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Aliases for TMEM223 Gene

Aliases for TMEM223 Gene

  • Transmembrane Protein 223 2 3 5

External Ids for TMEM223 Gene

Previous GeneCards Identifiers for TMEM223 Gene

  • GC11M062315
  • GC11M062557
  • GC11M058886
  • GC11M062540

Summaries for TMEM223 Gene

GeneCards Summary for TMEM223 Gene

TMEM223 (Transmembrane Protein 223) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM223 Gene

Genomics for TMEM223 Gene

Regulatory Elements for TMEM223 Gene

Promoters for TMEM223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM223 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM223 Gene

Chromosome:
11
Start:
62,771,629 bp from pter
End:
62,792,021 bp from pter
Size:
20,393 bases
Orientation:
Minus strand

Genomic View for TMEM223 Gene

Genes around TMEM223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM223 Gene

Proteins for TMEM223 Gene

  • Protein details for TMEM223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJW6-TM223_HUMAN
    Recommended name:
    Transmembrane protein 223
    Protein Accession:
    A0PJW6
    Secondary Accessions:
    • Q504S0
    • Q86YD4
    • Q8WUC5
    • Q96HG0

    Protein attributes for TMEM223 Gene

    Size:
    202 amino acids
    Molecular mass:
    22049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20914.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM223 Gene

Proteomics data for TMEM223 Gene at MOPED

Post-translational modifications for TMEM223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM223 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM223 Gene

Domains & Families for TMEM223 Gene

Protein Domains for TMEM223 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PJW6

UniProtKB/Swiss-Prot:

TM223_HUMAN :
  • Belongs to the TMEM223 family.
Family:
  • Belongs to the TMEM223 family.
genes like me logo Genes that share domains with TMEM223: view

No data available for Gene Families for TMEM223 Gene

Function for TMEM223 Gene

Phenotypes for TMEM223 Gene

genes like me logo Genes that share phenotypes with TMEM223: view

Animal Model Products

CRISPR Products

miRNA for TMEM223 Gene

miRTarBase miRNAs that target TMEM223

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM223 Gene

Localization for TMEM223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM223 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM223 Gene COMPARTMENTS Subcellular localization image for TMEM223 gene
Compartment Confidence
mitochondrion 3
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMEM223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with TMEM223: view

Pathways & Interactions for TMEM223 Gene

SuperPathways for TMEM223 Gene

No Data Available

Interacting Proteins for TMEM223 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303987%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000354762%0d%0a9606.ENSP00000360671%0d%0a
Selected Interacting proteins: A0PJW6-TM223_HUMAN ENSP00000303987 for TMEM223 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TMEM223 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM223 Gene

Drugs & Compounds for TMEM223 Gene

No Compound Related Data Available

Transcripts for TMEM223 Gene

Unigene Clusters for TMEM223 Gene

Transmembrane protein 223:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM223 Gene

No ASD Table

Relevant External Links for TMEM223 Gene

GeneLoc Exon Structure for
TMEM223
ECgene alternative splicing isoforms for
TMEM223

Expression for TMEM223 Gene

mRNA expression in normal human tissues for TMEM223 Gene

Protein differential expression in normal tissues from HIPED for TMEM223 Gene

This gene is overexpressed in Urine (40.3) and Bone (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM223 Gene



SOURCE GeneReport for Unigene cluster for TMEM223 Gene Hs.530463

genes like me logo Genes that share expression patterns with TMEM223: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM223 Gene

Orthologs for TMEM223 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM223 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM223 35
  • 82.34 (n)
  • 79.21 (a)
TMEM223 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM223 35
  • 83 (n)
  • 77.72 (a)
TMEM223 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM223 35
  • 99.67 (n)
  • 99.01 (a)
TMEM223 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911695 35
  • 99.83 (n)
  • 99.5 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM223 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem223 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM223 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem223 35
  • 55.97 (n)
  • 48.66 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem223 35
  • 51.42 (n)
  • 48.94 (a)
tmem223 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005148 35
  • 47.54 (n)
  • 39.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12935 35
  • 46.29 (n)
  • 37.14 (a)
CG12935 36
  • 29 (a)
OneToOne
Species with no ortholog for TMEM223:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM223 Gene

ENSEMBL:
Gene Tree for TMEM223 (if available)
TreeFam:
Gene Tree for TMEM223 (if available)

Paralogs for TMEM223 Gene

(1) SIMAP similar genes for TMEM223 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM223: view

No data available for Paralogs for TMEM223 Gene

Variants for TMEM223 Gene

Sequence variations from dbSNP and Humsavar for TMEM223 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_039357 -
VAR_039358 -
rs481272 -- 62,791,235(-) GCGCC(A/G)TGCCC intron-variant
rs11231220 -- 62,791,407(+) cgctt(A/G)ctacc intron-variant
rs115969060 -- 62,791,607(+) ACTCT(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM223 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
nsv897624 CNV Loss 21882294

Variation tolerance for TMEM223 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM223 Gene

HapMap Linkage Disequilibrium report
TMEM223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM223 Gene

Disorders for TMEM223 Gene

Relevant External Links for TMEM223

Genetic Association Database (GAD)
TMEM223
Human Genome Epidemiology (HuGE) Navigator
TMEM223
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM223

No disorders were found for TMEM223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM223 Gene

Publications for TMEM223 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K. … Suzuki Y. (Genome Res. 2007) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for TMEM223 Gene

Sources for TMEM223 Gene

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