TMEM241 Gene
protein-coding GIFtS : 41
GCID: GC18 M020777
transmembrane protein 241 (Previous name: chromosome 18 open reading frame 45 ) (Previous symbol: C18orf45 )
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Aliasesfor TMEM241 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane Protein 241 1 2 HVVT1 C18orf451 2 3 Putative Vertebrate Vrg4-Like Nucleotide-Sugar Transporter Truncated Variant22 FLJ442591 Putative Vertebrate Vrg4-Like Nucleotide-Sugar Transporter Variant12 MGC113861 Transmembrane Protein C18orf452 Chromosome 18 Open Reading Frame 451
Export aliases for TMEM241 gene to outside databases
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Summariesfor TMEM241 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TMEM241 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000018.9 NC_018929.1 NT_010966.14 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TMEM241 Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM241 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM241
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2 TMEM241 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18M020777: view genomic region
(about GC identifiers )
Start:
20,777,108 bp from pter
End:
21,017,925 bp from pter
Size:
240,818 bases
Orientation:
minus strand
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Proteinsfor TMEM241 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TM241_HUMAN, Q24JQ0 (See
protein sequence )Recommended Name: Transmembrane protein 241 Size : 296 amino acids; 32647 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : I0J130 Q6ZTS7 Q6ZW41Alternative splicing : 3 isoforms : Q24JQ0-1 Q24JQ0-2 Q24JQ0-3 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for TMEM241: NX_Q24JQ0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q24JQ0 TMEM241 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_116322.3 ENSEMBL proteins: ENSP00000462199 ENSP00000372720 ENSP00000437280 ENSP00000431584 ENSP00000433795 ENSP00000464174 ENSP00000435139 ENSP00000433605 ENSP00000464008 ENSP00000463348 ENSP00000462979 ENSP00000414899 ENSP00000440152 ENSP00000382615 Human Recombinant Protein Products for TMEM241: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
TMEM241 for ontologies About GeneDecksing TMEM241 Antibody Products: Assay Products for TMEM241:
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Protein
Domains / Familiesfor TMEM241 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q24JQ0
UniProtKB/Swiss-Prot: TM241_HUMAN, Q24JQ0 Similarity : Belongs to the TMEM241 family
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Functionfor TMEM241 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM241 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM241 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TMEM241 Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM241 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM241
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM241
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Pathways & Interactionsfor TMEM241 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM241 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)3 Interacting proteins for TMEM241 (Q24JQ0 2 , 3 ENSP00000414899 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor TMEM241 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM241 Search CenterWatch for drugs/clinical trials and news about TMEM241 / TM241
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Transcriptsfor TMEM241 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMEM241 gene: NM_032933.4 Unigene Cluster for TMEM241:
Transmembrane protein 241 Hs.137562 [show with all ESTs ] Unigene Representative Sequence: NM_032933 18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19 ): ENST00000584625 ENST00000581444 ENST00000578790 ENST00000475185 (uc002kue.3 )ENST00000383233 ENST00000477053 (uc002kuh.3 ) ENST00000473688 (uc002kuf.3 uc010xar.2 uc002kug.3 )ENST00000583048 ENST00000577448 ENST00000460322 ENST00000578520 ENST00000482411 ENST00000497608 ENST00000577531 ENST00000582336 ENST00000580025 ENST00000450466 (uc010xaq.2 )ENST00000542162 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM241 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM241 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TMEM241 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM241 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM241
Additional cDNA sequence: AB253738.1 AB253739.1 AK294916.1 AK303553.1 AK314123.1 BC006280.2 BC054507.1 BC082984.1 BC114561.1
10 DOTS entries : DT.95158285 DT.91669424
DT.92414312 DT.97787960 DT.121084885 DT.102824228 DT.121084846 DT.70103503 DT.95297375 DT.97824418 24/47 AceView cDNA sequences (see all 47 ):
BX109184 CR610638 AA027232 BE046469 BE407667 CB994115 BC006280 AK123623 AI206063 BE867486 BE743750 AI146821 BX409689 BX333058 NM_032933 BU956123 BC054507 BE409871 BX484275 BU164764 AK126247 AW452107 BE407723 AA027233 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM241 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b SP1 :             -       -             -   -   -         SP2 :     -               -   -   -   -       -   -   -         SP3 :                               -   -   -         SP4 :                                   -         SP5 :                                          
ECgene alternative splicing isoforms for TMEM241
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Expression for TMEM241 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM241 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTTCTCATTAbout this image TMEM241 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TMEM241 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM241 SOURCE GeneReport for Unigene cluster: Hs.137562 SABiosciences Custom PCR Arrays for TMEM241 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM241Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TMEM241 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM241 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM241 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM241
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Orthologsfor TMEM241 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TMEM241 gene from 3/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for TMEM241 (if available)TreeFam Gene Tree for TMEM241 (if available)
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Paralogsfor TMEM241 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMEM241 gene 2 SIMAP similar genes for TMEM241 using alignment to 9 protein entries: TM241_HUMAN (see all proteins ):hVVT C18orf45
TMEM241 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for TMEM241 PGOHUM00000244783
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Genomic Variantsfor TMEM241 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 18 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM241 (20777108 - 21017925 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TMEM241: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM241
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Disorders
/ Diseasesfor TMEM241 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor TMEM241 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM241 gene integrated from 9 sources : (articles sorted by number of sources associating them with TMEM241) Utopia : connect your pdf to the dynamic world of online information
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Hyperactivity of the Ero1a oxidase elicits endoplasmic reticulum stress but no broad antioxidant response. (PubMed id 23027870) 1 Hansen H.G....Ellgaard L. (2012) The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612) 1 Zhao J....Grant S.F. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) DNA sequence and analysis of human chromosome 18. (PubMed id 16177791) 2 Nusbaum C.... Lander E.S. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for TMEM241 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM241 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM241 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TMEM241 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM241 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM241 gene: Search GeneIP for patents involving TMEM241 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM241 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM241 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM241 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM241 OriGene Protein Over-expression Lysate for TMEM241 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM241 OriGene 3'-UTR Clone for TMEM241 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM241 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM241 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM241 OriGene Custom Protein Services for TMEM241 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM241 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM241 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM241 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM241 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM241 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM241
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TMEM241 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM241
ThermoFisher Antibodies for TMEM241
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM241
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Aliases for TMEM241
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Disorders / Diseases for TMEM241
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Expression for TMEM241
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