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TMEM214 Gene

protein-coding   GIFtS: 48
GCID: GC02P027255

Transmembrane Protein 214

  Search for TMEM214
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 2141 2

External Ids:    HGNC: 259831   Entrez Gene: 548672   Ensembl: ENSG000001197777   UniProtKB: Q6NUQ43   

Export aliases for TMEM214 gene to outside databases

Previous GC identifers: GC02P027110 GC02P026997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM214 Gene:
TMEM214 (transmembrane protein 214) is a protein-coding gene.

UniProtKB/Swiss-Prot: TM214_HUMAN, Q6NUQ4
Function: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis.
Required or the activation of CASP4 following endoplasmic reticulum stress




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM214 gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx3-1 v4   p300   E2F-2   Nkx3-1 v2   E2F   E2F-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM214 promoter sequence
   Search Chromatin IP Primers for TMEM214

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM214


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

TMEM214 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM214 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027255:  view genomic region     (about GC identifiers)

Start:
27,255,774 bp from pter      End:
27,264,565 bp from pter
Size:
8,792 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM214_HUMAN, Q6NUQ4 (See protein sequence)
Recommended Name: Transmembrane protein 214  
Size: 689 amino acids; 77151 Da
Subunit: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER
Sequence caution: Sequence=AAL55739.1; Type=Erroneous initiation; Sequence=BAA91038.1; Type=Erroneous initiation;
Sequence=BAC11331.1; Type=Frameshift; Positions=94; Sequence=CAH10591.1; Type=Erroneous initiation;
Secondary accessions: A6NNF2 B3KUI9 B5MCD8 D6W547 Q53SW1 Q69YH4 Q8NC45 Q8WZ37 Q9NXH2
Alternative splicing: 2 isoforms:  Q6NUQ4-1   Q6NUQ4-2   

Explore the universe of human proteins at neXtProt for TMEM214: NX_Q6NUQ4

Explore proteomics data for TMEM214 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys240, Lys444, Lys453
  • Glycosylation2 at Asn269, Asn307
  • Modification sites at PhosphoSitePlus

  • See TMEM214 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001077059.1  NP_060197.4  

    ENSEMBL proteins: 
     ENSP00000319469   ENSP00000238788   ENSP00000384417   ENSP00000395061   ENSP00000393490  
     ENSP00000392442   ENSP00000389729  

    TMEM214 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMEM214

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019308 DUF2359_TMEM214

    Graphical View of Domain Structure for InterPro Entry Q6NUQ4

    ProtoNet protein and cluster: Q6NUQ4

    UniProtKB/Swiss-Prot: TM214_HUMAN, Q6NUQ4
    Similarity: Belongs to the TMEM214 family


    Find genes that share domains with TMEM214           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM214_HUMAN, Q6NUQ4
    Function: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis.
    Required or the activation of CASP4 following endoplasmic reticulum stress

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM214
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM214
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM214

    miRNA
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    miRTarBase miRNAs that target TMEM214:
    hsa-mir-15a-5p (MIRT051346)

    Block miRNA regulation of human, mouse, rat TMEM214 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TMEM214:
    hsa-miR-593* hsa-miR-1207-5p hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM214 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM214

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM214_HUMAN, Q6NUQ4: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005881cytoplasmic microtubule IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM214           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM214
    Interactions:

        Search GeneGlobe Interaction Network for TMEM214

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for TMEM214 (Q6NUQ41, 3 ENSP000002387884) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSM1O151161, 3, ENSP000003105964EBI-372318,EBI-347619 I2D: score=4 STRING: ENSP00000310596
    DMDP115323I2D: score=3 
    PAXBP1Q9Y5B63I2D: score=3 
    RAD54LQ926983I2D: score=3 
    ADAT3Q96EY93I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    Find genes that share ontologies with TMEM214           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM214 (TM214)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM214 gene (2 alternative transcripts): 
    NM_001083590.1  NM_017727.4  

    Unigene Cluster for TMEM214:

    Transmembrane protein 214
    Hs.533934  [show with all ESTs]
    Unigene Representative Sequence: NM_017727
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495312 ENST00000321326 ENST00000238788(uc002ria.4 uc002rib.4)
    ENST00000404032 ENST00000478980 ENST00000435172 ENST00000475258 ENST00000425720
    ENST00000460904 ENST00000444135 ENST00000434544 ENST00000460665 ENST00000469445

