Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM214 Gene

Aliases for TMEM214 Gene

  • Transmembrane Protein 214 2 3 5

External Ids for TMEM214 Gene

Previous GeneCards Identifiers for TMEM214 Gene

  • GC02P027110
  • GC02P027255

Summaries for TMEM214 Gene

GeneCards Summary for TMEM214 Gene

TMEM214 (Transmembrane Protein 214) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM214 Gene

  • Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM214 Gene

Genomics for TMEM214 Gene

Regulatory Elements for TMEM214 Gene

Enhancers for TMEM214 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM214 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM214 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM214 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM214 Gene

27,032,906 bp from pter
27,041,697 bp from pter
8,792 bases
Plus strand

Genomic View for TMEM214 Gene

Genes around TMEM214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM214 Gene

Proteins for TMEM214 Gene

  • Protein details for TMEM214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 214
    Protein Accession:
    Secondary Accessions:
    • A6NNF2
    • B3KUI9
    • B5MCD8
    • D6W547
    • Q53SW1
    • Q69YH4
    • Q8NC45
    • Q8WZ37
    • Q9NXH2

    Protein attributes for TMEM214 Gene

    689 amino acids
    Molecular mass:
    77151 Da
    Quaternary structure:
    • Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
    • Sequence=AAL55739.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91038.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11331.1; Type=Frameshift; Positions=94; Evidence={ECO:0000305}; Sequence=CAH10591.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM214 Gene


neXtProt entry for TMEM214 Gene

Proteomics data for TMEM214 Gene at MOPED

Post-translational modifications for TMEM214 Gene

  • Ubiquitination at Lys 240, Lys 444, and Lys 453
  • Glycosylation at Asn 269 and Asn 307
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM214 Gene

No data available for DME Specific Peptides for TMEM214 Gene

Domains & Families for TMEM214 Gene

Protein Domains for TMEM214 Gene


Suggested Antigen Peptide Sequences for TMEM214 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM214 family.
  • Belongs to the TMEM214 family.
genes like me logo Genes that share domains with TMEM214: view

No data available for Gene Families for TMEM214 Gene

Function for TMEM214 Gene

Molecular function for TMEM214 Gene

UniProtKB/Swiss-Prot Function:
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

Phenotypes for TMEM214 Gene

genes like me logo Genes that share phenotypes with TMEM214: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM214 Gene

Localization for TMEM214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM214 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM214 Gene COMPARTMENTS Subcellular localization image for TMEM214 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with TMEM214: view

Pathways & Interactions for TMEM214 Gene

SuperPathways for TMEM214 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM214 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM214 Gene

Drugs & Compounds for TMEM214 Gene

No Compound Related Data Available

Transcripts for TMEM214 Gene

Unigene Clusters for TMEM214 Gene

Transmembrane protein 214:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM214 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10: - -
SP11: -

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20

Relevant External Links for TMEM214 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM214 Gene

mRNA expression in normal human tissues for TMEM214 Gene

Protein differential expression in normal tissues from HIPED for TMEM214 Gene

This gene is overexpressed in Bone (38.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM214 Gene

SOURCE GeneReport for Unigene cluster for TMEM214 Gene Hs.533934

genes like me logo Genes that share expression patterns with TMEM214: view

Protein tissue co-expression partners for TMEM214 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM214 Gene

Orthologs for TMEM214 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM214 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM214 35
  • 88.31 (n)
  • 87.92 (a)
TMEM214 36
  • 88 (a)
(Canis familiaris)
Mammalia TMEM214 35
  • 86.49 (n)
  • 87.61 (a)
TMEM214 36
  • 88 (a)
(Mus musculus)
Mammalia Tmem214 35
  • 83.65 (n)
  • 81.66 (a)
Tmem214 16
Tmem214 36
  • 82 (a)
(Pan troglodytes)
Mammalia TMEM214 35
  • 99.32 (n)
  • 98.84 (a)
TMEM214 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem214 35
  • 83.8 (n)
  • 81.75 (a)
(Monodelphis domestica)
Mammalia TMEM214 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM214 36
  • 69 (a)
(Gallus gallus)
Aves TMEM214 35
  • 65.46 (n)
  • 60.45 (a)
TMEM214 36
  • 59 (a)
(Anolis carolinensis)
Reptilia TMEM214 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8215 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6069 35
(Danio rerio)
Actinopterygii Dr.4892 35
tmem214 35
  • 60.14 (n)
  • 53.36 (a)
tmem214 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009823 35
  • 44.67 (n)
  • 32.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33129 35
  • 43.44 (n)
  • 28.47 (a)
CG33129 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5886 36
  • 26 (a)
Species with no ortholog for TMEM214:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM214 Gene

Gene Tree for TMEM214 (if available)
Gene Tree for TMEM214 (if available)

Paralogs for TMEM214 Gene

(1) SIMAP similar genes for TMEM214 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM214: view

No data available for Paralogs for TMEM214 Gene

Variants for TMEM214 Gene

Sequence variations from dbSNP and Humsavar for TMEM214 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1124649 - 27,037,601(-) CAGCA(C/T)TTTCA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1866654 -- 27,040,254(-) TTCCC(A/G)GAATT intron-variant
rs1045062 -- 27,041,444(+) TGCCT(C/T)TAAGC nc-transcript-variant, utr-variant-3-prime
rs1045099 -- 27,041,537(+) AGCTT(C/T)TCTCC nc-transcript-variant, utr-variant-3-prime
rs1045133 -- 27,041,646(+) TGGTT(C/T)TTGGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM214 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354

Variation tolerance for TMEM214 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.92; 91.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM214 Gene

Disorders for TMEM214 Gene

Relevant External Links for TMEM214

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM214 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM214 Gene

Publications for TMEM214 Gene

  1. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. (PMID: 23661706) Li C. … Shu H.B. (J. Biol. Chem. 2013) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Probing nuclear pore complex architecture with proximity-dependent biotinylation. (PMID: 24927568) Kim D.I. … Roux K.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for TMEM214 Gene

Sources for TMEM214 Gene