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Aliases for TMEM238 Gene

Aliases for TMEM238 Gene

  • Transmembrane Protein 238 2 3 5

External Ids for TMEM238 Gene

Previous GeneCards Identifiers for TMEM238 Gene

  • GC19M055891

Summaries for TMEM238 Gene

GeneCards Summary for TMEM238 Gene

TMEM238 (Transmembrane Protein 238) is a Protein Coding gene. An important paralog of this gene is LINC00675.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM238 Gene

Genomics for TMEM238 Gene

Regulatory Elements for TMEM238 Gene

Enhancers for TMEM238 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055337 1.8 FANTOM5 ENCODE dbSUPER 12.7 +44.8 44771 4.0 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC LENG8-AS1 ENSG00000235681 U2AF2 FAM71E2 KMT5C PPP6R1 ZNF628 TMEM238 IL11 TMEM190
GH19G055246 1.7 Ensembl ENCODE dbSUPER 11.2 +130.7 130740 14.5 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC HSPBP1 TMEM86B NAT14 FIZ1 PPP6R1 BRSK1 RPL28 TMEM238 SYT5 UBE2S
GH19G055111 1.8 FANTOM5 ENCODE dbSUPER 9.5 +269.2 269216 8.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 EPS8L1 RDH13 TNNT1 RPL28 TMEM238 PPP1R12C ZNF865 SHISA7 PPP6R1 FCAR
GH19G055320 1.5 FANTOM5 Ensembl ENCODE 10.6 +61.3 61273 5.7 PKNOX1 SCRT2 CREM CEBPB ELF1 ZNF592 ZNF579 SMARCA4 CEBPA IKZF1 FCAR TMEM150B FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 TMEM238 RPL28
GH19G055291 1.1 Ensembl ENCODE 11.8 +92.6 92565 1.0 HDAC1 ELF3 TBP PKNOX1 FOXA2 ARNT ARID4B SIN3A RAD21 RFX5 ZNF581 U2AF2 ENSG00000267523 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF628 PPP6R1 RPL28 TMEM238
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM238 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM238 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000289207 698 1001 TBP RB1 SREBF2 SIN3A ZBTB40 BRCA1 RAD21 ZBTB11 GATAD2B SMARCB1

Genomic Location for TMEM238 Gene

Chromosome:
19
Start:
55,379,244 bp from pter
End:
55,384,598 bp from pter
Size:
5,355 bases
Orientation:
Minus strand

Genomic View for TMEM238 Gene

Genes around TMEM238 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM238 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM238 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM238 Gene

Proteins for TMEM238 Gene

  • Protein details for TMEM238 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JI98-TM238_HUMAN
    Recommended name:
    Transmembrane protein 238
    Protein Accession:
    C9JI98

    Protein attributes for TMEM238 Gene

    Size:
    176 amino acids
    Molecular mass:
    18040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM238 Gene

Post-translational modifications for TMEM238 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM238 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM238 Gene

Domains & Families for TMEM238 Gene

Protein Domains for TMEM238 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM238: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM238 Gene

Function for TMEM238 Gene

Animal Model Products

CRISPR Products

miRNA for TMEM238 Gene

miRTarBase miRNAs that target TMEM238

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM238 Gene

Localization for TMEM238 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM238 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM238 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM238 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM238: view

Pathways & Interactions for TMEM238 Gene

SuperPathways for TMEM238 Gene

No Data Available

Interacting Proteins for TMEM238 Gene

Gene Ontology (GO) - Biological Process for TMEM238 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM238 Gene

Drugs & Compounds for TMEM238 Gene

No Compound Related Data Available

Transcripts for TMEM238 Gene

mRNA/cDNA for TMEM238 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM238 Gene

Transmembrane protein 238:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM238 Gene

No ASD Table

Relevant External Links for TMEM238 Gene

GeneLoc Exon Structure for
TMEM238
ECgene alternative splicing isoforms for
TMEM238

Expression for TMEM238 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM238 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM238 Gene

This gene is overexpressed in Colon - Transverse (x6.7) and Pancreas (x5.0).

Protein differential expression in normal tissues from HIPED for TMEM238 Gene

This gene is overexpressed in Lung (58.2) and Fetal gut (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM238 Gene



Protein tissue co-expression partners for TMEM238 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM238 Gene:

TMEM238

SOURCE GeneReport for Unigene cluster for TMEM238 Gene:

Hs.534672
genes like me logo Genes that share expression patterns with TMEM238: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM238 Gene

Orthologs for TMEM238 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM238 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM238 34 35
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia TMEM238 34
  • 92.07 (n)
cow
(Bos Taurus)
Mammalia TMEM238 34
  • 89.96 (n)
mouse
(Mus musculus)
Mammalia Tmem238 34 16 35
  • 86.55 (n)
rat
(Rattus norvegicus)
Mammalia Tmem238 34
  • 84.95 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM238 35
  • 13 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem238 34
  • 61.4 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem238 35
  • 44 (a)
OneToOne
Species where no ortholog for TMEM238 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM238 Gene

ENSEMBL:
Gene Tree for TMEM238 (if available)
TreeFam:
Gene Tree for TMEM238 (if available)

Paralogs for TMEM238 Gene

Paralogs for TMEM238 Gene

genes like me logo Genes that share paralogs with TMEM238: view

Variants for TMEM238 Gene

Sequence variations from dbSNP and Humsavar for TMEM238 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000302654 -- 55,386,249(+) CAAGT(G/T)CCCAG intron-variant, upstream-variant-2KB
rs1000426297 -- 55,380,677(+) GCCTC(A/G)GCCTC intron-variant
rs1000594492 -- 55,385,528(+) TCCAA(A/C)GGTGC upstream-variant-2KB
rs1000744197 -- 55,379,195(+) CTCGT(C/G)TCCAT downstream-variant-500B
rs1000775961 -- 55,380,511(+) CCTCC(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM238 Gene

Variant ID Type Subtype PubMed ID
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for TMEM238 Gene

Gene Damage Index Score: 1.02; 21.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM238 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM238

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM238 Gene

Disorders for TMEM238 Gene

Relevant External Links for TMEM238

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM238

No disorders were found for TMEM238 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM238 Gene

Publications for TMEM238 Gene

  1. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM238 Gene

Sources for TMEM238 Gene

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