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Aliases for TMEM214 Gene

Aliases for TMEM214 Gene

  • Transmembrane Protein 214 2 3

External Ids for TMEM214 Gene

Summaries for TMEM214 Gene

GeneCards Summary for TMEM214 Gene

TMEM214 (Transmembrane Protein 214) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM214 Gene

  • Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM214 Gene

Genomics for TMEM214 Gene

Genomic Location for TMEM214 Gene

Start:
27,032,906 bp from pter
End:
27,041,697 bp from pter
Size:
8,792 bases
Orientation:
Plus strand

Genomic View for TMEM214 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM214 Gene

Regulatory Elements for TMEM214 Gene

Proteins for TMEM214 Gene

  • Protein details for TMEM214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUQ4-TM214_HUMAN
    Recommended name:
    Transmembrane protein 214
    Protein Accession:
    Q6NUQ4
    Secondary Accessions:
    • A6NNF2
    • B3KUI9
    • B5MCD8
    • D6W547
    • Q53SW1
    • Q69YH4
    • Q8NC45
    • Q8WZ37
    • Q9NXH2

    Protein attributes for TMEM214 Gene

    Size:
    689 amino acids
    Molecular mass:
    77151 Da
    Quaternary structure:
    • Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER
    SequenceCaution:
    • Sequence=AAL55739.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91038.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11331.1; Type=Frameshift; Positions=94; Evidence={ECO:0000305}; Sequence=CAH10591.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM214 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM214 Gene

Proteomics data for TMEM214 Gene at MOPED

Post-translational modifications for TMEM214 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys240, Lys444, and Lys453
  • Glycosylation at Asn269 and Asn307

Other Protein References for TMEM214 Gene

No data available for DME Specific Peptides for TMEM214 Gene

Domains for TMEM214 Gene

Protein Domains for TMEM214 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM214_HUMAN
Family:
  • Belongs to the TMEM214 family.:
    • Q6NUQ4
genes like me logo Genes that share domains with TMEM214: view

No data available for Gene Families for TMEM214 Gene

Function for TMEM214 Gene

Molecular function for TMEM214 Gene

UniProtKB/Swiss-Prot Function: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.

miRNA for TMEM214 Gene

miRTarBase miRNAs that target TMEM214

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM214 Gene

Localization for TMEM214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM214 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM214 Gene COMPARTMENTS Subcellular localization image for TMEM214 gene
Compartment Confidence
cytoskeleton 5
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with TMEM214: view

Pathways for TMEM214 Gene

SuperPathways for TMEM214 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TMEM214: view

No data available for Pathways by source for TMEM214 Gene

Transcripts for TMEM214 Gene

Unigene Clusters for TMEM214 Gene

Transmembrane protein 214:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM214 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10: - -
SP11: -
SP12:
SP13:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TMEM214 Gene

GeneLoc Exon Structure for
TMEM214
ECgene alternative splicing isoforms for
TMEM214

Expression for TMEM214 Gene

mRNA expression in normal human tissues for TMEM214 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM214 Gene

SOURCE GeneReport for Unigene cluster for TMEM214 Gene Hs.533934

genes like me logo Genes that share expressions with TMEM214: view

Orthologs for TMEM214 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM214 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM214 36
  • 99.32 (n)
  • 98.84 (a)
TMEM214 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM214 36
  • 88.31 (n)
  • 87.92 (a)
TMEM214 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM214 36
  • 86.49 (n)
  • 87.61 (a)
TMEM214 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem214 36
  • 83.65 (n)
  • 81.66 (a)
Tmem214 16
Tmem214 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM214 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM214 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem214 36
  • 83.8 (n)
  • 81.75 (a)
chicken
(Gallus gallus)
Aves TMEM214 36
  • 65.46 (n)
  • 60.45 (a)
TMEM214 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM214 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6069 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8215 36
zebrafish
(Danio rerio)
Actinopterygii Dr.4892 36
tmem214 36
  • 60.14 (n)
  • 53.36 (a)
tmem214 37
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009823 36
  • 44.67 (n)
  • 32.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33129 36
  • 43.44 (n)
  • 28.47 (a)
CG33129 37
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5886 37
  • 26 (a)
OneToOne
Species with no ortholog for TMEM214:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM214 Gene

ENSEMBL:
Gene Tree for TMEM214 (if available)
TreeFam:
Gene Tree for TMEM214 (if available)

Paralogs for TMEM214 Gene

Selected SIMAP similar genes for TMEM214 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM214: view

No data available for Paralogs for TMEM214 Gene

Variants for TMEM214 Gene

Sequence variations from dbSNP and Humsavar for TMEM214 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1045062 -- 27,041,444(+) TGCCT(C/T)TAAGC utr-variant-3-prime, nc-transcript-variant
rs1045099 -- 27,041,537(+) AGCTT(C/T)TCTCC utr-variant-3-prime, nc-transcript-variant
rs1045133 -- 27,041,646(+) TGGTT(C/T)TTGGG utr-variant-3-prime, nc-transcript-variant
rs1124649 - 27,037,601(-) CAGCA(C/T)TTTCA missense, reference, upstream-variant-2KB, nc-transcript-variant
rs1866654 -- 27,040,254(-) TTCCC(A/G)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM214 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354

Relevant External Links for TMEM214 Gene

HapMap Linkage Disequilibrium report
TMEM214

Disorders for TMEM214 Gene

No disorders were found for TMEM214 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM214 Gene

Publications for TMEM214 Gene

  1. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. (PMID: 23661706) Li C. … Shu H.B. (J. Biol. Chem. 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for TMEM214 Gene

  • antibodies-online peptides for TMEM214
  • antibodies-online antibodies for TMEM214
  • antibodies-online kits for TMEM214

Sources for TMEM214 Gene

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