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TMEM237 Gene

protein-coding   GIFtS: 45
GCID: GC02M202484

Transmembrane Protein 237

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbol: ALS2CR4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 2371 2
ALS2CR41 2 3 5
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 41 2
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 4
Protein2 3
JBTS142 5

External Ids:    HGNC: 144321   Entrez Gene: 650622   Ensembl: ENSG000001557557   OMIM: 6144235   UniProtKB: Q96Q453   

Export aliases for TMEM237 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM237 Gene:
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects
in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for TMEM237 Gene:
TMEM237 (transmembrane protein 237) is a protein-coding gene. Diseases associated with TMEM237 include joubert syndrome 14, and tmem237-related joubert syndrome.

UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45
Function: Component of the transition zone in primary cilia. Required for ciliogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM237
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM237 promoter sequence
   Search Chromatin IP Primers for TMEM237

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM237


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

TMEM237 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM237 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M202484:  view genomic region     (about GC identifiers)

Start:
202,484,907 bp from pter      End:
202,508,293 bp from pter
Size:
23,387 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45 (See protein sequence)
Recommended Name: Transmembrane protein 237  
Size: 408 amino acids; 45526 Da
Sequence caution: Sequence=AAY14694.1; Type=Erroneous gene model prediction; Sequence=AAY15056.1; Type=Erroneous
gene model prediction;
Secondary accessions: B4E1R8 B4E2R8 E9PAR8 E9PBF8 E9PG24 E9PGX0 Q53TS9 Q53TT2 Q7Z3B6 Q8IZ18
Q8NBF8 Q96CY1
Alternative splicing: 5 isoforms:  Q96Q45-1   Q96Q45-2   Q96Q45-3   Q96Q45-4   Q96Q45-5   

Explore the universe of human proteins at neXtProt for TMEM237: NX_Q96Q45

Explore proteomics data for TMEM237 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys209
  • Modification sites at PhosphoSitePlus

  • See TMEM237 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001037850.1  NP_689601.2  

    ENSEMBL proteins: 
     ENSP00000387203   ENSP00000386264   ENSP00000286196   ENSP00000413230   ENSP00000402681  

    TMEM237 Human Recombinant Protein Products:

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    Novus Biologicals TMEM237 Protein
    Novus Biologicals TMEM237 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TMEM237 Antibody Products:

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    Search for Antibodies for TMEM237 at Abcam
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    LSBio Antibodies in human, mouse, rat for TMEM237

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96Q45

    UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45
    Similarity: Belongs to the TMEM237 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM237_HUMAN, Q96Q45
    Function: Component of the transition zone in primary cilia. Required for ciliogenesis

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM237
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM237
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM237

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM237:
    hsa-mir-149-5p (MIRT045657)

    Block miRNA regulation of human, mouse, rat TMEM237 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM237 (see all 39):
    hsa-miR-429 hsa-miR-200a hsa-miR-16-1* hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l hsa-miR-3167 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTMEM237 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM237

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    Sino Biological Human cDNA Clone for TMEM237
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM237
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM237

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM237 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM237


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM237_HUMAN, Q96Q45: Membrane; Multi-pass membrane protein (Potential). Cell projection, cilium. Note=Localizes
    at the proximal region of primary cilia were observed, consistent with localization to the transition zone.
    Anchored to the transition zone by RPGRIP1L

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0035869ciliary transition zone IDA--

    TMEM237 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM237
    Interactions:

        Search GeneGlobe Interaction Network for TMEM237

    2 Interacting proteins for TMEM237 (Q96Q452, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=1 
    --P310162MINT-8107846
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030111regulation of Wnt signaling pathway IMP--
    GO:0042384cilium assembly IMP--

    TMEM237 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM237 (TM237)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM237 gene (2 alternative transcripts): 
    NM_001044385.2  NM_152388.3  

    Unigene Cluster for TMEM237:

    Transmembrane protein 237
    Hs.12319  [show with all ESTs]
    Unigene Representative Sequence: NM_152388
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409444(uc021vvd.1 uc021vve.1) ENST00000409883(uc010zho.1 uc021vvf.1 uc021vvg.1)
    ENST00000495329 ENST00000286196(uc010zhp.1) ENST00000471318 ENST00000466641
    ENST00000466839 ENST00000432684 ENST00000444047 ENST00000489550 ENST00000480124
    ENST00000463205
    miRNA
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    Block miRNA regulation of human, mouse, rat TMEM237 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM237 (see all 39):
    hsa-miR-429 hsa-miR-200a hsa-miR-16-1* hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l hsa-miR-3167 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTMEM237 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM237
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM237
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM237
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM237
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM237
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM237
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM237
      QuantiFast Probe-based Assays in human, mouse, rat TMEM237

    Additional mRNA sequence: 

