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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM215 Gene

protein-coding   GIFtS: 34
GCID: GC09P032783

transmembrane protein 215
  Search for TMEM215
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM215    

Aliases
for TMEM215 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane Protein 2151 2

External Ids:    HGNC: 338161   Entrez Gene: 4014982   Ensembl: ENSG000001881337   UniProtKB: Q68D423   

Export aliases for TMEM215 gene to outside databases

Previous GC identifers: GC09P032775 GC09P032741


Summaries
for TMEM215 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TMEM215 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM215 gene promoter:
         Max1   C/EBPbeta   AML1a   Olf-1   GATA-1   Arnt   E2F-1   E2F   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM215 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM215

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM215


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.1   Ensembl cytogenetic band:  9p21.1   HGNC cytogenetic band: 9p21.1

TMEM215 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM215 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P032783:  view genomic region     (about GC identifiers)

Start:
 32,783,497 bp from pter      End:
 32,789,199 bp from pter
Size:
 5,703 bases      Orientation:
 plus strand

Proteins
for TMEM215 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TM215_HUMAN, Q68D42 (See protein sequence)
Recommended Name: Transmembrane protein 215  
Size: 235 amino acids; 25806 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6ZUU2

Explore the universe of human proteins at neXtProt for TMEM215: NX_Q68D42

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68D42

    • TMEM215 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_997723.2  
    ENSEMBL proteins: 
     ENSP00000345468  

    Human Recombinant Protein Products: 
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    Uscn Proteins for TMEM215

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    TMEM215 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TMEM215 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q68D42


    Function
    for TMEM215 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Inhib. RNA
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    Pathways & Interactions
    for TMEM215 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM215

    Drugs & Compounds
    for TMEM215 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM215
    Search CenterWatch for drugs/clinical trials and news about TMEM215 / TM215 

    Transcripts
    for TMEM215 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEM215 gene: 
    NM_212558.2  

    Unigene Cluster for TMEM215:

    Transmembrane protein 215
    Hs.522063  [show with all ESTs]
    Unigene Representative Sequence: NM_212558
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000342743(uc003zri.4)

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    hsa-miR-411* hsa-miR-579 hsa-miR-379* hsa-miR-520d-5p hsa-miR-4263 hsa-miR-3653 hsa-miR-4260 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM215 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM215 (see all 4)
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    Additional cDNA sequence: 

    AK125320.1 BX647550.1 CR749589.1 

    2 DOTS entries:

    DT.102820955  DT.97773874 

    6 AceView cDNA sequences:

    CR749589 NM_212558 BQ184240 BX647550 BM726513 AK125320 

    GeneLoc Exon Structure


    Expression
    for TMEM215 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM215 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCATTCCTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMEM215 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM215 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.522063
        SABiosciences Custom PCR Arrays for TMEM215
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM215

    Orthologs
    for TMEM215 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM215 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmem2151 , 5 transmembrane protein 2151, 5 87.94(n)1
    92.34(a)1    		   4 (20.28 cM)5
    3205001  NM_001166009.11  NP_001159481.11 
     404721805 
    chicken
    (Gallus gallus)    		 Aves TMEM2151 transmembrane protein 215 70.65(n)
    65.93(a)    		   427341  XM_424919.2  XP_424919.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TMEM2156
    		 --
    		 55(a)
    		 1 ↔ 1
    		 GL343463.1(205111-205827)


    ENSEMBL Gene Tree for TMEM215 (if available)
    TreeFam Gene Tree for TMEM215 (if available) 

    Paralogs
    for TMEM215 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TMEM215 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 NCBI SNPs in TMEM215 are shown (see all 143)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1511812361,2
    		--32781630(+) AGATGC/GCTATC 1 -- us2k10--------
    rs1827574791,2
    		--32781644(+) TTGGGG/TGGGCT 1 -- us2k10--------
    rs1179829701,2
    		F,--32781709(+) TTTTAC/GCCTTT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1857914171,2
    		--32781733(+) TCTTCC/TCTCCT 1 -- us2k10--------
    rs1402075441,2
    		--32781784(+) TCATGA/GGTACA 1 -- us2k10--------
    rs1913799431,2
    		--32781821(+) GAAAAC/TGAGAA 1 -- us2k10--------
    rs125536151,2
    		C,H--32781946(+) CCTCAG/CATCTG 1 -- us2k14Minor allele frequency- C:0.00NS EA 410
    rs1145307801,2
    		C,F,--32781963(+) TCCAAC/TTCCTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1832533201,2
    		--32781975(+) ACCAGA/CCCGAC 1 -- us2k10--------
    rs1450829101,2
    		--32782183(+) TTAGTA/CTCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM215 (32783497 - 32789199 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM215: --

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    Disorders / Diseases
    for TMEM215 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TMEM215 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM215 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM215)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of host genetic determ inants of the antibody response to Anthrax Vaccine Adsorbed. (PubMed id 22658931)1 Pajewski N.M....Kaslow R.A. (2012)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for TMEM215 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMEM215 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401498 HGNC: 33816 AceView: LOC401498 Ensembl:ENSG00000188133 euGenes: HUgn401498
    ECgene: TMEM215 H-InvDB: TMEM215

    Other Databases showing TMEM215 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMEM215 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM215 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM215 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM215 gene:
    Search GeneIP for patents involving TMEM215

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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