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Aliases for TMEM238 Gene

Aliases for TMEM238 Gene

  • Transmembrane Protein 238 2 3 5

External Ids for TMEM238 Gene

Previous GeneCards Identifiers for TMEM238 Gene

  • GC19M055891

Summaries for TMEM238 Gene

GeneCards Summary for TMEM238 Gene

TMEM238 (Transmembrane Protein 238) is a Protein Coding gene. An important paralog of this gene is LINC00675.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM238 Gene

Genomics for TMEM238 Gene

Regulatory Elements for TMEM238 Gene

Enhancers for TMEM238 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055337 1 FANTOM5 ENCODE 12.7 +44.8 44771 4.0 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LENG8-AS1 HSPBP1 FAM71E2 KMT5C PPP6R1 ZNF628 U2AF2 TMEM238 IL11 TMEM190
GH19F055417 0.8 Ensembl ENCODE 12 -33.8 -33784 0.8 PKNOX1 WRNIP1 ARID4B GLI4 ZNF2 RAD21 RFX5 ZNF143 FOS MIXL1 SHISA7 ISOC2 ZNF628 RPL28 MIR6805 TMEM238 TMEM190 BRSK1 HSPBP1 PPP6R1
GH19F055421 1.1 Ensembl ENCODE 11.9 -36.9 -36903 0.6 MAX MYC SHISA7 ISOC2 ZNF628 TMEM238 MIR6805 RPL28 BRSK1 TMEM190 TNNT1 HSPBP1
GH19F055347 0.4 ENCODE 11.8 +35.9 35853 1.8 GLIS2 POLR2A L3MBTL2 SCRT2 GLIS1 MAX EBF1 ZIC2 IL11 TMEM190 TMEM238 MIR6805 RPL28 BRSK1 HSPBP1 PPP6R1 UBE2S KMT5C
GH19F055344 0.6 ENCODE 11.8 +39.2 39186 2.2 CTCF KLF1 KLF17 MAX ZIC2 RAD21 ZFHX2 GLIS2 PATZ1 SMC3 IL11 TMEM190 TMEM238 MIR6805 RPL28 BRSK1 HSPBP1 PPP6R1 UBE2S TMEM86B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM238 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM238 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001818951 698 1401 BCOR TBP CTCF TAF1 SIN3A UBTF ZBTB40 BRCA1 RAD21 E2F1
ENSR00000348984 -1502 2201 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 SP3 SP5

Genomic Location for TMEM238 Gene

Chromosome:
19
Start:
55,379,244 bp from pter
End:
55,384,598 bp from pter
Size:
5,355 bases
Orientation:
Minus strand

Genomic View for TMEM238 Gene

Genes around TMEM238 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM238 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM238 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM238 Gene

Proteins for TMEM238 Gene

  • Protein details for TMEM238 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JI98-TM238_HUMAN
    Recommended name:
    Transmembrane protein 238
    Protein Accession:
    C9JI98

    Protein attributes for TMEM238 Gene

    Size:
    176 amino acids
    Molecular mass:
    18040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM238 Gene

Post-translational modifications for TMEM238 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM238 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM238 Gene

Domains & Families for TMEM238 Gene

Protein Domains for TMEM238 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM238: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM238 Gene

Function for TMEM238 Gene

Animal Model Products

miRNA for TMEM238 Gene

miRTarBase miRNAs that target TMEM238

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM238 Gene

Localization for TMEM238 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM238 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM238 Gene COMPARTMENTS Subcellular localization image for TMEM238 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM238 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM238: view

Pathways & Interactions for TMEM238 Gene

SuperPathways for TMEM238 Gene

No Data Available

Interacting Proteins for TMEM238 Gene

Gene Ontology (GO) - Biological Process for TMEM238 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM238 Gene

Transcripts for TMEM238 Gene

mRNA/cDNA for TMEM238 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM238 Gene

Transmembrane protein 238:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM238 Gene

No ASD Table

Relevant External Links for TMEM238 Gene

GeneLoc Exon Structure for
TMEM238
ECgene alternative splicing isoforms for
TMEM238

Expression for TMEM238 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM238 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM238 Gene

This gene is overexpressed in Colon - Transverse (x6.7) and Pancreas (x5.0).

Protein differential expression in normal tissues from HIPED for TMEM238 Gene

This gene is overexpressed in Lung (58.2) and Fetal gut (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM238 Gene



Protein tissue co-expression partners for TMEM238 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM238 Gene:

TMEM238

SOURCE GeneReport for Unigene cluster for TMEM238 Gene:

Hs.534672
genes like me logo Genes that share expression patterns with TMEM238: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM238 Gene

Orthologs for TMEM238 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM238 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM238 34 35
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia TMEM238 34
  • 92.07 (n)
cow
(Bos Taurus)
Mammalia TMEM238 34
  • 89.96 (n)
mouse
(Mus musculus)
Mammalia Tmem238 34 16 35
  • 86.55 (n)
rat
(Rattus norvegicus)
Mammalia Tmem238 34
  • 84.95 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM238 35
  • 13 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem238 34
  • 61.4 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem238 35
  • 44 (a)
OneToOne
Species where no ortholog for TMEM238 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM238 Gene

ENSEMBL:
Gene Tree for TMEM238 (if available)
TreeFam:
Gene Tree for TMEM238 (if available)

Paralogs for TMEM238 Gene

Paralogs for TMEM238 Gene

genes like me logo Genes that share paralogs with TMEM238: view

Variants for TMEM238 Gene

Sequence variations from dbSNP and Humsavar for TMEM238 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10420818 -- 55,385,813(+) GGAAG(C/T)AGCCG upstream-variant-2KB
rs10424959 -- 55,382,845(+) CTCCT(A/C/T)CTTTT intron-variant
rs10426501 -- 55,382,850(+) CCTTT(C/T)CTAGG intron-variant
rs111260854 -- 55,381,103(+) CTGGT(A/T)GCATT intron-variant
rs112083646 -- 55,382,235(+) CCATC(C/T)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM238 Gene

Variant ID Type Subtype PubMed ID
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for TMEM238 Gene

Gene Damage Index Score: 1.02; 21.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM238 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM238

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM238 Gene

Disorders for TMEM238 Gene

Relevant External Links for TMEM238

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM238

No disorders were found for TMEM238 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM238 Gene

Publications for TMEM238 Gene

  1. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM238 Gene

Sources for TMEM238 Gene

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