Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM237 Gene

protein-coding   GIFtS: 41
GCID: GC02M202484

transmembrane protein 237

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbol: ALS2CR4)
 Explore 5 diseases affiliated with
TMEM237 via our new
 Human Malady Compendium 
Biological research products
for TMEM237
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transmembrane Protein 2371 2
ALS2CR41 2 3
JBTS141 2
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 41 2
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 4 Protein2 3

External Ids:    HGNC: 144321   Entrez Gene: 650622   Ensembl: ENSG000001557557   OMIM: 6144235   UniProtKB: Q96Q453   

Export aliases for TMEM237 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM237:
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in
this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45
Function: Component of the transition zone in primary cilia. Required for ciliogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM237
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM237 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM237

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM237


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

TMEM237 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM237 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M202484:  view genomic region     (about GC identifiers)

Start:
202,484,907 bp from pter      End:
202,508,293 bp from pter
Size:
23,387 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45 (See protein sequence)
Recommended Name: Transmembrane protein 237  
Size: 408 amino acids; 45526 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cell projection, cilium. Note=Localizes at the
proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the
transition zone by RPGRIP1L
Sequence caution: Sequence=AAY14694.1; Type=Erroneous gene model prediction; Sequence=AAY15056.1; Type=Erroneous gene
model prediction;
Secondary accessions: B4E1R8 B4E2R8 E9PAR8 E9PBF8 E9PG24 E9PGX0 Q53TS9 Q53TT2 Q7Z3B6 Q8IZ18 Q8NBF8
Q96CY1
Alternative splicing: 5 isoforms:  Q96Q45-1   Q96Q45-2   Q96Q45-3   Q96Q45-4   Q96Q45-5   

Explore the universe of human proteins at neXtProt for TMEM237: NX_Q96Q45

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96Q45

  • TMEM237 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001037850.1  NP_689601.2  

    ENSEMBL proteins: 
     ENSP00000387203   ENSP00000386264   ENSP00000286196   ENSP00000413230   ENSP00000402681  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): TMEM237
    OriGene Custom Protein Services for TMEM237 
    GenScript Custom Purified and Recombinant Proteins Services for TMEM237
    Novus Biologicals TMEM237 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMEM237

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0035869ciliary transition zone IDA--


    TMEM237 for ontologies           About GeneDecksing



    TMEM237 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM237 
    GenScript Custom Superior Antibodies Services for TMEM237
    Novus Biologicals TMEM237 Antibody
    Search for Antibodies for TMEM237 at Abcam  
    Uscn Antibodies for TMEM237
    Search ThermoFisher Antibodies for TMEM237

    Assay Products for TMEM237: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM237
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TMEM237


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96Q45

    UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45
    Similarity: Belongs to the TMEM237 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45
    Function: Component of the transition zone in primary cilia. Required for ciliogenesis

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): TMEM237
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM237
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM237 (see all 39):
    hsa-miR-429 hsa-miR-200a hsa-miR-16-1* hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l hsa-miR-3167 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTMEM237 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM237 (see all 7)
    OriGene shRNA RFP: TMEM237
    OriGene siRNA: TMEM237
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM237

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM237

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM237 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM237 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for TMEM237
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM237
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM237 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM237
    Search LifeMap BioReagents cell lines for TMEM237

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM237


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM237

    2 Interacting proteins for TMEM237 (Q96Q452, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=1 
    --P310162MINT-8107846
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030111regulation of Wnt receptor signaling pathway IMP--
    GO:0042384cilium assembly IMP--


    TMEM237 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM237
    Search CenterWatch for drugs/clinical trials and news about TMEM237 / TM237 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM237 gene (2 alternative transcripts): 
    NM_001044385.2  NM_152388.3  

    Unigene Cluster for TMEM237:

    Transmembrane protein 237
    Hs.12319  [show with all ESTs]
    Unigene Representative Sequence: NM_152388
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409444(uc021vvd.1 uc021vve.1) ENST00000409883(uc010zho.1 uc021vvf.1 uc021vvg.1)
    ENST00000495329 ENST00000286196(uc010zhp.1) ENST00000471318 ENST00000466641
    ENST00000466839 ENST00000432684 ENST00000444047 ENST00000489550 ENST00000480124
    ENST00000463205

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): TMEM237
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM237
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM237 (see all 39):
    hsa-miR-429 hsa-miR-200a hsa-miR-16-1* hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l hsa-miR-3167 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTMEM237 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM237 (see all 7)
    OriGene shRNA RFP: TMEM237
    OriGene siRNA: TMEM237
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM237
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM237 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM237 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for TMEM237
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM237
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM237 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM237
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM237
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM237
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM237

    Additional cDNA sequence: 

    AB053301.1 AF212043.1 AK022836.1 AK090601.1 AK125841.1 AK303954.1 AK304395.1 BC013730.1 
    BC029611.1 BX538000.1 

    9 DOTS entries:

    DT.113993  DT.212444  DT.97821321  DT.97844325  DT.95070441  DT.100704876  DT.100781956  DT.100781957 
    DT.95153464 

    24/168 AceView cDNA sequences (see all 168):

