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Aliases for TMEM213 Gene

Aliases for TMEM213 Gene

  • Transmembrane Protein 213 2 3 5

External Ids for TMEM213 Gene

Previous GeneCards Identifiers for TMEM213 Gene

  • GC07P138134
  • GC07P138482
  • GC07P132793

Summaries for TMEM213 Gene

GeneCards Summary for TMEM213 Gene

TMEM213 (Transmembrane Protein 213) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM213 Gene

Genomics for TMEM213 Gene

Regulatory Elements for TMEM213 Gene

Enhancers for TMEM213 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G138841 1 Ensembl ENCODE 11.6 +44.3 44317 0.6 JUN TEAD4 BACH1 FOSL1 ZNF316 NFE2 MAFK L3MBTL2 NR4A1 MAFG RNU6-1272P TMEM213 ATP6V0A4 ZC3HAV1L PIR43003 GC07M138877
GH07G139724 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +934.2 934229 15.0 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 TBXAS1 HIPK2 FCF1P11 TTC26 ZC3HAV1L PARP12 KDM7A TMEM213 KIAA1549 LUC7L2
GH07G138844 0.6 ENCODE 11.5 +46.2 46196 0.2 PKNOX1 L3MBTL2 IKZF1 MAFG DPF2 NFE2 EMSY RNU6-1272P ATP6V0A4 TMEM213 ZC3HAV1L PIR43003 GC07M138877
GH07G138837 0.5 ENCODE 11.3 +40.5 40483 1.3 POLR2H RNF2 ZBTB33 ATP6V0A4 TMEM213 RNU6-1272P PIR43003 GC07M138877
GH07G138785 0.8 Ensembl ENCODE 6.4 -11.9 -11918 0.7 CTCF STAT1 POLR2A ZSCAN4 RAD21 RBFOX2 TEAD3 TMEM213 UQCRFS1P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM213 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM213 Gene

Chromosome:
7
Start:
138,797,915 bp from pter
End:
138,838,101 bp from pter
Size:
40,187 bases
Orientation:
Plus strand

Genomic View for TMEM213 Gene

Genes around TMEM213 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM213 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM213 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM213 Gene

Proteins for TMEM213 Gene

  • Protein details for TMEM213 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RRL7-TM213_HUMAN
    Recommended name:
    Transmembrane protein 213
    Protein Accession:
    A2RRL7
    Secondary Accessions:
    • A4D1R3
    • C9JH49
    • C9JX41
    • C9K0P0

    Protein attributes for TMEM213 Gene

    Size:
    107 amino acids
    Molecular mass:
    11520 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31698.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM213 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM213 Gene

Post-translational modifications for TMEM213 Gene

No Post-translational modifications

Other Protein References for TMEM213 Gene

No data available for DME Specific Peptides for TMEM213 Gene

Domains & Families for TMEM213 Gene

Protein Domains for TMEM213 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM213 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM213: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM213 Gene

Function for TMEM213 Gene

genes like me logo Genes that share phenotypes with TMEM213: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM213 Gene

Localization for TMEM213 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM213 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM213 gene
Compartment Confidence
extracellular 3
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM213: view

Pathways & Interactions for TMEM213 Gene

SuperPathways for TMEM213 Gene

No Data Available

Interacting Proteins for TMEM213 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000390407%0d%0a9606.ENSP00000303147%0d%0a
Selected Interacting proteins: A2RRL7-TM213_HUMAN ENSP00000390407 for TMEM213 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM213 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM213 Gene

Drugs & Compounds for TMEM213 Gene

No Compound Related Data Available

Transcripts for TMEM213 Gene

mRNA/cDNA for TMEM213 Gene

Unigene Clusters for TMEM213 Gene

Transmembrane protein 213:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM213 Gene

No ASD Table

Relevant External Links for TMEM213 Gene

GeneLoc Exon Structure for
TMEM213
ECgene alternative splicing isoforms for
TMEM213

Expression for TMEM213 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM213 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM213 Gene

This gene is overexpressed in Kidney - Cortex (x37.7), Minor Salivary Gland (x4.2), Skin - Not Sun Exposed (Suprapubic) (x4.1), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM213 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM213 Gene



Protein tissue co-expression partners for TMEM213 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM213 Gene:

TMEM213

SOURCE GeneReport for Unigene cluster for TMEM213 Gene:

Hs.567729
genes like me logo Genes that share expression patterns with TMEM213: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM213 Gene

Orthologs for TMEM213 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM213 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM213 34 35
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia TMEM213 34 35
  • 84.11 (n)
dog
(Canis familiaris)
Mammalia TMEM213 34 35
  • 82.24 (n)
rat
(Rattus norvegicus)
Mammalia Tmem213 34
  • 77.99 (n)
mouse
(Mus musculus)
Mammalia Tmem213 34 16 35
  • 77.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM213 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM213 34 35
  • 75.86 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM213 35
  • 74 (a)
OneToOne
Species where no ortholog for TMEM213 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM213 Gene

ENSEMBL:
Gene Tree for TMEM213 (if available)
TreeFam:
Gene Tree for TMEM213 (if available)

Paralogs for TMEM213 Gene

No data available for Paralogs for TMEM213 Gene

Variants for TMEM213 Gene

Sequence variations from dbSNP and Humsavar for TMEM213 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs199654929 Likely benign 138,798,082(+) GCACC(A/G)GGCAC intron-variant, reference, missense, utr-variant-5-prime
rs368646400 Likely benign 138,798,050(+) ACTCG(A/G)CACAA intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs200591064 Uncertain significance 138,798,153(+) GCCTG(C/G)CCTTT intron-variant, reference, missense, utr-variant-5-prime
rs373396667 Uncertain significance 138,798,161(+) TTTGC(C/T)TCCCT intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs746508351 Uncertain significance 138,798,119(+) CTCCC(C/T)GCTGC intron-variant, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM213 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
esv3615199 CNV gain 21293372
esv3615200 CNV gain 21293372
nsv1030956 CNV gain 25217958
nsv516706 CNV loss 19592680
nsv831154 CNV gain 17160897

Variation tolerance for TMEM213 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM213 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM213

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM213 Gene

Disorders for TMEM213 Gene

Relevant External Links for TMEM213

Genetic Association Database (GAD)
TMEM213
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM213

No disorders were found for TMEM213 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM213 Gene

Publications for TMEM213 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4 64

Products for TMEM213 Gene

Sources for TMEM213 Gene

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