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Aliases for TMEM217 Gene

Aliases for TMEM217 Gene

  • Transmembrane Protein 217 2 3 5
  • C6orf128 3 4
  • Chromosome 6 Open Reading Frame 128 2
  • DJ355M6.2 3

External Ids for TMEM217 Gene

Previous HGNC Symbols for TMEM217 Gene

  • C6orf128

Previous GeneCards Identifiers for TMEM217 Gene

  • GC06M037288
  • GC06M037179
  • GC06M036898

Summaries for TMEM217 Gene

GeneCards Summary for TMEM217 Gene

TMEM217 (Transmembrane Protein 217) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM217 Gene

Genomics for TMEM217 Gene

Regulatory Elements for TMEM217 Gene

Enhancers for TMEM217 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F037238 1.2 FANTOM5 Ensembl ENCODE 33.8 +16.2 16234 8.7 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 TMEM217 CDKN1A CMTR1 RAB44 COX6A1P2 FGD2 TBC1D22B PIR49359
GH06F037179 0.9 FANTOM5 Ensembl ENCODE 29.9 +72.5 72505 13.4 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B FEZF1 YY1 CBX5 TMEM217 CDKN1A RAB44 RNF8 PIM1 TBC1D22B PIR49359
GH06F037236 1.1 Ensembl ENCODE 26.6 +21.8 21835 1.0 HDGF ATF1 ARNT FOS MCM5 NCOA1 CREB3 ZSCAN16 SMARCA4 NBN TMEM217 CDKN1A RAB44 TBC1D22B COX6A1P2 FGD2 PIR49359
GH06F037282 0.4 ENCODE 26.2 -24.7 -24668 1.8 ZNF318 ATF3 ZSCAN16 HNF4G RAD21 TMEM217 TBC1D22B RNF8 MTCH1 FGD2 PIR45248 ENSG00000275550
GH06F037256 1.3 FANTOM5 Ensembl ENCODE 22.4 +0.1 86 3.9 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 TMEM217 CDKN1A RNF8 TBC1D22B CMTR1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM217 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM217 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001215788 605 2801 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 FOS

Genomic Location for TMEM217 Gene

Chromosome:
6
Start:
37,212,178 bp from pter
End:
37,259,005 bp from pter
Size:
46,828 bases
Orientation:
Minus strand

Genomic View for TMEM217 Gene

Genes around TMEM217 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM217 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM217 Gene

Proteins for TMEM217 Gene

  • Protein details for TMEM217 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7C4-TM217_HUMAN
    Recommended name:
    Transmembrane protein 217
    Protein Accession:
    Q8N7C4
    Secondary Accessions:
    • Q8TC54

    Protein attributes for TMEM217 Gene

    Size:
    229 amino acids
    Molecular mass:
    26582 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM217 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM217 Gene

Post-translational modifications for TMEM217 Gene

  • Glycosylation at Asn 39 and Asn 156

No data available for DME Specific Peptides for TMEM217 Gene

Domains & Families for TMEM217 Gene

Protein Domains for TMEM217 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM217 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM217: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM217 Gene

Function for TMEM217 Gene

genes like me logo Genes that share phenotypes with TMEM217: view

Animal Model Products

miRNA for TMEM217 Gene

miRTarBase miRNAs that target TMEM217

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM217 Gene

Localization for TMEM217 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM217 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM217 Gene COMPARTMENTS Subcellular localization image for TMEM217 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM217: view

Pathways & Interactions for TMEM217 Gene

SuperPathways for TMEM217 Gene

No Data Available

Interacting Proteins for TMEM217 Gene

Gene Ontology (GO) - Biological Process for TMEM217 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM217 Gene

Transcripts for TMEM217 Gene

Unigene Clusters for TMEM217 Gene

Transmembrane protein 217:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM217 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: - - -
SP3:
SP4: -

Relevant External Links for TMEM217 Gene

GeneLoc Exon Structure for
TMEM217
ECgene alternative splicing isoforms for
TMEM217

Expression for TMEM217 Gene

mRNA expression in normal human tissues for TMEM217 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM217 Gene

This gene is overexpressed in Testis (x14.9) and Adrenal Gland (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of TMEM217 Gene:

TMEM217

SOURCE GeneReport for Unigene cluster for TMEM217 Gene:

Hs.520101
genes like me logo Genes that share expression patterns with TMEM217: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM217 Gene

Orthologs for TMEM217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM217 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM217 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia TMEM217 34 35
  • 76.37 (n)
dog
(Canis familiaris)
Mammalia TMEM217 34 35
  • 76.37 (n)
mouse
(Mus musculus)
Mammalia Tmem217 34 16 35
  • 67.42 (n)
rat
(Rattus norvegicus)
Mammalia LOC687483 34
  • 66.48 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM217 35
  • 27 (a)
OneToOne
Species where no ortholog for TMEM217 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM217 Gene

ENSEMBL:
Gene Tree for TMEM217 (if available)
TreeFam:
Gene Tree for TMEM217 (if available)

Paralogs for TMEM217 Gene

No data available for Paralogs for TMEM217 Gene

Variants for TMEM217 Gene

Sequence variations from dbSNP and Humsavar for TMEM217 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10550751 -- 37,239,504(+) AATAA(-/ATAA)GTAAA intron-variant
rs1055460 -- 37,212,360(-) TGGAA(C/G)CCTCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1055461 -- 37,212,267(-) GGGCA(A/G)GTTGT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs10682242 -- 37,229,209(+) CTGTC(-/AGG)AGATT intron-variant
rs10947665 -- 37,231,354(+) cgtga(A/G)tgatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM217 Gene

Variant ID Type Subtype PubMed ID
nsv1015689 CNV gain 25217958
nsv1128228 CNV deletion 24896259
nsv527191 CNV loss 19592680

Variation tolerance for TMEM217 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM217 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM217

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM217 Gene

Disorders for TMEM217 Gene

Relevant External Links for TMEM217

Genetic Association Database (GAD)
TMEM217
Human Genome Epidemiology (HuGE) Navigator
TMEM217
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM217

No disorders were found for TMEM217 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM217 Gene

Publications for TMEM217 Gene

  1. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64

Products for TMEM217 Gene

Sources for TMEM217 Gene

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