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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM229A Gene

protein-coding   GIFtS: 35
GCID: GC07M123670

transmembrane protein 229A
  Search for TMEM229A
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM229A    

Aliases
for TMEM229A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane Protein 229A1 2

External Ids:    HGNC: 372791   Entrez Gene: 7301302   Ensembl: ENSG000002342247   UniProtKB: B2RXF03   

Export aliases for TMEM229A gene to outside databases

Previous GC identifers: GC07M123463 GC07M118035


Summaries
for TMEM229A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TMEM229A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM229A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM229A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM229A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.32   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.32

TMEM229A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM229A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M123670:  view genomic region     (about GC identifiers)

Start:
 123,670,970 bp from pter      End:
 123,673,523 bp from pter
Size:
 2,554 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 123,059,589-123,062,142     

Proteins
for TMEM229A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: T229A_HUMAN, B2RXF0 (See protein sequence)
Recommended Name: Transmembrane protein 229A  
Size: 380 amino acids; 42370 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=EAL24328.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D0X6

Explore the universe of human proteins at neXtProt for TMEM229A: NX_B2RXF0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_B2RXF0

    • TMEM229A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001129474.1  
    ENSEMBL proteins: 
     ENSP00000395244  

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    Uscn Proteins for TMEM229A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0042025host cell nucleus IEA--


    TMEM229A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TMEM229A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMEM229A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001831 IV_Tat

    Graphical View of Domain Structure for InterPro Entry B2RXF0

    ProtoNet protein and cluster: B2RXF0

    UniProtKB/Swiss-Prot: T229A_HUMAN, B2RXF0
    Similarity: Belongs to the TMEM229 family


    Function
    for TMEM229A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--


    TMEM229A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TMEM229A:
     Decreased Wnt reporter activit 


    Pathways & Interactions
    for TMEM229A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM229A

    Drugs & Compounds
    for TMEM229A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TMEM229A
    Search CenterWatch for drugs/clinical trials and news about TMEM229A / T229A 

    Transcripts
    for TMEM229A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for TMEM229A gene: 
    NM_001136002.1  

    Unigene Cluster for TMEM229A:

    Transmembrane protein 229A
    Hs.450249  [show with all ESTs]
    Unigene Representative Sequence: NM_001136002
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000455783(uc011kob.2)

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    hsa-miR-579 hsa-miR-30c hsa-miR-328 hsa-miR-25 hsa-miR-128 hsa-miR-30d hsa-miR-30a hsa-miR-3658
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    Inhib. RNA
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    Additional cDNA sequence: 

    BC157828.1 BC171809.1 

    4 DOTS entries:

    DT.99979614  DT.121054743  DT.424203  DT.40213880 

    GeneLoc Exon Structure


    Expression
    for TMEM229A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM229A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAACTTCAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMEM229A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM229A Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.450249
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    In Situ
    Assay Products:     
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    Orthologs
    for TMEM229A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM229A gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7947251 transmembrane protein 229A-like 62.25(n)
    57.35(a)    		   794725  XM_001334696.1  XP_001334732.1 


    ENSEMBL Gene Tree for TMEM229A (if available)
    TreeFam Gene Tree for TMEM229A (if available) 

    Paralogs
    for TMEM229A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM229A gene
    TMEM229B2  
    1 SIMAP similar gene for TMEM229A using alignment to 1 protein entry:     T229A_HUMAN:
    TMEM229B

    TMEM229A for paralogs           About GeneDecksing



    Genomic Variants
    for TMEM229A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/50 NCBI SNPs in TMEM229A are shown (see all 50)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs782248881,2
    		C,F,--123670548(+) AAACAT/CTTTTT 1 -- int11Minor allele frequency- C:0.14WA 118
    rs21584611,2
    		H--123670592(-) TATCAG/ACGAGC 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1471207731,2
    		--123670714(+) TTTTAC/TACATG 1 -- int10--------
    rs1850735251,2
    		--123670932(+) TAATGA/CAAACA 1 -- int10--------
    rs1384640971,2
    		--123670987(+) GAACAA/TTCAGG 1 -- ut310--------
    rs1440333241,2
    		--123671318(+) GTGCTG/TTCACA 1 -- ut310--------
    rs1116240701,2
    		--123671446(+) TAAAAT/AGAAAT 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs351417561,2
    		C,F--123671548(+) GCCAAA/-AAAAA 1 -- ut313Minor allele frequency- -:0.50NA 6
    rs1395169231,2
    		--123671664(+) TGGGCC/TTGTAA 1 -- ut310--------
    rs77858781,2
    		C,F,A,H,--123671671(+) GTAAAT/CGTTTT 1 -- ut3110Minor allele frequency- C:0.25NS EA NA WA CSA 663

    HapMap Linkage Disequilibrium report for TMEM229A (123670970 - 123673523 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM229A: --

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    Disorders / Diseases
    for TMEM229A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TMEM229A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM229A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM229A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for TMEM229A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMEM229A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 730130 HGNC: 37279 Ensembl:ENSG00000234224 euGenes: HUgn730130 ECgene: TMEM229A
    H-InvDB: TMEM229A

    Other Databases showing TMEM229A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMEM229A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM229A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM229A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM229A gene:
    Search GeneIP for patents involving TMEM229A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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