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TMEM213 Gene

protein-coding   GIFtS: 34
GCID: GC07P138482

Transmembrane Protein 213

  Search for TMEM213
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 2131 2

External Ids:    HGNC: 272201   Entrez Gene: 1550062   Ensembl: ENSG000002141287   UniProtKB: A2RRL73   

Export aliases for TMEM213 gene to outside databases

Previous GC identifers: GC07P138134 GC07P132793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM213 Gene:
TMEM213 (transmembrane protein 213) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM213 gene promoter:
         GR   AML1a   GR-beta   HNF-1A   HNF-1   Zic1   SEF-1 (1)   GR-alpha   ZIC2/Zic2   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM213


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TMEM213 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM213 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P138482:  view genomic region     (about GC identifiers)

Start:
138,482,695 bp from pter      End:
138,522,846 bp from pter
Size:
40,152 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 137,826,948-137,834,974     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM213_HUMAN, A2RRL7 (See protein sequence)
Recommended Name: Transmembrane protein 213 precursor  
Size: 107 amino acids; 11520 Da
Sequence caution: Sequence=AAI31698.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4D1R3 C9JH49 C9JX41 C9K0P0
Alternative splicing: 4 isoforms:  A2RRL7-1   A2RRL7-2   A2RRL7-3   A2RRL7-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for TMEM213: NX_A2RRL7

Explore proteomics data for TMEM213 at MOPED


See TMEM213 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001078898.1  
ENSEMBL proteins: 
 ENSP00000380727   ENSP00000390407   ENSP00000393891   ENSP00000401570   ENSP00000402388  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028121 TMEM213

Graphical View of Domain Structure for InterPro Entry A2RRL7

ProtoNet protein and cluster: A2RRL7


Find genes that share domains with TMEM213           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM213_HUMAN, A2RRL7: Membrane; Single-pass type I membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM213           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM213
Interactions:

    Search GeneGlobe Interaction Network for TMEM213

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM213 (TM213)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM213 gene: 
NM_001085429.1  

Unigene Cluster for TMEM213:

Transmembrane protein 213
Hs.567729  [show with all ESTs]
Unigene Representative Sequence: NM_001085429
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000397602 ENST00000442682(uc010lna.3 uc010lnb.3) ENST00000458494
ENST00000413208 ENST00000472775 ENST00000422794
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Additional mRNA sequence: 

AK055760.1 AK055841.1 BC058028.1 BC131697.1 

3 DOTS entries:

DT.75100743  DT.75157710  DT.91951018 

19 AceView cDNA sequences:

BI041753 AW295005 AI672404 BG401569 BC058028 AK055841 AK055760 AI245830 
AI769774 BI041929 AI991407 AW467103 AW299705 AW195031 AI766749 AI792934 
AW771283 BG399538 AA974952 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM213 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTCTTGTGT
TMEM213 Expression
About this image

TMEM213 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM213 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.567729
    Custom PCR Arrays for TMEM213
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TMEM213 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem2131 , 5 transmembrane protein 2131, 5 77.56(n)1
73.08(a)1
  6 (17.64 cM)5
775221  NM_029921.11  NP_084197.11 
 381093535 
chicken
(Gallus gallus)
Aves TMEM2131 transmembrane protein 213 75.86(n)
79.31(a)
  418103  XM_416337.2  XP_416337.1 
lizard
(Anolis carolinensis)
Reptilia TMEM2136
transmembrane protein 213
74(a)
1 ↔ 1
5(16475543-16475704)


ENSEMBL Gene Tree for TMEM213 (if available)
TreeFam Gene Tree for TMEM213 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM213 (see all 179)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1403396221,2
--138484948(+) GCAATA/GGAACC 1 -- int10--------
rs1499533401,2
--138484996(+) TTTTTA/CCTGAA 1 -- int10--------
rs1465245391,2
--138485023(+) TTAAAC/TAACCA 1 -- int10--------
rs624869791,2
C,F--138485087(+) TTCTTA/GTTGTC 1 -- int18Minor allele frequency- G:0.49NA WA CSA EA 366
rs1149777121,2
C,F--138485123(+) TCAGAT/CCCCTA 1 -- int11Minor allele frequency- C:0.05WA 118
rs1821161421,2
--138485155(+) CAACAA/GGACTT 1 -- int10--------
rs668644881,2
C--138485425(+) TTCTT-/CTTTTTTT 2 -- int1 cds11Minor allele frequency- CTT:0.00NA 2
rs1498459861,2
C--138485449(+) TTCTTC/TTTTTT 1 -- int10--------
rs750839591,2
F--138485469(+) TTAGAT/CGGAGT 1 -- int11Minor allele frequency- C:0.00NA 2
rs352539841,2
C--138485523(+) CACTG-/AAACCT 1 -- int10--------

HapMap Linkage Disequilibrium report for TMEM213 (138482695 - 138522846 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TMEM213:    About this table    
Variant IDTypeSubtypePubMed ID
esv2735212CNV Deletion23290073
nsv516706CNV Loss19592680
nsv831154CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for TMEM213

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with TMEM213           About GenesLikeMe

Genetic Association Database (GAD): TMEM213

Export disorders for TMEM213 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM213 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM213)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)
  5. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 155006 HGNC: 27220 AceView: LOC155006 Ensembl:ENSG00000214128 euGenes: HUgn155006
ECgene: TMEM213 H-InvDB: TMEM213

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM213 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM213 gene:
Search GeneIP for patents involving TMEM213

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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