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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM219 Gene

protein-coding   GIFtS: 37
GCID: GC16P029973

Transmembrane Protein 219

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2191 2 3
IGFBP-3R2 3
Insulin-Like Growth Factor Binding Protein-3 Receptor2
Insulin-Like Growth Factor-Binding Protein 3 Receptor2

External Ids:    HGNC: 252011   Entrez Gene: 1244462   Ensembl: ENSG000001499327   UniProtKB: Q86XT93   

Export aliases for TMEM219 gene to outside databases

Previous GC identifers: GC16P029880 GC16P027634


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM219 Gene: 
TMEM219 (transmembrane protein 219) is a protein-coding gene. Diseases associated with TMEM219 include prostate cancer, and prostatitis.

UniProtKB/Swiss-Prot: TM219_HUMAN, Q86XT9
Function: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM219 gene promoter:
         p53   GCNF   LUN-1   Cdc5   AREB6   CHOP-10   Pax-3   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM219 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM219

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM219


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TMEM219 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM219 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029973:  view genomic region     (about GC identifiers)

Start:
29,952,206 bp from pter      End:
29,984,373 bp from pter
Size:
32,168 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM219_HUMAN, Q86XT9 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 3 receptor precursor  
Size: 240 amino acids; 25724 Da
Subunit: Interacts with IGFBP3. Interacts with CASP8
Subcellular location: Cell membrane; Single-pass membrane protein
Secondary accessions: D5FK14 Q8WVV8

Explore the universe of human proteins at neXtProt for TMEM219: NX_Q86XT9

Explore proteomics data for TMEM219 at MOPED 

TMEM219 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM219 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001077082.1  NP_919256.1  

ENSEMBL proteins: 
 ENSP00000388485   ENSP00000473678   ENSP00000459732   ENSP00000456960   ENSP00000457492  
 ENSP00000459813   ENSP00000461124   ENSP00000454443   ENSP00000279396  

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Cloud-Clone Corp. Proteins for TMEM219 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

TMEM219 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q86XT9


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TM219_HUMAN, Q86XT9
Function: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding

Animal Models:

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM219 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM219

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process IEA--

TMEM219 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM219 (TM219)

Search CenterWatch for drugs/clinical trials and news about TMEM219 / TM219

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM219 gene (2 alternative transcripts): 
NM_001083613.1  NM_194280.3  

Unigene Cluster for TMEM219:

Transmembrane protein 219
Hs.460574  [show with all ESTs]
Unigene Representative Sequence: BM541945
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000414689(uc002duw.2) ENST00000602948 ENST00000575829 ENST00000561899
ENST00000566848 ENST00000570255(uc010bzl.1) ENST00000569445 ENST00000569481
ENST00000279396(uc002duy.2 uc010bzk.1)
miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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                     Customized lentivirus expression plasmids for stable overexpression of TMEM219 
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Additional mRNA sequence: 

BC031217.2 BC050051.1 FJ748884.1 

16 DOTS entries:

DT.448849  DT.95163339  DT.75112166  DT.100819092  DT.100800420  DT.100819086  DT.120697850  DT.100819085 
DT.120697841  DT.97768317  DT.100845157  DT.75127304  DT.100819089  DT.120695397  DT.120697545  DT.120695998 

24/284 AceView cDNA sequences (see all 284):

R06079 AA916824 CF453990 AI085888 H84185 CB529081 AA447814 BM915430 
AA235619 AI142945 AI028476 AI369290 AW303838 BE350039 BX403764 CB529578 
BF915540 CD674554 AA766077 AW511599 BF508776 BI833464 AA326907 AA302641 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM219    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1:                                                        -               
SP2:                                                                        
SP3:        -     -                                         -               
SP4:                                                                        
SP5:                                                                        


ECgene alternative splicing isoforms for TMEM219

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM219 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGCCTTGT
TMEM219 Expression
About this image


See TMEM219 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM219

SOURCE GeneReport for Unigene cluster: Hs.460574

UniProtKB/Swiss-Prot: TM219_HUMAN, Q86XT9
Tissue specificity: Widely expressed in normal tissues but suppressed in prostate and breast tumor

    SABiosciences Custom PCR Arrays for TMEM219
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM219

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TMEM219 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem2191 , 5 transmembrane protein 2191, 5 84.86(n)1
83.75(a)1
  7 (69.25 cM)5
687421  NM_026827.11  NP_081103.11 
 1268861715 


ENSEMBL Gene Tree for TMEM219 (if available)
TreeFam Gene Tree for TMEM219 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM219 gene
1 SIMAP similar gene for TMEM219 using alignment to 6 protein entries:     TM219_HUMAN (see all proteins):
TMEM248

TMEM219 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/229 SNPs in TMEM219 are shown (see all 229)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1896112511,2
--29971523(+) TTGCCC/TAGGCT 2 -- us2k10--------
rs1926462001,2
--29971533(+) TGGAGG/TGAAGT 2 -- us2k10--------
rs1473038771,2
--29971731(+) CGCCTC/TGGCCT 2 -- us2k10--------
rs1849865991,2
--29971769(+) GCCACC/TGTGCC 2 -- us2k10--------
rs1176730091,2
C,F--29971781(+) AGCCTG/ATTGTG 2 -- us2k11Minor allele frequency- A:0.03NA 120
rs1170774161,2
C,F--29971913(+) GAGGCG/AAGAGG 2 -- us2k11Minor allele frequency- A:0.07NA 120
rs1398424781,2
--29972250(+) GACCAC/TGAAGT 2 -- us2k10--------
rs1494855011,2
--29972361(+) ACTCGG/TAAGGC 2 -- us2k10--------
rs1896669841,2
--29972370(+) GCTGAA/GGCAGA 2 -- us2k10--------
rs1439483791,2
--29972399(+) GAGGCA/GGAGGT 2 -- us2k10--------

HapMap Linkage Disequilibrium report for TMEM219 (29952206 - 29984373 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TMEM219:    About this table     
Variant IDTypeSubtypePubMed ID
dgv2668n71CNV Loss21882294
nsv905717CNV Loss21882294
esv29470CNV Loss19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for TMEM219:    About MalaCards
prostate cancer    prostatitis


TMEM219 for disorders           About GeneDecksing


Export disorders for TMEM219 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM219 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM219)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel cell death receptor mediati ng IGFBP-3-induced anti-tumor effects in breast and prostate cancer. (PubMed id 20353938)1, 2 Ingermann A.R....Oh Y. (2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 124446 HGNC: 25201 AceView: LOC124446 Ensembl:ENSG00000149932 euGenes: HUgn124446
ECgene: TMEM219 H-InvDB: TMEM219

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM219 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM219 gene:
Search GeneIP for patents involving TMEM219

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM219
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM219
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM219
Customized:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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