Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM222 Gene

Aliases for TMEM222 Gene

  • Transmembrane Protein 222 2 3 5
  • C1orf160 3 4
  • Chromosome 1 Open Reading Frame 160 2

External Ids for TMEM222 Gene

Previous HGNC Symbols for TMEM222 Gene

  • C1orf160

Previous GeneCards Identifiers for TMEM222 Gene

  • GC01P027523
  • GC01P027648
  • GC01P025904

Summaries for TMEM222 Gene

GeneCards Summary for TMEM222 Gene

TMEM222 (Transmembrane Protein 222) is a Protein Coding gene.

Gene Wiki entry for TMEM222 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM222 Gene

Genomics for TMEM222 Gene

Regulatory Elements for TMEM222 Gene

Enhancers for TMEM222 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM222 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM222 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM222 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM222 Gene

Chromosome:
1
Start:
27,322,145 bp from pter
End:
27,336,400 bp from pter
Size:
14,256 bases
Orientation:
Plus strand

Genomic View for TMEM222 Gene

Genes around TMEM222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM222 Gene

Proteins for TMEM222 Gene

  • Protein details for TMEM222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R3-TM222_HUMAN
    Recommended name:
    Transmembrane protein 222
    Protein Accession:
    Q9H0R3
    Secondary Accessions:
    • D3DPL6
    • Q53HD8
    • Q5FVE9

    Protein attributes for TMEM222 Gene

    Size:
    208 amino acids
    Molecular mass:
    23230 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66618.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM222 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM222 Gene

Proteomics data for TMEM222 Gene at MOPED

Post-translational modifications for TMEM222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM222 Gene

Domains & Families for TMEM222 Gene

Protein Domains for TMEM222 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM222: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM222 Gene

Function for TMEM222 Gene

genes like me logo Genes that share phenotypes with TMEM222: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM222

CRISPR Products

miRNA for TMEM222 Gene

miRTarBase miRNAs that target TMEM222

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM222 Gene

Localization for TMEM222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM222 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM222 Gene COMPARTMENTS Subcellular localization image for TMEM222 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM222 Gene

Pathways & Interactions for TMEM222 Gene

SuperPathways for TMEM222 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM222 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM222 Gene

Drugs & Compounds for TMEM222 Gene

No Compound Related Data Available

Transcripts for TMEM222 Gene

Unigene Clusters for TMEM222 Gene

Transmembrane protein 222:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM222 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for TMEM222 Gene

GeneLoc Exon Structure for
TMEM222
ECgene alternative splicing isoforms for
TMEM222

Expression for TMEM222 Gene

mRNA expression in normal human tissues for TMEM222 Gene

Protein differential expression in normal tissues from HIPED for TMEM222 Gene

This gene is overexpressed in Frontal cortex (12.8), Peripheral blood mononuclear cells (8.6), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM222 Gene



SOURCE GeneReport for Unigene cluster for TMEM222 Gene Hs.469171

genes like me logo Genes that share expression patterns with TMEM222: view

Protein tissue co-expression partners for TMEM222 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM222 Gene

Orthologs for TMEM222 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM222 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM222 35
  • 93.75 (n)
  • 98.21 (a)
TMEM222 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM222 35
  • 91.19 (n)
  • 95.19 (a)
TMEM222 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem222 35
  • 88.14 (n)
  • 94.23 (a)
Tmem222 16
Tmem222 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem222 35
  • 89.9 (n)
  • 95.19 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM222 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM222 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM222 35
  • 79.33 (n)
  • 84.36 (a)
TMEM222 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM222 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem222 35
  • 67.22 (n)
  • 71.27 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem222a 35
  • 72.03 (n)
  • 70.69 (a)
tmem222a 36
  • 60 (a)
OneToMany
tmem222b 36
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012042 35
  • 62.24 (n)
  • 60.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8372 35
  • 68.96 (n)
  • 60.62 (a)
CG8372 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H20J04.6 36
  • 50 (a)
OneToOne
H20J04.6 35
  • 58.61 (n)
  • 54.9 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RTH 35
  • 49.51 (n)
  • 42.11 (a)
rice
(Oryza sativa)
Liliopsida Os03g0799500 35
  • 53.91 (n)
  • 45.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14692 35
Species with no ortholog for TMEM222:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM222 Gene

ENSEMBL:
Gene Tree for TMEM222 (if available)
TreeFam:
Gene Tree for TMEM222 (if available)

Paralogs for TMEM222 Gene

No data available for Paralogs for TMEM222 Gene

Variants for TMEM222 Gene

Sequence variations from dbSNP and Humsavar for TMEM222 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9203 -- 27,336,175(-) CTGAG(C/T)GCTGT nc-transcript-variant, utr-variant-3-prime
rs1134721 -- 27,329,248(-) TGGTA(A/C)ATAAG intron-variant
rs3813792 -- 27,335,744(+) TTCCC(G/T)CTGTA nc-transcript-variant, utr-variant-3-prime
rs4539159 -- 27,335,216(-) TGGGC(A/G)TGGTT intron-variant
rs4131279 -- 27,332,659(-) ACACT(G/T)ATGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM222 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680

Variation tolerance for TMEM222 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM222 Gene

HapMap Linkage Disequilibrium report
TMEM222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM222 Gene

Disorders for TMEM222 Gene

Relevant External Links for TMEM222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM222

No disorders were found for TMEM222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM222 Gene

Publications for TMEM222 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for TMEM222 Gene

Sources for TMEM222 Gene

Content