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Aliases for TMEM221 Gene

Aliases for TMEM221 Gene

  • Transmembrane Protein 221 2 3 5

External Ids for TMEM221 Gene

Previous GeneCards Identifiers for TMEM221 Gene

  • GC19M017409
  • GC19M017547
  • GC19M017112

Summaries for TMEM221 Gene

GeneCards Summary for TMEM221 Gene

TMEM221 (Transmembrane Protein 221) is a Protein Coding gene. An important paralog of this gene is ENSG00000269035.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM221 Gene

Genomics for TMEM221 Gene

Regulatory Elements for TMEM221 Gene

Enhancers for TMEM221 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F017441 0.9 Ensembl ENCODE 16.9 +6.8 6846 1.2 CBX3 PKNOX1 ZFP64 RAD21 RFX5 ZNF138 FOS ZNF362 ZNF654 NFYA ENSG00000268743 TMEM221 ENSG00000269578 C19orf44 ENSG00000267904 ENSG00000268087 ENSG00000269481
GH19F017507 0.6 Ensembl ENCODE 12.1 -61.6 -61609 5.6 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000269427 TMEM221 SMIM7 ENSG00000268199 ANO8 ENSG00000268743 PGLS PIR43275
GH19F017748 0.4 ENCODE 12 -300.1 -300095 0.3 HDGF PKNOX1 ATF1 CREB3L1 SIN3A YY1 SLC30A9 ELK1 ZNF143 KLF7 PLVAP TMEM221 MVB12A FCHO1 LOC105372299
GH19F017859 0.5 ENCODE 11.9 -414.2 -414163 7.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MVB12A ENSG00000268030 RPL18A ENSG00000268938 PLVAP TMEM221 PGLS ENSG00000268199 ENSG00000269815 UPF1
GH19F018168 1.2 FANTOM5 ENCODE 11.9 -723.3 -723263 7.4 MLX CREB3L1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000268030 ENSG00000268938 MVB12A UPF1 ENSG00000269191 COLGALT1 MPV17L2 KXD1 LRRC25 IFI30
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM221 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM221 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001816507 159 1000 HDAC1 RAD21 ZNF121 GLIS2 ZNF366 SP3 ZFP69B ZNF341 GLIS1 ZBTB33

Genomic Location for TMEM221 Gene

Chromosome:
19
Start:
17,435,509 bp from pter
End:
17,448,660 bp from pter
Size:
13,152 bases
Orientation:
Minus strand

Genomic View for TMEM221 Gene

Genes around TMEM221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM221 Gene

Proteins for TMEM221 Gene

  • Protein details for TMEM221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGB7-TM221_HUMAN
    Recommended name:
    Transmembrane protein 221
    Protein Accession:
    A6NGB7

    Protein attributes for TMEM221 Gene

    Size:
    291 amino acids
    Molecular mass:
    30293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM221 Gene

Post-translational modifications for TMEM221 Gene

No Post-translational modifications

Other Protein References for TMEM221 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM221 Gene

Domains & Families for TMEM221 Gene

Protein Domains for TMEM221 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM221 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM221: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM221 Gene

Function for TMEM221 Gene

Phenotypes for TMEM221 Gene

GenomeRNAi human phenotypes for TMEM221:
genes like me logo Genes that share phenotypes with TMEM221: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM221 Gene

Localization for TMEM221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM221 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM221 Gene COMPARTMENTS Subcellular localization image for TMEM221 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM221: view

Pathways & Interactions for TMEM221 Gene

SuperPathways for TMEM221 Gene

No Data Available

Interacting Proteins for TMEM221 Gene

Gene Ontology (GO) - Biological Process for TMEM221 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM221 Gene

Transcripts for TMEM221 Gene

mRNA/cDNA for TMEM221 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM221 Gene

Transmembrane protein 221:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM221 Gene

No ASD Table

Relevant External Links for TMEM221 Gene

GeneLoc Exon Structure for
TMEM221
ECgene alternative splicing isoforms for
TMEM221

Expression for TMEM221 Gene

mRNA expression in normal human tissues for TMEM221 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM221 Gene

This gene is overexpressed in Ovary (x10.7) and Adrenal Gland (x5.9).

Protein differential expression in normal tissues from HIPED for TMEM221 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM221 Gene



Protein tissue co-expression partners for TMEM221 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM221 Gene:

TMEM221

SOURCE GeneReport for Unigene cluster for TMEM221 Gene:

Hs.436603
genes like me logo Genes that share expression patterns with TMEM221: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM221 Gene

Orthologs for TMEM221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM221 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM221 34
  • 90.08 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
OneToMany
TMEM221 34
  • 86.83 (n)
cow
(Bos Taurus)
Mammalia TMEM221 34
  • 82.7 (n)
-- 35
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem221 34
  • 77.13 (n)
mouse
(Mus musculus)
Mammalia Tmem221 34 16 35
  • 76.23 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TMEM221 35
  • 34 (a)
OneToMany
Species where no ortholog for TMEM221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM221 Gene

ENSEMBL:
Gene Tree for TMEM221 (if available)
TreeFam:
Gene Tree for TMEM221 (if available)

Paralogs for TMEM221 Gene

Paralogs for TMEM221 Gene

genes like me logo Genes that share paralogs with TMEM221: view

Variants for TMEM221 Gene

Sequence variations from dbSNP and Humsavar for TMEM221 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1035872 -- 17,436,046(-) CATTT(C/T)ACAGA intron-variant, utr-variant-3-prime
rs10401315 -- 17,449,079(+) CGGGA(A/G)GCTGA upstream-variant-2KB
rs10402771 -- 17,449,015(+) cgtct(C/T)tacta upstream-variant-2KB
rs10647002 -- 17,446,196(+) CCATC(-/CATT)CATCC intron-variant
rs111274113 -- 17,435,166(+) AACCC(A/G)TCTCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM221 Gene

Variant ID Type Subtype PubMed ID
nsv833768 CNV loss 17160897

Variation tolerance for TMEM221 Gene

Gene Damage Index Score: 1.97; 36.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM221

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM221 Gene

Disorders for TMEM221 Gene

Relevant External Links for TMEM221

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM221

No disorders were found for TMEM221 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM221 Gene

Publications for TMEM221 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM221 Gene

Sources for TMEM221 Gene

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