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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM218 Gene

protein-coding   GIFtS: 34
GCID: GC11M124966

Transmembrane Protein 218

  Search for TMEM218
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2181 2

External Ids:    HGNC: 273441   Entrez Gene: 2198542   Ensembl: ENSG000001504337   UniProtKB: A2RU143   

Export aliases for TMEM218 gene to outside databases

Previous GC identifers: GC11M124472 GC11M120908


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM218 Gene: 
TMEM218 (transmembrane protein 218) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM218 gene promoter:
         GR   Pbx1a   AML1a   GCNF   GR-beta   RORalpha1   CP2   GCNF-1   GR-alpha   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM218

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM218


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

TMEM218 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM218 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M124966:  view genomic region     (about GC identifiers)

Start:
124,966,398 bp from pter      End:
124,981,659 bp from pter
Size:
15,262 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM218_HUMAN, A2RU14 (See protein sequence)
Recommended Name: Transmembrane protein 218  
Size: 115 amino acids; 12459 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B7ZM48

Explore the universe of human proteins at neXtProt for TMEM218: NX_A2RU14

Explore proteomics data for TMEM218 at MOPED 

TMEM218 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM218 Protein Expression

REFSEQ proteins (11 alternative transcripts): 
NP_001074015.1  NP_001245167.1  NP_001245168.1  NP_001245169.1  NP_001245170.1  NP_001245171.1  NP_001245172.1  NP_001245173.1  
NP_001245174.1  NP_001245175.1  NP_001245176.1  

ENSEMBL proteins: 
 ENSP00000436596   ENSP00000436578   ENSP00000433023   ENSP00000434597   ENSP00000279968  
 ENSP00000436177   ENSP00000435526   ENSP00000432624   ENSP00000433374   ENSP00000436162  
 ENSP00000433996   ENSP00000431411   ENSP00000436151   ENSP00000399803  

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Novus Biologicals TMEM218 Lysate
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Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TMEM218 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026771 Tmem218

Graphical View of Domain Structure for InterPro Entry A2RU14

ProtoNet protein and cluster: A2RU14

UniProtKB/Swiss-Prot: TM218_HUMAN, A2RU14
Similarity: Belongs to the TMEM218 family


TMEM218 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM218 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM218

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM218 
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miRNA
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Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM218


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM218

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM218 (TM218)

Search CenterWatch for drugs/clinical trials and news about TMEM218 / TM218

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM218 gene (11 alternative transcripts): 
NM_001080546.2  NM_001258238.1  NM_001258239.1  NM_001258240.1  NM_001258241.1  NM_001258242.1  NM_001258243.1  NM_001258244.1  
NM_001258245.1  NM_001258246.1  NM_001258247.1  

Unigene Cluster for TMEM218:

Transmembrane protein 218
Hs.7626  [show with all ESTs]
Unigene Representative Sequence: NM_001258243
18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000531909(uc010sax.2 uc010saw.2 uc001qbt.3 uc010say.2)
ENST00000527257 ENST00000528724 ENST00000531262 ENST00000532156 ENST00000532407
ENST00000279968 ENST00000531851 ENST00000526175 ENST00000527766 ENST00000529609
ENST00000529583 ENST00000527271 ENST00000524373 ENST00000533273 ENST00000529530
ENST00000532717 ENST00000455225(uc001qbs.3)
miRNA
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hsa-miR-587 hsa-miR-137 hsa-miR-320e hsa-miR-1909* hsa-miR-1208
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TMEM218
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM218
Clone
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OriGene clones in human, mouse for TMEM218 (see all 12)
OriGene ORF clones in mouse, rat for TMEM218
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TMEM218 (NM_001080546)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM218
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM218
Sirion Biotech Customized lentivirus for stable overexpression of TMEM218 
                     Customized lentivirus expression plasmids for stable overexpression of TMEM218 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TMEM218
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM218
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM218
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM218

Additional mRNA sequence: 

