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Aliases for TMEM225 Gene

Aliases for TMEM225 Gene

  • Transmembrane Protein 225 2 3
  • PMP22CD 3 4
  • Protein Phosphatase 1, Regulatory Subunit 154 3
  • PMP22 Claudin Domain-Containing Protein 3
  • PMP22 Claudin Domain Containing 2
  • Regulatory Subunit 154 2
  • Protein Phosphatase 1 2
  • PPP1R154 3

External Ids for TMEM225 Gene

Summaries for TMEM225 Gene

GeneCards Summary for TMEM225 Gene

TMEM225 (Transmembrane Protein 225) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM225 Gene

Genomics for TMEM225 Gene

Genomic Location for TMEM225 Gene

Start:
123,882,926 bp from pter
End:
123,885,642 bp from pter
Size:
2,717 bases
Orientation:
Minus strand

Genomic View for TMEM225 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM225 Gene

Regulatory Elements for TMEM225 Gene

Proteins for TMEM225 Gene

  • Protein details for TMEM225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GV28-TM225_HUMAN
    Recommended name:
    Transmembrane protein 225
    Protein Accession:
    Q6GV28
    Secondary Accessions:

    Protein attributes for TMEM225 Gene

    Size:
    225 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM225 Gene

Proteomics data for TMEM225 Gene at MOPED

Post-translational modifications for TMEM225 Gene

No Post-translational modifications

Other Protein References for TMEM225 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM225 Gene

Domains for TMEM225 Gene

Protein Domains for TMEM225 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM225: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM225 Gene

Function for TMEM225 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM225 Gene

Localization for TMEM225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM225 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM225 Gene COMPARTMENTS Subcellular localization image for TMEM225 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM225: view

Pathways for TMEM225 Gene

SuperPathways for TMEM225 Gene

No Data Available

Interacting Proteins for TMEM225 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364166%0d%0a9606.ENSP00000326031%0d%0a
Selected Interacting proteins: ENSP00000364166 for TMEM225 Gene via STRING

Symbol External ID(s) Details
PPP1CA

Gene Ontology (GO) - Biological Process for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with TMEM225: view

No data available for Pathways by source for TMEM225 Gene

Transcripts for TMEM225 Gene

mRNA/cDNA for TMEM225 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM225 Gene

Transmembrane protein 225:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM225 Gene

No ASD Table

Relevant External Links for TMEM225 Gene

GeneLoc Exon Structure for
TMEM225
ECgene alternative splicing isoforms for
TMEM225

Expression for TMEM225 Gene

mRNA expression in normal human tissues for TMEM225 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM225 Gene

This gene is overexpressed in Testis (52.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM225 Gene

SOURCE GeneReport for Unigene cluster for TMEM225 Gene Hs.98377

genes like me logo Genes that share expressions with TMEM225: view

Orthologs for TMEM225 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM225 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM225 36
  • 97.78 (n)
  • 94.22 (a)
TMEM225 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM225 36
  • 69.96 (n)
  • 47.09 (a)
TMEM225 37
  • 44 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM225 36
  • 72.92 (n)
  • 54.91 (a)
TMEM225 37
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem225 36
  • 66.07 (n)
  • 47.3 (a)
Tmem225 16
Tmem225 37
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM225 37
  • 25 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem225 36
  • 65.62 (n)
  • 45.95 (a)
Species with no ortholog for TMEM225:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM225 Gene

ENSEMBL:
Gene Tree for TMEM225 (if available)
TreeFam:
Gene Tree for TMEM225 (if available)

Paralogs for TMEM225 Gene

No data available for Paralogs for TMEM225 Gene

Variants for TMEM225 Gene

Sequence variations from dbSNP and Humsavar for TMEM225 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs728177 -- 123,885,012(-) CTGGG(A/C)ATTTG intron-variant
rs728178 -- 123,884,893(-) ATTGC(A/G)GTATT intron-variant
rs1054041 -- 123,882,979(-) CTGAA(C/T)GAATA utr-variant-3-prime
rs1939926 -- 123,886,129(-) ATGAT(G/T)GTCCA upstream-variant-2KB
rs1939927 - 123,883,230(-) CAGAA(C/T)GCACT missense, reference

Relevant External Links for TMEM225 Gene

HapMap Linkage Disequilibrium report
TMEM225

No data available for Structural Variations from Database of Genomic Variants (DGV) for TMEM225 Gene

Disorders for TMEM225 Gene

Relevant External Links for TMEM225

Genetic Association Database (GAD)
TMEM225
genes like me logo Genes that share disorders with TMEM225: view

No data available for UniProtKB/Swiss-Prot for TMEM225 Gene

Publications for TMEM225 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3
  2. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  3. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 49

Products for TMEM225 Gene

Sources for TMEM225 Gene

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