Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM218 Gene

Aliases for TMEM218 Gene

  • Transmembrane Protein 218 2 3

External Ids for TMEM218 Gene

Previous GeneCards Identifiers for TMEM218 Gene

  • GC11M124472
  • GC11M124966
  • GC11M120908

Summaries for TMEM218 Gene

GeneCards Summary for TMEM218 Gene

TMEM218 (Transmembrane Protein 218) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM218 Gene

Genomics for TMEM218 Gene

Regulatory Elements for TMEM218 Gene

Genomic Location for TMEM218 Gene

Start:
125,094,370 bp from pter
End:
125,111,763 bp from pter
Size:
17,394 bases
Orientation:
Minus strand

Genomic View for TMEM218 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM218 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM218 Gene

Proteins for TMEM218 Gene

  • Protein details for TMEM218 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU14-TM218_HUMAN
    Recommended name:
    Transmembrane protein 218
    Protein Accession:
    A2RU14
    Secondary Accessions:
    • B7ZM48

    Protein attributes for TMEM218 Gene

    Size:
    115 amino acids
    Molecular mass:
    12459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM218 Gene

Proteomics data for TMEM218 Gene at MOPED

Post-translational modifications for TMEM218 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM218 Gene

Domains for TMEM218 Gene

Protein Domains for TMEM218 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM218 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2RU14

UniProtKB/Swiss-Prot:

TM218_HUMAN :
  • A2RU14
Family:
  • Belongs to the TMEM218 family.
genes like me logo Genes that share domains with TMEM218: view

No data available for Gene Families for TMEM218 Gene

Function for TMEM218 Gene

Gene Ontology (GO) - Molecular Function for TMEM218 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM218: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM218 Gene

Localization for TMEM218 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM218 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM218 Gene COMPARTMENTS Subcellular localization image for TMEM218 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM218 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM218: view

Pathways for TMEM218 Gene

SuperPathways for TMEM218 Gene

No Data Available

Interacting Proteins for TMEM218 Gene

Gene Ontology (GO) - Biological Process for TMEM218 Gene

None

No data available for Pathways by source for TMEM218 Gene

Transcripts for TMEM218 Gene

Unigene Clusters for TMEM218 Gene

Transmembrane protein 218:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM218

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM218 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for TMEM218 Gene

GeneLoc Exon Structure for
TMEM218
ECgene alternative splicing isoforms for
TMEM218

Expression for TMEM218 Gene

mRNA expression in normal human tissues for TMEM218 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TMEM218 Gene Hs.7626

genes like me logo Genes that share expressions with TMEM218: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for TMEM218 Gene

Orthologs for TMEM218 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM218 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM218 35
  • 99.71 (n)
  • 100 (a)
TMEM218 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM218 35
  • 83.77 (n)
  • 80.87 (a)
TMEM218 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM218 35
  • 85.51 (n)
  • 86.09 (a)
TMEM218 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem218 35
  • 82.16 (n)
  • 81.58 (a)
Tmem218 16
Tmem218 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM218 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem218 35
  • 82.16 (n)
  • 82.46 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM218 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem218 35
  • 63.69 (n)
  • 56.25 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
tmem218 35
  • 60.29 (n)
  • 53.91 (a)
tmem218 36
  • 54 (a)
OneToOne
Species with no ortholog for TMEM218:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM218 Gene

ENSEMBL:
Gene Tree for TMEM218 (if available)
TreeFam:
Gene Tree for TMEM218 (if available)

Paralogs for TMEM218 Gene

No data available for Paralogs for TMEM218 Gene

Variants for TMEM218 Gene

Sequence variations from dbSNP and Humsavar for TMEM218 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7030 -- 125,097,259(-) AGCAC(A/C)TGGGC utr-variant-3-prime, nc-transcript-variant
rs14065 -- 125,102,312(+) AGTGC(A/G)ACACA utr-variant-5-prime, missense, reference, intron-variant, nc-transcript-variant
rs14985 -- 125,097,270(+) TTTTT(C/T)CCCAA utr-variant-3-prime, nc-transcript-variant
rs920485 -- 125,113,735(+) TCTGG(A/G)GTGGC upstream-variant-2KB
rs1043821 -- 125,097,591(-) AGGAA(A/T)ACGAA utr-variant-3-prime, nc-transcript-variant

Relevant External Links for TMEM218 Gene

HapMap Linkage Disequilibrium report
TMEM218

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM218 Gene

Disorders for TMEM218 Gene

Relevant External Links for TMEM218

Genetic Association Database (GAD)
TMEM218
genes like me logo Genes that share disorders with TMEM218: view

No data available for UniProtKB/Swiss-Prot for TMEM218 Gene

Publications for TMEM218 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM218 Gene

Sources for TMEM218 Gene

Back to Top

Content