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Aliases for TMEM235 Gene

Aliases for TMEM235 Gene

  • Transmembrane Protein 235 2 3
  • Transmembrane Protein ENSP00000364084 3
  • ARGM1 3

External Ids for TMEM235 Gene

Summaries for TMEM235 Gene

GeneCards Summary for TMEM235 Gene

TMEM235 (Transmembrane Protein 235) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is TMEM114.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM235 Gene

Genomics for TMEM235 Gene

Genomic Location for TMEM235 Gene

Start:
78,231,310 bp from pter
End:
78,240,987 bp from pter
Size:
9,678 bases
Orientation:
Plus strand

Genomic View for TMEM235 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM235 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM235 Gene

No data available for Regulatory Elements for TMEM235 Gene

Proteins for TMEM235 Gene

  • Protein details for TMEM235 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFC5-TM235_HUMAN
    Recommended name:
    Transmembrane protein 235
    Protein Accession:
    A6NFC5
    Secondary Accessions:
    • C9JRE6

    Protein attributes for TMEM235 Gene

    Size:
    223 amino acids
    Molecular mass:
    23360 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW89517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM235 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM235 Gene

Proteomics data for TMEM235 Gene at MOPED

Post-translational modifications for TMEM235 Gene

No data available for DME Specific Peptides for TMEM235 Gene

Domains for TMEM235 Gene

Protein Domains for TMEM235 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM235 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFC5

UniProtKB/Swiss-Prot:

TM235_HUMAN
Family:
  • Belongs to the PMP-22/EMP/MP20 family.:
    • A6NFC5
genes like me logo Genes that share domains with TMEM235: view

No data available for Gene Families for TMEM235 Gene

Function for TMEM235 Gene

Gene Ontology (GO) - Molecular Function for TMEM235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with TMEM235: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM235 Gene

Localization for TMEM235 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM235 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for TMEM235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with TMEM235: view

No data available for Subcellular locations from COMPARTMENTS for TMEM235 Gene

Pathways for TMEM235 Gene

SuperPathways for TMEM235 Gene

No Data Available

Interacting Proteins for TMEM235 Gene

Gene Ontology (GO) - Biological Process for TMEM235 Gene

None

No data available for Pathways by source for TMEM235 Gene

Transcripts for TMEM235 Gene

mRNA/cDNA for TMEM235 Gene

(12) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM235 Gene

Transmembrane protein 235:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM235 Gene

No ASD Table

Relevant External Links for TMEM235 Gene

GeneLoc Exon Structure for
TMEM235
ECgene alternative splicing isoforms for
TMEM235

Expression for TMEM235 Gene

mRNA expression in normal human tissues for TMEM235 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM235 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.1), Brain - Substantia nigra (6.8), Brain - Hippocampus (6.4), Brain - Putamen (basal ganglia) (6.0), Brain - Amygdala (4.9), Brain - Caudate (basal ganglia) (4.7), and Brain - Hypothalamus (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM235 Gene

SOURCE GeneReport for Unigene cluster for TMEM235 Gene Hs.632228

genes like me logo Genes that share expressions with TMEM235: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM235 Gene

Orthologs for TMEM235 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM235 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM235 35
  • 98.64 (n)
  • 97.45 (a)
cow
(Bos Taurus)
Mammalia TMEM235 35
  • 86.42 (n)
  • 81.48 (a)
TMEM235 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM235 35
  • 83.52 (n)
  • 78.41 (a)
TMEM235 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem235 35
  • 80.15 (n)
  • 73.41 (a)
Tmem235 16
Tmem235 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem235 35
  • 78.81 (n)
  • 71.68 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM235 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01013481.2 36
  • 46 (a)
OneToMany
si:ch73-369d14.2 35
  • 55.42 (n)
  • 47.24 (a)
TMEM235 (1 of 2) 36
  • 41 (a)
OneToMany
Species with no ortholog for TMEM235:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM235 Gene

ENSEMBL:
Gene Tree for TMEM235 (if available)
TreeFam:
Gene Tree for TMEM235 (if available)

Paralogs for TMEM235 Gene

Paralogs for TMEM235 Gene

Selected SIMAP similar genes for TMEM235 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM235: view

Variants for TMEM235 Gene

Sequence variations from dbSNP and Humsavar for TMEM235 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs880190 -- 78,238,934(-) ATCCC(C/T)GGCCC intron-variant
rs1109627 -- 78,237,825(+) GTCCT(C/T)CCTCC intron-variant
rs1109628 -- 78,238,094(+) CAGTC(A/G)GCGCC intron-variant
rs4789022 -- 78,238,261(+) TGCCC(A/G)CCACC intron-variant
rs7211218 -- 78,240,873(+) CCTTA(A/C)GTAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM235 Gene

Variant ID Type Subtype PubMed ID
dgv3278n71 CNV Loss 21882294
nsv524306 CNV Gain 19592680
nsv908876 CNV Gain 21882294
nsv908877 CNV Loss 21882294
nsv470608 CNV Loss 18288195

Relevant External Links for TMEM235 Gene

HapMap Linkage Disequilibrium report
TMEM235

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM235 Gene

Disorders for TMEM235 Gene

No disorders were found for TMEM235 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM235 Gene

Publications for TMEM235 Gene

  1. The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PMID: 21689651) Maher G.J. … Manson F.D. (FEBS Lett. 2011) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM235 Gene

Sources for TMEM235 Gene

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