Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM214 Gene

Aliases for TMEM214 Gene

  • Transmembrane Protein 214 2 3 5

External Ids for TMEM214 Gene

Previous GeneCards Identifiers for TMEM214 Gene

  • GC02P027110
  • GC02P027255

Summaries for TMEM214 Gene

GeneCards Summary for TMEM214 Gene

TMEM214 (Transmembrane Protein 214) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM214 Gene

  • Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

Additional gene information for TMEM214 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM214 Gene

Genomics for TMEM214 Gene

Regulatory Elements for TMEM214 Gene

Enhancers for TMEM214 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H027069 2 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +43.6 43588 14.9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YBX1 YY1 GTF3C2 CAD GPN1 SNX17 KHK NRBP1 EMILIN1 ATRAID EIF2B4 LOC105374363
GH02H026717 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.5 -310.7 -310652 10.1 HDGF FOXA2 MLX SIN3A DMAP1 YY1 ZNF766 FOS SP5 REST EIF2B4 GPN1 CAD NRBP1 GTF3C2-AS1 ASXL2 CENPA LOC105374363 KCNK3 TMEM214
GH02H027049 1.2 ENCODE 20.8 +18.2 18163 3.2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF512 CAD EIF2B4 NRBP1 IFT172 SUPT7L GPN1 KHK LOC105374363 ATRAID
GH02H026754 2 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -275.5 -275497 5.8 PKNOX1 FOXA2 ARNT SIN3A YY1 SLC30A9 ZNF766 FOS SP3 SP5 EIF2B4 GPN1 CAD LOC105374363 GTF3C2 NRBP1 TMEM214 KCNK3 KHK SUPT7L
GH02H027031 1.3 ENCODE dbSUPER 13.2 +0.3 257 2.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF207 ZNF143 KHK GPN1 CAD LOC105374363 EIF2B4 NRBP1 TMEM214 GTF3C2-AS1 EMILIN1 ATRAID
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM214 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM214 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114367 94 1601 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF207 ZNF143

Genomic Locations for TMEM214 Gene

Genomic Locations for TMEM214 Gene
chr2:27,032,906-27,041,697
(GRCh38/hg38)
Size:
8,792 bases
Orientation:
Plus strand
chr2:27,255,774-27,264,565
(GRCh37/hg19)

Genomic View for TMEM214 Gene

Genes around TMEM214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM214 Gene

Proteins for TMEM214 Gene

  • Protein details for TMEM214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUQ4-TM214_HUMAN
    Recommended name:
    Transmembrane protein 214
    Protein Accession:
    Q6NUQ4
    Secondary Accessions:
    • A6NNF2
    • B3KUI9
    • B5MCD8
    • D6W547
    • Q53SW1
    • Q69YH4
    • Q8NC45
    • Q8WZ37
    • Q9NXH2

    Protein attributes for TMEM214 Gene

    Size:
    689 amino acids
    Molecular mass:
    77151 Da
    Quaternary structure:
    • Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
    SequenceCaution:
    • Sequence=AAL55739.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91038.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11331.1; Type=Frameshift; Positions=94; Evidence={ECO:0000305}; Sequence=CAH10591.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM214 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM214 Gene

Post-translational modifications for TMEM214 Gene

  • Ubiquitination at posLast=240240, posLast=444444, and posLast=453453
  • Glycosylation at posLast=269269 and posLast=307307
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM214 Gene

Domains & Families for TMEM214 Gene

Gene Families for TMEM214 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM214 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM214 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUQ4

UniProtKB/Swiss-Prot:

TM214_HUMAN :
  • Belongs to the TMEM214 family.
Family:
  • Belongs to the TMEM214 family.
genes like me logo Genes that share domains with TMEM214: view

Function for TMEM214 Gene

Molecular function for TMEM214 Gene

UniProtKB/Swiss-Prot Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

Phenotypes From GWAS Catalog for TMEM214 Gene

Phenotypes for TMEM214 Gene

genes like me logo Genes that share phenotypes with TMEM214: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM214 Gene

Localization for TMEM214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM214 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM214 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with TMEM214: view

Pathways & Interactions for TMEM214 Gene

SuperPathways for TMEM214 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TMEM214: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM214 Gene

Drugs & Compounds for TMEM214 Gene

No Compound Related Data Available

Transcripts for TMEM214 Gene

Unigene Clusters for TMEM214 Gene

Transmembrane protein 214:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM214 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10: - -
SP11: -
SP12:
SP13:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM214 Gene

GeneLoc Exon Structure for
TMEM214
ECgene alternative splicing isoforms for
TMEM214

Expression for TMEM214 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM214 Gene

Protein differential expression in normal tissues from HIPED for TMEM214 Gene

This gene is overexpressed in Bone (38.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM214 Gene



Protein tissue co-expression partners for TMEM214 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM214 Gene:

TMEM214

SOURCE GeneReport for Unigene cluster for TMEM214 Gene:

Hs.533934

Evidence on tissue expression from TISSUES for TMEM214 Gene

  • Nervous system(4.6)
  • Intestine(4.4)
  • Stomach(4.3)
  • Skin(2.4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with TMEM214: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM214 Gene

Orthologs for TMEM214 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM214 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM214 33 34
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia TMEM214 33 34
  • 88.31 (n)
dog
(Canis familiaris)
Mammalia TMEM214 33 34
  • 86.49 (n)
rat
(Rattus norvegicus)
Mammalia Tmem214 33
  • 83.8 (n)
mouse
(Mus musculus)
Mammalia Tmem214 33 16 34
  • 83.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM214 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM214 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM214 33 34
  • 65.46 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM214 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8215 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6069 33
zebrafish
(Danio rerio)
Actinopterygii tmem214 33 34
  • 60.14 (n)
Dr.4892 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009823 33
  • 44.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33129 33 34
  • 43.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5886 34
  • 26 (a)
OneToOne
Species where no ortholog for TMEM214 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM214 Gene

ENSEMBL:
Gene Tree for TMEM214 (if available)
TreeFam:
Gene Tree for TMEM214 (if available)

Paralogs for TMEM214 Gene

(1) SIMAP similar genes for TMEM214 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM214: view

No data available for Paralogs for TMEM214 Gene

Variants for TMEM214 Gene

Sequence variations from dbSNP and Humsavar for TMEM214 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000071269 -- 27,038,304(+) TGTCC(C/T)ATGGC intron-variant
rs1000124712 -- 27,038,650(+) ATGAA(C/G)CAGGA intron-variant
rs1000723320 -- 27,032,943(+) GGAGA(C/G)GTGGC nc-transcript-variant, utr-variant-5-prime
rs1000901104 -- 27,031,798(+) GGCTG(A/T)CCCAG upstream-variant-2KB
rs1000942485 -- 27,033,080(+) GGGGT(-/CGGCGC)CGGCG nc-transcript-variant, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for TMEM214 Gene

Variant ID Type Subtype PubMed ID
nsv817673 CNV gain 17921354
nsv455974 CNV loss 19166990
dgv6744n54 CNV loss 21841781

Variation tolerance for TMEM214 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.92; 91.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM214 Gene

Disorders for TMEM214 Gene

Relevant External Links for TMEM214

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM214

No disorders were found for TMEM214 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM214 Gene

Publications for TMEM214 Gene

  1. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. (PMID: 23661706) Li C … Shu HB (The Journal of biological chemistry 2013) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for TMEM214 Gene

Sources for TMEM214 Gene

Content
Loading form....