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Aliases for TMEM218 Gene

Aliases for TMEM218 Gene

  • Transmembrane Protein 218 2 3 5

External Ids for TMEM218 Gene

Previous GeneCards Identifiers for TMEM218 Gene

  • GC11M124472
  • GC11M124966
  • GC11M120908

Summaries for TMEM218 Gene

GeneCards Summary for TMEM218 Gene

TMEM218 (Transmembrane Protein 218) is a Protein Coding gene. Diseases associated with TMEM218 include joubert syndrome with orofaciodigital defect and meckel syndrome 1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM218 Gene

Genomics for TMEM218 Gene

Regulatory Elements for TMEM218 Gene

Promoters for TMEM218 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM218 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM218 Gene

Chromosome:
11
Start:
125,094,370 bp from pter
End:
125,111,763 bp from pter
Size:
17,394 bases
Orientation:
Minus strand

Genomic View for TMEM218 Gene

Genes around TMEM218 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM218 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM218 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM218 Gene

Proteins for TMEM218 Gene

  • Protein details for TMEM218 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU14-TM218_HUMAN
    Recommended name:
    Transmembrane protein 218
    Protein Accession:
    A2RU14
    Secondary Accessions:
    • B7ZM48

    Protein attributes for TMEM218 Gene

    Size:
    115 amino acids
    Molecular mass:
    12459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM218 Gene

Proteomics data for TMEM218 Gene at MOPED

Post-translational modifications for TMEM218 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM218 Gene

Domains & Families for TMEM218 Gene

Protein Domains for TMEM218 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM218 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2RU14

UniProtKB/Swiss-Prot:

TM218_HUMAN :
  • Belongs to the TMEM218 family.
Family:
  • Belongs to the TMEM218 family.
genes like me logo Genes that share domains with TMEM218: view

No data available for Gene Families for TMEM218 Gene

Function for TMEM218 Gene

genes like me logo Genes that share phenotypes with TMEM218: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM218 Gene

Localization for TMEM218 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM218 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM218 Gene COMPARTMENTS Subcellular localization image for TMEM218 gene
Compartment Confidence
plasma membrane 4
cytosol 2
endoplasmic reticulum 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM218 Gene

Pathways & Interactions for TMEM218 Gene

SuperPathways for TMEM218 Gene

No Data Available

Interacting Proteins for TMEM218 Gene

Gene Ontology (GO) - Biological Process for TMEM218 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM218 Gene

Drugs & Compounds for TMEM218 Gene

No Compound Related Data Available

Transcripts for TMEM218 Gene

Unigene Clusters for TMEM218 Gene

Transmembrane protein 218:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM218 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for TMEM218 Gene

GeneLoc Exon Structure for
TMEM218
ECgene alternative splicing isoforms for
TMEM218

Expression for TMEM218 Gene

mRNA expression in normal human tissues for TMEM218 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TMEM218 Gene Hs.7626

genes like me logo Genes that share expression patterns with TMEM218: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM218 Gene

Orthologs for TMEM218 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM218 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM218 35
  • 99.71 (n)
  • 100 (a)
TMEM218 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM218 36
  • 81 (a)
OneToOne
TMEM218 35
  • 83.77 (n)
  • 80.87 (a)
dog
(Canis familiaris)
Mammalia TMEM218 35
  • 85.51 (n)
  • 86.09 (a)
TMEM218 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem218 16
Tmem218 35
  • 82.16 (n)
  • 81.58 (a)
Tmem218 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM218 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem218 35
  • 82.16 (n)
  • 82.46 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM218 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem218 35
  • 63.69 (n)
  • 56.25 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
tmem218 35
  • 60.29 (n)
  • 53.91 (a)
tmem218 36
  • 54 (a)
OneToOne
Species with no ortholog for TMEM218:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM218 Gene

ENSEMBL:
Gene Tree for TMEM218 (if available)
TreeFam:
Gene Tree for TMEM218 (if available)

Paralogs for TMEM218 Gene

No data available for Paralogs for TMEM218 Gene

Variants for TMEM218 Gene

Sequence variations from dbSNP and Humsavar for TMEM218 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7030 -- 125,097,259(-) AGCAC(A/C)TGGGC nc-transcript-variant, utr-variant-3-prime
rs1043821 -- 125,097,591(-) AGGAA(A/T)ACGAA nc-transcript-variant, utr-variant-3-prime
rs1320671 -- 125,110,624(-) AAGTC(A/C)TCTTA intron-variant
rs2155662 -- 125,094,276(+) GATTC(A/G)TTTCC downstream-variant-500B
rs2155663 -- 125,102,481(+) AAAGC(C/T)TTTCT intron-variant

Variation tolerance for TMEM218 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM218 Gene

HapMap Linkage Disequilibrium report
TMEM218

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM218 Gene

Disorders for TMEM218 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM218 Gene - From: DISEASES

Disorder Aliases PubMed IDs
joubert syndrome with orofaciodigital defect
  • orofaciodigital syndrome vi
meckel syndrome 1
  • meckel syndrome
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM218

Genetic Association Database (GAD)
TMEM218
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM218
genes like me logo Genes that share disorders with TMEM218: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM218 Gene

Publications for TMEM218 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM218 Gene

Sources for TMEM218 Gene

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