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Aliases for TMEM241 Gene

Aliases for TMEM241 Gene

  • Transmembrane Protein 241 2 3 5
  • C18orf45 3 4
  • Putative Vertebrate Vrg4-Like Nucleotide-Sugar Transporter Truncated Variant2 3
  • Putative Vertebrate Vrg4-Like Nucleotide-Sugar Transporter Variant1 3
  • Chromosome 18 Open Reading Frame 45 2
  • Transmembrane Protein C18orf45 3
  • HVVT 3

External Ids for TMEM241 Gene

Previous HGNC Symbols for TMEM241 Gene

  • C18orf45

Previous GeneCards Identifiers for TMEM241 Gene

  • GC18M020777

Summaries for TMEM241 Gene

GeneCards Summary for TMEM241 Gene

TMEM241 (Transmembrane Protein 241) is a Protein Coding gene. Diseases associated with TMEM241 include Myeloproliferative Syndrome, Transient.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM241 Gene

Genomics for TMEM241 Gene

Regulatory Elements for TMEM241 Gene

Enhancers for TMEM241 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G023356 1.2 Ensembl ENCODE 15.2 +80.1 80072 3.3 FOXA2 WRNIP1 YY1 SLC30A9 ZNF143 ZNF207 PPARG TBX21 PBX2 RCOR2 TMEM241 CABLES1 ANKRD29 NPC1 ENSG00000266495
GH18G023224 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.6 +209.5 209482 8.6 HDGF PKNOX1 ATF1 WRNIP1 YBX1 ZNF121 ZNF766 GATA2 ZNF143 ZNF207 CABLES1 TMEM241 NPC1 C18orf8 RBBP8 PIR48090 GC18M023230
GH18G023400 1.2 Ensembl ENCODE 11.1 +36.4 36395 2.5 FOXA2 MLX ARID4B DMAP1 ZNF48 GATA2 FOS SP5 MIER2 PPARG TMEM241 CABLES1 ANKRD29 NPC1 ENSG00000266495
GH18G023514 1.1 ENCODE dbSUPER 10.8 -77.9 -77870 1.7 ELF3 PKNOX1 ATF1 RB1 ARNT ARID4B RAD21 ZNF143 CREM ZHX1 NPC1 TMEM241 ANKRD29 C18orf8 GC18M023583 ENSG00000199366
GH18G023459 1 ENCODE dbSUPER 11.8 -23.0 -23028 2.2 SOX13 ZNF792 SAP130 ZMYM3 ZNF644 YY1 TEAD3 NCOR1 HNF4G NR2F6 C18orf8 TMEM241 CABLES1 ENSG00000199357 GC18P023472
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM241 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM241 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000101435 169 1201 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF143

Genomic Location for TMEM241 Gene

Chromosome:
18
Start:
23,197,144 bp from pter
End:
23,437,969 bp from pter
Size:
240,826 bases
Orientation:
Minus strand

Genomic View for TMEM241 Gene

Genes around TMEM241 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM241 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM241 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM241 Gene

Proteins for TMEM241 Gene

  • Protein details for TMEM241 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q24JQ0-TM241_HUMAN
    Recommended name:
    Transmembrane protein 241
    Protein Accession:
    Q24JQ0
    Secondary Accessions:
    • I0J130
    • Q6ZTS7
    • Q6ZW41

    Protein attributes for TMEM241 Gene

    Size:
    296 amino acids
    Molecular mass:
    32647 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM241 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM241 Gene

Post-translational modifications for TMEM241 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM241 Gene

Domains & Families for TMEM241 Gene

Protein Domains for TMEM241 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM241 Gene

Graphical View of Domain Structure for InterPro Entry

Q24JQ0

UniProtKB/Swiss-Prot:

TM241_HUMAN :
  • Belongs to the TMEM241 family.
Family:
  • Belongs to the TMEM241 family.
genes like me logo Genes that share domains with TMEM241: view

No data available for Gene Families for TMEM241 Gene

Function for TMEM241 Gene

Molecular function for TMEM241 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by inducers of the unfolded protein response (UPR), including tunicamycin and thapsigargin.

