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Aliases for TMEM223 Gene

Aliases for TMEM223 Gene

  • Transmembrane Protein 223 2 3

External Ids for TMEM223 Gene

Previous GeneCards Identifiers for TMEM223 Gene

  • GC11M062315
  • GC11M062557
  • GC11M058886
  • GC11M062540

Summaries for TMEM223 Gene

GeneCards Summary for TMEM223 Gene

TMEM223 (Transmembrane Protein 223) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM223 Gene

Genomics for TMEM223 Gene

Regulatory Elements for TMEM223 Gene

Genomic Location for TMEM223 Gene

Start:
62,771,629 bp from pter
End:
62,792,021 bp from pter
Size:
20,393 bases
Orientation:
Minus strand

Genomic View for TMEM223 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM223 Gene

Proteins for TMEM223 Gene

  • Protein details for TMEM223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJW6-TM223_HUMAN
    Recommended name:
    Transmembrane protein 223
    Protein Accession:
    A0PJW6
    Secondary Accessions:
    • Q504S0
    • Q86YD4
    • Q8WUC5
    • Q96HG0

    Protein attributes for TMEM223 Gene

    Size:
    202 amino acids
    Molecular mass:
    22049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20914.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM223 Gene

Proteomics data for TMEM223 Gene at MOPED

Post-translational modifications for TMEM223 Gene

No Post-translational modifications

Other Protein References for TMEM223 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM223 Gene

Domains for TMEM223 Gene

Protein Domains for TMEM223 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PJW6

UniProtKB/Swiss-Prot:

TM223_HUMAN :
  • A0PJW6
Family:
  • Belongs to the TMEM223 family.
genes like me logo Genes that share domains with TMEM223: view

No data available for Gene Families for TMEM223 Gene

Function for TMEM223 Gene

miRNA for TMEM223 Gene

miRTarBase miRNAs that target TMEM223

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM223 Gene

Localization for TMEM223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM223 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM223 Gene COMPARTMENTS Subcellular localization image for TMEM223 gene
Compartment Confidence
mitochondrion 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM223: view

Pathways for TMEM223 Gene

SuperPathways for TMEM223 Gene

No Data Available

Interacting Proteins for TMEM223 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303987%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000354762%0d%0a9606.ENSP00000360671%0d%0a
Selected Interacting proteins: ENSP00000303987 A0PJW6-TM223_HUMAN for TMEM223 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM223 Gene

None

No data available for Pathways by source for TMEM223 Gene

Transcripts for TMEM223 Gene

mRNA/cDNA for TMEM223 Gene

Unigene Clusters for TMEM223 Gene

Transmembrane protein 223:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM223 Gene

No ASD Table

Relevant External Links for TMEM223 Gene

GeneLoc Exon Structure for
TMEM223
ECgene alternative splicing isoforms for
TMEM223

Expression for TMEM223 Gene

mRNA expression in normal human tissues for TMEM223 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM223 Gene

SOURCE GeneReport for Unigene cluster for TMEM223 Gene Hs.530463

genes like me logo Genes that share expressions with TMEM223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM223 Gene

Orthologs for TMEM223 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM223 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM223 35
  • 99.67 (n)
  • 99.01 (a)
TMEM223 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM223 35
  • 82.34 (n)
  • 79.21 (a)
TMEM223 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM223 35
  • 83 (n)
  • 77.72 (a)
TMEM223 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem223 16
Tmem223 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM223 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM223 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911695 35
  • 99.83 (n)
  • 99.5 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem223 35
  • 55.97 (n)
  • 48.66 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem223 35
  • 51.42 (n)
  • 48.94 (a)
tmem223 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005148 35
  • 47.54 (n)
  • 39.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12935 35
  • 46.29 (n)
  • 37.14 (a)
CG12935 36
  • 29 (a)
OneToOne
Species with no ortholog for TMEM223:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM223 Gene

ENSEMBL:
Gene Tree for TMEM223 (if available)
TreeFam:
Gene Tree for TMEM223 (if available)

Paralogs for TMEM223 Gene

Selected SIMAP similar genes for TMEM223 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM223: view

No data available for Paralogs for TMEM223 Gene

Variants for TMEM223 Gene

Sequence variations from dbSNP and Humsavar for TMEM223 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs481272 -- 62,791,235(-) GCGCC(A/G)TGCCC intron-variant
rs11231220 -- 62,791,407(+) cgctt(A/G)ctacc intron-variant
rs115547919 -- 62,791,536(+) CCGCG(C/G)CCGGC intron-variant
rs115969060 -- 62,791,607(+) ACTCT(C/T)CCTGC intron-variant
rs138663947 -- 62,791,444(+) AGTAG(-/AC)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM223 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
nsv897624 CNV Loss 21882294

Relevant External Links for TMEM223 Gene

HapMap Linkage Disequilibrium report
TMEM223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM223 Gene

Disorders for TMEM223 Gene

Relevant External Links for TMEM223

Genetic Association Database (GAD)
TMEM223
Human Genome Epidemiology (HuGE) Navigator
TMEM223
genes like me logo Genes that share disorders with TMEM223: view

No data available for UniProtKB/Swiss-Prot for TMEM223 Gene

Publications for TMEM223 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for TMEM223 Gene

Sources for TMEM223 Gene

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