    AB053301.1 AF212043.1 AK022836.1 AK090601.1 AK125841.1 AK303954.1 AK304395.1 BC013730.1 
    BC029611.1 BX538000.1 

    9 DOTS entries:

    DT.113993  DT.212444  DT.97821321  DT.97844325  DT.95070441  DT.100704876  DT.100781956  DT.100781957 
    DT.95153464 

    Selected AceView cDNA sequences (see all 168):

    AA404455 AI087401 AA018852 BX095550 CR608801 CD679579 AA588216 AA371121 
    AA350506 BQ434823 BM715205 CB143438 CA429872 AW069590 AA588221 AA934561 
    C20815 CA413028 AW188120 F03251 CR603031 BE621274 BM704073 F12785 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM237 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                    -     -                 -                             -                     
    SP2:                    -                       -                                                   
    SP3:                                                                                                
    SP4:                                                                    -     -                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for TMEM237

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM237 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATTTGTA
    TMEM237 Expression
    About this image


    TMEM237 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Oviduct
    TMEM237 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM237 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12319
        Custom PCR Arrays for TMEM237
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM237

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM237 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2371 , 5 amyotrophic lateral sclerosis 2 (juvenile) chromosome more5
    transmembrane protein 2371
    84.51(n)1
    84.07(a)1
      1 (29.20 cM)5
    3812591  NM_001037812.21  NP_001032901.11 
     591005945 
    chicken
    (Gallus gallus)
    Aves TMEM2371 transmembrane protein 237 69.53(n)
    69.44(a)
      424084  XM_004942616.1  XP_004942673.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2376
    transmembrane protein 237
    65(a)
    1 ↔ 1
    GL343478.1(190241-216027)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.40122 Xenopus laevis transcribed sequences 71.93(n)    48031546 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb9922 sbcb992 72.03(n)   386786  57046956 


    ENSEMBL Gene Tree for TMEM237 (if available)
    TreeFam Gene Tree for TMEM237 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM237 gene
    3 SIMAP similar genes for TMEM237 using alignment to 4 protein entries:     TM237_HUMAN (see all proteins):
    ENO1    ENO3    ENO2

    TMEM237 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM237 (see all 533)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994697071,2
    Cpathogenic1201894756(-) CTCCAC/TGAGCT 4 R * stg10--------
    rs1498272671,2
    C--201875050(+) TGATGA/TCATTA 2 -- ut310--------
    rs1447608151,2
    --201875107(+) AACTAA/GCTTGG 2 -- ut310--------
    rs1886374291,2
    --201875135(+) CATGGG/TAAATT 2 -- ut310--------
    rs1485396311,2
    --201875161(+) ACTCTA/GGAAAA 2 -- ut310--------
    rs1428529561,2
    C--201875376(+) ATACAC/TACAAC 2 -- ut310--------
    rs756555541,2
    C,F--201875615(+) AAACCA/CTGATG 2 -- ut311Minor allele frequency- C:0.02WA 118
    rs1158966801,2
    C--201875649(+) CTTGCA/GTGTCA 2 -- ut310--------
    rs1423556571,2
    C--201875664(+) AGTCCA/CCTGTA 2 -- ut310--------
    rs1446137501,2
    C--201875699(+) TCATCA/GACGGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM237 (202484907 - 202508293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM237:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875709CNV Gain21882294

    Human Gene Mutation Database (HGMD): TMEM237
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM237
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM237

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614423   
    OMIM disorders: 614424  
    UniProtKB/Swiss-Prot: TM237_HUMAN, Q96Q45
  • Joubert syndrome 14 (JBTS14) [MIM:614424]: An autosomal recessive disorder characterized by severe mental
    retardation, hypotonia, breathing abnormalities in infancy, and dysmorphic facial features. Neuroradiologically,
    it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar
    peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial
    slices (molar tooth sign). Additional variable features include renal disease, abnormal eye movements, and
    postaxial polydactyly. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 16 diseases for TMEM237:    
    About MalaCards
    joubert syndrome 14    tmem237-related joubert syndrome    joubert syndrome with renal anomalies    joubert syndrome 15
    joubert syndrome and related disorders    joubert syndrome 2    amyotrophic lateral sclerosis 2, juvenile    was-related disorders
    lateral sclerosis    joubert syndrome    amyotrophic lateral sclerosis    polydactyly
    hypotonia    mental retardation    multiple myeloma    myeloma


    TMEM237 for disorders           About GeneDecksing


    Export disorders for TMEM237 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM237 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TMEM237)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)1, 2, 3 Hadano S....Ikeda J.-E. (Nat. Genet. 2001)
    2. TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. (PubMed id 22152675)1, 2 Huang L.... Boycott K.M. (Am. J. Hum. Genet. 2011)
    3. Deciphering the structure and function of Als2cr4 in the mouse retina. (PubMed id 20375344)1, 3 Zuniga F.I. and Craft C.M. (amp 2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65062 HGNC: 14432 AceView: ALS2CR4 Ensembl:ENSG00000155755 euGenes: HUgn65062
    ECgene: TMEM237 H-InvDB: TMEM237

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM237 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM237 gene:
    Search GeneIP for patents involving TMEM237

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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