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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM233 Gene

protein-coding   GIFtS: 37
GCID: GC12P120031

Transmembrane Protein 233

  Search for TMEM233
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2331 2
Interferon Induced Transmembrane Protein Domain Containing 21 2
Dispanin Subfamily B Member 22 3
Interferon-Induced Transmembrane Domain-Containing Protein D22 3
DSPB22 3
IFITMD22 3

External Ids:    HGNC: 372191   Entrez Gene: 3878902   Ensembl: ENSG000002249827   UniProtKB: B4DJY23   

Export aliases for TMEM233 gene to outside databases

Previous GC identifers: GC12P118516 GC12P117039


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM233 Gene: 
TMEM233 (transmembrane protein 233) is a protein-coding gene. An important paralog of this gene is PRRT2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM233
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM233

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM233


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.23

TMEM233 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM233 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120031:  view genomic region     (about GC identifiers)

Start:
120,031,264 bp from pter      End:
120,079,363 bp from pter
Size:
48,100 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM233_HUMAN, B4DJY2 (See protein sequence)
Recommended Name: Transmembrane protein 233  
Size: 109 amino acids; 12074 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for TMEM233: NX_B4DJY2

Explore proteomics data for TMEM233 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_B4DJY2

  • TMEM233 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM233 Protein Expression
    REFSEQ proteins: NP_001130006.1  
    ENSEMBL proteins: 
     ENSP00000403130  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM233 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007593 Interferon-induced_TM_protein

    Graphical View of Domain Structure for InterPro Entry B4DJY2

    ProtoNet protein and cluster: B4DJY2

    UniProtKB/Swiss-Prot: TM233_HUMAN, B4DJY2
    Similarity: Belongs to the CD225/Dispanin family


    TMEM233 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM233 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM233

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009607response to biotic stimulus IEA--

    TMEM233 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM233 (TM233)

    Search CenterWatch for drugs/clinical trials and news about TMEM233 / TM233

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM233 gene: 
    NM_001136534.1  

    Unigene Cluster for TMEM233:

    Transmembrane protein 233
    Hs.530965  [show with all ESTs]
    Unigene Representative Sequence: NM_001136534
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426426(uc010szd.1) ENST00000453450
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM233 (see all 17):
    hsa-miR-579 hsa-miR-4254 hsa-miR-765 hsa-miR-128 hsa-miR-342-3p hsa-miR-3649 hsa-miR-4324 hsa-miR-516b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM233
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM233
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM233
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM233 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM233 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM233
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM233

    Additional mRNA sequence: AK296289.1 

    2 DOTS entries:

    DT.75165787  DT.97778267 

    22 AceView cDNA sequences:

    BQ549328 BQ267401 CK825384 CA392015 AJ572396 BX092262 AA565851 BM888469 
    BQ774663 CA418054 CA425947 BQ581156 F30631 AA476740 F34570 AA476739 
    F33765 BF352646 BQ270196 CK825385 AV753294 CA392014 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM233 expression in normal human tissues (normalized intensities)      TMEM233 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACTTCCT
    TMEM233 Expression
    About this image


    TMEM233 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Human corneal endothelial cells
     
     Eye (Sensory Organs)
             Human corneal endothelial cells

    See TMEM233 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.530965
        SABiosciences Custom PCR Arrays for TMEM233
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM233
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM233
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM233

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM233 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2331 , 5 transmembrane protein 2331, 5 83.64(n)1
    87.04(a)1
      5 (56.10 cM)5
    5457981  NM_001101546.11  NP_001095016.11 
     1160387555 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2336
    transmembrane protein 233
    46(a)
    1 ↔ 1
    GL343338.1(256131-263812)
    zebrafish
    (Danio rerio)
    Actinopterygii BX005328.16
    Uncharacterized protein
    48(a)
    1 ↔ 1
    8(41616553-41625475)


    ENSEMBL Gene Tree for TMEM233 (if available)
    TreeFam Gene Tree for TMEM233 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM233 gene
    PRRT22  TUSC52  
    1 SIMAP similar gene for TMEM233 using alignment to 1 protein entry:     TM233_HUMAN:
    TUSC5

    TMEM233 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/948 SNPs in TMEM233 are shown (see all 948)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354177771,2
    C--120029267(+) ATCTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs710725371,2
    C--120029268(+) AAAAAA/-GTACA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1897615551,2
    --120029339(+) CTTGAC/TCAAAA 1 -- us2k10--------
    rs1509276711,2
    --120029353(+) GAAAAC/TCATTT 1 -- us2k10--------
    rs1835217721,2
    --120029386(+) TTGGTC/TAATTC 1 -- us2k10--------
    rs47678291,2
    C,F,A,H--120029388(+) GGTCAA/GTTCAT 1 -- us2k112Minor allele frequency- G:0.30NS EA NA WA 786
    rs1877623431,2
    --120029403(+) GAAACA/GTTTCT 1 -- us2k10--------
    rs1420035021,2
    C--120029461(+) GTTCTC/GAACAG 1 -- us2k10--------
    rs11191181,2
    C,F,H--120029500(+) ACAAAG/CAGTGA 1 -- us2k117Minor allele frequency- C:0.44NS EA NA WA CSA 798
    rs50055561,2
    C,F,A,H--120029538(+) GACACG/ACTACA 1 -- us2k119Minor allele frequency- A:0.20NS EA NA WA 2340

    HapMap Linkage Disequilibrium report for TMEM233 (120031264 - 120079363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM233:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832529CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMEM233 for disorders           About MalaCards

    TMEM233 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM233
    Human Genome Epidemiology (HuGE) Navigator: TMEM233 (1 document)

    Export disorders for TMEM233 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM233 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM233)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)2 Sallman Almen M.... Schioth H.B. (2012)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disea se. (PubMed id 20622878)4 Remmers E.F....GA1l A. (2010)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387890 HGNC: 37219 AceView: LOC387890 Ensembl:ENSG00000224982 euGenes: HUgn387890
    ECgene: TMEM233 H-InvDB: TMEM233

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM233 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM233 gene:
    Search GeneIP for patents involving TMEM233

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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