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Aliases for TMEM219 Gene

Aliases for TMEM219 Gene

  • Transmembrane Protein 219 2 3 4
  • IGFBP-3R 3 4
  • Insulin-Like Growth Factor Binding Protein-3 Receptor 3
  • Insulin-Like Growth Factor-Binding Protein 3 Receptor 3

External Ids for TMEM219 Gene

Summaries for TMEM219 Gene

GeneCards Summary for TMEM219 Gene

TMEM219 (Transmembrane Protein 219) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM219 Gene

  • Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM219 Gene

Genomics for TMEM219 Gene

Genomic Location for TMEM219 Gene

29,940,885 bp from pter
29,973,052 bp from pter
32,168 bases
Plus strand

Genomic View for TMEM219 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM219 Gene

Regulatory Elements for TMEM219 Gene

Proteins for TMEM219 Gene

  • Protein details for TMEM219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like growth factor-binding protein 3 receptor
    Protein Accession:
    Secondary Accessions:
    • D5FK14
    • Q8WVV8

    Protein attributes for TMEM219 Gene

    240 amino acids
    Molecular mass:
    25724 Da
    Quaternary structure:
    • Interacts with IGFBP3. Interacts with CASP8.

neXtProt entry for TMEM219 Gene

Proteomics data for TMEM219 Gene at MOPED

Post-translational modifications for TMEM219 Gene

  • Glycosylation at Asn73, Asn101, and Asn167

No data available for DME Specific Peptides for TMEM219 Gene

Domains for TMEM219 Gene

Protein Domains for TMEM219 Gene

genes like me logo Genes that share domains with TMEM219: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM219 Gene

Function for TMEM219 Gene

Molecular function for TMEM219 Gene

UniProtKB/Swiss-Prot Function: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM219 Gene

Localization for TMEM219 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM219 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM219 Gene COMPARTMENTS Subcellular localization image for TMEM219 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM219: view

Pathways for TMEM219 Gene

SuperPathways for TMEM219 Gene

No Data Available

Interacting Proteins for TMEM219 Gene

Gene Ontology (GO) - Biological Process for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TMEM219: view

No data available for Pathways by source for TMEM219 Gene

Transcripts for TMEM219 Gene

Unigene Clusters for TMEM219 Gene

Transmembrane protein 219:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM219 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP3: - - -

Relevant External Links for TMEM219 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM219 Gene

mRNA expression in normal human tissues for TMEM219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM219 Gene

SOURCE GeneReport for Unigene cluster for TMEM219 Gene Hs.460574

mRNA Expression by UniProt/SwissProt for TMEM219 Gene

Tissue specificity: Widely expressed in normal tissues but suppressed in prostate and breast tumor.
genes like me logo Genes that share expressions with TMEM219: view

Orthologs for TMEM219 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM219 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM219 36
  • 99.72 (n)
  • 99.58 (a)
TMEM219 37
  • 100 (a)
(Bos Taurus)
Mammalia TMEM219 36
  • 89.68 (n)
  • 88.7 (a)
TMEM219 37
  • 88 (a)
(Canis familiaris)
Mammalia TMEM219 36
  • 90.42 (n)
  • 92.08 (a)
TMEM219 37
  • 90 (a)
(Mus musculus)
Mammalia Tmem219 36
  • 84.86 (n)
  • 83.75 (a)
Tmem219 16
Tmem219 37
  • 84 (a)
(Monodelphis domestica)
Mammalia TMEM219 37
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM219 37
  • 58 (a)
(Rattus norvegicus)
Mammalia Tmem219 36
  • 83.54 (n)
  • 82.85 (a)
Species with no ortholog for TMEM219:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM219 Gene

Gene Tree for TMEM219 (if available)
Gene Tree for TMEM219 (if available)

Paralogs for TMEM219 Gene

Selected SIMAP similar genes for TMEM219 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM219: view

No data available for Paralogs for TMEM219 Gene

Variants for TMEM219 Gene

Sequence variations from dbSNP and Humsavar for TMEM219 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1131591 -- 29,962,813(+) ATCCT(C/T)GCCCC intron-variant, nc-transcript-variant
rs4787486 -- 29,966,241(+) tctgt(A/T)ttcat intron-variant
rs4788201 -- 29,961,369(+) ATGAT(C/T)CTCTT upstream-variant-2KB
rs4788202 -- 29,966,682(+) atggt(C/T)gtggg intron-variant
rs4788203 -- 29,967,506(+) CTCAG(A/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM219 Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294
esv29470 CNV Loss 19812545

Relevant External Links for TMEM219 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TMEM219 Gene

No disorders were found for TMEM219 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM219 Gene

Publications for TMEM219 Gene

  1. Identification of a novel cell death receptor mediating IGFBP-3- induced anti-tumor effects in breast and prostate cancer. (PMID: 20353938) Ingermann A.R. … Oh Y. (J. Biol. Chem. 2010) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM219 Gene

Sources for TMEM219 Gene

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