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Aliases for TMEM220 Gene

Aliases for TMEM220 Gene

  • Transmembrane Protein 220 2 3

External Ids for TMEM220 Gene

Previous GeneCards Identifiers for TMEM220 Gene

  • GC17M010558
  • GC17M010516
  • GC17M010616

Summaries for TMEM220 Gene

GeneCards Summary for TMEM220 Gene

TMEM220 (Transmembrane Protein 220) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM220 Gene

Genomics for TMEM220 Gene

Regulatory Elements for TMEM220 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM220 Gene

10,699,015 bp from pter
10,730,329 bp from pter
31,315 bases
Minus strand

Genomic View for TMEM220 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM220 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM220 Gene

Proteins for TMEM220 Gene

  • Protein details for TMEM220 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 220
    Protein Accession:
    Secondary Accessions:
    • A1YRJ4
    • B2RNE4
    • B4DJ52
    • B9EGW3

    Protein attributes for TMEM220 Gene

    160 amino acids
    Molecular mass:
    17754 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM220 Gene


neXtProt entry for TMEM220 Gene

Proteomics data for TMEM220 Gene at MOPED

Post-translational modifications for TMEM220 Gene

No Post-translational modifications

Other Protein References for TMEM220 Gene

No data available for DME Specific Peptides for TMEM220 Gene

Domains for TMEM220 Gene

Protein Domains for TMEM220 Gene


Suggested Antigen Peptide Sequences for TMEM220 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM220: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM220 Gene

Function for TMEM220 Gene

Phenotypes for TMEM220 Gene

GenomeRNAi human phenotypes for TMEM220:
genes like me logo Genes that share phenotypes with TMEM220: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM220 Gene

Localization for TMEM220 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM220 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM220 Gene COMPARTMENTS Subcellular localization image for TMEM220 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM220 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM220: view

Pathways for TMEM220 Gene

SuperPathways for TMEM220 Gene

No Data Available

Interacting Proteins for TMEM220 Gene

Gene Ontology (GO) - Biological Process for TMEM220 Gene


No data available for Pathways by source for TMEM220 Gene

Transcripts for TMEM220 Gene

Unigene Clusters for TMEM220 Gene

Transmembrane protein 220:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM220

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM220

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM220 Gene

No ASD Table

Relevant External Links for TMEM220 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM220 Gene

mRNA expression in normal human tissues for TMEM220 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM220 Gene

This gene is overexpressed in Liver (7.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM220 Gene

SOURCE GeneReport for Unigene cluster for TMEM220 Gene Hs.462230

genes like me logo Genes that share expressions with TMEM220: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM220 Gene

Orthologs for TMEM220 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM220 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM220 35
  • 99.37 (n)
  • 99.37 (a)
TMEM220 36
  • 99 (a)
(Bos Taurus)
Mammalia TMEM220 35
  • 80.71 (n)
  • 77.36 (a)
TMEM220 36
  • 73 (a)
(Canis familiaris)
Mammalia TMEM220 35
  • 85.27 (n)
  • 78.99 (a)
TMEM220 36
  • 65 (a)
(Mus musculus)
Mammalia Tmem220 35
  • 82.6 (n)
  • 77.99 (a)
Tmem220 16
Tmem220 36
  • 65 (a)
(Monodelphis domestica)
Mammalia TMEM220 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM220 36
  • 51 (a)
(Rattus norvegicus)
Mammalia Tmem220 35
  • 81.34 (n)
  • 79.25 (a)
(Gallus gallus)
Aves TMEM220 35
  • 69.68 (n)
  • 66.45 (a)
TMEM220 36
  • 62 (a)
(Anolis carolinensis)
Reptilia TMEM220 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11850 35
tmem220 35
  • 61.94 (n)
  • 57.42 (a)
(Danio rerio)
Actinopterygii LOC100536710 35
  • 52.14 (n)
  • 41.03 (a)
TMEM220 36
  • 38 (a)
Species with no ortholog for TMEM220:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM220 Gene

Gene Tree for TMEM220 (if available)
Gene Tree for TMEM220 (if available)

Paralogs for TMEM220 Gene Pseudogenes for TMEM220 Gene

genes like me logo Genes that share paralogs with TMEM220: view

No data available for Paralogs for TMEM220 Gene

Variants for TMEM220 Gene

Sequence variations from dbSNP and Humsavar for TMEM220 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs365271 -- 10,721,073(-) tcata(C/T)atatg intron-variant
rs367351 -- 10,721,072(-) catat(A/G)tatgt intron-variant
rs368500 -- 10,713,593(-) CCTTT(A/G)GTATT utr-variant-3-prime
rs369095 -- 10,718,783(-) gacca(C/T)ggtgc intron-variant
rs374034 -- 10,714,413(-) AGTAA(C/T)CCTAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM220 Gene

Variant ID Type Subtype PubMed ID
nsv907682 CNV Gain 21882294
nsv833367 CNV Loss 17160897
esv2675560 CNV Deletion 23128226

Relevant External Links for TMEM220 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM220 Gene

Disorders for TMEM220 Gene

Relevant External Links for TMEM220

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TMEM220: view

No data available for UniProtKB/Swiss-Prot for TMEM220 Gene

Publications for TMEM220 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. (PMID: 24068947) Brandler W.M. … Paracchini S. (PLoS Genet. 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM220 Gene

Sources for TMEM220 Gene

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