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Aliases for TMEM230 Gene

Aliases for TMEM230 Gene

  • Transmembrane Protein 230 2 3 5
  • C20orf30 3 4
  • UPF0414 Transmembrane Protein C20orf30 3
  • Chromosome 20 Open Reading Frame 30 2
  • DJ1116H23.2.1 3
  • HSPC274 3

External Ids for TMEM230 Gene

Previous HGNC Symbols for TMEM230 Gene

  • C20orf30

Previous GeneCards Identifiers for TMEM230 Gene

  • GC20M005084
  • GC20M005086
  • GC20M005089

Summaries for TMEM230 Gene

GeneCards Summary for TMEM230 Gene

TMEM230 (Transmembrane Protein 230) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM230 Gene

Genomics for TMEM230 Gene

Regulatory Elements for TMEM230 Gene

Enhancers for TMEM230 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM230 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM230 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM230 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM230 Gene

Chromosome:
20
Start:
5,068,232 bp from pter
End:
5,113,103 bp from pter
Size:
44,872 bases
Orientation:
Minus strand

Genomic View for TMEM230 Gene

Genes around TMEM230 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM230 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM230 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM230 Gene

Proteins for TMEM230 Gene

  • Protein details for TMEM230 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A57-TM230_HUMAN
    Recommended name:
    Transmembrane protein 230
    Protein Accession:
    Q96A57
    Secondary Accessions:
    • B2RDM8
    • D3DVZ9
    • Q0VGC8
    • Q5TDS5
    • Q96ES2
    • Q9P0A7

    Protein attributes for TMEM230 Gene

    Size:
    120 amino acids
    Molecular mass:
    13188 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM230 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM230 Gene

Proteomics data for TMEM230 Gene at MOPED

Post-translational modifications for TMEM230 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM230 Gene

Domains & Families for TMEM230 Gene

Protein Domains for TMEM230 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM230 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A57

UniProtKB/Swiss-Prot:

TM230_HUMAN :
  • Belongs to the TMEM134/TMEM230 family.
Family:
  • Belongs to the TMEM134/TMEM230 family.
genes like me logo Genes that share domains with TMEM230: view

No data available for Gene Families for TMEM230 Gene

Function for TMEM230 Gene

genes like me logo Genes that share phenotypes with TMEM230: view

Animal Model Products

CRISPR Products

miRNA for TMEM230 Gene

miRTarBase miRNAs that target TMEM230

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM230 Gene

Localization for TMEM230 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM230 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM230 Gene COMPARTMENTS Subcellular localization image for TMEM230 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM230 Gene

Pathways & Interactions for TMEM230 Gene

SuperPathways for TMEM230 Gene

No Data Available

Interacting Proteins for TMEM230 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341364%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000378426%0d%0a9606.ENSP00000356298%0d%0a9606.ENSP00000401450%0d%0a
Selected Interacting proteins: Q96A57-TM230_HUMAN ENSP00000341364 for TMEM230 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TMEM230 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM230 Gene

Drugs & Compounds for TMEM230 Gene

No Compound Related Data Available

Transcripts for TMEM230 Gene

Unigene Clusters for TMEM230 Gene

Transmembrane protein 230:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM230 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - -
SP19: - - -
SP20: - - - - - - -
SP21: - - - - - - - - -
SP22: - - - - - - - -
SP23: - - - - - - -

ExUns: 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i · 9j · 9k · 9l · 9m · 9n · 9o · 9p
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for TMEM230 Gene

GeneLoc Exon Structure for
TMEM230
ECgene alternative splicing isoforms for
TMEM230

Expression for TMEM230 Gene

mRNA expression in normal human tissues for TMEM230 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM230 Gene

This gene is overexpressed in Bone (29.1) and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM230 Gene



SOURCE GeneReport for Unigene cluster for TMEM230 Gene Hs.472024

genes like me logo Genes that share expression patterns with TMEM230: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM230 Gene

Orthologs for TMEM230 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM230 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM230 35
  • 92.5 (n)
  • 98.33 (a)
TMEM230 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM230 35
  • 92.5 (n)
  • 98.33 (a)
TMEM230 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem230 35
  • 91.11 (n)
  • 96.67 (a)
Tmem230 16
Tmem230 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM230 35
  • 98.41 (n)
  • 98.41 (a)
TMEM230 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem230 35
  • 91.39 (n)
  • 98.33 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM230 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves C22H20ORF30 35
  • 78.89 (n)
  • 90 (a)
TMEM230 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9040 35
tmem230 35
  • 76.11 (n)
  • 87.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16046 35
zebrafish
(Danio rerio)
Actinopterygii zgc:101123 35
  • 70.28 (n)
  • 75.83 (a)
TMEM230 (1 of 2) 36
  • 76 (a)
OneToMany
TMEM230 (2 of 2) 36
  • 74 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3506 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for TMEM230:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM230 Gene

ENSEMBL:
Gene Tree for TMEM230 (if available)
TreeFam:
Gene Tree for TMEM230 (if available)

Paralogs for TMEM230 Gene

(1) SIMAP similar genes for TMEM230 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM230: view

No data available for Paralogs for TMEM230 Gene

Variants for TMEM230 Gene

Sequence variations from dbSNP and Humsavar for TMEM230 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2715 -- 5,100,403(+) ataaa(A/C/T)tactt utr-variant-3-prime
rs2716 -- 5,100,359(+) GGTAG(A/G)GATAA utr-variant-3-prime
rs1040783 -- 5,106,078(-) tgtgt(G/T)tgtCC intron-variant
rs1077045 -- 5,099,462(-) gaagt(A/G)agGGA downstream-variant-500B
rs382857 -- 5,102,826(-) ttttt(C/G)ttttt intron-variant

Variation tolerance for TMEM230 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMEM230 Gene

Disorders for TMEM230 Gene

Relevant External Links for TMEM230

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM230

No disorders were found for TMEM230 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM230 Gene

Publications for TMEM230 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  3. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A. … MA1ller C.R. (Thromb. Haemost. 2011) 3

Products for TMEM230 Gene

Sources for TMEM230 Gene

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