AL833215.1 BC132716.1 BC132718.1 BC144270.1 BC144276.1 BC144277.1 NR_047586.1 NR_047587.1 
NR_047588.1 NR_047589.1 NR_047590.1 NR_047591.1 NR_047592.1 

14 DOTS entries:

DT.100807448  DT.310125  DT.113957  DT.443609  DT.91700106  DT.100807440  DT.100807450  DT.95275924 
DT.95275925  DT.95275926  DT.97843022  DT.120717960  DT.91700104  DT.92002266 

24/183 AceView cDNA sequences (see all 183):

BQ681518 BE673711 AW205404 AI470992 BX341308 AI880429 AA251984 AW026544 
BU733304 BM927952 CA306743 BQ653538 BE858281 BX363404 CR593246 AI200681 
AW162411 AW290929 BQ684376 CB139408 BE326725 CR626017 CR607861 AW160878 

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM218 (see all 7)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1:              -                       -     -                                                   
SP2:              -     -                 -                                                         
SP3:              -     -                 -     -                                                   
SP4:              -     -     -           -                                                         
SP5:                    -                 -                                                         


ECgene alternative splicing isoforms for TMEM218

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM218 expression in normal human tissues (normalized intensities)      TMEM218 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTCCATTTT
TMEM218 Expression
About this image


TMEM218 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Retina
         retina   
 
 Placenta (Extraembryonic Tissues)

 -- (Endocrine System)
         pituitary gland   

See TMEM218 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM218

SOURCE GeneReport for Unigene cluster: Hs.7626
    SABiosciences Custom PCR Arrays for TMEM218
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM218
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM218

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM218 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem2181 , 5 transmembrane protein 2181, 5 82.16(n)1
81.58(a)1
  9 (20.74 cM)5
662791  NM_025464.21  NP_079740.11 
 372083335 
lizard
(Anolis carolinensis)
Reptilia TMEM2186
transmembrane protein 218
69(a)
1 ↔ 1
GL343367.1(672708-683171)
zebrafish
(Danio rerio)
Actinopterygii BC054131.12   -- 72.95(n)   393369  BC054131.1 


ENSEMBL Gene Tree for TMEM218 (if available)
TreeFam Gene Tree for TMEM218 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/422 SNPs in TMEM218 are shown (see all 422)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1476339801,2
--124963881(+) GTTTAC/TGCCTA 18 -- ds50010--------
rs1822775921,2
--124964037(+) TTGACA/CTGTGG 18 -- ds50010--------
rs21556621,2
C,F,H--124964172(+) GATTCG/ATTTCC 18 -- ds500119Minor allele frequency- A:0.10NS EA NA WA 2194
rs1501296301,2
--124964215(+) TTTCTA/GTGTAA 18 -- ds50010--------
rs1385831021,2
--124964353(+) TACAAA/GCAGCT 18 -- nc-transcript-variantut310--------
rs1864774891,2
C--124964405(+) AAAGTC/TAAAAG 18 -- nc-transcript-variantut310--------
rs761713731,2
C--124964542(+) AATCA-/ASSCAG 36 -- nc-transcript-variantut310--------
rs38313961,2
C--124964543(+) ATCACA/-GCAGG 18 -- ut31 nc-transcript-variant1Minor allele frequency- -:0.00NA 2
rs1471749051,2
--124964577(+) ATAAA-/CCAG  
        
AAACA
18 -- nc-transcript-variantut310--------
rs1925480701,2
--124964599(+) GCAACA/CACCAT 18 -- nc-transcript-variantut310--------

HapMap Linkage Disequilibrium report for TMEM218 (124966398 - 124981659 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMEM218: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TMEM218
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM218

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM218 for disorders           About MalaCards

TMEM218 for disorders           About GeneDecksing

Genetic Association Database (GAD): TMEM218

Export disorders for TMEM218 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM218 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM218)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 219854 HGNC: 27344 AceView: LOC219854 Ensembl:ENSG00000150433 euGenes: HUgn219854
ECgene: TMEM218 H-InvDB: TMEM218

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM218 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM218 gene:
Search GeneIP for patents involving TMEM218

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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