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Aliases for TMEM232 Gene

Aliases for TMEM232 Gene

  • Transmembrane Protein 232 2 3 5

External Ids for TMEM232 Gene

Previous GeneCards Identifiers for TMEM232 Gene

  • GC05M109755
  • GC05M109624
  • GC05M104934

Summaries for TMEM232 Gene

GeneCards Summary for TMEM232 Gene

TMEM232 (Transmembrane Protein 232) is a Protein Coding gene.

Additional gene information for TMEM232 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM232 Gene

Genomics for TMEM232 Gene

GeneHancer (GH) Regulatory Elements for TMEM232 Gene

Promoters and enhancers for TMEM232 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I110737 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.2 -161 2.3 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B SLC25A46 TMEM232 GC05P110816
GH05I110726 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.4 +12.2 12155 0.8 HDAC1 MEIS2 CTCF MXI1 USF1 ATF1 FOXA2 SAP130 ARID4B MAX GC05M110647 TMEM232 SLC25A46
GH05I110053 Enhancer 1 Ensembl ENCODE 20.9 +684.8 684797 1 PKNOX1 SMAD1 NFIB ZNF529 MZF1 ZNF195 FEZF1 RAD21 ZNF350 RUNX3 TMEM232 SLC25A46 PIR60171 GC05P109911
GH05I111091 Promoter/Enhancer 1.6 Ensembl ENCODE 10.4 -353.9 -353898 2.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 WDR36 ENSG00000253613 RPS3AP21 TSLP SLC25A46 TMEM232 BCLAF1P1 STARD4-AS1 GC05P111128
GH05I110751 Enhancer 0.8 ENCODE 9.4 -13.5 -13483 2.1 PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 ZNF207 ATF7 ETV6 FOS TMEM232 SLC25A46 GC05P110816
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM232 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM232 Gene

Genomic Locations for TMEM232 Gene
chr5:110,289,233-110,738,956
(GRCh38/hg38)
Size:
449,724 bases
Orientation:
Minus strand
chr5:109,624,934-110,074,657
(GRCh37/hg19)

Genomic View for TMEM232 Gene

Genes around TMEM232 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM232 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM232 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM232 Gene

Proteins for TMEM232 Gene

  • Protein details for TMEM232 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JQI7-TM232_HUMAN
    Recommended name:
    Transmembrane protein 232
    Protein Accession:
    C9JQI7
    Secondary Accessions:
    • B4DKF4

    Protein attributes for TMEM232 Gene

    Size:
    657 amino acids
    Molecular mass:
    76453 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM232 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM232 Gene

Post-translational modifications for TMEM232 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM232 Gene

Domains & Families for TMEM232 Gene

Gene Families for TMEM232 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM232 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM232 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM232: view

No data available for UniProtKB/Swiss-Prot for TMEM232 Gene

Function for TMEM232 Gene

Phenotypes From GWAS Catalog for TMEM232 Gene

Phenotypes for TMEM232 Gene

GenomeRNAi human phenotypes for TMEM232:
genes like me logo Genes that share phenotypes with TMEM232: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM232 Gene

Localization for TMEM232 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM232 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM232 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for TMEM232 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM232: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM232 Gene

Pathways & Interactions for TMEM232 Gene

SuperPathways for TMEM232 Gene

No Data Available

Interacting Proteins for TMEM232 Gene

Gene Ontology (GO) - Biological Process for TMEM232 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM232 Gene

Drugs & Compounds for TMEM232 Gene

No Compound Related Data Available

Transcripts for TMEM232 Gene

mRNA/cDNA for TMEM232 Gene

(19) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM232 Gene

Transmembrane protein 232:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM232 Gene

No ASD Table

Relevant External Links for TMEM232 Gene

GeneLoc Exon Structure for
TMEM232
ECgene alternative splicing isoforms for
TMEM232

Expression for TMEM232 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM232 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM232 Gene

This gene is overexpressed in Testis (x8.5).

