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Aliases for TMEM221 Gene

Aliases for TMEM221 Gene

  • Transmembrane Protein 221 2 3 5

External Ids for TMEM221 Gene

Previous GeneCards Identifiers for TMEM221 Gene

  • GC19M017409
  • GC19M017547
  • GC19M017112

Summaries for TMEM221 Gene

GeneCards Summary for TMEM221 Gene

TMEM221 (Transmembrane Protein 221) is a Protein Coding gene. An important paralog of this gene is ENSG00000269035.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM221 Gene

Genomics for TMEM221 Gene

Regulatory Elements for TMEM221 Gene

Promoters for TMEM221 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM221 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM221 Gene

17,435,509 bp from pter
17,448,660 bp from pter
13,152 bases
Minus strand

Genomic View for TMEM221 Gene

Genes around TMEM221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM221 Gene

Proteins for TMEM221 Gene

  • Protein details for TMEM221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 221
    Protein Accession:

    Protein attributes for TMEM221 Gene

    291 amino acids
    Molecular mass:
    30293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM221 Gene

Proteomics data for TMEM221 Gene at MOPED

Post-translational modifications for TMEM221 Gene

No Post-translational modifications

Other Protein References for TMEM221 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM221 Gene

Domains & Families for TMEM221 Gene

Protein Domains for TMEM221 Gene


Suggested Antigen Peptide Sequences for TMEM221 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM221: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM221 Gene

Function for TMEM221 Gene

Phenotypes for TMEM221 Gene

GenomeRNAi human phenotypes for TMEM221:
genes like me logo Genes that share phenotypes with TMEM221: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM221 Gene

Localization for TMEM221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM221 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM221 Gene COMPARTMENTS Subcellular localization image for TMEM221 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM221 Gene

Pathways & Interactions for TMEM221 Gene

SuperPathways for TMEM221 Gene

No Data Available

Interacting Proteins for TMEM221 Gene

Gene Ontology (GO) - Biological Process for TMEM221 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM221 Gene

Drugs & Compounds for TMEM221 Gene

No Compound Related Data Available

Transcripts for TMEM221 Gene

mRNA/cDNA for TMEM221 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM221 Gene

Transmembrane protein 221:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM221 Gene

No ASD Table

Relevant External Links for TMEM221 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM221 Gene

mRNA expression in normal human tissues for TMEM221 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM221 Gene

This gene is overexpressed in Ovary (x10.7) and Adrenal Gland (x5.9).

Protein differential expression in normal tissues from HIPED for TMEM221 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM221 Gene

SOURCE GeneReport for Unigene cluster for TMEM221 Gene Hs.436603

genes like me logo Genes that share expression patterns with TMEM221: view

Protein tissue co-expression partners for TMEM221 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM221 Gene

Orthologs for TMEM221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM221 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM221 35
  • 90.08 (n)
  • 87.6 (a)
(Bos Taurus)
Mammalia TMEM221 35
  • 82.7 (n)
  • 80.76 (a)
-- 36
  • 81 (a)
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
TMEM221 35
  • 86.83 (n)
  • 86.94 (a)
(Mus musculus)
Mammalia Tmem221 35
  • 76.23 (n)
  • 75.22 (a)
Tmem221 36
  • 75 (a)
Tmem221 16
(Rattus norvegicus)
Mammalia Tmem221 35
  • 77.13 (n)
  • 73.45 (a)
(Gallus gallus)
Aves -- 36
  • 48 (a)
(Danio rerio)
Actinopterygii TMEM221 36
  • 34 (a)
Species with no ortholog for TMEM221:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM221 Gene

Gene Tree for TMEM221 (if available)
Gene Tree for TMEM221 (if available)

Paralogs for TMEM221 Gene

Paralogs for TMEM221 Gene

genes like me logo Genes that share paralogs with TMEM221: view

Variants for TMEM221 Gene

Sequence variations from dbSNP and Humsavar for TMEM221 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2364557 -- 17,444,811(+) atata(G/T)ttttt intron-variant
rs1035872 -- 17,436,046(-) CATTT(C/T)ACAGA intron-variant, utr-variant-3-prime
rs3810209 -- 17,445,245(+) GCCAC(A/G)TGTCT reference, synonymous-codon
rs7250963 -- 17,435,886(+) CACAG(C/G)CCGAG utr-variant-3-prime
rs8101151 -- 17,444,118(+) ccctt(C/G)ttgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM221 Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
nsv911201 CNV Loss 21882294
dgv3761n71 CNV Loss 21882294
nsv911203 CNV Loss 21882294
nsv911205 CNV Loss 21882294

Variation tolerance for TMEM221 Gene

Gene Damage Index Score: 1.97; 36.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM221 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM221 Gene

Disorders for TMEM221 Gene

Relevant External Links for TMEM221

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM221 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM221 Gene

Publications for TMEM221 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM221 Gene

Sources for TMEM221 Gene

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