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Aliases for TMEM225 Gene

Aliases for TMEM225 Gene

  • Transmembrane Protein 225 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 154 2 3
  • Spermatogenesis Associated 47 2 3
  • PMP22CD 3 4
  • PMP22 Claudin Domain-Containing Protein 3
  • PMP22 Claudin Domain Containing 2
  • PPP1R154 3
  • SPATA47 3

External Ids for TMEM225 Gene

Previous GeneCards Identifiers for TMEM225 Gene

  • GC11M123260
  • GC11M123753
  • GC11M119693

Summaries for TMEM225 Gene

GeneCards Summary for TMEM225 Gene

TMEM225 (Transmembrane Protein 225) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM225 Gene

  • Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM225 Gene

Genomics for TMEM225 Gene

Regulatory Elements for TMEM225 Gene

Enhancers for TMEM225 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G124241 0.4 FANTOM5 79.3 -355.6 -355590 0.1 NFE2 TMEM225 SPA17 VWA5A OR8G5 OR8G1
GH11G123773 0.9 ENCODE dbSUPER 10.3 +109.4 109431 4.6 CHD7 ETS1 JUND ZNF316 POLR2A BCL11A SMARCA4 POU5F1 EMSY MAFK ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 RNU1-21P LOC105369544
GH11G123740 1.4 FANTOM5 ENCODE 5.9 +143.6 143577 3.8 HNRNPUL1 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 ZNF202 OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P OR4D5 TMEM225 OR6T1 OR8D4
GH11G123821 0.5 ENCODE 9.8 +63.0 63027 1.5 PBX2 CEBPB CEBPG TMEM225 GC11M123818 OR6M1
GH11G123799 0.6 ENCODE 7.9 +85.0 85027 3.1 CTCF MXI1 RAD51 POLR2A SMARCA4 EP300 ZNF202 TMEM225 LOC105369544 OR6M1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM225 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM225 Gene

Chromosome:
11
Start:
123,882,920 bp from pter
End:
123,885,650 bp from pter
Size:
2,731 bases
Orientation:
Minus strand

Genomic View for TMEM225 Gene

Genes around TMEM225 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM225 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM225 Gene

Proteins for TMEM225 Gene

  • Protein details for TMEM225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GV28-TM225_HUMAN
    Recommended name:
    Transmembrane protein 225
    Protein Accession:
    Q6GV28

    Protein attributes for TMEM225 Gene

    Size:
    225 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    • Interacts (via RVxF motif) with PPP1CC.

neXtProt entry for TMEM225 Gene

Post-translational modifications for TMEM225 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM225 Gene

No data available for DME Specific Peptides for TMEM225 Gene

Domains & Families for TMEM225 Gene

Gene Families for TMEM225 Gene

Protein Domains for TMEM225 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM225 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM225: view

No data available for UniProtKB/Swiss-Prot for TMEM225 Gene

Function for TMEM225 Gene

Molecular function for TMEM225 Gene

UniProtKB/Swiss-Prot Function:
Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.

Phenotypes for TMEM225 Gene

GenomeRNAi human phenotypes for TMEM225:
genes like me logo Genes that share phenotypes with TMEM225: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM225 Gene

Localization for TMEM225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM225 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM225 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TMEM225: view

Pathways & Interactions for TMEM225 Gene

SuperPathways for TMEM225 Gene

No Data Available

Interacting Proteins for TMEM225 Gene

Selected Interacting proteins: Q6GV28-TM225_HUMAN for TMEM225 Gene via IID

Symbol External ID(s) Details
PPP1CA

Gene Ontology (GO) - Biological Process for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA,IEA 19389623
genes like me logo Genes that share ontologies with TMEM225: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM225 Gene

Drugs & Compounds for TMEM225 Gene

No Compound Related Data Available

Transcripts for TMEM225 Gene

mRNA/cDNA for TMEM225 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM225 Gene

Transmembrane protein 225:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM225 Gene

No ASD Table

Relevant External Links for TMEM225 Gene

GeneLoc Exon Structure for
TMEM225
ECgene alternative splicing isoforms for
TMEM225

Expression for TMEM225 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM225 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM225 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for TMEM225 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM225 Gene



Protein tissue co-expression partners for TMEM225 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM225 Gene:

TMEM225

SOURCE GeneReport for Unigene cluster for TMEM225 Gene:

Hs.98377
genes like me logo Genes that share expression patterns with TMEM225: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM225 Gene

Orthologs for TMEM225 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM225 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM225 34 35
  • 97.78 (n)
dog
(Canis familiaris)
Mammalia TMEM225 34 35
  • 72.92 (n)
cow
(Bos Taurus)
Mammalia TMEM225 34 35
  • 69.96 (n)
mouse
(Mus musculus)
Mammalia Tmem225 34 16 35
  • 66.07 (n)
rat
(Rattus norvegicus)
Mammalia Tmem225 34
  • 65.62 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM225 35
  • 25 (a)
OneToOne
Species where no ortholog for TMEM225 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM225 Gene

ENSEMBL:
Gene Tree for TMEM225 (if available)
TreeFam:
Gene Tree for TMEM225 (if available)

Paralogs for TMEM225 Gene

No data available for Paralogs for TMEM225 Gene

Variants for TMEM225 Gene

Sequence variations from dbSNP and Humsavar for TMEM225 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000561039 -- 123,883,725(+) CTGTA(C/T)TCCCA intron-variant
rs1001158022 -- 123,887,655(+) TGTGC(A/G)TGTCA upstream-variant-2KB
rs1001357645 -- 123,886,481(+) ATACA(C/T)TTAAT upstream-variant-2KB, utr-variant-5-prime
rs1001646877 -- 123,888,370(+) TTTGA(G/T)TTCAC upstream-variant-2KB
rs1001808686 -- 123,885,275(+) ATCAT(-/C)CCAAG intron-variant, reference, frameshift-variant

Variation tolerance for TMEM225 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM225 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM225

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM225 Gene

Disorders for TMEM225 Gene

Relevant External Links for TMEM225

Genetic Association Database (GAD)
TMEM225
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM225

No disorders were found for TMEM225 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM225 Gene

Publications for TMEM225 Gene

  1. TMEM225: a possible protein phosphatase 1I^2 (PP1I^2) regulator localizes to the equatorial segment in mouse spermatozoa. (PMID: 25605614) Matsuura M. … Yogo K. (Mol. Reprod. Dev. 2015) 2 3 64
  2. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3 64
  3. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3 64
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64

Products for TMEM225 Gene

Sources for TMEM225 Gene

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