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Aliases for TMEM223 Gene

Aliases for TMEM223 Gene

  • Transmembrane Protein 223 2 3 5

External Ids for TMEM223 Gene

Previous GeneCards Identifiers for TMEM223 Gene

  • GC11M062315
  • GC11M062557
  • GC11M058886
  • GC11M062540
  • GC11M062772

Summaries for TMEM223 Gene

GeneCards Summary for TMEM223 Gene

TMEM223 (Transmembrane Protein 223) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM223 Gene

Genomics for TMEM223 Gene

Regulatory Elements for TMEM223 Gene

Enhancers for TMEM223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G062790 1.1 ENCODE 8.3 +0.3 313 2.8 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 BSCL2 SNHG1 TMEM223 PIR49413
GH11G062785 1.2 ENCODE 7.4 +4.9 4911 2.6 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D TAF6L SNHG1 METTL12 RTN3 TMEM223 TMEM179B WDR74 ENSG00000269176
GH11G062852 1.8 FANTOM5 ENCODE dbSUPER 4.6 -63.8 -63817 5.9 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 SNHG1 MTA2 EML3 STX5 NXF1 TMEM179B INTS5 METTL12 LOC105369332 TTC9C
GH11G062851 1.2 Ensembl ENCODE 6.8 -59.8 -59837 1.6 HNRNPUL1 PKNOX1 FOXA2 ARNT AGO1 SIN3A NSD2 TCF12 PAF1 REST SNHG1 TMEM223 TMEM179B GC11M062910 SNORD22 GC11M062842 WDR74 RNU2-2P
GH11G062887 1.5 Ensembl ENCODE dbSUPER 5.2 -97.7 -97739 4.0 PKNOX1 MLX ARID4B DMAP1 TCF12 ZNF121 DEK PAF1 NCOA1 PPARG BSCL2 TAF6L SLC3A2 SNHG1 SNORD28 SNORD22 SLC22A6 AHNAK TTC9C TMEM223
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM223 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040475 421 1201 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TMEM223 Gene

Chromosome:
11
Start:
62,771,629 bp from pter
End:
62,792,021 bp from pter
Size:
20,393 bases
Orientation:
Minus strand

Genomic View for TMEM223 Gene

Genes around TMEM223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM223 Gene

Proteins for TMEM223 Gene

  • Protein details for TMEM223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJW6-TM223_HUMAN
    Recommended name:
    Transmembrane protein 223
    Protein Accession:
    A0PJW6
    Secondary Accessions:
    • Q504S0
    • Q86YD4
    • Q8WUC5
    • Q96HG0

    Protein attributes for TMEM223 Gene

    Size:
    202 amino acids
    Molecular mass:
    22049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20914.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM223 Gene

Post-translational modifications for TMEM223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM223 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM223 Gene

Domains & Families for TMEM223 Gene

Protein Domains for TMEM223 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PJW6

UniProtKB/Swiss-Prot:

TM223_HUMAN :
  • Belongs to the TMEM223 family.
Family:
  • Belongs to the TMEM223 family.
genes like me logo Genes that share domains with TMEM223: view

No data available for Gene Families for TMEM223 Gene

Function for TMEM223 Gene

Phenotypes for TMEM223 Gene

genes like me logo Genes that share phenotypes with TMEM223: view

Animal Model Products

CRISPR Products

miRNA for TMEM223 Gene

miRTarBase miRNAs that target TMEM223

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM223 Gene

Localization for TMEM223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM223 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM223 gene
Compartment Confidence
mitochondrion 3
plasma membrane 2
nucleus 2
extracellular 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM223: view

Pathways & Interactions for TMEM223 Gene

SuperPathways for TMEM223 Gene

No Data Available

Interacting Proteins for TMEM223 Gene

Gene Ontology (GO) - Biological Process for TMEM223 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM223 Gene

Drugs & Compounds for TMEM223 Gene

No Compound Related Data Available

Transcripts for TMEM223 Gene

Unigene Clusters for TMEM223 Gene

Transmembrane protein 223:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM223 Gene

No ASD Table

Relevant External Links for TMEM223 Gene

GeneLoc Exon Structure for
TMEM223
ECgene alternative splicing isoforms for
TMEM223

Expression for TMEM223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM223 Gene

Protein differential expression in normal tissues from HIPED for TMEM223 Gene

This gene is overexpressed in Urine (40.3) and Bone (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM223 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM223 Gene:

TMEM223

SOURCE GeneReport for Unigene cluster for TMEM223 Gene:

Hs.530463

Evidence on tissue expression from TISSUES for TMEM223 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with TMEM223: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM223 Gene

Orthologs for TMEM223 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM223 Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia LOC100911695 34
  • 99.83 (n)
chimpanzee
(Pan troglodytes)
Mammalia TMEM223 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia TMEM223 34 35
  • 83 (n)
cow
(Bos Taurus)
Mammalia TMEM223 34 35
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Tmem223 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM223 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM223 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem223 34
  • 55.97 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem223 34 35
  • 51.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005148 34
  • 47.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12935 34 35
  • 46.29 (n)
Species where no ortholog for TMEM223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM223 Gene

ENSEMBL:
Gene Tree for TMEM223 (if available)
TreeFam:
Gene Tree for TMEM223 (if available)

Paralogs for TMEM223 Gene

(1) SIMAP similar genes for TMEM223 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM223: view

No data available for Paralogs for TMEM223 Gene

Variants for TMEM223 Gene

Sequence variations from dbSNP and Humsavar for TMEM223 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000374223 -- 62,791,454(+) GGGTT(G/T)GACGG intron-variant
rs1001757888 -- 62,791,581(+) CGCCA(A/C)TCTCG intron-variant
rs1002808637 -- 62,792,751(+) AATGC(A/C)AGCTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1004119860 -- 62,790,931(+) GGCAG(A/C)GATTG intron-variant
rs1004324732 -- 62,790,697(+) CAAGA(A/G)GAAAT downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM223 Gene

Variant ID Type Subtype PubMed ID
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Variation tolerance for TMEM223 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM223 Gene

Disorders for TMEM223 Gene

Relevant External Links for TMEM223

Genetic Association Database (GAD)
TMEM223
Human Genome Epidemiology (HuGE) Navigator
TMEM223
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM223

No disorders were found for TMEM223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM223 Gene

Publications for TMEM223 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  4. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PMID: 17567985) Tsuritani K. … Suzuki Y. (Genome Res. 2007) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TMEM223 Gene

Sources for TMEM223 Gene

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