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Aliases for TMEM229B Gene

Aliases for TMEM229B Gene

  • Transmembrane Protein 229B 2 3 5
  • C14orf83 3 4
  • Chromosome 14 Open Reading Frame 83 2

External Ids for TMEM229B Gene

Previous HGNC Symbols for TMEM229B Gene

  • C14orf83

Previous GeneCards Identifiers for TMEM229B Gene

  • GC14M067006
  • GC14M067914
  • GC14M048106

Summaries for TMEM229B Gene

GeneCards Summary for TMEM229B Gene

TMEM229B (Transmembrane Protein 229B) is a Protein Coding gene. An important paralog of this gene is TMEM229A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM229B Gene

Genomics for TMEM229B Gene

Regulatory Elements for TMEM229B Gene

Enhancers for TMEM229B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F067531 1.4 FANTOM5 ENCODE 9.1 +0.4 407 2.8 ATF1 SIN3A FEZF1 ZNF48 GLIS2 FOS ZNF263 SP3 REST SMARCB1 TMEM229B PLEKHH1
GH14F067512 0.8 ENCODE 13.9 +19.7 19732 3.1 IRF2 SIN3A ZIC2 E2F1 GATA3 GLIS2 ZBTB48 POLR2A PATZ1 PRDM10 TMEM229B ENSG00000201529 ARG2 PLEKHH1 LOC105370542
GH14F067540 1.1 Ensembl ENCODE 8.8 -8.1 -8100 3.0 TBP PKNOX1 CBX3 NFRKB ETV1 FEZF1 ZBTB40 ZNF366 POLR2A ZSCAN29 TMEM229B PLEKHH1 PIR48522
GH14F067516 0.5 Ensembl 13.4 +16.9 16938 0.8 CTCF MAX RAD21 FOXA1 TMEM229B PLEKHH1 LOC105370542
GH14F067815 1.1 ENCODE 4.4 -285.2 -285193 7.3 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZFYVE26 RPL12P7 TMEM229B RAD51B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM229B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM229B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000419665 338 1999 SIN3A FEZF1 ZNF48 GLIS2 FOS ZNF263 SP3 REST SMARCB1 KAT8

Genomic Location for TMEM229B Gene

Chromosome:
14
Start:
67,447,084 bp from pter
End:
67,533,739 bp from pter
Size:
86,656 bases
Orientation:
Minus strand

Genomic View for TMEM229B Gene

Genes around TMEM229B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM229B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM229B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM229B Gene

Proteins for TMEM229B Gene

  • Protein details for TMEM229B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBD8-T229B_HUMAN
    Recommended name:
    Transmembrane protein 229B
    Protein Accession:
    Q8NBD8

    Protein attributes for TMEM229B Gene

    Size:
    167 amino acids
    Molecular mass:
    19531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM229B Gene

Post-translational modifications for TMEM229B Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM229B Gene

Domains & Families for TMEM229B Gene

Protein Domains for TMEM229B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM229B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBD8

UniProtKB/Swiss-Prot:

T229B_HUMAN :
  • Belongs to the TMEM229 family.
Family:
  • Belongs to the TMEM229 family.
genes like me logo Genes that share domains with TMEM229B: view

No data available for Gene Families for TMEM229B Gene

Function for TMEM229B Gene

Phenotypes for TMEM229B Gene

GenomeRNAi human phenotypes for TMEM229B:
genes like me logo Genes that share phenotypes with TMEM229B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM229B Gene

Localization for TMEM229B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM229B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM229B gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM229B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM229B: view

Pathways & Interactions for TMEM229B Gene

SuperPathways for TMEM229B Gene

No Data Available

Interacting Proteins for TMEM229B Gene

Gene Ontology (GO) - Biological Process for TMEM229B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM229B Gene

Transcripts for TMEM229B Gene

mRNA/cDNA for TMEM229B Gene

Unigene Clusters for TMEM229B Gene

Transmembrane protein 229B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM229B Gene

No ASD Table

Relevant External Links for TMEM229B Gene

GeneLoc Exon Structure for
TMEM229B
ECgene alternative splicing isoforms for
TMEM229B

Expression for TMEM229B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM229B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM229B Gene

This gene is overexpressed in Brain - Cerebellum (x5.5) and Brain - Cerebellar Hemisphere (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of TMEM229B Gene:

TMEM229B

SOURCE GeneReport for Unigene cluster for TMEM229B Gene:

Hs.509707
genes like me logo Genes that share expression patterns with TMEM229B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM229B Gene

Orthologs for TMEM229B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM229B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM229B 34 35
  • 96.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM229B 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM229B 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM229B 34 35
  • 95.98 (n)
mouse
(Mus musculus)
Mammalia Gm5423 35
  • 95 (a)
OneToMany
Tmem229b 34 16 35
  • 90.42 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM229B 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem229b 34
  • 91.42 (n)
chicken
(Gallus gallus)
Aves TMEM229B 34 35
  • 78.04 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM229B 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem229b 34
  • 70.66 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem229b 34 35
  • 73.12 (n)
Species where no ortholog for TMEM229B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM229B Gene

ENSEMBL:
Gene Tree for TMEM229B (if available)
TreeFam:
Gene Tree for TMEM229B (if available)

Paralogs for TMEM229B Gene

Paralogs for TMEM229B Gene

(1) SIMAP similar genes for TMEM229B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TMEM229B Gene

genes like me logo Genes that share paralogs with TMEM229B: view

Variants for TMEM229B Gene

Sequence variations from dbSNP and Humsavar for TMEM229B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10047825 -- 67,526,454(+) TATGC(A/G)TTGCT intron-variant
rs10129316 -- 67,492,383(+) GGCAG(C/T)GGCTG intron-variant
rs10130096 -- 67,520,936(+) AAGCA(A/G)TGAAT intron-variant
rs10133015 -- 67,521,597(+) GGACT(A/C)TGCAG intron-variant
rs10133618 -- 67,514,686(+) ACCCT(C/G)CTGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM229B Gene

Variant ID Type Subtype PubMed ID
dgv1929n100 CNV gain 25217958
esv3892557 CNV gain 25118596
nsv1116031 CNV deletion 24896259
nsv1320 CNV deletion 18451855
nsv1322 CNV insertion 18451855
nsv456331 CNV gain 19166990
nsv470651 CNV gain 18288195
nsv526811 CNV loss 19592680
nsv564961 CNV gain 21841781
nsv826970 CNV gain 20364138

Variation tolerance for TMEM229B Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM229B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM229B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM229B Gene

Disorders for TMEM229B Gene

Relevant External Links for TMEM229B

Genetic Association Database (GAD)
TMEM229B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM229B

No disorders were found for TMEM229B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM229B Gene

Publications for TMEM229B Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. (PMID: 25064009) Nalls M.A. … Singleton A.B. (Nat. Genet. 2014) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for TMEM229B Gene

Sources for TMEM229B Gene

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