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Aliases for TMEM221 Gene

Aliases for TMEM221 Gene

  • Transmembrane Protein 221 2 3

External Ids for TMEM221 Gene

Summaries for TMEM221 Gene

GeneCards Summary for TMEM221 Gene

TMEM221 (Transmembrane Protein 221) is a Protein Coding gene. An important paralog of this gene is ENSG00000269035.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM221 Gene

Genomics for TMEM221 Gene

Genomic Location for TMEM221 Gene

Start:
17,435,509 bp from pter
End:
17,448,567 bp from pter
Size:
13,059 bases
Orientation:
Minus strand

Genomic View for TMEM221 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM221 Gene

Regulatory Elements for TMEM221 Gene

Proteins for TMEM221 Gene

  • Protein details for TMEM221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGB7-TM221_HUMAN
    Recommended name:
    Transmembrane protein 221
    Protein Accession:
    A6NGB7
    Secondary Accessions:

    Protein attributes for TMEM221 Gene

    Size:
    291 amino acids
    Molecular mass:
    30293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM221 Gene

Proteomics data for TMEM221 Gene at MOPED

Post-translational modifications for TMEM221 Gene

No Post-translational modifications

Other Protein References for TMEM221 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM221 Gene

Domains for TMEM221 Gene

Protein Domains for TMEM221 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM221: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM221 Gene

Function for TMEM221 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM221 Gene

Localization for TMEM221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM221 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM221 Gene COMPARTMENTS Subcellular localization image for TMEM221 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM221: view

Pathways for TMEM221 Gene

SuperPathways for TMEM221 Gene

No Data Available

Interacting Proteins for TMEM221 Gene

Gene Ontology (GO) - Biological Process for TMEM221 Gene

None

No data available for Pathways by source for TMEM221 Gene

Transcripts for TMEM221 Gene

mRNA/cDNA for TMEM221 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM221 Gene

Transmembrane protein 221:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM221 Gene

No ASD Table

Relevant External Links for TMEM221 Gene

GeneLoc Exon Structure for
TMEM221
ECgene alternative splicing isoforms for
TMEM221

Expression for TMEM221 Gene

mRNA expression in normal human tissues for TMEM221 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM221 Gene

This gene is overexpressed in Ovary (10.7) and Adrenal Gland (5.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM221 Gene

SOURCE GeneReport for Unigene cluster for TMEM221 Gene Hs.436603

genes like me logo Genes that share expressions with TMEM221: view

Orthologs for TMEM221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM221 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM221 36
  • 90.08 (n)
  • 87.6 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 81 (a)
OneToMany
TMEM221 36
  • 82.7 (n)
  • 80.76 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 87 (a)
OneToMany
TMEM221 36
  • 86.83 (n)
  • 86.94 (a)
mouse
(Mus musculus)
Mammalia Tmem221 36
  • 76.23 (n)
  • 75.22 (a)
Tmem221 16
Tmem221 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem221 36
  • 77.13 (n)
  • 73.45 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TMEM221 37
  • 34 (a)
OneToMany
Species with no ortholog for TMEM221:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM221 Gene

ENSEMBL:
Gene Tree for TMEM221 (if available)
TreeFam:
Gene Tree for TMEM221 (if available)

Paralogs for TMEM221 Gene

Paralogs for TMEM221 Gene

genes like me logo Genes that share paralogs with TMEM221: view

Variants for TMEM221 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM221 Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
nsv911201 CNV Loss 21882294
dgv3761n71 CNV Loss 21882294
nsv911203 CNV Loss 21882294
nsv911205 CNV Loss 21882294

Relevant External Links for TMEM221 Gene

HapMap Linkage Disequilibrium report
TMEM221

No data available for Sequence variations from dbSNP and Humsavar for TMEM221 Gene

Disorders for TMEM221 Gene

No disorders were found for TMEM221 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM221 Gene

Publications for TMEM221 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM221 Gene

Sources for TMEM221 Gene

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