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Aliases for TMEM242 Gene

Aliases for TMEM242 Gene

  • Transmembrane Protein 242 2 3 5
  • C6orf35 3 4
  • UPF0463 Transmembrane Protein C6orf35 3
  • Chromosome 6 Open Reading Frame 35 2
  • BM033 3

External Ids for TMEM242 Gene

Previous HGNC Symbols for TMEM242 Gene

  • C6orf35

Previous GeneCards Identifiers for TMEM242 Gene

  • GC06M157714

Summaries for TMEM242 Gene

GeneCards Summary for TMEM242 Gene

TMEM242 (Transmembrane Protein 242) is a Protein Coding gene.

Gene Wiki entry for TMEM242 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM242 Gene

Genomics for TMEM242 Gene

Regulatory Elements for TMEM242 Gene

Enhancers for TMEM242 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM242 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM242 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM242 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM242 Gene

Chromosome:
6
Start:
157,289,022 bp from pter
End:
157,324,259 bp from pter
Size:
35,238 bases
Orientation:
Minus strand

Genomic View for TMEM242 Gene

Genes around TMEM242 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM242 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM242 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM242 Gene

Proteins for TMEM242 Gene

  • Protein details for TMEM242 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWH2-TM242_HUMAN
    Recommended name:
    Transmembrane protein 242
    Protein Accession:
    Q9NWH2
    Secondary Accessions:
    • B9EJD0
    • Q9NZ88
    • Q9P094

    Protein attributes for TMEM242 Gene

    Size:
    141 amino acids
    Molecular mass:
    14758 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF67621.1; Type=Frameshift; Positions=130; Evidence={ECO:0000305};

neXtProt entry for TMEM242 Gene

Proteomics data for TMEM242 Gene at MOPED

Post-translational modifications for TMEM242 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM242 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM242 Gene

Domains & Families for TMEM242 Gene

Protein Domains for TMEM242 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM242 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWH2

UniProtKB/Swiss-Prot:

TM242_HUMAN :
  • Belongs to the TMEM242 family.
Family:
  • Belongs to the TMEM242 family.
genes like me logo Genes that share domains with TMEM242: view

No data available for Gene Families for TMEM242 Gene

Function for TMEM242 Gene

genes like me logo Genes that share phenotypes with TMEM242: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM242 Gene

Localization for TMEM242 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM242 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM242 Gene COMPARTMENTS Subcellular localization image for TMEM242 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytoskeleton 1
cytosol 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM242 Gene

Pathways & Interactions for TMEM242 Gene

SuperPathways for TMEM242 Gene

No Data Available

Interacting Proteins for TMEM242 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383594%0d%0a9606.ENSP00000338964%0d%0a9606.ENSP00000378426%0d%0a
Selected Interacting proteins: ENSP00000383594 Q9NWH2-TM242_HUMAN for TMEM242 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM242 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM242 Gene

Drugs & Compounds for TMEM242 Gene

No Compound Related Data Available

Transcripts for TMEM242 Gene

mRNA/cDNA for TMEM242 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM242 Gene

Transmembrane protein 242:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM242 Gene

No ASD Table

Relevant External Links for TMEM242 Gene

GeneLoc Exon Structure for
TMEM242
ECgene alternative splicing isoforms for
TMEM242

Expression for TMEM242 Gene

mRNA expression in normal human tissues for TMEM242 Gene

Protein differential expression in normal tissues from HIPED for TMEM242 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM242 Gene



SOURCE GeneReport for Unigene cluster for TMEM242 Gene Hs.157212

genes like me logo Genes that share expression patterns with TMEM242: view

Protein tissue co-expression partners for TMEM242 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM242 Gene

Orthologs for TMEM242 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM242 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM242 35
  • 85.05 (n)
  • 83.82 (a)
C9H6ORF35 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM242 35
  • 87.71 (n)
  • 89.36 (a)
TMEM242 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem242 35
  • 83.33 (n)
  • 86.43 (a)
Tmem242 16
Tmem242 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM242 35
  • 97.64 (n)
  • 96.46 (a)
TMEM242 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C1H6orf35 35
  • 81.67 (n)
  • 83.57 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM242 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H6ORF35 35
  • 74.04 (n)
  • 79.51 (a)
TMEM242 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM242 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem242 35
  • 65.25 (n)
  • 70.21 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem242 35
  • 61.03 (n)
  • 63.08 (a)
tmem242 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009165 35
  • 48.92 (n)
  • 46.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11699 35
  • 47.62 (n)
  • 37.5 (a)
CG11699 36
  • 32 (a)
OneToOne
Species with no ortholog for TMEM242:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM242 Gene

ENSEMBL:
Gene Tree for TMEM242 (if available)
TreeFam:
Gene Tree for TMEM242 (if available)

Paralogs for TMEM242 Gene

Pseudogenes.org Pseudogenes for TMEM242 Gene

genes like me logo Genes that share paralogs with TMEM242: view

No data available for Paralogs for TMEM242 Gene

Variants for TMEM242 Gene

Sequence variations from dbSNP and Humsavar for TMEM242 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1133482 -- 157,323,976(-) CTGTT(A/G)GGAAG utr-variant-5-prime
rs1135259 -- 157,289,401(-) CATTA(A/G)ATGAT utr-variant-3-prime
rs1136157 -- 157,292,630(-) AAATG(A/G)TTCTG utr-variant-3-prime
rs5881205 -- 157,304,494(+) AAAGA(A/G)AGAGA intron-variant
rs6605502 -- 157,290,745(+) TTCAC(C/T)TTTGC utr-variant-3-prime

Variation tolerance for TMEM242 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMEM242 Gene

Disorders for TMEM242 Gene

Relevant External Links for TMEM242

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM242

No disorders were found for TMEM242 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM242 Gene

Publications for TMEM242 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM242 Gene

Sources for TMEM242 Gene

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