Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM243 Gene

Aliases for TMEM243 Gene

  • Transmembrane Protein 243 2 3 5
  • Transmembrane Protein 243, Mitochondrial 2 3
  • C7orf23 3 4
  • MDR1 And Mitochondrial Taxol Resistance Associated Gene 2
  • MDR1 And Mitochondrial Taxol Resistance Associated 3
  • Chromosome 7 Open Reading Frame 23 2
  • Transmembrane Protein C7orf23 3
  • MM-TRAG 3

External Ids for TMEM243 Gene

Previous HGNC Symbols for TMEM243 Gene

  • C7orf23

Previous GeneCards Identifiers for TMEM243 Gene

  • GC07M086826

Summaries for TMEM243 Gene

GeneCards Summary for TMEM243 Gene

TMEM243 (Transmembrane Protein 243) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM243 Gene

Genomics for TMEM243 Gene

Genomic Location for TMEM243 Gene

Chromosome:
7
Start:
87,196,160 bp from pter
End:
87,220,587 bp from pter
Size:
24,428 bases
Orientation:
Minus strand

Genomic View for TMEM243 Gene

Genes around TMEM243 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM243 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM243 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM243 Gene

No data available for Regulatory Elements for TMEM243 Gene

Proteins for TMEM243 Gene

  • Protein details for TMEM243 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU79-TM243_HUMAN
    Recommended name:
    Transmembrane protein 243
    Protein Accession:
    Q9BU79
    Secondary Accessions:
    • A4D1C6
    • B2R9I4
    • D6W5P1

    Protein attributes for TMEM243 Gene

    Size:
    118 amino acids
    Molecular mass:
    13391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM243 Gene

Proteomics data for TMEM243 Gene at MOPED

Post-translational modifications for TMEM243 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM243 Gene

No data available for DME Specific Peptides for TMEM243 Gene

Domains & Families for TMEM243 Gene

Protein Domains for TMEM243 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM243 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU79

UniProtKB/Swiss-Prot:

TM243_HUMAN :
  • Belongs to the TMEM243 family.
Family:
  • Belongs to the TMEM243 family.
genes like me logo Genes that share domains with TMEM243: view

No data available for Gene Families for TMEM243 Gene

Function for TMEM243 Gene

genes like me logo Genes that share phenotypes with TMEM243: view

Animal Model Products

CRISPR Products

miRNA for TMEM243 Gene

miRTarBase miRNAs that target TMEM243

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM243 Gene

Localization for TMEM243 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM243 Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TMEM243 Gene

Pathways & Interactions for TMEM243 Gene

SuperPathways for TMEM243 Gene

No Data Available

Interacting Proteins for TMEM243 Gene

Gene Ontology (GO) - Biological Process for TMEM243 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM243 Gene

Drugs & Compounds for TMEM243 Gene

No Compound Related Data Available

Transcripts for TMEM243 Gene

Unigene Clusters for TMEM243 Gene

Transmembrane protein 243, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM243 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for TMEM243 Gene

GeneLoc Exon Structure for
TMEM243
ECgene alternative splicing isoforms for
TMEM243

Expression for TMEM243 Gene

mRNA expression in normal human tissues for TMEM243 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM243 Gene

This gene is overexpressed in Blymphocyte (58.4) and NK cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM243 Gene



SOURCE GeneReport for Unigene cluster for TMEM243 Gene Hs.619593

genes like me logo Genes that share expression patterns with TMEM243: view

Protein tissue co-expression partners for TMEM243 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM243 Gene

Orthologs for TMEM243 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM243 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM243 35
  • 94.07 (n)
  • 96.61 (a)
TMEM243 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14H7orf23 35
  • 86.42 (n)
  • 87.04 (a)
TMEM243 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem243 35
  • 94.07 (n)
  • 97.46 (a)
Tmem243 16
Tmem243 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf23 35
  • 99.72 (n)
  • 100 (a)
TMEM243 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem243 35
  • 90.96 (n)
  • 94.92 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM243 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM243 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7ORF23 35
  • 82.44 (n)
  • 81.72 (a)
TMEM243 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM243 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem243 35
  • 73.73 (n)
  • 79.66 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem243b 35
  • 70.06 (n)
  • 78.81 (a)
tmem243a 36
  • 42 (a)
OneToMany
tmem243b 36
  • 70 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for TMEM243:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM243 Gene

ENSEMBL:
Gene Tree for TMEM243 (if available)
TreeFam:
Gene Tree for TMEM243 (if available)

Paralogs for TMEM243 Gene

No data available for Paralogs for TMEM243 Gene

Variants for TMEM243 Gene

Sequence variations from dbSNP and Humsavar for TMEM243 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs757961 -- 87,220,194(+) TGGAT(C/T)CCCTC intron-variant, upstream-variant-2KB
rs886787 -- 87,220,894(+) TTGTT(C/T)GCATG upstream-variant-2KB
rs1062274 -- 87,214,559(-) AGGTG(A/G)TGTGG intron-variant
rs2057984 -- 87,197,224(+) TTCTT(C/T)TTCGG intron-variant, downstream-variant-500B
rs2373362 -- 87,216,413(+) tgcac(C/T)ccgat intron-variant

Variation tolerance for TMEM243 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM243 Gene

HapMap Linkage Disequilibrium report
TMEM243

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM243 Gene

Disorders for TMEM243 Gene

Relevant External Links for TMEM243

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM243

No disorders were found for TMEM243 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM243 Gene

Publications for TMEM243 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is associated with the taxol- and doxorubicin-resistant phenotype in human cancer cell lines. (PMID: 15556294) Duan Z. … Seiden M.V. (Gene 2004) 3 23
  3. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. (PMID: 20351715) Liu Y. … Sullivan P.F. (Mol. Psychiatry 2011) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. (PMID: 18510171) Rajkumar T. … Yamuna M. (Anticancer Drugs 2008) 3

Products for TMEM243 Gene

Sources for TMEM243 Gene

Back to Top

Content