Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM220 Gene

Aliases for TMEM220 Gene

  • Transmembrane Protein 220 2 3 5

External Ids for TMEM220 Gene

Previous GeneCards Identifiers for TMEM220 Gene

  • GC17M010558
  • GC17M010516
  • GC17M010616

Summaries for TMEM220 Gene

GeneCards Summary for TMEM220 Gene

TMEM220 (Transmembrane Protein 220) is a Protein Coding gene.

Additional gene information for TMEM220 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM220 Gene

Genomics for TMEM220 Gene

GeneHancer (GH) Regulatory Elements for TMEM220 Gene

Promoters and enhancers for TMEM220 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I010728 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 589.4 +0.2 174 3.6 RB1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF548 THAP11 EGR2 TMEM220 TMEM220-AS1 ADPRM ENSG00000261433 MAGOH2P
GH17I010723 Enhancer 1 ENCODE dbSUPER 19 +4.5 4455 4 FOXA2 MLX MAX ZNF644 RAD21 RARA YY1 GATA3 HNF4G NR2F6 ADPRM TMEM220 MYH3 TMEM220-AS1 MAGOH2P
GH17I010732 Enhancer 0.4 ENCODE dbSUPER 37.8 -3.5 -3503 2.3 ADPRM TMEM220 SCO1 MYH3 TMEM220-AS1 ENSG00000240813
GH17I010736 Enhancer 1 ENCODE dbSUPER 11.8 -8.0 -8029 3.7 ELF3 FOXA2 KLF17 THRB RAD21 RARA YY1 ZNF366 ZNF143 ZNF654 TMEM220 RNU6-1065P RPL15P21 SCO1 ADPRM MYH3 TMEM220-AS1 ENSG00000264016 ENSG00000240813
GH17I010784 Enhancer 0.7 ENCODE dbSUPER 6.8 -55.9 -55894 3.4 CTBP1 HLF DPF2 FOS ADPRM RNU6-1065P RPL15P21 MYH3 SCO1 TMEM220 TMEM220-AS1 ENSG00000266114 GC17M010779
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM220 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM220 gene promoter:

Genomic Locations for TMEM220 Gene

Genomic Locations for TMEM220 Gene
chr17:10,699,015-10,730,329
(GRCh38/hg38)
Size:
31,315 bases
Orientation:
Minus strand
chr17:10,602,332-10,633,646
(GRCh37/hg19)

Genomic View for TMEM220 Gene

Genes around TMEM220 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM220 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM220 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM220 Gene

Proteins for TMEM220 Gene

  • Protein details for TMEM220 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QAJ8-TM220_HUMAN
    Recommended name:
    Transmembrane protein 220
    Protein Accession:
    Q6QAJ8
    Secondary Accessions:
    • A1YRJ4
    • B2RNE4
    • B4DJ52
    • B9EGW3

    Protein attributes for TMEM220 Gene

    Size:
    160 amino acids
    Molecular mass:
    17754 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM220 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM220 Gene

Post-translational modifications for TMEM220 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM220 Gene

Domains & Families for TMEM220 Gene

Gene Families for TMEM220 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM220 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM220 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM220: view

No data available for UniProtKB/Swiss-Prot for TMEM220 Gene

Function for TMEM220 Gene

Phenotypes From GWAS Catalog for TMEM220 Gene

genes like me logo Genes that share phenotypes with TMEM220: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM220 Gene

Localization for TMEM220 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM220 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM220 gene
Compartment Confidence
plasma membrane 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM220 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM220: view

Pathways & Interactions for TMEM220 Gene

SuperPathways for TMEM220 Gene

No Data Available

Interacting Proteins for TMEM220 Gene

Gene Ontology (GO) - Biological Process for TMEM220 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM220 Gene

Drugs & Compounds for TMEM220 Gene

No Compound Related Data Available

Transcripts for TMEM220 Gene

Unigene Clusters for TMEM220 Gene

Transmembrane protein 220:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM220 Gene

No ASD Table

Relevant External Links for TMEM220 Gene

GeneLoc Exon Structure for
TMEM220
ECgene alternative splicing isoforms for
TMEM220

Expression for TMEM220 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM220 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM220 Gene

This gene is overexpressed in Liver (x7.8).

Protein differential expression in normal tissues from HIPED for TMEM220 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM220 Gene



Protein tissue co-expression partners for TMEM220 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM220 Gene:

TMEM220

SOURCE GeneReport for Unigene cluster for TMEM220 Gene:

Hs.462230

Evidence on tissue expression from TISSUES for TMEM220 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TMEM220: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM220 Gene

Orthologs for TMEM220 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM220 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM220 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia TMEM220 33 34
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Tmem220 33 16 34
  • 82.6 (n)
rat
(Rattus norvegicus)
Mammalia Tmem220 33
  • 81.34 (n)
cow
(Bos Taurus)
Mammalia TMEM220 33 34
  • 80.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM220 34
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM220 34
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM220 33 34
  • 69.68 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM220 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem220 33
  • 61.94 (n)
Str.11850 33
zebrafish
(Danio rerio)
Actinopterygii LOC100536710 33
  • 52.14 (n)
TMEM220 34
  • 38 (a)
OneToOne
Species where no ortholog for TMEM220 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM220 Gene

ENSEMBL:
Gene Tree for TMEM220 (if available)
TreeFam:
Gene Tree for TMEM220 (if available)

Paralogs for TMEM220 Gene

Pseudogenes.org Pseudogenes for TMEM220 Gene

genes like me logo Genes that share paralogs with TMEM220: view

No data available for Paralogs for TMEM220 Gene

Variants for TMEM220 Gene

Sequence variations from dbSNP and Humsavar for TMEM220 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000033580 -- 10,729,953(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000274791 -- 10,729,786(-) C/A coding_sequence_variant, missense_variant
rs1000734270 -- 10,713,546(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000782246 -- 10,728,026(-) G/A intron_variant
rs1000787964 -- 10,719,622(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM220 Gene

Variant ID Type Subtype PubMed ID
esv2675560 CNV deletion 23128226
esv3639941 CNV loss 21293372
nsv1058835 CNV loss 25217958
nsv1063900 CNV gain 25217958
nsv1065819 CNV gain 25217958
nsv833367 CNV loss 17160897

Variation tolerance for TMEM220 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM220 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM220

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM220 Gene

Disorders for TMEM220 Gene

Additional Disease Information for TMEM220

No disorders were found for TMEM220 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM220 Gene

Publications for TMEM220 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. MAL and TMEM220 are novel DNA methylation markers in human gastric cancer. (PMID: 27329150) Choi B … Yang HK (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017) 3 58
  3. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. (PMID: 24068947) Brandler WM … Paracchini S (PLoS genetics 2013) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for TMEM220 Gene

Sources for TMEM220 Gene

Content
Loading form....