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Aliases for TMEM229A Gene

Aliases for TMEM229A Gene

  • Transmembrane Protein 229A 2 3 5

External Ids for TMEM229A Gene

Previous GeneCards Identifiers for TMEM229A Gene

  • GC07M123463
  • GC07M123670
  • GC07M118035

Summaries for TMEM229A Gene

GeneCards Summary for TMEM229A Gene

TMEM229A (Transmembrane Protein 229A) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TMEM229B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM229A Gene

Genomics for TMEM229A Gene

Regulatory Elements for TMEM229A Gene

Enhancers for TMEM229A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM229A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM229A Gene

124,030,916 bp from pter
124,033,469 bp from pter
2,554 bases
Minus strand

Genomic View for TMEM229A Gene

Genes around TMEM229A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM229A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM229A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM229A Gene

Proteins for TMEM229A Gene

  • Protein details for TMEM229A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 229A
    Protein Accession:
    Secondary Accessions:
    • A4D0X6

    Protein attributes for TMEM229A Gene

    380 amino acids
    Molecular mass:
    42370 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAL24328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM229A Gene

Proteomics data for TMEM229A Gene at MOPED

Post-translational modifications for TMEM229A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM229A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM229A Gene

Domains & Families for TMEM229A Gene

Protein Domains for TMEM229A Gene


Suggested Antigen Peptide Sequences for TMEM229A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM229 family.
  • Belongs to the TMEM229 family.
genes like me logo Genes that share domains with TMEM229A: view

No data available for Gene Families for TMEM229A Gene

Function for TMEM229A Gene

Phenotypes for TMEM229A Gene

genes like me logo Genes that share phenotypes with TMEM229A: view

Animal Model Products

CRISPR Products

miRNA for TMEM229A Gene

miRTarBase miRNAs that target TMEM229A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM229A Gene

Localization for TMEM229A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM229A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM229A Gene COMPARTMENTS Subcellular localization image for TMEM229A gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for TMEM229A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with TMEM229A: view

Pathways & Interactions for TMEM229A Gene

SuperPathways for TMEM229A Gene

No Data Available

Interacting Proteins for TMEM229A Gene

Gene Ontology (GO) - Biological Process for TMEM229A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM229A Gene

Drugs & Compounds for TMEM229A Gene

No Compound Related Data Available

Transcripts for TMEM229A Gene

mRNA/cDNA for TMEM229A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM229A Gene

Transmembrane protein 229A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM229A Gene

No ASD Table

Relevant External Links for TMEM229A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM229A Gene

mRNA expression in normal human tissues for TMEM229A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM229A Gene

This gene is overexpressed in Brain - Substantia nigra (x5.5), Brain - Spinal cord (cervical c-1) (x5.3), Brain - Putamen (basal ganglia) (x4.5), Brain - Hippocampus (x4.1), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM229A Gene

This gene is overexpressed in Plasma (46.3) and Testis (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM229A Gene

SOURCE GeneReport for Unigene cluster for TMEM229A Gene Hs.450249

genes like me logo Genes that share expression patterns with TMEM229A: view

Protein tissue co-expression partners for TMEM229A Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM229A Gene

Orthologs for TMEM229A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM229A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM229A 35
  • 88.4 (n)
  • 87.67 (a)
(Canis familiaris)
Mammalia TMEM229A 35
  • 84.61 (n)
  • 79.23 (a)
TMEM229A 36
  • 78 (a)
(Mus musculus)
Mammalia Tmem229a 35
  • 84.82 (n)
  • 82.38 (a)
Tmem229a 16
Tmem229a 36
  • 82 (a)
(Pan troglodytes)
Mammalia TMEM229A 35
  • 99.47 (n)
  • 99.47 (a)
TMEM229A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem229a 35
  • 84.37 (n)
  • 82.11 (a)
(Monodelphis domestica)
Mammalia TMEM229A 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem229a 35
  • 64.97 (n)
  • 59.37 (a)
(Danio rerio)
Actinopterygii LOC794725 35
  • 61.53 (n)
  • 56.27 (a)
Species with no ortholog for TMEM229A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM229A Gene

Gene Tree for TMEM229A (if available)
Gene Tree for TMEM229A (if available)

Paralogs for TMEM229A Gene

Paralogs for TMEM229A Gene

(1) SIMAP similar genes for TMEM229A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM229A: view

Variants for TMEM229A Gene

Sequence variations from dbSNP and Humsavar for TMEM229A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6976786 -- 124,033,130(+) gcgcA(A/G)GGAGC utr-variant-5-prime
rs13239813 -- 124,033,992(+) CCAGA(A/G)TTTGT upstream-variant-2KB
rs13240140 -- 124,034,252(+) ttcct(A/C)ccctc upstream-variant-2KB
rs13242878 -- 124,034,257(+) cccct(A/C)ccctc upstream-variant-2KB
rs13242883 -- 124,034,265(+) ctccc(C/G)tcccc upstream-variant-2KB

Variation tolerance for TMEM229A Gene

Gene Damage Index Score: 8.50; 85.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMEM229A Gene

Disorders for TMEM229A Gene

Relevant External Links for TMEM229A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM229A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM229A Gene

Publications for TMEM229A Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for TMEM229A Gene

Sources for TMEM229A Gene