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Aliases for TMEM229A Gene

Aliases for TMEM229A Gene

  • Transmembrane Protein 229A 2 3 5

External Ids for TMEM229A Gene

Previous GeneCards Identifiers for TMEM229A Gene

  • GC07M123463
  • GC07M123670
  • GC07M118035

Summaries for TMEM229A Gene

GeneCards Summary for TMEM229A Gene

TMEM229A (Transmembrane Protein 229A) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TMEM229B.

Additional gene information for TMEM229A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM229A Gene

Genomics for TMEM229A Gene

Regulatory Elements for TMEM229A Gene

Enhancers for TMEM229A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H124072 0.8 ENCODE 11 -40.2 -40216 2.7 FOXA2 INSM2 FEZF1 ZEB1 ZNF366 RCOR1 FOS ZNF362 CEBPB TSHZ1 TMEM229A PIR43907 PIR39500
GH07H124084 0.6 ENCODE 11.8 -51.6 -51649 2 GATA3 JUND POLR2A JUN MAX RCOR1 TMEM229A PIR43907 PIR39500
GH07H124037 0.3 FANTOM5 7.8 -4.0 -3982 0 TMEM229A PIR43907
GH07H124038 0.2 ENCODE 6 -5.0 -4995 0.6 TMEM229A PIR43907
GH07H124203 0.3 FANTOM5 2.4 -169.7 -169729 0.1 TMEM229A PIR39500 LOC105375484
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM229A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM229A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217546 469 801 SIN3A ZNF2 GLIS2 SCRT2 EGR2 SP3 ZEB2 REST ZNF843 ZNF341

Genomic Locations for TMEM229A Gene

Genomic Locations for TMEM229A Gene
2,554 bases
Minus strand

Genomic View for TMEM229A Gene

Genes around TMEM229A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM229A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM229A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM229A Gene

Proteins for TMEM229A Gene

  • Protein details for TMEM229A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 229A
    Protein Accession:
    Secondary Accessions:
    • A4D0X6

    Protein attributes for TMEM229A Gene

    380 amino acids
    Molecular mass:
    42370 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAL24328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM229A Gene

Post-translational modifications for TMEM229A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM229A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM229A Gene

Domains & Families for TMEM229A Gene

Gene Families for TMEM229A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM229A Gene


Suggested Antigen Peptide Sequences for TMEM229A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM229 family.
  • Belongs to the TMEM229 family.
genes like me logo Genes that share domains with TMEM229A: view

Function for TMEM229A Gene

Gene Ontology (GO) - Molecular Function for TMEM229A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001070 RNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with TMEM229A: view

Phenotypes for TMEM229A Gene

genes like me logo Genes that share phenotypes with TMEM229A: view

Animal Model Products

miRNA for TMEM229A Gene

miRTarBase miRNAs that target TMEM229A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM229A Gene

Localization for TMEM229A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM229A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM229A gene
Compartment Confidence
peroxisome 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM229A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with TMEM229A: view

Pathways & Interactions for TMEM229A Gene

SuperPathways for TMEM229A Gene

No Data Available

Interacting Proteins for TMEM229A Gene

Gene Ontology (GO) - Biological Process for TMEM229A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050434 positive regulation of viral transcription IEA --
GO:2001141 regulation of RNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with TMEM229A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM229A Gene

Drugs & Compounds for TMEM229A Gene

No Compound Related Data Available

Transcripts for TMEM229A Gene

mRNA/cDNA for TMEM229A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM229A Gene

Transmembrane protein 229A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM229A Gene

No ASD Table

Relevant External Links for TMEM229A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM229A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM229A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM229A Gene

This gene is overexpressed in Brain - Substantia nigra (x5.5), Brain - Spinal cord (cervical c-1) (x5.3), Brain - Putamen (basal ganglia) (x4.5), Brain - Hippocampus (x4.1), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM229A Gene

This gene is overexpressed in Plasma (46.3) and Testis (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM229A Gene

Protein tissue co-expression partners for TMEM229A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM229A Gene:


SOURCE GeneReport for Unigene cluster for TMEM229A Gene:

genes like me logo Genes that share expression patterns with TMEM229A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM229A Gene

Orthologs for TMEM229A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM229A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM229A 33 34
  • 99.47 (n)
(Bos Taurus)
Mammalia TMEM229A 33
  • 88.4 (n)
(Mus musculus)
Mammalia Tmem229a 33 16 34
  • 84.82 (n)
(Canis familiaris)
Mammalia TMEM229A 33 34
  • 84.61 (n)
(Rattus norvegicus)
Mammalia Tmem229a 33
  • 84.37 (n)
(Monodelphis domestica)
Mammalia TMEM229A 34
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem229a 33
  • 64.97 (n)
(Danio rerio)
Actinopterygii LOC794725 33
  • 61.53 (n)
Species where no ortholog for TMEM229A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM229A Gene

Gene Tree for TMEM229A (if available)
Gene Tree for TMEM229A (if available)

Paralogs for TMEM229A Gene

Paralogs for TMEM229A Gene

(1) SIMAP similar genes for TMEM229A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM229A: view

Variants for TMEM229A Gene

Sequence variations from dbSNP and Humsavar for TMEM229A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000164968 -- 124,030,617(+) AGGAT(A/G)TTCGT downstream-variant-500B
rs1000200121 -- 124,033,819(+) GCCAG(C/T)TGTGT upstream-variant-2KB
rs1000314449 -- 124,034,152(+) CAGAA(A/T)TGGAG upstream-variant-2KB
rs1000535897 -- 124,035,432(+) CAGCA(-/T)TTTAA upstream-variant-2KB
rs1000567418 -- 124,034,882(+) TGAGC(A/G)CCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM229A Gene

Variant ID Type Subtype PubMed ID
nsv1145157 CNV deletion 24896259

Variation tolerance for TMEM229A Gene

Gene Damage Index Score: 8.50; 85.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM229A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM229A Gene

Disorders for TMEM229A Gene

Relevant External Links for TMEM229A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM229A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM229A Gene

Publications for TMEM229A Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  2. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for TMEM229A Gene

Sources for TMEM229A Gene

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