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM244 Gene

Drugs & Compounds for TMEM244 Gene

No Compound Related Data Available

Transcripts for TMEM244 Gene

mRNA/cDNA for TMEM244 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM244 Gene

Transmembrane protein 244:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM244
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM244 Gene

No ASD Table

Relevant External Links for TMEM244 Gene

GeneLoc Exon Structure for
TMEM244
ECgene alternative splicing isoforms for
TMEM244

Expression for TMEM244 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM244 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM244 Gene

This gene is overexpressed in Pituitary (x18.6), Brain - Spinal cord (cervical c-1) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.4), Brain - Hippocampus (x4.4), and Brain - Substantia nigra (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TMEM244 Gene:

TMEM244

SOURCE GeneReport for Unigene cluster for TMEM244 Gene:

Hs.448372
genes like me logo Genes that share expression patterns with TMEM244: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM244 Gene

Orthologs for TMEM244 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM244 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM244 33 34
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia LOC100848594 33
  • 85.03 (n)
dog
(Canis familiaris)
Mammalia C1H6orf191 33
  • 83.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM244 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H6ORF191 33
  • 71.04 (n)
TMEM244 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM244 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem244 33 34
  • 56.37 (n)
Species where no ortholog for TMEM244 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM244 Gene

ENSEMBL:
Gene Tree for TMEM244 (if available)
TreeFam:
Gene Tree for TMEM244 (if available)

Paralogs for TMEM244 Gene

No data available for Paralogs for TMEM244 Gene

Variants for TMEM244 Gene

Sequence variations from dbSNP and Humsavar for TMEM244 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000236427 -- 129,852,439(+) TATGA(C/T)TCATC intron-variant
rs1000358891 -- 129,847,173(+) AACAC(C/T)TAAAG intron-variant
rs1000368616 -- 129,846,897(+) GAATC(A/T)GAAAG intron-variant
rs1000439853 -- 129,836,128(+) ACCCC(C/T)GTGTA intron-variant
rs1000475266 -- 129,841,301(+) CATTA(C/T)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM244 Gene

Variant ID Type Subtype PubMed ID
esv3610778 CNV gain 21293372
nsv604663 CNV gain 21841781
nsv830805 CNV gain 17160897

Variation tolerance for TMEM244 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.39; 98.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM244 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM244

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM244 Gene

Disorders for TMEM244 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM244 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sezary's disease
  • sezary disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM244

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM244
genes like me logo Genes that share disorders with TMEM244: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM244 Gene

Publications for TMEM244 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60

Products for TMEM244 Gene

Sources for TMEM244 Gene

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