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Aliases for TMEM219 Gene

Aliases for TMEM219 Gene

  • Transmembrane Protein 219 2 3 4 5
  • IGFBP-3R 3 4
  • Insulin-Like Growth Factor-Binding Protein 3 Receptor 3
  • Testicular Tissue Protein Li 203 3

External Ids for TMEM219 Gene

Previous GeneCards Identifiers for TMEM219 Gene

  • GC16P029880
  • GC16P027634

Summaries for TMEM219 Gene

GeneCards Summary for TMEM219 Gene

TMEM219 (Transmembrane Protein 219) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Death Genes.

UniProtKB/Swiss-Prot for TMEM219 Gene

  • Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM219 Gene

Genomics for TMEM219 Gene

Regulatory Elements for TMEM219 Gene

Enhancers for TMEM219 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F029961 0.2 ENCODE 12.6 +21.5 21503 2.5 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 INO80E ZNF764 ENSG00000260853 ENSG00000260367 ZNF747 ZNF785 SMG1P2 NPIPB13 BCL7C PRR14
GH16F029915 0.6 ENCODE 12.4 -25.1 -25133 1.3 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF207 DEK TMEM219 INO80E HIRIP3 YPEL3 DOC2A TAOK2 C16orf92 FAM57B MVP MIR762HG
GH16F029898 0.7 ENCODE 12.1 -40.3 -40338 3.8 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 CDIPT-AS1 ZNF785 ENSG00000260114 KCTD13 CA5AP1 CDIPT TMEM219 C16orf92 FAM57B DOC2A
GH16F029876 0.9 Ensembl ENCODE 11.9 -63.8 -63843 2.1 HDGF KLF1 PKNOX1 CBX3 ZMYM3 ZNF140 ZNF384 POLR2A NFYB PRDM10 MVP NPIPB13 ZNF764 SEZ6L2 ASPHD1 ZNF785 TMEM219 TAOK2 DOC2A ZNF747
GH16F029972 1.1 ENCODE 11.8 +34.7 34672 6.1 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NPIPB13 ZNF747 ZNF764 INO80E ENSG00000260367 ZNF785 SMG1P2 BCL7C NPIPB11 CDIPT
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM219 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM219 Gene

Chromosome:
16
Start:
29,940,885 bp from pter
End:
29,973,052 bp from pter
Size:
32,168 bases
Orientation:
Plus strand

Genomic View for TMEM219 Gene

Genes around TMEM219 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM219 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM219 Gene

Proteins for TMEM219 Gene

  • Protein details for TMEM219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XT9-TM219_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 3 receptor
    Protein Accession:
    Q86XT9
    Secondary Accessions:
    • D5FK14
    • Q8WVV8

    Protein attributes for TMEM219 Gene

    Size:
    240 amino acids
    Molecular mass:
    25724 Da
    Quaternary structure:
    • Interacts with IGFBP3. Interacts with CASP8.

neXtProt entry for TMEM219 Gene

Post-translational modifications for TMEM219 Gene

  • Glycosylation at Asn 73, Asn 101, and Asn 167

No data available for DME Specific Peptides for TMEM219 Gene

Domains & Families for TMEM219 Gene

Protein Domains for TMEM219 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM219: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM219 Gene

Function for TMEM219 Gene

Molecular function for TMEM219 Gene

UniProtKB/Swiss-Prot Function:
Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
genes like me logo Genes that share phenotypes with TMEM219: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM219 Gene

Localization for TMEM219 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM219 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM219 Gene COMPARTMENTS Subcellular localization image for TMEM219 gene
Compartment Confidence
plasma membrane 4
extracellular 3

Gene Ontology (GO) - Cellular Components for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM219: view

Pathways & Interactions for TMEM219 Gene

genes like me logo Genes that share pathways with TMEM219: view

Interacting Proteins for TMEM219 Gene

Selected Interacting proteins: Q86XT9-TM219_HUMAN for TMEM219 Gene via IID

Gene Ontology (GO) - Biological Process for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with TMEM219: view

No data available for SIGNOR curated interactions for TMEM219 Gene

Transcripts for TMEM219 Gene

Unigene Clusters for TMEM219 Gene

Transmembrane protein 219:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM219 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: - - -
SP4:
SP5:

Relevant External Links for TMEM219 Gene

GeneLoc Exon Structure for
TMEM219
ECgene alternative splicing isoforms for
TMEM219

Expression for TMEM219 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM219 Gene

This gene is overexpressed in Placenta (37.4) and Pancreas (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM219 Gene



Protein tissue co-expression partners for TMEM219 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM219 Gene:

TMEM219

SOURCE GeneReport for Unigene cluster for TMEM219 Gene:

Hs.460574

mRNA Expression by UniProt/SwissProt for TMEM219 Gene:

Q86XT9-TM219_HUMAN
Tissue specificity: Widely expressed in normal tissues but suppressed in prostate and breast tumor.
genes like me logo Genes that share expression patterns with TMEM219: view

Primer Products

No data available for mRNA differential expression in normal tissues for TMEM219 Gene

Orthologs for TMEM219 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM219 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM219 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia TMEM219 34 35
  • 90.42 (n)
cow
(Bos Taurus)
Mammalia TMEM219 34 35
  • 89.68 (n)
mouse
(Mus musculus)
Mammalia Tmem219 34 16 35
  • 84.86 (n)
rat
(Rattus norvegicus)
Mammalia Tmem219 34
  • 83.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM219 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM219 35
  • 58 (a)
OneToOne
Species where no ortholog for TMEM219 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM219 Gene

ENSEMBL:
Gene Tree for TMEM219 (if available)
TreeFam:
Gene Tree for TMEM219 (if available)

Paralogs for TMEM219 Gene

(1) SIMAP similar genes for TMEM219 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM219: view

No data available for Paralogs for TMEM219 Gene

Variants for TMEM219 Gene

Sequence variations from dbSNP and Humsavar for TMEM219 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10624125 -- 29,971,290(+) TAACA(-/TTTTCCC)ATTTT intron-variant
rs111485792 -- 29,967,031(+) ACCTT(C/T)TAATG intron-variant
rs111632120 -- 29,967,665(+) GCTCA(C/T)GCCTG intron-variant
rs111747400 -- 29,965,805(+) CGATC(C/T)CAGCT intron-variant
rs111888463 -- 29,960,789(+) TTTGA(C/T)TGTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM219 Gene

Variant ID Type Subtype PubMed ID
esv29470 CNV loss 19812545
esv3638377 CNV loss 21293372

Variation tolerance for TMEM219 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM219 Gene

Human Gene Mutation Database (HGMD)
TMEM219
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM219

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM219 Gene

Disorders for TMEM219 Gene

Relevant External Links for TMEM219

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM219

No disorders were found for TMEM219 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM219 Gene

Publications for TMEM219 Gene

  1. Identification of a novel cell death receptor mediating IGFBP-3- induced anti-tumor effects in breast and prostate cancer. (PMID: 20353938) Ingermann A.R. … Oh Y. (J. Biol. Chem. 2010) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM219 Gene

Sources for TMEM219 Gene

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