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Aliases for TMEM233 Gene

Aliases for TMEM233 Gene

  • Transmembrane Protein 233 2 3 5
  • Interferon-Induced Transmembrane Domain-Containing Protein D2 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 2 2 3
  • Dispanin Subfamily B Member 2 3 4
  • IFITMD2 3 4
  • DSPB2 3 4

External Ids for TMEM233 Gene

Previous GeneCards Identifiers for TMEM233 Gene

  • GC12P118516
  • GC12P120031
  • GC12P117039

Summaries for TMEM233 Gene

GeneCards Summary for TMEM233 Gene

TMEM233 (Transmembrane Protein 233) is a Protein Coding gene. An important paralog of this gene is PRRT2.

Additional gene information for TMEM233 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM233 Gene

Genomics for TMEM233 Gene

GeneHancer (GH) Regulatory Elements for TMEM233 Gene

Promoters and enhancers for TMEM233 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I119593 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 558.7 +2.6 2609 3.5 SUZ12 ZNF398 REST NR2F2 GABPA SCRT2 CTBP2 PRDM10 EZH2 TMEM233 LOC105370027 PRKAB1 RN7SKP197
GH12I119666 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.8 +78.5 78516 8.4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PRKAB1 RPLP0 TMEM233 LOC105370027 ENSG00000255692
GH12I119715 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.8 +123.8 123799 2 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A YY1 FOS RXRA REST CIT TMEM233 PRKAB1 MIR1178 GC12P119728
GH12I119642 Enhancer 0.3 FANTOM5 28.4 +50.0 49954 0.1 RNF2 TMEM233 RN7SKP197 LOC105370027 PRKAB1
GH12I119691 Enhancer 1.2 Ensembl ENCODE dbSUPER 6.2 +100.5 100530 4 CTCF KLF1 JUN MAX FEZF1 RAD21 RFX5 POLR2A SCRT2 SMC3 TMEM233 ENSG00000255692 LOC105370027 CIT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM233 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM233 Gene

Genomic Locations for TMEM233 Gene
chr12:119,592,636-119,654,442
(GRCh38/hg38)
Size:
61,807 bases
Orientation:
Plus strand
chr12:120,031,264-120,079,363
(GRCh37/hg19)

Genomic View for TMEM233 Gene

Genes around TMEM233 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM233 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM233 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM233 Gene

Proteins for TMEM233 Gene

  • Protein details for TMEM233 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DJY2-TM233_HUMAN
    Recommended name:
    Transmembrane protein 233
    Protein Accession:
    B4DJY2

    Protein attributes for TMEM233 Gene

    Size:
    109 amino acids
    Molecular mass:
    12074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM233 Gene

Post-translational modifications for TMEM233 Gene

Other Protein References for TMEM233 Gene

No data available for DME Specific Peptides for TMEM233 Gene

Domains & Families for TMEM233 Gene

Gene Families for TMEM233 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM233 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM233 Gene

Graphical View of Domain Structure for InterPro Entry

B4DJY2

UniProtKB/Swiss-Prot:

TM233_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TMEM233: view

Function for TMEM233 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM233 Gene

Localization for TMEM233 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM233 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM233 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM233: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM233 Gene

Pathways & Interactions for TMEM233 Gene

SuperPathways for TMEM233 Gene

No Data Available

Interacting Proteins for TMEM233 Gene

Gene Ontology (GO) - Biological Process for TMEM233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with TMEM233: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM233 Gene

Drugs & Compounds for TMEM233 Gene

No Compound Related Data Available

Transcripts for TMEM233 Gene

mRNA/cDNA for TMEM233 Gene

Unigene Clusters for TMEM233 Gene

Transmembrane protein 233:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM233 Gene

No ASD Table

Relevant External Links for TMEM233 Gene

GeneLoc Exon Structure for
TMEM233
ECgene alternative splicing isoforms for
TMEM233

Expression for TMEM233 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM233 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM233 Gene

This gene is overexpressed in Muscle - Skeletal (x37.6).

NURSA nuclear receptor signaling pathways regulating expression of TMEM233 Gene:

TMEM233

SOURCE GeneReport for Unigene cluster for TMEM233 Gene:

Hs.530965

Evidence on tissue expression from TISSUES for TMEM233 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM233: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM233 Gene

Orthologs for TMEM233 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM233 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM233 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia TMEM233 33 34
  • 92.05 (n)
cow
(Bos Taurus)
Mammalia TMEM233 33
  • 87.42 (n)
mouse
(Mus musculus)
Mammalia Tmem233 33 16 34
  • 83.64 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM233 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMEM233 33
  • 71.87 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM233 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem233 33
  • 66.98 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885033 33
  • 57.93 (n)
BX005328.1 34
  • 47 (a)
OneToOne
Species where no ortholog for TMEM233 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM233 Gene

ENSEMBL:
Gene Tree for TMEM233 (if available)
TreeFam:
Gene Tree for TMEM233 (if available)

Paralogs for TMEM233 Gene

Paralogs for TMEM233 Gene

(1) SIMAP similar genes for TMEM233 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM233: view

Variants for TMEM233 Gene

Sequence variations from dbSNP and Humsavar for TMEM233 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000174550 -- 119,610,595(+) G/C intron_variant
rs1000178563 -- 119,636,904(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000180431 -- 119,610,257(+) T/C intron_variant
rs1000205886 -- 119,594,070(+) G/A intron_variant
rs1000208897 -- 119,654,764(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM233 Gene

Variant ID Type Subtype PubMed ID
esv3630908 CNV gain 21293372
esv3630909 CNV gain 21293372
esv3630910 CNV loss 21293372
nsv832529 CNV loss 17160897

Variation tolerance for TMEM233 Gene

Gene Damage Index Score: 0.61; 13.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM233 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM233

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM233 Gene

Disorders for TMEM233 Gene

Additional Disease Information for TMEM233

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM233 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM233 Gene

Publications for TMEM233 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Benefits of random-priming: exhaustive survey of a cDNA library from lung tissue of a SARS patient. (PMID: 21328370) Wu H … Wang X (Journal of medical virology 2011) 3 58
  4. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. (PMID: 20622878) Remmers EF … Gül A (Nature genetics 2010) 44 58
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58

Products for TMEM233 Gene

Sources for TMEM233 Gene

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