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Aliases for TMEM235 Gene

Aliases for TMEM235 Gene

  • Transmembrane Protein 235 2 3 5
  • Transmembrane Protein ENSP00000364084 3
  • ARGM1 3

External Ids for TMEM235 Gene

Previous GeneCards Identifiers for TMEM235 Gene

  • GC17P076228

Summaries for TMEM235 Gene

GeneCards Summary for TMEM235 Gene

TMEM235 (Transmembrane Protein 235) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is TMEM114.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM235 Gene

Genomics for TMEM235 Gene

Regulatory Elements for TMEM235 Gene

Enhancers for TMEM235 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F078115 1 FANTOM5 23 -116.0 -115989 0.5 HIC1 ZNF274 POLR2A GLIS1 ZIC2 SUPT5H ZNF7 TMEM235 TNRC6C TNRC6C-AS1 TMC8
GH17F078236 1.1 FANTOM5 Ensembl ENCODE 19.9 +6.1 6077 1.4 ELF3 HDAC1 PKNOX1 ARID4B THRB ZNF121 ZBTB11 HDAC8 CREB3 POLR2H TMEM235 BIRC5 THA1P TNRC6C LOC105371910
GH17F078197 1.6 FANTOM5 Ensembl ENCODE 12 -32.5 -32458 3.4 PKNOX1 ARNT FEZF1 YY1 ZNF548 PAF1 ZHX2 NCOA1 JUNB REST PGS1 TMEM235 SYNGR2 C17orf99 TNRC6C-AS1 ENSG00000200063 RNU6-625P SOCS3 TMC6 TMC8
GH17F078265 1.2 FANTOM5 Ensembl ENCODE 11.7 +38.4 38443 9.3 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 PGS1 TMEM235 ENSG00000200063 TMC8 TMC6 SOCS3 TNRC6C LINC01993 THA1P
GH17F078260 0.2 ENCODE 11.7 +29.2 29225 0.2 BCOR PKNOX1 TAL1 ZBTB40 FOSL1 POLR2A NCOR1 ADNP TRIM24 SMARCE1 TMEM235 SOCS3 PGS1 TK1 AFMID ENSG00000200063 THA1P LINC01993
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM235 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM235 Gene

Chromosome:
17
Start:
78,231,310 bp from pter
End:
78,240,987 bp from pter
Size:
9,678 bases
Orientation:
Plus strand

Genomic View for TMEM235 Gene

Genes around TMEM235 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM235 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM235 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM235 Gene

Proteins for TMEM235 Gene

  • Protein details for TMEM235 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFC5-TM235_HUMAN
    Recommended name:
    Transmembrane protein 235
    Protein Accession:
    A6NFC5
    Secondary Accessions:
    • C9JRE6

    Protein attributes for TMEM235 Gene

    Size:
    223 amino acids
    Molecular mass:
    23360 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW89517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM235 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM235 Gene

Post-translational modifications for TMEM235 Gene

No data available for DME Specific Peptides for TMEM235 Gene

Domains & Families for TMEM235 Gene

Protein Domains for TMEM235 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM235 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFC5

UniProtKB/Swiss-Prot:

TM235_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with TMEM235: view

No data available for Gene Families for TMEM235 Gene

Function for TMEM235 Gene

Phenotypes for TMEM235 Gene

GenomeRNAi human phenotypes for TMEM235:
genes like me logo Genes that share phenotypes with TMEM235: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM235 Gene

Localization for TMEM235 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM235 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM235 Gene COMPARTMENTS Subcellular localization image for TMEM235 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with TMEM235: view

Pathways & Interactions for TMEM235 Gene

SuperPathways for TMEM235 Gene

No Data Available

Interacting Proteins for TMEM235 Gene

Gene Ontology (GO) - Biological Process for TMEM235 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM235 Gene

Transcripts for TMEM235 Gene

mRNA/cDNA for TMEM235 Gene

(9) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM235 Gene

Transmembrane protein 235:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM235 Gene

No ASD Table

Relevant External Links for TMEM235 Gene

GeneLoc Exon Structure for
TMEM235
ECgene alternative splicing isoforms for
TMEM235

Expression for TMEM235 Gene

mRNA expression in normal human tissues for TMEM235 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM235 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.8), Brain - Hippocampus (x6.4), Brain - Putamen (basal ganglia) (x6.0), Brain - Amygdala (x4.9), Brain - Caudate (basal ganglia) (x4.7), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM235 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM235 Gene



Protein tissue co-expression partners for TMEM235 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM235 Gene:

TMEM235

SOURCE GeneReport for Unigene cluster for TMEM235 Gene:

Hs.632228
genes like me logo Genes that share expression patterns with TMEM235: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM235 Gene

Orthologs for TMEM235 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM235 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM235 34
  • 98.64 (n)
cow
(Bos Taurus)
Mammalia TMEM235 34 35
  • 86.42 (n)
dog
(Canis familiaris)
Mammalia TMEM235 34 35
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Tmem235 34 16 35
  • 80.15 (n)
rat
(Rattus norvegicus)
Mammalia Tmem235 34
  • 78.81 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM235 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-369d14.2 34
  • 55.42 (n)
CABZ01013481.2 35
  • 46 (a)
OneToMany
TMEM235 (1 of 2) 35
  • 41 (a)
OneToMany
Species where no ortholog for TMEM235 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM235 Gene

ENSEMBL:
Gene Tree for TMEM235 (if available)
TreeFam:
Gene Tree for TMEM235 (if available)

Paralogs for TMEM235 Gene

Paralogs for TMEM235 Gene

(1) SIMAP similar genes for TMEM235 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM235: view

Variants for TMEM235 Gene

Sequence variations from dbSNP and Humsavar for TMEM235 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10775357 -- 78,242,442(+) CTCAC(C/G)CCTCT utr-variant-3-prime
rs10852708 -- 78,242,366(+) CCCTA(G/T)GCCCA utr-variant-3-prime
rs11077350 -- 78,234,648(+) GTGTG(C/T)GGCTG intron-variant, nc-transcript-variant, reference, synonymous-codon
rs11077351 -- 78,237,607(+) AGGAA(G/T)TGGGG intron-variant
rs1109627 -- 78,237,825(+) GTCCT(C/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM235 Gene

Variant ID Type Subtype PubMed ID
nsv1066985 CNV gain 25217958
nsv470608 CNV loss 18288195
nsv524306 CNV gain 19592680
nsv952373 CNV deletion 24416366

Variation tolerance for TMEM235 Gene

Gene Damage Index Score: 6.46; 77.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM235 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM235

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM235 Gene

Disorders for TMEM235 Gene

Relevant External Links for TMEM235

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM235

No disorders were found for TMEM235 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM235 Gene

Publications for TMEM235 Gene

  1. The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PMID: 21689651) Maher G.J. … Manson F.D. (FEBS Lett. 2011) 2 3 4 64
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM235 Gene

Sources for TMEM235 Gene

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