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Aliases for TMEM225 Gene

Aliases for TMEM225 Gene

  • Transmembrane Protein 225 2 3
  • PMP22CD 3 4
  • Protein Phosphatase 1, Regulatory Subunit 154 3
  • PMP22 Claudin Domain-Containing Protein 3
  • PMP22 Claudin Domain Containing 2
  • Regulatory Subunit 154 2
  • Protein Phosphatase 1 2
  • PPP1R154 3

External Ids for TMEM225 Gene

Previous GeneCards Identifiers for TMEM225 Gene

  • GC11M123260
  • GC11M123753
  • GC11M119693

Summaries for TMEM225 Gene

GeneCards Summary for TMEM225 Gene

TMEM225 (Transmembrane Protein 225) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM225 Gene

Genomics for TMEM225 Gene

Regulatory Elements for TMEM225 Gene

Genomic Location for TMEM225 Gene

123,882,920 bp from pter
123,885,650 bp from pter
2,731 bases
Minus strand

Genomic View for TMEM225 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM225 Gene

Proteins for TMEM225 Gene

  • Protein details for TMEM225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 225
    Protein Accession:

    Protein attributes for TMEM225 Gene

    225 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM225 Gene

Proteomics data for TMEM225 Gene at MOPED

Post-translational modifications for TMEM225 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM225 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM225 Gene

Domains & Families for TMEM225 Gene

Gene Families for TMEM225 Gene

Protein Domains for TMEM225 Gene


Suggested Antigen Peptide Sequences for TMEM225 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM225: view

No data available for UniProtKB/Swiss-Prot for TMEM225 Gene

Function for TMEM225 Gene

Phenotypes for TMEM225 Gene

GenomeRNAi human phenotypes for TMEM225:
genes like me logo Genes that share phenotypes with TMEM225: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM225 Gene

Localization for TMEM225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM225 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM225: view

No data available for Subcellular locations from COMPARTMENTS for TMEM225 Gene

Pathways & Interactions for TMEM225 Gene

SuperPathways for TMEM225 Gene

No Data Available

Interacting Proteins for TMEM225 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000364166 for TMEM225 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with TMEM225: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM225 Gene

Drugs & Compounds for TMEM225 Gene

No Compound Related Data Available

Transcripts for TMEM225 Gene

mRNA/cDNA for TMEM225 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM225 Gene

Transmembrane protein 225:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM225

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM225 Gene

No ASD Table

Relevant External Links for TMEM225 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM225 Gene

mRNA expression in normal human tissues for TMEM225 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM225 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for TMEM225 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM225 Gene

SOURCE GeneReport for Unigene cluster for TMEM225 Gene Hs.98377

genes like me logo Genes that share expression patterns with TMEM225: view

Protein tissue co-expression partners for TMEM225 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM225 Gene

Orthologs for TMEM225 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM225 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM225 35
  • 69.96 (n)
  • 47.09 (a)
TMEM225 36
  • 44 (a)
(Canis familiaris)
Mammalia TMEM225 35
  • 72.92 (n)
  • 54.91 (a)
TMEM225 36
  • 54 (a)
(Mus musculus)
Mammalia Tmem225 35
  • 66.07 (n)
  • 47.3 (a)
Tmem225 16
Tmem225 36
  • 44 (a)
(Pan troglodytes)
Mammalia TMEM225 35
  • 97.78 (n)
  • 94.22 (a)
TMEM225 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Tmem225 35
  • 65.62 (n)
  • 45.95 (a)
(Monodelphis domestica)
Mammalia TMEM225 36
  • 25 (a)
Species with no ortholog for TMEM225:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM225 Gene

Gene Tree for TMEM225 (if available)
Gene Tree for TMEM225 (if available)

Paralogs for TMEM225 Gene

No data available for Paralogs for TMEM225 Gene

Variants for TMEM225 Gene

Sequence variations from dbSNP and Humsavar for TMEM225 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs728177 -- 123,885,012(-) CTGGG(A/C)ATTTG intron-variant
rs728178 -- 123,884,893(-) ATTGC(A/G)GTATT intron-variant
rs1054041 -- 123,882,979(-) CTGAA(C/T)GAATA utr-variant-3-prime
rs1939926 -- 123,886,129(-) ATGAT(G/T)GTCCA upstream-variant-2KB
rs1939927 - 123,883,230(-) CAGAA(C/T)GCACT missense, reference

Variation tolerance for TMEM225 Gene

Residual Variation Intolerance Score: 84.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM225 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM225 Gene

Disorders for TMEM225 Gene

Relevant External Links for TMEM225

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM225: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM225 Gene

Publications for TMEM225 Gene

  1. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 67
  2. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 67
  3. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 67

Products for TMEM225 Gene

Sources for TMEM225 Gene

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