    BX095550 CR608801 CD679579 AA588216 AA371121 BM715205 CB143438 BQ434823 
    AA350506 CA429872 AW069590 AA588221 CA413028 C20815 AA934561 AI470612 
    AW188120 AA350505 F03251 BM704073 BX538000 BM969337 AI206988 CR603031 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM237 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                    -     -                 -                             -                     
    SP2:                    -                       -                                                   
    SP3:                                                                                                
    SP4:                                                                    -     -                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for TMEM237

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM237 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATTTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TMEM237 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM237

    SOURCE GeneReport for Unigene cluster: Hs.12319
        SABiosciences Custom PCR Arrays for TMEM237
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM237
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM237
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM237
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM237
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM237

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM237 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2371 , 5 amyotrophic lateral sclerosis 2 (juvenile) chromosome more5
    transmembrane protein 2371
    84.51(n)1
    84.07(a)1
      1 (29.20 cM)5
    3812591  NM_001033449.11  NP_001028621.11 
     591005945 
    chicken
    (Gallus gallus)
    Aves TMEM2371 transmembrane protein 237 69.71(n)
    70.24(a)
      424084  XM_421939.3  XP_421939.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2376
    --
    61(a)
    1 ↔ 1
    GL343478.1(199293-216018)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.40122 Xenopus laevis transcribed sequences 71.93(n)    48031546 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb9922 sbcb992 72.03(n)   386786  57046956 


    ENSEMBL Gene Tree for TMEM237 (if available)
    TreeFam Gene Tree for TMEM237 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/416 NCBI SNPs in TMEM237 are shown (see all 416    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994697071,2
    Cpathogenic202505638(-) CTCCAC/TGAGCT 4 R * stg10--------
    rs1461618921,2
    --202484412(+) TCAGAC/TACATT 6 -- us2k1 ds50010--------
    rs1853189491,2
    --202484678(+) AATGAC/GAACAC 6 -- us2k1 ds50010--------
    rs800558771,2
    F--202484683(+) GAACAC/TGTGGA 6 -- us2k1 ds50013Minor allele frequency- T:0.38NA 8
    rs1897842191,2
    --202484796(+) GGTGAC/TGAAAT 6 -- ds5001 us2k10--------
    rs585930691,2
    C,F,--202484816(+) ACCCCC/TATGAC 6 -- us2k1 ds50015Minor allele frequency- T:0.11WA NA CSA 243
    rs1807475011,2
    --202485072(+) GCTTTC/TAGTTA 6 -- us2k1 ut310--------
    rs1873281361,2
    --202485123(+) ACTGCC/TATATC 6 -- us2k1 ut310--------
    rs1432186671,2
    --202485465(+) CTTTT-/AATGAT 6 -- us2k1 ut310--------
    rs777716151,2
    --202485525(+) TCCCCA/CGCTCT 6 -- us2k1 ut310--------

    HapMap Linkage Disequilibrium report for TMEM237 (202484907 - 202508293 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM237: --
    Human Gene Mutation Database (HGMD): TMEM237

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM237
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM237

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMEM237 for disorders           About GeneDecksing

    OMIM gene information: 614423    OMIM disorders: --

    UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45
  • Defects in TMEM237 are the cause of Joubert syndrome type 14 (JBTS14) [MIM:614424]. An autosomal recessive
  • disorder characterized by severe mental retardation, hypotonia, breathing abnormalities in infancy, and dysmorphic
    facial features. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and
    reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a
    molar tooth on transaxial slices (molar tooth sign). Additional variable JBTS14 features include renal disease,
    abnormal eye movements, and postaxial polydactyly

    5 diseases for TMEM237:    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis    joubert syndrome    joubert syndrome and related disorders
    was-related disorders


    Export disorders for TMEM237 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM237 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TMEM237)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)1, 2, 3 Hadano S....Ikeda J.-E. (2001)
    2. TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. (PubMed id 22152675)1, 2 Huang L.... Boycott K.M. (2011)
    3. Deciphering the structure and function of Als2cr4 in the mouse retina. (PubMed id 20375344)1, 3 Zuniga F.I. and Craft C.M. (2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65062 HGNC: 14432 AceView: ALS2CR4 Ensembl:ENSG00000155755 euGenes: HUgn65062
    ECgene: TMEM237 H-InvDB: TMEM237

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM237 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM237 gene:
    Search GeneIP for patents involving TMEM237

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TMEM237  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM237   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM237  
     OriGene Protein Over-expression Lysate for TMEM237   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TMEM237   OriGene 3'-UTR Clone for TMEM237  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM237   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM237  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMEM237   OriGene Custom Protein Services for TMEM237  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM237
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM237
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM237
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM237
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM237
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM237
     GenScript Custom Purified and Recombinant Proteins Services for TMEM237 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TMEM237
     GenScript Custom Assay Services for TMEM237 GenScript Custom Superior Antibodies Services for TMEM237
     GenScript Custom overexpressing Cell Line Services for TMEM237 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for TMEM237
     Search Chromatin IP Primers for TMEM237
     RT2 qPCR Primer Assay in human, mouse, rat TMEM237
     Search GNC Networks for TMEM237
     SABiosciences Custom PCR Arrays for TMEM237
     Search Tocris compounds for TMEM237
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMEM237 antibodies
     TMEM237 lysates
     Search for Antibodies for TMEM237 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TMEM237
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TMEM237 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TMEM237
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM237
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM237
     SwitchGear Promoter luciferase reporter plasmids for TMEM237
     Search ThermoFisher Antibodies for TMEM237
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM237
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMEM237 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4