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Aliases for TMEM233 Gene

Aliases for TMEM233 Gene

  • Transmembrane Protein 233 2 3 5
  • Interferon-Induced Transmembrane Domain-Containing Protein D2 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 2 2 3
  • Dispanin Subfamily B Member 2 3 4
  • IFITMD2 3 4
  • DSPB2 3 4

External Ids for TMEM233 Gene

Previous GeneCards Identifiers for TMEM233 Gene

  • GC12P118516
  • GC12P120031
  • GC12P117039

Summaries for TMEM233 Gene

GeneCards Summary for TMEM233 Gene

TMEM233 (Transmembrane Protein 233) is a Protein Coding gene. An important paralog of this gene is TUSC5.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM233 Gene

Genomics for TMEM233 Gene

Regulatory Elements for TMEM233 Gene

Enhancers for TMEM233 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G119715 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.8 +123.8 123799 2.0 FOXA2 MLX ARID4B SIN3A YY1 FOS PPARG KAT8 ZNF579 RCOR2 CIT TMEM233 PRKAB1 MIR1178 GC12P119728
GH12G119642 0.4 FANTOM5 28.4 +50.0 49954 0.1 RNF2 TMEM233 RN7SKP197 PRKAB1
GH12G119666 1.4 ENCODE dbSUPER 6.8 +78.5 78517 8.4 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PRKAB1 TMEM233 LOC105370027 ENSG00000255692
GH12G119678 1.6 Ensembl ENCODE dbSUPER 5.5 +90.8 90795 9.7 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 PRKAB1 MIR1178 CIT LOC105370027 TMEM233 ENSG00000255692
GH12G119593 1 Ensembl ENCODE 8.7 +2.6 2610 3.5 TFAP4 RNF2 SUZ12 CBX2 REST RBBP5 ZNF398 NR2F2 ZNF121 SCRT2 LOC105370027 TMEM233 PRKAB1 RN7SKP197
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM233 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM233 Gene

Chromosome:
12
Start:
119,592,636 bp from pter
End:
119,654,442 bp from pter
Size:
61,807 bases
Orientation:
Plus strand

Genomic View for TMEM233 Gene

Genes around TMEM233 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM233 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM233 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM233 Gene

Proteins for TMEM233 Gene

  • Protein details for TMEM233 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DJY2-TM233_HUMAN
    Recommended name:
    Transmembrane protein 233
    Protein Accession:
    B4DJY2

    Protein attributes for TMEM233 Gene

    Size:
    109 amino acids
    Molecular mass:
    12074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM233 Gene

Post-translational modifications for TMEM233 Gene

  • Ubiquitination at posLast=1111
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM233 Gene

No data available for DME Specific Peptides for TMEM233 Gene

Domains & Families for TMEM233 Gene

Protein Domains for TMEM233 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM233 Gene

Graphical View of Domain Structure for InterPro Entry

B4DJY2

UniProtKB/Swiss-Prot:

TM233_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TMEM233: view

No data available for Gene Families for TMEM233 Gene

Function for TMEM233 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM233 Gene

Localization for TMEM233 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM233 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM233 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM233: view

Pathways & Interactions for TMEM233 Gene

SuperPathways for TMEM233 Gene

No Data Available

Interacting Proteins for TMEM233 Gene

Gene Ontology (GO) - Biological Process for TMEM233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with TMEM233: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM233 Gene

Drugs & Compounds for TMEM233 Gene

No Compound Related Data Available

Transcripts for TMEM233 Gene

mRNA/cDNA for TMEM233 Gene

Unigene Clusters for TMEM233 Gene

Transmembrane protein 233:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM233 Gene

No ASD Table

Relevant External Links for TMEM233 Gene

GeneLoc Exon Structure for
TMEM233
ECgene alternative splicing isoforms for
TMEM233

Expression for TMEM233 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM233 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM233 Gene

This gene is overexpressed in Muscle - Skeletal (x37.6).

NURSA nuclear receptor signaling pathways regulating expression of TMEM233 Gene:

TMEM233

SOURCE GeneReport for Unigene cluster for TMEM233 Gene:

Hs.530965

Evidence on tissue expression from TISSUES for TMEM233 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM233: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM233 Gene

Orthologs for TMEM233 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM233 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM233 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia TMEM233 34 35
  • 92.05 (n)
cow
(Bos Taurus)
Mammalia TMEM233 34
  • 87.42 (n)
mouse
(Mus musculus)
Mammalia Tmem233 34 16 35
  • 83.64 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM233 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMEM233 34
  • 71.87 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM233 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem233 34
  • 66.98 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885033 34
  • 57.93 (n)
BX005328.1 35
  • 47 (a)
OneToOne
Species where no ortholog for TMEM233 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM233 Gene

ENSEMBL:
Gene Tree for TMEM233 (if available)
TreeFam:
Gene Tree for TMEM233 (if available)

Paralogs for TMEM233 Gene

Paralogs for TMEM233 Gene

(1) SIMAP similar genes for TMEM233 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM233: view

Variants for TMEM233 Gene

Sequence variations from dbSNP and Humsavar for TMEM233 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000174550 -- 119,610,595(+) TGATA(C/G)TGAGT intron-variant
rs1000178563 -- 119,636,904(+) CACAC(A/G)TGGTA intron-variant
rs1000180431 -- 119,610,257(+) TCCTA(C/T)TGTAT intron-variant
rs1000205886 -- 119,594,070(+) GAGGA(A/G)AGACC intron-variant
rs1000208897 -- 119,654,764(+) CTTTA(A/G)TTAGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM233 Gene

Variant ID Type Subtype PubMed ID
esv3630908 CNV gain 21293372
esv3630909 CNV gain 21293372
esv3630910 CNV loss 21293372
nsv832529 CNV loss 17160897

Variation tolerance for TMEM233 Gene

Gene Damage Index Score: 0.61; 13.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM233 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM233

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM233 Gene

Disorders for TMEM233 Gene

Relevant External Links for TMEM233

Genetic Association Database (GAD)
TMEM233
Human Genome Epidemiology (HuGE) Navigator
TMEM233
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM233

No disorders were found for TMEM233 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM233 Gene

Publications for TMEM233 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disease. (PMID: 20622878) Remmers E.F. … GA1l A. (Nat. Genet. 2010) 46 64
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for TMEM233 Gene

Sources for TMEM233 Gene

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