Gene Ontology (GO) - Molecular Function for TMEM241 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005457 GDP-fucose transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TMEM241: view
genes like me logo Genes that share phenotypes with TMEM241: view

Animal Models for TMEM241 Gene

MGI Knock Outs for TMEM241:

Animal Model Products

CRISPR Products

miRNA for TMEM241 Gene

miRTarBase miRNAs that target TMEM241

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM241 Gene

Localization for TMEM241 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM241 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM241 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for TMEM241 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM241: view

Pathways & Interactions for TMEM241 Gene

SuperPathways for TMEM241 Gene

No Data Available

Interacting Proteins for TMEM241 Gene

Selected Interacting proteins: Q24JQ0-TM241_HUMAN for TMEM241 Gene via IID

Gene Ontology (GO) - Biological Process for TMEM241 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0036085 GDP-fucose import into Golgi lumen IEA --
genes like me logo Genes that share ontologies with TMEM241: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM241 Gene

Transcripts for TMEM241 Gene

Unigene Clusters for TMEM241 Gene

Transmembrane protein 241:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM241 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for TMEM241 Gene

GeneLoc Exon Structure for
TMEM241
ECgene alternative splicing isoforms for
TMEM241

Expression for TMEM241 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM241 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM241 Gene:

TMEM241

SOURCE GeneReport for Unigene cluster for TMEM241 Gene:

Hs.137562

Evidence on tissue expression from TISSUES for TMEM241 Gene

  • Nervous system(4.1)
  • Liver(4)
genes like me logo Genes that share expression patterns with TMEM241: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM241 Gene

Orthologs for TMEM241 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM241 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM241 34 35
  • 98.99 (n)
dog
(Canis familiaris)
Mammalia TMEM241 34 35
  • 90.77 (n)
cow
(Bos Taurus)
Mammalia TMEM241 34 35
  • 89.41 (n)
mouse
(Mus musculus)
Mammalia Tmem241 34 16 35
  • 85.75 (n)
rat
(Rattus norvegicus)
Mammalia Tmem241 34
  • 85.25 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM241 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM241 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H18ORF45 34
  • 74.1 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM241 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem241 34
  • 70.87 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885957 34
  • 60.32 (n)
TMEM241 (2 of 2) 35
  • 54 (a)
OneToMany
TMEM241 (1 of 2) 35
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for TMEM241 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM241 Gene

ENSEMBL:
Gene Tree for TMEM241 (if available)
TreeFam:
Gene Tree for TMEM241 (if available)

Paralogs for TMEM241 Gene

(2) SIMAP similar genes for TMEM241 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for TMEM241 Gene

genes like me logo Genes that share paralogs with TMEM241: view

No data available for Paralogs for TMEM241 Gene

Variants for TMEM241 Gene

Sequence variations from dbSNP and Humsavar for TMEM241 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000002065 -- 23,342,644(+) AACTA(C/T)CAAAC intron-variant
rs1000034644 -- 23,387,598(+) TTCTT(C/T)ATCTT intron-variant
rs1000057030 -- 23,302,151(+) CCAGC(C/T)ACCTG intron-variant
rs1000069960 -- 23,289,606(+) CTTTA(A/C)CACTA intron-variant
rs1000070076 -- 23,432,558(+) CGCCT(A/G)TAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM241 Gene

Variant ID Type Subtype PubMed ID
dgv5873n54 CNV loss 21841781
esv2758716 CNV loss 17122850
esv32657 CNV loss 17666407
esv34149 CNV loss 18971310
esv3440871 CNV duplication 20981092
nsv1060220 CNV loss 25217958
nsv131131 CNV deletion 16902084
nsv473748 CNV novel sequence insertion 20440878

Variation tolerance for TMEM241 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.74; 91.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM241 Gene

Human Gene Mutation Database (HGMD)
TMEM241
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM241

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM241 Gene

Disorders for TMEM241 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM241 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myeloproliferative syndrome, transient
  • transient myeloproliferative syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM241

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM241
genes like me logo Genes that share disorders with TMEM241: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM241 Gene

Publications for TMEM241 Gene

  1. Hyperactivity of the Ero1I+ oxidase elicits endoplasmic reticulum stress but no broad antioxidant response. (PMID: 23027870) Hansen H.G. … Ellgaard L. (J. Biol. Chem. 2012) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3 64
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 64

Products for TMEM241 Gene

Sources for TMEM241 Gene

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