TMEM219 Gene
protein-coding GIFtS: 37
GCID: GC16P029973
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Transmembrane Protein 219
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Aliases
for TMEM219 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 2191 2 3 | | IGFBP-3R2 3 | | Insulin-Like Growth Factor Binding Protein-3 Receptor2 | | Insulin-Like Growth Factor-Binding Protein 3 Receptor2 |
Export aliases for TMEM219 gene to outside databasesPrevious GC identifers: GC16P029880 GC16P027634 |
Summaries
for TMEM219 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for TMEM219 Gene: 
TMEM219 (transmembrane protein 219) is a protein-coding gene. Diseases associated with TMEM219 include prostate cancer, and prostatitis.
UniProtKB/Swiss-Prot: TM219_HUMAN, Q86XT9Function: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding
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Genomic Views
for TMEM219 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NT_010393.16 NC_018927.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM219 gene promoter:
p53 GCNF LUN-1 Cdc5 AREB6 CHOP-10 Pax-3 GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM219
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM219 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2TMEM219 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P029973: view genomic region
(about GC identifiers)
Start:
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29,952,206 bp from pter |
End:
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29,984,373 bp from pter |
Size:
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32,168 bases |
Orientation:
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plus strand |
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Proteins
for TMEM219 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: TM219_HUMAN, Q86XT9 (See
protein sequence)Recommended Name: Insulin-like growth factor-binding protein 3 receptor precursor Size: 240 amino acids; 25724 Da
Subunit: Interacts with IGFBP3. Interacts with CASP8
Subcellular location: Cell membrane; Single-pass membrane protein
Secondary accessions: D5FK14 Q8WVV8Explore the universe of human proteins at neXtProt for TMEM219: NX_Q86XT9
Explore proteomics data for TMEM219 at MOPED
TMEM219 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001077082.1 NP_919256.1
ENSEMBL proteins: ENSP00000388485 ENSP00000473678 ENSP00000459732 ENSP00000456960 ENSP00000457492 ENSP00000459813 ENSP00000461124 ENSP00000454443 ENSP00000279396
Human Recombinant Protein Products for TMEM219:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM219 for ontologies About GeneDecksing
TMEM219 Antibody Products:
Assay Products for TMEM219: |
Protein
Domains /
Families
for TMEM219 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86XT9 |
Function
for TMEM219 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TM219_HUMAN, Q86XT9Function: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand bindingAnimal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TMEM219 | |  | Search LifeMap BioReagents cell lines for TMEM219 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM219 |
Pathways & Interactions
for TMEM219 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM219
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
IEA | -- |
TMEM219 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM219 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM219 (TM219)
Search CenterWatch for drugs/clinical trials and news about TMEM219 / TM219
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Transcripts
for TMEM219 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM219 gene (2 alternative transcripts): NM_001083613.1 NM_194280.3 Unigene Cluster for TMEM219: Transmembrane protein 219 Hs.460574 [show with all ESTs]Unigene Representative Sequence: BM5419459 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000414689(uc002duw.2) ENST00000602948 ENST00000575829 ENST00000561899
ENST00000566848 ENST00000570255(uc010bzl.1) ENST00000569445 ENST00000569481
ENST00000279396(uc002duy.2 uc010bzk.1)
Primer
Products: |  | OriGene qPCR primer pairs and template standards for TMEM219
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM219
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM219 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM219 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM219 |
Additional mRNA sequence: BC031217.2 BC050051.1 FJ748884.1 16 DOTS entries: DT.448849 DT.95163339 DT.75112166 DT.100819092 DT.100800420 DT.100819086 DT.120697850 DT.100819085 DT.120697841 DT.97768317 DT.100845157 DT.75127304 DT.100819089 DT.120695397 DT.120697545 DT.120695998 24/284 AceView cDNA sequences (see all 284): R06079 AA916824 CF453990 AI085888 H84185 CB529081 AA447814 BM915430 AA235619 AI142945 AI028476 AI369290 AW303838 BE350039 BX403764 CB529578 BF915540 CD674554 AA766077 AW511599 BF508776 BI833464 AA326907 AA302641
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM219 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM219
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Expression
for TMEM219 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM219 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGCCTTGT
About this image
See TMEM219 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM219
SOURCE GeneReport for Unigene cluster: Hs.460574
UniProtKB/Swiss-Prot: TM219_HUMAN, Q86XT9Tissue specificity: Widely expressed in normal tissues but suppressed in prostate and breast tumor
SABiosciences Custom PCR Arrays for TMEM219
Primer
Products: | | OriGene qPCR primer pairs and template standards for TMEM219
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM219
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM219 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM219 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM219 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM219 |
Orthologs
for TMEM219 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for TMEM219 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for TMEM219 (if available)
TreeFam Gene Tree for TMEM219 (if available) |
Paralogs
for TMEM219 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM219 gene
1 SIMAP similar gene for TMEM219 using alignment to 6 protein entries: TM219_HUMAN (see all proteins):TMEM248
TMEM219 for paralogs About GeneDecksing
|
Genomic Variants
for TMEM219 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM219 (29952206 - 29984373 bp)
Structural Variations
Database of Genomic Variants (DGV) 3 variations for TMEM219: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing TMEM219 |
|
Disorders
/ Diseases
for TMEM219 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| 2  diseases for TMEM219: About MalaCardsprostate cancer prostatitis
TMEM219 for disorders About GeneDecksing
Export disorders for TMEM219 gene to outside databases
|
Publications
for TMEM219 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM219 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM219) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel cell death receptor mediati ng IGFBP-3-induced anti-tumor effects in breast and prostate cancer. (PubMed id 20353938)1, 2 Ingermann A.R....Oh Y. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM219 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM219 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM219 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM219 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM219 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMEM219 gene:
Search GeneIP for patents involving TMEM219
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM219 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM219 | | | QIAGEN SeqTarget long-range PCR primers for resequencing TMEM219 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM219 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM219 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM219 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM219 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM219 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM219 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM219 |
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GeneCards Homepage -
Last full update: 23 Oct 2013 -
Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014
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