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Aliases for TMEM236 Gene

Aliases for TMEM236 Gene

  • Transmembrane Protein 236 2 3 5
  • Family With Sequence Similarity 23, Member B 2 3
  • Family With Sequence Similarity 23, Member A 2 3
  • FAM23A 3 4
  • FAM23B 3 4
  • BA162I21.2 3
  • BA16O1.2 3

External Ids for TMEM236 Gene

Previous HGNC Symbols for TMEM236 Gene

  • FAM23B
  • FAM23A

Previous GeneCards Identifiers for TMEM236 Gene

  • GC10P017796

Summaries for TMEM236 Gene

GeneCards Summary for TMEM236 Gene

TMEM236 (Transmembrane Protein 236) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM236 Gene

Genomics for TMEM236 Gene

Regulatory Elements for TMEM236 Gene

Enhancers for TMEM236 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM236 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM236 Gene

Chromosome:
10
Start:
17,752,210 bp from pter
End:
17,800,887 bp from pter
Size:
48,678 bases
Orientation:
Plus strand

Genomic View for TMEM236 Gene

Genes around TMEM236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM236 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM236 Gene

Proteins for TMEM236 Gene

  • Protein details for TMEM236 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0B7-TM236_HUMAN
    Recommended name:
    Transmembrane protein 236
    Protein Accession:
    Q5W0B7
    Secondary Accessions:
    • B2RXH7

    Protein attributes for TMEM236 Gene

    Size:
    351 amino acids
    Molecular mass:
    39663 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM236 Gene

Proteomics data for TMEM236 Gene at MOPED

Post-translational modifications for TMEM236 Gene

  • Glycosylation at Asn 193
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM236 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM236 Gene

Domains & Families for TMEM236 Gene

Protein Domains for TMEM236 Gene

Suggested Antigen Peptide Sequences for TMEM236 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0B7

UniProtKB/Swiss-Prot:

TM236_HUMAN :
  • Belongs to the TMEM236 family.
Family:
  • Belongs to the TMEM236 family.
genes like me logo Genes that share domains with TMEM236: view

No data available for Gene Families for TMEM236 Gene

Function for TMEM236 Gene

genes like me logo Genes that share phenotypes with TMEM236: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM236 Gene

Localization for TMEM236 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM236 Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TMEM236 Gene

Pathways & Interactions for TMEM236 Gene

SuperPathways for TMEM236 Gene

No Data Available

Interacting Proteins for TMEM236 Gene

Gene Ontology (GO) - Biological Process for TMEM236 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM236 Gene

Drugs & Compounds for TMEM236 Gene

No Compound Related Data Available

Transcripts for TMEM236 Gene

mRNA/cDNA for TMEM236 Gene

(9) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM236 Gene

Transmembrane protein 236:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM236 Gene

No ASD Table

Relevant External Links for TMEM236 Gene

GeneLoc Exon Structure for
TMEM236
ECgene alternative splicing isoforms for
TMEM236

Expression for TMEM236 Gene

mRNA expression in normal human tissues for TMEM236 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM236 Gene

This gene is overexpressed in Colon - Transverse (x19.1) and Small Intestine - Terminal Ileum (x13.3).

Protein differential expression in normal tissues from HIPED for TMEM236 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM236 Gene



SOURCE GeneReport for Unigene cluster for TMEM236 Gene Hs.564139

genes like me logo Genes that share expression patterns with TMEM236: view

Protein tissue co-expression partners for TMEM236 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM236 Gene

Orthologs for TMEM236 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM236 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM236 35
  • 78.13 (n)
  • 70.77 (a)
-- 36
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM236 35
  • 78.57 (n)
  • 71.43 (a)
-- 36
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem236 35
  • 77.52 (n)
  • 75.87 (a)
Tmem236 16
Tmem236 36
  • 76 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM236 35
  • 99.43 (n)
  • 98.86 (a)
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem236 35
  • 78.32 (n)
  • 76.01 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-32m20.1 35
  • 49.95 (n)
  • 41.3 (a)
CR376779.2 36
  • 40 (a)
ManyToMany
si:dkey-32m20.1 36
  • 37 (a)
ManyToMany
Species with no ortholog for TMEM236:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM236 Gene

ENSEMBL:
Gene Tree for TMEM236 (if available)
TreeFam:
Gene Tree for TMEM236 (if available)

Paralogs for TMEM236 Gene

No data available for Paralogs for TMEM236 Gene

Variants for TMEM236 Gene

Sequence variations from dbSNP and Humsavar for TMEM236 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1925555 -- 17,762,816(+) CACCT(A/G)ACTAA intron-variant
rs1970922 -- 17,799,164(+) ATTCA(C/T)ACTTA intron-variant, utr-variant-3-prime
rs1984420 -- 17,781,576(+) CCCCG(A/T)TTCTA intron-variant
rs1998751 -- 17,751,757(+) TTAGA(A/G)AGTTG upstream-variant-2KB
rs1998752 -- 17,751,774(+) TGAAT(A/T)CAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM236 Gene

Variant ID Type Subtype PubMed ID
esv2674193 CNV Deletion 23128226
esv21990 CNV Loss 19812545
nsv508572 CNV Loss 20534489
esv23919 CNV Loss 19812545

Variation tolerance for TMEM236 Gene

Gene Damage Index Score: 5.39; 71.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM236 Gene

Disorders for TMEM236 Gene

Relevant External Links for TMEM236

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM236

No disorders were found for TMEM236 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM236 Gene

Publications for TMEM236 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 67
  2. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for TMEM236 Gene

Sources for TMEM236 Gene

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