Protein differential expression in normal tissues from HIPED for TMEM232 Gene

This gene is overexpressed in Cerebrospinal fluid (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM232 Gene



Protein tissue co-expression partners for TMEM232 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM232 Gene:

TMEM232

SOURCE GeneReport for Unigene cluster for TMEM232 Gene:

Hs.729154

Evidence on tissue expression from TISSUES for TMEM232 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM232: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM232 Gene

Orthologs for TMEM232 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM232 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM232 33 34
  • 96.46 (n)
dog
(Canis familiaris)
Mammalia TMEM232 33 34
  • 85.62 (n)
cow
(Bos Taurus)
Mammalia TMEM232 33 34
  • 81.61 (n)
mouse
(Mus musculus)
Mammalia Tmem232 33 16 34
  • 75.31 (n)
rat
(Rattus norvegicus)
Mammalia Tmem232 33
  • 73.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM232 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM232 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM232 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem232 33
  • 55.25 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem232 33 34
  • 48.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
Species where no ortholog for TMEM232 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM232 Gene

ENSEMBL:
Gene Tree for TMEM232 (if available)
TreeFam:
Gene Tree for TMEM232 (if available)

Paralogs for TMEM232 Gene

No data available for Paralogs for TMEM232 Gene

Variants for TMEM232 Gene

Sequence variations from dbSNP and Humsavar for TMEM232 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1057519416 pathogenic, NEUROPATHY, HEREDITARY MOTOR AND SENSORY, TYPE VIB 110,739,285(-) C/CC upstream_transcript_variant
rs145421520 benign, NEUROPATHY, HEREDITARY MOTOR AND SENSORY, TYPE VIB 110,739,266(-) C/A/T upstream_transcript_variant
rs758140632 uncertain-significance, NEUROPATHY, HEREDITARY MOTOR AND SENSORY, TYPE VIB 110,739,315(-) G/A/T upstream_transcript_variant
rs1064795772 pathogenic, not provided 110,739,130(-) G/GTG upstream_transcript_variant
rs1000000399 -- 110,739,565(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM232 Gene

Variant ID Type Subtype PubMed ID
esv2667285 CNV deletion 23128226
esv2759369 CNV loss 17122850
esv2763903 CNV loss 21179565
esv3304779 CNV mobile element insertion 20981092
esv3445252 CNV insertion 20981092
esv34732 CNV loss 17911159
esv3606248 CNV loss 21293372
esv3606250 CNV loss 21293372
esv3606251 CNV loss 21293372
esv3606252 CNV loss 21293372
esv3606254 CNV loss 21293372
esv3890709 CNV loss 25118596
nsv1016061 CNV loss 25217958
nsv1016954 CNV loss 25217958
nsv1020009 CNV loss 25217958
nsv1024152 CNV loss 25217958
nsv1026064 CNV loss 25217958
nsv1027985 CNV loss 25217958
nsv1034262 CNV loss 25217958
nsv10742 CNV loss 18304495
nsv10743 CNV gain 18304495
nsv4957 CNV deletion 18451855
nsv525752 CNV loss 19592680
nsv599355 CNV loss 21841781
nsv818375 CNV loss 17921354
nsv819920 CNV gain 19587683
nsv823172 CNV loss 20364138
nsv830445 CNV gain 17160897
nsv830446 CNV loss 17160897

Variation tolerance for TMEM232 Gene

Gene Damage Index Score: 7.33; 81.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM232 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM232

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM232 Gene

Disorders for TMEM232 Gene

Additional Disease Information for TMEM232

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM232 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM232 Gene

Publications for TMEM232 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan RS … Blankenberg S (JAMA 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Scanning indels in the 5q22.1 region and identification of the TMEM232 susceptibility gene that is associated with atopic dermatitis in the Chinese Han population. (PMID: 28351738) Wu YY … Xiao FL (Gene 2017) 3 58

Products for TMEM232 Gene

Sources for TMEM232 Gene

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