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TMEM212 Gene

protein-coding   GIFtS: 36
GCID: GC03P171561

Transmembrane Protein 212

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 2121 2

External Ids:    HGNC: 342951   Entrez Gene: 3891772   Ensembl: ENSG000001863297   UniProtKB: A6NML53   

Export aliases for TMEM212 gene to outside databases

Previous GC identifers: GC03P173044 GC03P168931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM212 Gene:
TMEM212 (transmembrane protein 212) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM212
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM212


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.31   Ensembl cytogenetic band:  3q26.31   HGNC cytogenetic band: 3q26.31

TMEM212 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM212 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P171561:  view genomic region     (about GC identifiers)

Start:
171,561,139 bp from pter      End:
171,656,505 bp from pter
Size:
95,367 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: TM212_HUMAN, A6NML5 (See protein sequence)
Recommended Name: Transmembrane protein 212  
Size: 194 amino acids; 21425 Da

Explore the universe of human proteins at neXtProt for TMEM212: NX_A6NML5

Explore proteomics data for TMEM212 at MOPED


See TMEM212 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001157908.1  
ENSEMBL proteins: 
 ENSP00000334072   ENSP00000410327   ENSP00000393684  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007237 CD20-like

Graphical View of Domain Structure for InterPro Entry A6NML5

ProtoNet protein and cluster: A6NML5


Find genes that share domains with TMEM212           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TMEM212

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM212_HUMAN, A6NML5: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM212           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM212
Interactions:

    Search GeneGlobe Interaction Network for TMEM212

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM212 (TM212)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM212 gene: 
NM_001164436.1  

Unigene Cluster for TMEM212:

Transmembrane protein 212
Hs.642307  [show with all ESTs]
Unigene Representative Sequence: NM_001164436
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000334567(uc003fhw.2) ENST00000420375 ENST00000450693 ENST00000469981

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Additional mRNA sequence: AK026825.1 

1 DOTS entry:

DT.97765974 

5 AceView cDNA sequences:

AK026825 CF887221 CF890921 CA315059 CD689572 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM212 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TMEM212 Expression
About this image

TMEM212 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM212 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.642307
    Custom PCR Arrays for TMEM212
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TMEM212 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem2121 , 5 transmembrane protein 2121, 5 80.29(n)1
79.03(a)1
  3 (11.05 cM)5
2086131  NM_001164437.11  NP_001157909.11 
 278660665 
lizard
(Anolis carolinensis)
Reptilia TMEM2126
transmembrane protein 212
58(a)
1 ↔ 1
3(6787380-6819699)
tropical clawed frog
(Xenopus tropicalis)
Amphibia tmem2121 transmembrane protein 212 62.11(n)
53.01(a)
  100497136  XM_002931569.2  XP_002931615.2 


ENSEMBL Gene Tree for TMEM212 (if available)
TreeFam Gene Tree for TMEM212 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM212 (see all 356)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1823064031,2
--171559143(+) CAGCAC/TATTGA 1 -- us2k10--------
rs1461251221,2
--171559164(+) AGCTAC/TAACCT 1 -- us2k10--------
rs1388590751,2
--171559262(+) CCCCAA/TATCAG 1 -- us2k10--------
rs168567241,2
C,F--171559306(+) GGTGGA/TTTCAC 1 -- us2k15Minor allele frequency- T:0.02NA WA 262
rs1428048031,2
--171559427(+) GCTCTA/GATGCA 1 -- us2k10--------
rs1469724481,2
C--171559431(+) TGATGC/TAGACA 1 -- us2k10--------
rs764248811,2
C,F--171559595(+) CCAGAA/GAGCAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
rs1483253281,2
--171559735(+) TTCCAA/CCACAT 1 -- us2k10--------
rs1870646201,2
--171559771(+) ACCAAA/GTTGTT 1 -- us2k10--------
rs38501881,2
C,F,A,H--171559827(+) AAAACA/CACAAT 1 -- us2k1 tfbs324Minor allele frequency- C:0.28EA NS NA WA CSA 2130

HapMap Linkage Disequilibrium report for TMEM212 (171561139 - 171656505 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TMEM212:    About this table    
Variant IDTypeSubtypePubMed ID
esv2672519CNV Deletion23128226
nsv877985CNV Gain21882294
nsv7356OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with TMEM212           About GenesLikeMe

Genetic Association Database (GAD): TMEM212

Export disorders for TMEM212 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM212 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM212)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (Hypertension 2012)
  4. Genetic variants affecting the neural processing of human facial expressions: evidence using a genome-wide functional imaging approach. (PubMed id 22828495)1 Brown A.A....Andreassen O.A. (Transl Psychiatry 2012)
  5. Genome-wide association of BMI in African Americans. (PubMed id 21701570)1 Ng M.C....Bowden D.W. (Obesity (Silver Spring) 2012)
  6. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PubMed id 20889312)1 Wang K.S....Aragam N. (Schizophr. Res. 2010)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 389177 HGNC: 34295 AceView: LOC389177 Ensembl:ENSG00000186329 euGenes: HUgn389177
ECgene: TMEM212 H-InvDB: TMEM212

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM212 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM212 gene:
Search GeneIP for patents involving TMEM212

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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