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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM242 Gene

protein-coding   GIFtS: 32
GCID: GC06M157714

Transmembrane Protein 242

(Previous name: chromosome 6 open reading frame 35)
(Previous symbol: C6orf35)
  Search for TMEM242
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2421 2
C6orf351 2 3
Chromosome 6 Open Reading Frame 351
BM0332
UPF0463 Transmembrane Protein C6orf352

External Ids:    HGNC: 172061   Entrez Gene: 7295152   Ensembl: ENSG000002157127   UniProtKB: Q9NWH23   

Export aliases for TMEM242 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM242 Gene: 
TMEM242 (transmembrane protein 242) is a protein-coding gene.

Gene Wiki entry for TMEM242 (C6orf35) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM242
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM242

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM242


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

TMEM242 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM242 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M157714:  view genomic region     (about GC identifiers)

Start:
157,710,054 bp from pter      End:
157,745,253 bp from pter
Size:
35,200 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM242_HUMAN, Q9NWH2 (See protein sequence)
Recommended Name: Transmembrane protein 242  
Size: 141 amino acids; 14758 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAF28965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAF67621.1; Type=Frameshift; Positions=130;
Secondary accessions: B9EJD0 Q9NZ88 Q9P094

Explore the universe of human proteins at neXtProt for TMEM242: NX_Q9NWH2

Explore proteomics data for TMEM242 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NWH2

  • TMEM242 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM242 Protein Expression
    REFSEQ proteins: NP_060922.2  
    ENSEMBL proteins: 
     ENSP00000383594   ENSP00000356112  

    Human Recombinant Protein Products for TMEM242: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM242 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009792 DUF1358

    Graphical View of Domain Structure for InterPro Entry Q9NWH2

    ProtoNet protein and cluster: Q9NWH2

    UniProtKB/Swiss-Prot: TM242_HUMAN, Q9NWH2
    Similarity: Belongs to the TMEM242 family


    TMEM242 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM242 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM242

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM242 (TM242)

    Search CenterWatch for drugs/clinical trials and news about TMEM242 / TM242

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM242 gene: 
    NM_018452.4  

    Unigene Cluster for TMEM242:

    Transmembrane protein 242
    Hs.157212  [show with all ESTs]
    Unigene Representative Sequence: NM_018452
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400788(uc003sih.4) ENST00000367144
    miRNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM242
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM242

    Additional mRNA sequence: 

    AF161405.1 AF217510.1 AK000891.1 BC029130.1 BC146893.1 BC146895.1 

    8 DOTS entries:

    DT.446868  DT.202877  DT.100751399  DT.438859  DT.100665995  DT.121619633  DT.95267863  DT.95267866 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM242 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGATTGC
    TMEM242 Expression
    About this image


    See TMEM242 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM242

    SOURCE GeneReport for Unigene cluster: Hs.157212
        SABiosciences Custom PCR Arrays for TMEM242
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM242
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM242

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM242 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2421 , 5 RIKEN cDNA 5730437N04 gene5
    transmembrane protein 2421
    83.33(n)1
    86.43(a)1
      17 (3.16 cM)5
    705441  NM_027457.41  NP_081733.31 
     54108645 
    chicken
    (Gallus gallus)
    Aves TMEM2421 transmembrane protein 242 71.57(n)
    77.21(a)
      421652  XM_419691.3  XP_419691.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2426
    transmembrane protein 242
    73(a)
    1 ↔ 1
    1(213280869-213298218)
    zebrafish
    (Danio rerio)
    Actinopterygii tmem2421 transmembrane protein 242 61.03(n)
    63.08(a)
      569632  NM_001160014.1  NP_001153486.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116991 CG11699 46.99(n)
    35.25(a)
      32101  NM_132500.2  NP_572728.1 


    ENSEMBL Gene Tree for TMEM242 (if available)
    TreeFam Gene Tree for TMEM242 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM242 gene

    TMEM242 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMEM242
    PGOHUM00000239824


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1077 SNPs in TMEM242 are shown (see all 1077)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453353451,2
    --157709579(+) GCCACA/GTAGCC 1 -- int10--------
    rs1492033011,2
    --157709605(+) GAAACA/TTGGTG 1 -- int10--------
    rs1891095001,2
    C--157709642(+) AGTCGG/TAGAAG 1 -- int10--------
    rs1817151651,2
    --157709688(+) ACCCAC/GCTTGG 1 -- int10--------
    rs95058581,2
    C--157709734(+) CTGTAC/TAGACC 1 -- int10--------
    rs1849115461,2
    --157709814(+) GGGAGC/TGCCGG 1 -- int10--------
    rs1509462261,2
    --157709850(+) GACATC/TGCCTG 1 -- int10--------
    rs1899009511,2
    --157710366(+) GCTCAC/TAAAAT 1 -- ut310--------
    rs1420809811,2
    C--157710591(+) GATGAA/TACATA 1 -- ut310--------
    rs1811736291,2
    --157710643(+) TTTAAC/TCTTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM242 (157710054 - 157745253 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM242: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM242
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM242

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM242 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM242)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Identification of VKORC1 interaction partners by spli t-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (2011)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729515 HGNC: 17206 Ensembl:ENSG00000215712 euGenes: HUgn729515 ECgene: TMEM242
    H-InvDB: TMEM242

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM242 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM242 gene:
    Search GeneIP for patents involving TMEM242

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMEM242 antibodies
     TMEM242 lysates
     Search for Antibodies for TMEM242 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TMEM242
     Custom Antibody / Protein Production Service
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
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     Browse ELISAs at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for TMEM242
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM242
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMEM242
     Browse SwitchGear Promoter luciferase reporter plasmids for TMEM242
     Search ThermoFisher Antibodies for TMEM242
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM242
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM242
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM242
    Customized:
     lentivirus for stable overexpression of TMEM242
     lentivirus expression plasmids for stable overexpression of TMEM242
     adenovirus for overexpression of TMEM242
     Search LSBio for Antibodies for TMEM242
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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