Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM234 Gene

Aliases for TMEM234 Gene

  • Transmembrane Protein 234 2 3 5
  • C1orf91 3 4
  • Chromosome 1 Open Reading Frame 91 2
  • RP4-622L5 3
  • DJ622L5.7 3
  • AASL548 3
  • PRO1105 3

External Ids for TMEM234 Gene

Previous HGNC Symbols for TMEM234 Gene

  • C1orf91

Previous GeneCards Identifiers for TMEM234 Gene

  • GC01M032681

Summaries for TMEM234 Gene

GeneCards Summary for TMEM234 Gene

TMEM234 (Transmembrane Protein 234) is a Protein Coding gene.

Additional gene information for TMEM234 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM234 Gene

Genomics for TMEM234 Gene

Regulatory Elements for TMEM234 Gene

Enhancers for TMEM234 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H031924 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.6 +286.5 286527 22 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B PUM1 EIF3I
GH01H032262 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -43.0 -43029 4 ZNF493 ZFP64 RARA SCRT2 ZNF654 ZNF680 ZC3H11A CEBPB OVOL3 REST TXLNA RBBP4 KHDRBS1 SNRNP40 TMEM39B ZBTB8A ZNF362 DCDC2B TSSK3 S100PBP
GH01H031787 1.7 FANTOM5 ENCODE dbSUPER 10.1 +433.4 433414 2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 DEK SP3 COL16A1 FAM229A ADGRB2 TSSK3 ENSG00000235790 SNRNP40 RBBP4 TMEM39B PEF1 DCDC2B
GH01H032813 1.7 FANTOM5 ENCODE dbSUPER 10.1 -594.9 -594883 7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A RBBP4 KHDRBS1 ZBTB8A TXLNA TMEM39B S100PBP KPNA6 ZSCAN20 TSSK3 FAM229A
GH01H032319 1.5 Ensembl ENCODE dbSUPER 11.2 -99.2 -99243 4 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF121 ZNF143 ATF7 LOC105378629 HDAC1 ENSG00000252450 TMEM234 EIF3I DCDC2B ENSG00000224066 IQCC CCDC28B MTMR9LP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM234 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM234 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004333 -41 1601 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 ETS1 GLIS2 ELK1

Genomic Location for TMEM234 Gene

Chromosome:
1
Start:
32,204,806 bp from pter
End:
32,222,359 bp from pter
Size:
17,554 bases
Orientation:
Minus strand

Genomic View for TMEM234 Gene

Genes around TMEM234 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM234 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM234 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM234 Gene

Proteins for TMEM234 Gene

  • Protein details for TMEM234 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY98-TM234_HUMAN
    Recommended name:
    Transmembrane protein 234
    Protein Accession:
    Q8WY98
    Secondary Accessions:
    • B2R535
    • D3DPP7
    • Q6UWY9
    • Q8N2H6
    • Q9BSR2
    • Q9NU76

    Protein attributes for TMEM234 Gene

    Size:
    164 amino acids
    Molecular mass:
    17601 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM234 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM234 Gene

Post-translational modifications for TMEM234 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM234 Gene

Domains & Families for TMEM234 Gene

Gene Families for TMEM234 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM234 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM234 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY98

UniProtKB/Swiss-Prot:

TM234_HUMAN :
  • Belongs to the TMEM234 family.
Family:
  • Belongs to the TMEM234 family.
genes like me logo Genes that share domains with TMEM234: view

Function for TMEM234 Gene

Gene Ontology (GO) - Molecular Function for TMEM234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM234: view
genes like me logo Genes that share phenotypes with TMEM234: view

Animal Models for TMEM234 Gene

MGI Knock Outs for TMEM234:

Animal Model Products

CRISPR Products

miRNA for TMEM234 Gene

miRTarBase miRNAs that target TMEM234

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM234
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM234 Gene

Localization for TMEM234 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM234 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM234 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM234: view

Pathways & Interactions for TMEM234 Gene

SuperPathways for TMEM234 Gene

No Data Available

Interacting Proteins for TMEM234 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309792%0d%0a9606.ENSP00000434939%0d%0a
Selected Interacting proteins: Q8WY98-TM234_HUMAN ENSP00000309792 for TMEM234 Gene via MINT STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for TMEM234 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM234 Gene

Drugs & Compounds for TMEM234 Gene

No Compound Related Data Available

Transcripts for TMEM234 Gene

Unigene Clusters for TMEM234 Gene

Transmembrane protein 234:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM234
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM234 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12: - - - - - - - -

Relevant External Links for TMEM234 Gene

GeneLoc Exon Structure for
TMEM234
ECgene alternative splicing isoforms for
TMEM234

Expression for TMEM234 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM234 Gene

Protein differential expression in normal tissues from HIPED for TMEM234 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM234 Gene



Protein tissue co-expression partners for TMEM234 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM234 Gene:

TMEM234

SOURCE GeneReport for Unigene cluster for TMEM234 Gene:

Hs.272299

Evidence on tissue expression from TISSUES for TMEM234 Gene

  • Thyroid gland(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM234: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM234 Gene

Orthologs for TMEM234 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM234 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM234 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia TMEM234 33 34
  • 91.19 (n)
dog
(Canis familiaris)
Mammalia TMEM234 33 34
  • 90.95 (n)
mouse
(Mus musculus)
Mammalia Tmem234 33 16 34
  • 85.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM234 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM234 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM234 33
  • 65.35 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM234 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem234 33
  • 59.71 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem234 33 34
  • 59.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12929 33 34
  • 46.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta U546_ANOGA 33
  • 43.83 (n)
Species where no ortholog for TMEM234 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM234 Gene

ENSEMBL:
Gene Tree for TMEM234 (if available)
TreeFam:
Gene Tree for TMEM234 (if available)

Paralogs for TMEM234 Gene

No data available for Paralogs for TMEM234 Gene

Variants for TMEM234 Gene

Sequence variations from dbSNP and Humsavar for TMEM234 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs140234450 Benign 32,204,317(+) CTGAG(A/G)GGCTG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs1000142594 -- 32,210,524(+) AAAAG(-/A)AAAAA intron-variant, upstream-variant-2KB
rs1000174145 -- 32,210,326(+) CATCT(-/AAAAAAAAAAAA)AAAAA intron-variant, upstream-variant-2KB
rs1000383939 -- 32,204,373(+) CTGCT(A/T)AGCAA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon
rs1000506821 -- 32,208,946(+) GGGAT(A/G)AAACC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM234 Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for TMEM234 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM234 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM234

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM234 Gene

Disorders for TMEM234 Gene

Relevant External Links for TMEM234

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM234

No disorders were found for TMEM234 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM234 Gene

Publications for TMEM234 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 60
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60

Products for TMEM234 Gene

Sources for TMEM234 Gene

Content
Loading form....