Aliases for TMEM219 Gene
Aliases for TMEM219 Gene
External Ids for TMEM219 Gene
- HGNC: 25201
- Entrez Gene: 124446
- Ensembl: ENSG00000149932
- UniProtKB: Q86XT9
Previous GeneCards Identifiers for TMEM219 Gene
- GC16P029880
- GC16P027634
Summaries for TMEM219 Gene
GeneCards Summary for TMEM219 Gene
TMEM219 (Transmembrane Protein 219) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Death Genes.
UniProtKB/Swiss-Prot for TMEM219 Gene
-
Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM219 Gene
Genomics for TMEM219 Gene
Regulatory Elements for TMEM219 Gene
Enhancers for TMEM219 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TMEM219 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TMEM219 Gene
- Chromosome:
- 16
- Start:
- 29,940,885 bp from pter
- End:
- 29,973,052 bp from pter
- Size:
- 32,168 bases
- Orientation:
- Plus strand
Genomic View for TMEM219 Gene
Genes around TMEM219 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
TMEM219 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM219 Gene
Proteins for TMEM219 Gene
-
Protein details for TMEM219 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86XT9-TM219_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein 3 receptor
- Protein Accession:
- Q86XT9
- D5FK14
- Q8WVV8
Protein attributes for TMEM219 Gene
- Size:
- 240 amino acids
- Molecular mass:
- 25724 Da
- Quaternary structure:
-
- Interacts with IGFBP3. Interacts with CASP8.
Protein Expression for TMEM219 Gene
Post-translational modifications for TMEM219 Gene
- Glycosylation at Asn 73, Asn 101, and Asn 167
Other Protein References for TMEM219 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TMEM219 (TMEM219)
- Novus Biologicals Antibodies for TMEM219
-
Abcam antibodies for TMEM219
- Invitrogen Antibodies for TMEM219
- Search GeneTex for Antibodies for TMEM219
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM219
- Origene Custom Protein Services for TMEM219
- Novus Biologicals proteins for TMEM219
- Search GeneTex for Proteins for TMEM219
Assay Products
No data available for DME Specific Peptides for TMEM219 Gene
Domains & Families for TMEM219 Gene
Protein Domains for TMEM219 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM219 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM219 Gene
Function for TMEM219 Gene
Molecular function for TMEM219 Gene
- UniProtKB/Swiss-Prot Function:
- Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
Phenotypes for TMEM219 Gene
- GenomeRNAi human phenotypes for TMEM219:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM219
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM219 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM219 gene
- Search ViGene Biosciences for TMEM219
CRISPR Products
-
OriGene CRISPR knockouts for TMEM219
- GenScript: Design CRISPR guide RNA sequences for TMEM219
miRNA Products
- Search ViGene Biosciences for TMEM219
Inhibitory RNA Products
- Origene RNAi, mouse_rna, siRNA, and shRNA products in human, mouse, rat for TMEM219
- Browse OriGene Inhibitory RNA Products For TMEM219
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM219 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TMEM219
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM219
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TMEM219
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM219 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM219 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM219 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM219 Gene
Localization for TMEM219 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM219 Gene
- Cell membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TMEM219 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | TP53 Regulates Transcription of Cell Death Genes | ||
| 3 | Regulation of TP53 Activity | ||
Pathways by source for TMEM219 Gene
Interacting Proteins for TMEM219 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0042981 | regulation of apoptotic process | TAS | -- |
No data available for SIGNOR curated interactions for TMEM219 Gene
Transcripts for TMEM219 Gene
mRNA/cDNA for TMEM219 Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (284) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM219 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM219
- GenScript: Design CRISPR guide RNA sequences for TMEM219
miRNA Products
- Search ViGene Biosciences for TMEM219
Inhibitory RNA Products
- Origene RNAi, mouse_rna, siRNA, and shRNA products in human, mouse, rat for TMEM219
- Browse OriGene Inhibitory RNA Products For TMEM219
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM219 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TMEM219
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM219
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: |
Expression for TMEM219 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Placenta (37.4) and Pancreas (31.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM219 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TMEM219 Gene:
TMEM219SOURCE GeneReport for Unigene cluster for TMEM219 Gene:
Hs.460574mRNA Expression by UniProt/SwissProt for TMEM219 Gene:
Q86XT9-TM219_HUMAN
Tissue specificity:
Widely expressed in normal tissues but suppressed in prostate and breast tumor.
Primer Products
-
OriGene qPCR primer pairs for TMEM219
-
OriGene qPCR primer pairs and template standards for TMEM219
No data available for mRNA differential expression in normal tissues for TMEM219 Gene
Orthologs for TMEM219 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM219 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TMEM219 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TMEM219 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Tmem219 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tmem219 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TMEM219 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM219 35 |
|
OneToOne |
- Species where no ortholog for TMEM219 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TMEM219 Gene
(1) SIMAP similar genes for TMEM219 Gene using alignment to 6 proteins:
No data available for Paralogs for TMEM219 Gene
Variants for TMEM219 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10624125 | -- | 29,971,290(+) | TAACA(-/TTTTCCC)ATTTT | intron-variant | |
| rs111485792 | -- | 29,967,031(+) | ACCTT(C/T)TAATG | intron-variant | |
| rs111632120 | -- | 29,967,665(+) | GCTCA(C/T)GCCTG | intron-variant | |
| rs111747400 | -- | 29,965,805(+) | CGATC(C/T)CAGCT | intron-variant | |
| rs111888463 | -- | 29,960,789(+) | TTTGA(C/T)TGTGC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3638377 | CNV | loss | 21293372 |
| esv29470 | CNV | loss | 19812545 |
Residual Variation Intolerance Score:
59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.62;
13.22% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TMEM219 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM219 Gene
Disorders for TMEM219 Gene
Relevant External Links for TMEM219
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TMEM219
No disorders were found for TMEM219 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM219 Gene
Publications for TMEM219 Gene
- Identification of a novel cell death receptor mediating IGFBP-3- induced anti-tumor effects in breast and prostate cancer. (PMID: 20353938) Ingermann A.R. … Oh Y. (J. Biol. Chem. 2010) 2 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for TMEM219 Gene
- R&D Systems Antibodies for TMEM219 (TMEM219)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM219
- Origene Custom Protein Services for TMEM219
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for TMEM219
- Browse OriGene Inhibitory RNA Products For TMEM219
- OriGene qPCR primer pairs and template standards for TMEM219
- OriGene qPCR primer pairs for TMEM219
- OriGene CRISPR knockouts for TMEM219
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMEM219
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TMEM219
- GenScript Custom Assay Services for TMEM219
- GenScript Custom overexpressing Cell Line Services for TMEM219
- GenScript: Design CRISPR guide RNA sequences for TMEM219
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TMEM219
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for TMEM219
- Novus Biologicals proteins for TMEM219
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for TMEM219 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM219 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM219 gene
- Search ViGene Biosciences for TMEM219
- Horizon Cell Lines for TMEM219
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM219
- VectorBuilder custom plasmid, inducible vectors for TMEM219
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM219
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TMEM219 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab