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Aliases for TMEM222 Gene

Aliases for TMEM222 Gene

  • Transmembrane Protein 222 2 3
  • C1orf160 3 4
  • Chromosome 1 Open Reading Frame 160 2

External Ids for TMEM222 Gene

Previous HGNC Symbols for TMEM222 Gene

  • C1orf160

Previous GeneCards Identifiers for TMEM222 Gene

  • GC01P027523
  • GC01P027648
  • GC01P025904

Summaries for TMEM222 Gene

GeneCards Summary for TMEM222 Gene

TMEM222 (Transmembrane Protein 222) is a Protein Coding gene.

Gene Wiki entry for TMEM222 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM222 Gene

Genomics for TMEM222 Gene

Regulatory Elements for TMEM222 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM222 Gene

27,322,145 bp from pter
27,336,400 bp from pter
14,256 bases
Plus strand

Genomic View for TMEM222 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM222 Gene

Proteins for TMEM222 Gene

  • Protein details for TMEM222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 222
    Protein Accession:
    Secondary Accessions:
    • D3DPL6
    • Q53HD8
    • Q5FVE9

    Protein attributes for TMEM222 Gene

    208 amino acids
    Molecular mass:
    23230 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB66618.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM222 Gene


neXtProt entry for TMEM222 Gene

Proteomics data for TMEM222 Gene at MOPED

Post-translational modifications for TMEM222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM222 Gene

Domains for TMEM222 Gene

Protein Domains for TMEM222 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM222: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM222 Gene

Function for TMEM222 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM222

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM222 Gene

Localization for TMEM222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM222 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM222 Gene COMPARTMENTS Subcellular localization image for TMEM222 gene
Compartment Confidence
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM222: view

Pathways for TMEM222 Gene

SuperPathways for TMEM222 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM222 Gene


No data available for Pathways by source for TMEM222 Gene

Transcripts for TMEM222 Gene

Unigene Clusters for TMEM222 Gene

Transmembrane protein 222:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM222

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM222 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for TMEM222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM222 Gene

mRNA expression in normal human tissues for TMEM222 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM222 Gene

SOURCE GeneReport for Unigene cluster for TMEM222 Gene Hs.469171

genes like me logo Genes that share expressions with TMEM222: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM222 Gene

Orthologs for TMEM222 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM222 36
  • 96 (a)
(Bos Taurus)
Mammalia TMEM222 35
  • 93.75 (n)
  • 98.21 (a)
TMEM222 36
  • 90 (a)
(Canis familiaris)
Mammalia TMEM222 35
  • 91.19 (n)
  • 95.19 (a)
TMEM222 36
  • 95 (a)
(Mus musculus)
Mammalia Tmem222 35
  • 88.14 (n)
  • 94.23 (a)
Tmem222 16
Tmem222 36
  • 94 (a)
(Monodelphis domestica)
Mammalia TMEM222 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Tmem222 35
  • 89.9 (n)
  • 95.19 (a)
(Gallus gallus)
Aves TMEM222 35
  • 79.33 (n)
  • 84.36 (a)
TMEM222 36
  • 75 (a)
(Anolis carolinensis)
Reptilia TMEM222 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem222 35
  • 67.22 (n)
  • 71.27 (a)
(Danio rerio)
Actinopterygii tmem222a 35
  • 72.03 (n)
  • 70.69 (a)
tmem222a 36
  • 60 (a)
tmem222b 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012042 35
  • 62.24 (n)
  • 60.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8372 35
  • 68.96 (n)
  • 60.62 (a)
CG8372 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea H20J04.6 35
  • 58.61 (n)
  • 54.9 (a)
H20J04.6 36
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RTH 35
  • 49.51 (n)
  • 42.11 (a)
(Oryza sativa)
Liliopsida Os03g0799500 35
  • 53.91 (n)
  • 45.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14692 35
Species with no ortholog for TMEM222:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM222 Gene

Gene Tree for TMEM222 (if available)
Gene Tree for TMEM222 (if available)

Paralogs for TMEM222 Gene

No data available for Paralogs for TMEM222 Gene

Variants for TMEM222 Gene

Sequence variations from dbSNP and Humsavar for TMEM222 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9203 -- 27,336,175(-) CTGAG(C/T)GCTGT utr-variant-3-prime, nc-transcript-variant
rs1134721 -- 27,329,248(-) TGGTA(A/C)ATAAG intron-variant
rs3813792 -- 27,335,744(+) TTCCC(G/T)CTGTA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs3934805 -- 27,327,344(+) ATATC(G/T)GAGCA intron-variant
rs4131279 -- 27,332,659(-) ACACT(G/T)ATGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM222 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680

Relevant External Links for TMEM222 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM222 Gene

Disorders for TMEM222 Gene

No disorders were found for TMEM222 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM222 Gene

Publications for TMEM222 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for TMEM222 Gene

Sources for TMEM222 Gene

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