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Aliases for TMEM229B Gene

Aliases for TMEM229B Gene

  • Transmembrane Protein 229B 2 3 5
  • C14orf83 3 4
  • Chromosome 14 Open Reading Frame 83 2

External Ids for TMEM229B Gene

Previous HGNC Symbols for TMEM229B Gene

  • C14orf83

Previous GeneCards Identifiers for TMEM229B Gene

  • GC14M067006
  • GC14M067914
  • GC14M048106

Summaries for TMEM229B Gene

GeneCards Summary for TMEM229B Gene

TMEM229B (Transmembrane Protein 229B) is a Protein Coding gene. An important paralog of this gene is TMEM229A.

Additional gene information for TMEM229B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM229B Gene

Genomics for TMEM229B Gene

GeneHancer (GH) Regulatory Elements for TMEM229B Gene

Promoters and enhancers for TMEM229B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I067531 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.1 +0.4 407 2.8 ATF1 ARNT SIN3A ZBTB7B ZNF48 POLR2B GLIS2 ATF7 SP3 REST TMEM229B PLEKHH1 ZFYVE26
GH14I067512 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 563.9 +19.6 19608 3.3 SIN3A ZNF335 GLIS2 ZNF350 RCOR1 SMARCA5 ZBTB11 ZEB2 ZNF148 PRDM6 TMEM229B ENSG00000201529 ARG2 ZFYVE26 PLEKHH1 LOC105370542
GH14I067505 Promoter 0.5 EPDnew 550.3 +28.3 28320 0.1 TMEM229B PLEKHH1 LOC105370542
GH14I067540 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.8 -8.1 -8099 3 HDAC1 PKNOX1 ARNT NFRKB ZBTB40 POLR2B ZNF766 GATA2 REST ELF1 TMEM229B PLEKHH1 PIR48522
GH14I067815 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.4 -285.2 -285192 7.3 PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZFYVE26 RAD51B RPL12P7 TMEM229B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM229B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM229B Gene

Genomic Locations for TMEM229B Gene
chr14:67,447,084-67,533,739
(GRCh38/hg38)
Size:
86,656 bases
Orientation:
Minus strand
chr14:67,913,801-68,000,456
(GRCh37/hg19)

Genomic View for TMEM229B Gene

Genes around TMEM229B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM229B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM229B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM229B Gene

Proteins for TMEM229B Gene

  • Protein details for TMEM229B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBD8-T229B_HUMAN
    Recommended name:
    Transmembrane protein 229B
    Protein Accession:
    Q8NBD8

    Protein attributes for TMEM229B Gene

    Size:
    167 amino acids
    Molecular mass:
    19531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM229B Gene

Post-translational modifications for TMEM229B Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM229B Gene

Domains & Families for TMEM229B Gene

Gene Families for TMEM229B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM229B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM229B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBD8

UniProtKB/Swiss-Prot:

T229B_HUMAN :
  • Belongs to the TMEM229 family.
Family:
  • Belongs to the TMEM229 family.
genes like me logo Genes that share domains with TMEM229B: view

Function for TMEM229B Gene

Phenotypes From GWAS Catalog for TMEM229B Gene

Phenotypes for TMEM229B Gene

GenomeRNAi human phenotypes for TMEM229B:
genes like me logo Genes that share phenotypes with TMEM229B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM229B Gene

Localization for TMEM229B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM229B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM229B gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM229B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM229B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM229B Gene

Pathways & Interactions for TMEM229B Gene

SuperPathways for TMEM229B Gene

No Data Available

Interacting Proteins for TMEM229B Gene

Gene Ontology (GO) - Biological Process for TMEM229B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM229B Gene

Drugs & Compounds for TMEM229B Gene

No Compound Related Data Available

Transcripts for TMEM229B Gene

mRNA/cDNA for TMEM229B Gene

Unigene Clusters for TMEM229B Gene

Transmembrane protein 229B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM229B Gene

No ASD Table

Relevant External Links for TMEM229B Gene

GeneLoc Exon Structure for
TMEM229B
ECgene alternative splicing isoforms for
TMEM229B

Expression for TMEM229B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM229B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM229B Gene

This gene is overexpressed in Brain - Cerebellum (x5.5) and Brain - Cerebellar Hemisphere (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of TMEM229B Gene:

TMEM229B

SOURCE GeneReport for Unigene cluster for TMEM229B Gene:

Hs.509707

Evidence on tissue expression from TISSUES for TMEM229B Gene

  • Nervous system(4.7)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with TMEM229B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM229B Gene

Orthologs for TMEM229B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM229B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM229B 33 34
  • 96.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM229B 34
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM229B 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM229B 33 34
  • 95.98 (n)
mouse
(Mus musculus)
Mammalia Gm5423 34
  • 95 (a)
OneToMany
Tmem229b 33 16 34
  • 90.42 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM229B 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem229b 33
  • 91.42 (n)
chicken
(Gallus gallus)
Aves TMEM229B 33 34
  • 78.04 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM229B 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem229b 33
  • 70.66 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem229b 33 34
  • 73.12 (n)
Species where no ortholog for TMEM229B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM229B Gene

ENSEMBL:
Gene Tree for TMEM229B (if available)
TreeFam:
Gene Tree for TMEM229B (if available)

Paralogs for TMEM229B Gene

Paralogs for TMEM229B Gene

(1) SIMAP similar genes for TMEM229B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TMEM229B Gene

genes like me logo Genes that share paralogs with TMEM229B: view

Variants for TMEM229B Gene

Sequence variations from dbSNP and Humsavar for TMEM229B Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000053876 -- 67,534,514(-) TTGTTGT/TTGT upstream_transcript_variant
rs1000060501 -- 67,494,761(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000190515 -- 67,489,746(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000223497 -- 67,510,438(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000363665 -- 67,524,065(-) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM229B Gene

Variant ID Type Subtype PubMed ID
dgv1929n100 CNV gain 25217958
esv3892557 CNV gain 25118596
nsv1116031 CNV deletion 24896259
nsv1320 CNV deletion 18451855
nsv1322 CNV insertion 18451855
nsv456331 CNV gain 19166990
nsv470651 CNV gain 18288195
nsv526811 CNV loss 19592680
nsv564961 CNV gain 21841781
nsv826970 CNV gain 20364138

Variation tolerance for TMEM229B Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM229B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM229B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM229B Gene

Disorders for TMEM229B Gene

Additional Disease Information for TMEM229B

No disorders were found for TMEM229B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM229B Gene

Publications for TMEM229B Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A … EUROSPAN consortium (PLoS genetics 2012) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. (PMID: 25064009) Nalls MA … Singleton AB (Nature genetics 2014) 3 58
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for TMEM229B Gene

Sources for TMEM229B Gene

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