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Aliases for TMEM219 Gene

Aliases for TMEM219 Gene

  • Transmembrane Protein 219 2 3 4 5
  • IGFBP-3R 3 4
  • Insulin-Like Growth Factor Binding Protein-3 Receptor 3
  • Testicular Tissue Protein Li 203 3

External Ids for TMEM219 Gene

Previous GeneCards Identifiers for TMEM219 Gene

  • GC16P029880
  • GC16P027634

Summaries for TMEM219 Gene

GeneCards Summary for TMEM219 Gene

TMEM219 (Transmembrane Protein 219) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity.

UniProtKB/Swiss-Prot for TMEM219 Gene

  • Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM219 Gene

Genomics for TMEM219 Gene

Regulatory Elements for TMEM219 Gene

Genomic Location for TMEM219 Gene

Chromosome:
16
Start:
29,940,885 bp from pter
End:
29,973,052 bp from pter
Size:
32,168 bases
Orientation:
Plus strand

Genomic View for TMEM219 Gene

Genes around TMEM219 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM219 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM219 Gene

Proteins for TMEM219 Gene

  • Protein details for TMEM219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XT9-TM219_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 3 receptor
    Protein Accession:
    Q86XT9
    Secondary Accessions:
    • D5FK14
    • Q8WVV8

    Protein attributes for TMEM219 Gene

    Size:
    240 amino acids
    Molecular mass:
    25724 Da
    Quaternary structure:
    • Interacts with IGFBP3. Interacts with CASP8.

neXtProt entry for TMEM219 Gene

Proteomics data for TMEM219 Gene at MOPED

Post-translational modifications for TMEM219 Gene

  • Glycosylation at Asn 73, Asn 101, and Asn 167

No data available for DME Specific Peptides for TMEM219 Gene

Domains & Families for TMEM219 Gene

Protein Domains for TMEM219 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM219: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM219 Gene

Function for TMEM219 Gene

Molecular function for TMEM219 Gene

UniProtKB/Swiss-Prot Function:
Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
genes like me logo Genes that share phenotypes with TMEM219: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM219 Gene

Localization for TMEM219 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM219 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM219 Gene COMPARTMENTS Subcellular localization image for TMEM219 gene
Compartment Confidence
plasma membrane 4
extracellular 3

Gene Ontology (GO) - Cellular Components for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TMEM219: view

Pathways & Interactions for TMEM219 Gene

genes like me logo Genes that share pathways with TMEM219: view

Interacting Proteins for TMEM219 Gene

Gene Ontology (GO) - Biological Process for TMEM219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TMEM219: view

No data available for SIGNOR curated interactions for TMEM219 Gene

Drugs & Compounds for TMEM219 Gene

No Compound Related Data Available

Transcripts for TMEM219 Gene

Unigene Clusters for TMEM219 Gene

Transmembrane protein 219:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM219 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: - - -
SP4:
SP5:

Relevant External Links for TMEM219 Gene

GeneLoc Exon Structure for
TMEM219
ECgene alternative splicing isoforms for
TMEM219

Expression for TMEM219 Gene

mRNA expression in normal human tissues for TMEM219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM219 Gene

This gene is overexpressed in Placenta (37.4) and Pancreas (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM219 Gene



SOURCE GeneReport for Unigene cluster for TMEM219 Gene Hs.460574

mRNA Expression by UniProt/SwissProt for TMEM219 Gene

Q86XT9-TM219_HUMAN
Tissue specificity: Widely expressed in normal tissues but suppressed in prostate and breast tumor.
genes like me logo Genes that share expression patterns with TMEM219: view

Protein tissue co-expression partners for TMEM219 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMEM219 Gene

Orthologs for TMEM219 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM219 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM219 35
  • 99.72 (n)
  • 99.58 (a)
TMEM219 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM219 36
  • 88 (a)
OneToOne
TMEM219 35
  • 89.68 (n)
  • 88.7 (a)
dog
(Canis familiaris)
Mammalia TMEM219 35
  • 90.42 (n)
  • 92.08 (a)
TMEM219 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem219 36
  • 84 (a)
OneToOne
Tmem219 16
Tmem219 35
  • 84.86 (n)
  • 83.75 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM219 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM219 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem219 35
  • 83.54 (n)
  • 82.85 (a)
Species with no ortholog for TMEM219:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM219 Gene

ENSEMBL:
Gene Tree for TMEM219 (if available)
TreeFam:
Gene Tree for TMEM219 (if available)

Paralogs for TMEM219 Gene

(1) SIMAP similar genes for TMEM219 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM219: view

No data available for Paralogs for TMEM219 Gene

Variants for TMEM219 Gene

Sequence variations from dbSNP and Humsavar for TMEM219 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1131591 -- 29,962,813(+) ATCCT(C/T)GCCCC intron-variant, nc-transcript-variant
rs4787486 -- 29,966,241(+) tctgt(A/T)ttcat intron-variant
rs4788201 -- 29,961,369(+) ATGAT(C/T)CTCTT upstream-variant-2KB
rs4788202 -- 29,966,682(+) atggt(C/T)gtggg intron-variant
rs4788203 -- 29,967,506(+) CTCAG(A/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM219 Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294
esv29470 CNV Loss 19812545

Variation tolerance for TMEM219 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM219 Gene

HapMap Linkage Disequilibrium report
TMEM219
Human Gene Mutation Database (HGMD)
TMEM219

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM219 Gene

Disorders for TMEM219 Gene

Relevant External Links for TMEM219

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM219

No disorders were found for TMEM219 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM219 Gene

Publications for TMEM219 Gene

  1. Identification of a novel cell death receptor mediating IGFBP-3- induced anti-tumor effects in breast and prostate cancer. (PMID: 20353938) Ingermann A.R. … Oh Y. (J. Biol. Chem. 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM219 Gene

Sources for TMEM219 Gene

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