Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM217 Gene

Aliases for TMEM217 Gene

  • Transmembrane Protein 217 2 3 5
  • C6orf128 3 4
  • Chromosome 6 Open Reading Frame 128 2
  • DJ355M6.2 3

External Ids for TMEM217 Gene

Previous HGNC Symbols for TMEM217 Gene

  • C6orf128

Previous GeneCards Identifiers for TMEM217 Gene

  • GC06M037288
  • GC06M037179
  • GC06M036898
  • GC06M037317

Summaries for TMEM217 Gene

GeneCards Summary for TMEM217 Gene

TMEM217 (Transmembrane Protein 217) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM217 Gene

Genomics for TMEM217 Gene

Regulatory Elements for TMEM217 Gene

Enhancers for TMEM217 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G037238 2 FANTOM5 Ensembl ENCODE dbSUPER 33.8 +16.2 16234 8.7 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 TMEM217 CDKN1A RAB44 COX6A1P2 FGD2 TBC1D22B PIR49359
GH06G037189 2 FANTOM5 Ensembl ENCODE dbSUPER 29.9 +68.0 68015 4.0 PKNOX1 ARNT FEZF1 ZNF766 REST ZNF592 MEF2D ZNF610 SMARCA4 RCOR2 TMEM217 CDKN1A RAB44 PIM1 TBC1D22B PIR49359
GH06G037047 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +208.9 208908 5.5 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MEF2D SSRP1 ZNF610 TMEM217 PIM1 CDKN1A FGD2 SRSF3 TBC1D22B CMTR1 COX6A1P2 GC06P041065
GH06G037256 1.8 FANTOM5 ENCODE dbSUPER 22.4 +0.1 86 3.9 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TMEM217 RNF8 TBC1D22B CMTR1
GH06G037187 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21 +71.3 71321 1.4 PKNOX1 CREB3L1 MLX ZFP64 ZNF48 YY1 ZNF766 GATA2 CBX5 SP5 TMEM217 PIM1 TBC1D22B PIR49359
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM217 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM217 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196378 905 1801 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for TMEM217 Gene

Chromosome:
6
Start:
37,212,178 bp from pter
End:
37,259,005 bp from pter
Size:
46,828 bases
Orientation:
Minus strand

Genomic View for TMEM217 Gene

Genes around TMEM217 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM217 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM217 Gene

Proteins for TMEM217 Gene

  • Protein details for TMEM217 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7C4-TM217_HUMAN
    Recommended name:
    Transmembrane protein 217
    Protein Accession:
    Q8N7C4
    Secondary Accessions:
    • Q8TC54

    Protein attributes for TMEM217 Gene

    Size:
    229 amino acids
    Molecular mass:
    26582 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM217 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM217 Gene

Post-translational modifications for TMEM217 Gene

  • Glycosylation at Asn39 and posLast=156156

No data available for DME Specific Peptides for TMEM217 Gene

Domains & Families for TMEM217 Gene

Protein Domains for TMEM217 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM217 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM217: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM217 Gene

Function for TMEM217 Gene

genes like me logo Genes that share phenotypes with TMEM217: view

Animal Model Products

CRISPR Products

miRNA for TMEM217 Gene

miRTarBase miRNAs that target TMEM217

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM217 Gene

Localization for TMEM217 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM217 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM217 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM217: view

Pathways & Interactions for TMEM217 Gene

SuperPathways for TMEM217 Gene

No Data Available

Interacting Proteins for TMEM217 Gene

Gene Ontology (GO) - Biological Process for TMEM217 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM217 Gene

Transcripts for TMEM217 Gene

Unigene Clusters for TMEM217 Gene

Transmembrane protein 217:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM217 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: - - -
SP3:
SP4: -

Relevant External Links for TMEM217 Gene

GeneLoc Exon Structure for
TMEM217
ECgene alternative splicing isoforms for
TMEM217

Expression for TMEM217 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM217 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM217 Gene

This gene is overexpressed in Testis (x14.9) and Adrenal Gland (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of TMEM217 Gene:

TMEM217

SOURCE GeneReport for Unigene cluster for TMEM217 Gene:

Hs.520101
genes like me logo Genes that share expression patterns with TMEM217: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM217 Gene

Orthologs for TMEM217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM217 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM217 35 34
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM217 34 35
  • 76.37 (n)
dog
(Canis familiaris)
Mammalia TMEM217 35 34
  • 76.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem217 35 16 34
  • 67.42 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC687483 34
  • 66.48 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM217 35
  • 27 (a)
OneToOne
Species where no ortholog for TMEM217 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM217 Gene

ENSEMBL:
Gene Tree for TMEM217 (if available)
TreeFam:
Gene Tree for TMEM217 (if available)

Paralogs for TMEM217 Gene

No data available for Paralogs for TMEM217 Gene

Variants for TMEM217 Gene

Sequence variations from dbSNP and Humsavar for TMEM217 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000051521 -- 37,222,714(+) GCCCA(A/G)GAGGG intron-variant
rs1000157819 -- 37,212,767(+) TGATG(A/G)TGGTG nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1000224420 -- 37,244,932(+) GATAA(C/G)TTAGG intron-variant
rs1000246978 -- 37,251,021(+) CTGAC(C/T)CTTTC intron-variant
rs1000281311 -- 37,229,552(+) TTAGC(C/G)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM217 Gene

Variant ID Type Subtype PubMed ID
nsv1015689 CNV gain 25217958
nsv1128228 CNV deletion 24896259
nsv527191 CNV loss 19592680

Variation tolerance for TMEM217 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM217 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM217

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM217 Gene

Disorders for TMEM217 Gene

Relevant External Links for TMEM217

Genetic Association Database (GAD)
TMEM217
Human Genome Epidemiology (HuGE) Navigator
TMEM217
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM217

No disorders were found for TMEM217 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM217 Gene

Publications for TMEM217 Gene

  1. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64

Products for TMEM217 Gene

Sources for TMEM217 Gene

Content
Loading form....