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM214 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TMEM214:
    hsa-miR-593* hsa-miR-1207-5p hsa-miR-181a-2*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM214 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM214
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM214
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM214 (NM_001083590)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM214
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM214
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM214
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM214
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM214
      QuantiFast Probe-based Assays in human, mouse, rat TMEM214

    Additional mRNA sequence: 

    AF289555.1 AK000261.1 AK074981.1 AK097308.1 AK296575.1 AK297150.1 AK315359.1 AL833725.1 
    AL834157.1 BC002467.2 

    Selected DOTS entries (see all 27):

    DT.101986371  DT.117152  DT.97772670  DT.100742226  DT.100037901  DT.95156836  DT.120940533  DT.95156842 
    DT.100796147  DT.40210901  DT.100765373  DT.100796164  DT.100796165  DT.99943265  DT.120940547  DT.91654231 
    DT.92463423  DT.92463472  DT.92465375  DT.120984739  DT.121495261  DT.121622246  DT.121640421  DT.455017 

    Selected AceView cDNA sequences (see all 335):

    CB140615 AA297469 CA488216 AK097308 CK431165 BM557384 AA479791 BC002467 
    CD671740 BE734304 BG481402 BG575827 CN482464 AW953641 AI523553 AL602718 
    AI688113 BU849822 BQ432271 AK000261 BG058649 AA477188 AI082243 BU177428 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM214 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
    SP1:                          -                                   -                             -     -     -                                         -         
    SP2:                          -                                   -                             -     -     -                                         -         
    SP3:                          -     -                             -                             -     -     -                                         -         
    SP4:                                                              -                                         -                                                   
    SP5:                                                                                                        -                                         -         

    ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for TMEM214

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM214 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGGGTCT
    TMEM214 Expression
    About this image

    TMEM214 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM214 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533934
        Custom PCR Arrays for TMEM214
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM214

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM214 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2141 , 5 transmembrane protein 2141, 5 83.65(n)1
    81.66(a)1
      5 (16.90 cM)5
    687961  NM_144525.31  NP_653108.21 
     308695795 
    chicken
    (Gallus gallus)
    Aves TMEM2141 transmembrane protein 214 65.46(n)
    60.45(a)
      428658  XM_426216.4  XP_426216.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2146
    transmembrane protein 214
    60(a)
    1 ↔ 1
    GL343593.1(68302-98065)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60692 Xenopus laevis transcribed sequence with moderate similarity more 75.7(n)    48017295 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.48922 Danio rerio cDNA clone IMAGE5605364, partial cds 74.51(n)    BC054691.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG331291 CG33129 43.44(n)
    28.47(a)
      34514  NM_176009.2  NP_788023.1 


    ENSEMBL Gene Tree for TMEM214 (if available)
    TreeFam Gene Tree for TMEM214 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM214 gene
    1 SIMAP similar gene for TMEM214 using alignment to 6 protein entries:     TM214_HUMAN (see all proteins):
    DKFZp761L1314

    Find genes that share paralogs with TMEM214           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM214 (see all 306)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494006301,2
    --27253966(+) TGGAGA/TGCAGT 2 -- us2k10--------
    rs1447505191,2
    --27254139(+) AACTCC/TTGACC 2 -- us2k10--------
    rs1824018111,2
    --27254312(+) TTCATC/GCTGTA 2 -- us2k10--------
    rs1485278671,2
    --27254420(+) TAATTG/TTGATA 2 -- us2k10--------
    rs760037361,2
    --27254715(+) AGAGGC/TCAGGA 2 -- us2k10--------
    rs1870350521,2
    --27254722(+) AGGAGC/TGGTGG 2 -- us2k10--------
    rs347326131,2
    C--27254796(+) TGAGAC/TCAGCC 2 -- us2k14Minor allele frequency- T:0.49NA WA EA 360
    rs1472359571,2
    --27254894(+) TCACCC/TGAGCC 2 -- us2k10--------
    rs1912791241,2
    --27254932(+) GATCGC/TGCCAC 2 -- us2k10--------
    rs359328071,2
    C--27254992(+) AAAAA-/ATTATT 2 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for TMEM214 (27255774 - 27264565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM214:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv455974CNV Loss19166990
    nsv817673CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM214
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM214

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM214 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TMEM214)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. (PubMed id 23661706)1, 2, 3 Li C....Shu H.B. (J. Biol. Chem. 2013)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54867 HGNC: 25983 AceView: FLJ20254 Ensembl:ENSG00000119777 euGenes: HUgn54867
    ECgene: TMEM214 H-InvDB: TMEM214

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM214 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM214 gene:
    Search GeneIP for patents involving TMEM214

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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