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Aliases for TMEM234 Gene

Aliases for TMEM234 Gene

  • Transmembrane Protein 234 2 3 5
  • C1orf91 3 4
  • Chromosome 1 Open Reading Frame 91 2
  • RP4-622L5 3
  • DJ622L5.7 3
  • AASL548 3
  • PRO1105 3

External Ids for TMEM234 Gene

Previous HGNC Symbols for TMEM234 Gene

  • C1orf91

Previous GeneCards Identifiers for TMEM234 Gene

  • GC01M032681

Summaries for TMEM234 Gene

GeneCards Summary for TMEM234 Gene

TMEM234 (Transmembrane Protein 234) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM234 Gene

Genomics for TMEM234 Gene

Regulatory Elements for TMEM234 Gene

Promoters for TMEM234 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM234 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM234 Gene

Chromosome:
1
Start:
32,204,806 bp from pter
End:
32,222,359 bp from pter
Size:
17,554 bases
Orientation:
Minus strand

Genomic View for TMEM234 Gene

Genes around TMEM234 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM234 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM234 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM234 Gene

Proteins for TMEM234 Gene

  • Protein details for TMEM234 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY98-TM234_HUMAN
    Recommended name:
    Transmembrane protein 234
    Protein Accession:
    Q8WY98
    Secondary Accessions:
    • B2R535
    • D3DPP7
    • Q6UWY9
    • Q8N2H6
    • Q9BSR2
    • Q9NU76

    Protein attributes for TMEM234 Gene

    Size:
    164 amino acids
    Molecular mass:
    17601 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM234 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM234 Gene

Proteomics data for TMEM234 Gene at MOPED

Post-translational modifications for TMEM234 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM234 Gene

Domains & Families for TMEM234 Gene

Protein Domains for TMEM234 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM234 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY98

UniProtKB/Swiss-Prot:

TM234_HUMAN :
  • Belongs to the TMEM234 family.
Family:
  • Belongs to the TMEM234 family.
genes like me logo Genes that share domains with TMEM234: view

No data available for Gene Families for TMEM234 Gene

Function for TMEM234 Gene

genes like me logo Genes that share phenotypes with TMEM234: view

Animal Model Products

CRISPR Products

miRNA for TMEM234 Gene

miRTarBase miRNAs that target TMEM234

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM234 Gene

Localization for TMEM234 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM234 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM234 Gene COMPARTMENTS Subcellular localization image for TMEM234 gene
Compartment Confidence
extracellular 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM234 Gene

Pathways & Interactions for TMEM234 Gene

SuperPathways for TMEM234 Gene

No Data Available

Interacting Proteins for TMEM234 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309792%0d%0a9606.ENSP00000434939%0d%0a
Selected Interacting proteins: Q8WY98-TM234_HUMAN ENSP00000309792 for TMEM234 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for TMEM234 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM234 Gene

Drugs & Compounds for TMEM234 Gene

No Compound Related Data Available

Transcripts for TMEM234 Gene

Unigene Clusters for TMEM234 Gene

Transmembrane protein 234:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM234 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12: - - - - - - - -

Relevant External Links for TMEM234 Gene

GeneLoc Exon Structure for
TMEM234
ECgene alternative splicing isoforms for
TMEM234

Expression for TMEM234 Gene

mRNA expression in normal human tissues for TMEM234 Gene

Protein differential expression in normal tissues from HIPED for TMEM234 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM234 Gene



SOURCE GeneReport for Unigene cluster for TMEM234 Gene Hs.272299

genes like me logo Genes that share expression patterns with TMEM234: view

Protein tissue co-expression partners for TMEM234 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM234 Gene

Orthologs for TMEM234 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM234 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM234 35
  • 91.19 (n)
  • 88.57 (a)
TMEM234 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM234 35
  • 90.95 (n)
  • 87.86 (a)
TMEM234 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem234 35
  • 85.99 (n)
  • 86.23 (a)
Tmem234 16
Tmem234 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM234 35
  • 99.44 (n)
  • 100 (a)
TMEM234 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM234 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM234 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM234 35
  • 65.35 (n)
  • 60.63 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM234 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem234 35
  • 59.71 (n)
  • 55.65 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem234 35
  • 59.32 (n)
  • 55.93 (a)
tmem234 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta U546_ANOGA 35
  • 43.83 (n)
  • 39.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12929 35
  • 46.5 (n)
  • 39.5 (a)
CG12929 36
  • 35 (a)
OneToOne
Species with no ortholog for TMEM234:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM234 Gene

ENSEMBL:
Gene Tree for TMEM234 (if available)
TreeFam:
Gene Tree for TMEM234 (if available)

Paralogs for TMEM234 Gene

No data available for Paralogs for TMEM234 Gene

Variants for TMEM234 Gene

Sequence variations from dbSNP and Humsavar for TMEM234 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs479014 -- 32,216,783(-) GTGAG(C/T)GGATG intron-variant, utr-variant-3-prime
rs12129323 -- 32,216,957(+) GATAA(C/T)AGGCA intron-variant, utr-variant-3-prime
rs11584993 -- 32,218,163(+) ctcac(A/G)cctgt intron-variant
rs34803305 -- 32,218,859(+) TTGAA(-/A)CCTGG intron-variant
rs34386790 -- 32,217,858(+) TTAAA(-/A)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM234 Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV Insertion 18451855

Variation tolerance for TMEM234 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM234 Gene

HapMap Linkage Disequilibrium report
TMEM234

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM234 Gene

Disorders for TMEM234 Gene

Relevant External Links for TMEM234

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM234

No disorders were found for TMEM234 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM234 Gene

Publications for TMEM234 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM234 Gene

Sources for TMEM234 Gene

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