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Aliases for TMEM235 Gene

Aliases for TMEM235 Gene

  • Transmembrane Protein 235 2 3 5
  • Transmembrane Protein ENSP00000364084 3
  • ARGM1 3

External Ids for TMEM235 Gene

Previous GeneCards Identifiers for TMEM235 Gene

  • GC17P076228

Summaries for TMEM235 Gene

GeneCards Summary for TMEM235 Gene

TMEM235 (Transmembrane Protein 235) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is TMEM114.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM235 Gene

Genomics for TMEM235 Gene

Regulatory Elements for TMEM235 Gene

Enhancers for TMEM235 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM235 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM235 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM235 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM235 Gene

Chromosome:
17
Start:
78,231,310 bp from pter
End:
78,240,987 bp from pter
Size:
9,678 bases
Orientation:
Plus strand

Genomic View for TMEM235 Gene

Genes around TMEM235 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM235 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM235 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM235 Gene

Proteins for TMEM235 Gene

  • Protein details for TMEM235 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFC5-TM235_HUMAN
    Recommended name:
    Transmembrane protein 235
    Protein Accession:
    A6NFC5
    Secondary Accessions:
    • C9JRE6

    Protein attributes for TMEM235 Gene

    Size:
    223 amino acids
    Molecular mass:
    23360 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW89517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM235 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM235 Gene

Proteomics data for TMEM235 Gene at MOPED

Post-translational modifications for TMEM235 Gene

No data available for DME Specific Peptides for TMEM235 Gene

Domains & Families for TMEM235 Gene

Protein Domains for TMEM235 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM235 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFC5

UniProtKB/Swiss-Prot:

TM235_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with TMEM235: view

No data available for Gene Families for TMEM235 Gene

Function for TMEM235 Gene

Phenotypes for TMEM235 Gene

GenomeRNAi human phenotypes for TMEM235:
genes like me logo Genes that share phenotypes with TMEM235: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM235 Gene

Localization for TMEM235 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM235 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM235 Gene COMPARTMENTS Subcellular localization image for TMEM235 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with TMEM235: view

Pathways & Interactions for TMEM235 Gene

SuperPathways for TMEM235 Gene

No Data Available

Interacting Proteins for TMEM235 Gene

Gene Ontology (GO) - Biological Process for TMEM235 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM235 Gene

Drugs & Compounds for TMEM235 Gene

No Compound Related Data Available

Transcripts for TMEM235 Gene

mRNA/cDNA for TMEM235 Gene

(12) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM235 Gene

Transmembrane protein 235:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM235 Gene

No ASD Table

Relevant External Links for TMEM235 Gene

GeneLoc Exon Structure for
TMEM235
ECgene alternative splicing isoforms for
TMEM235

Expression for TMEM235 Gene

mRNA expression in normal human tissues for TMEM235 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM235 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.8), Brain - Hippocampus (x6.4), Brain - Putamen (basal ganglia) (x6.0), Brain - Amygdala (x4.9), Brain - Caudate (basal ganglia) (x4.7), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM235 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM235 Gene



SOURCE GeneReport for Unigene cluster for TMEM235 Gene Hs.632228

genes like me logo Genes that share expression patterns with TMEM235: view

Protein tissue co-expression partners for TMEM235 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM235 Gene

Orthologs for TMEM235 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM235 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM235 35
  • 86.42 (n)
  • 81.48 (a)
TMEM235 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM235 35
  • 83.52 (n)
  • 78.41 (a)
TMEM235 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem235 35
  • 80.15 (n)
  • 73.41 (a)
Tmem235 16
Tmem235 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM235 35
  • 98.64 (n)
  • 97.45 (a)
rat
(Rattus norvegicus)
Mammalia Tmem235 35
  • 78.81 (n)
  • 71.68 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM235 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-369d14.2 35
  • 55.42 (n)
  • 47.24 (a)
CABZ01013481.2 36
  • 46 (a)
OneToMany
TMEM235 (1 of 2) 36
  • 41 (a)
OneToMany
Species with no ortholog for TMEM235:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM235 Gene

ENSEMBL:
Gene Tree for TMEM235 (if available)
TreeFam:
Gene Tree for TMEM235 (if available)

Paralogs for TMEM235 Gene

Paralogs for TMEM235 Gene

(1) SIMAP similar genes for TMEM235 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM235: view

Variants for TMEM235 Gene

Sequence variations from dbSNP and Humsavar for TMEM235 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1109627 -- 78,237,825(+) GTCCT(C/T)CCTCC intron-variant
rs1109628 -- 78,238,094(+) CAGTC(A/G)GCGCC intron-variant
rs880190 -- 78,238,934(-) ATCCC(C/T)GGCCC intron-variant
rs4789022 -- 78,238,261(+) TGCCC(A/G)CCACC intron-variant
rs7211218 -- 78,240,873(+) CCTTA(A/C)GTAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM235 Gene

Variant ID Type Subtype PubMed ID
dgv3278n71 CNV Loss 21882294
nsv524306 CNV Gain 19592680
nsv908876 CNV Gain 21882294
nsv908877 CNV Loss 21882294
nsv470608 CNV Loss 18288195

Variation tolerance for TMEM235 Gene

Gene Damage Index Score: 6.46; 77.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM235 Gene

Disorders for TMEM235 Gene

Relevant External Links for TMEM235

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM235

No disorders were found for TMEM235 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM235 Gene

Publications for TMEM235 Gene

  1. The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PMID: 21689651) Maher G.J. … Manson F.D. (FEBS Lett. 2011) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM235 Gene

Sources for TMEM235 Gene

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