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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM211 Gene

protein-coding   GIFtS: 36
GCID: GC22M025331

Transmembrane Protein 211

  Search for TMEM211
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2111 2
bA9F11.12

External Ids:    HGNC: 337251   Entrez Gene: 2553492   Ensembl: ENSG000002060697   UniProtKB: Q6ICI03   

Export aliases for TMEM211 gene to outside databases

Previous GC identifers: GC22M023661 GC22M008279


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM211 Gene: 
TMEM211 (transmembrane protein 211) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM211 gene promoter:
         ER-alpha   Elk-1   HNF-1A   c-Ets-1   C/EBPalpha   E47   CREB   AREB6   HNF-1   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM211 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM211

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM211


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

TMEM211 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM211 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M025331:  view genomic region     (about GC identifiers)

Start:
25,331,077 bp from pter      End:
25,342,662 bp from pter
Size:
11,586 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM211_HUMAN, Q6ICI0 (See protein sequence)
Recommended Name: Transmembrane protein 211  
Size: 200 amino acids; 21740 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAI30648.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI30650.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAG30274.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI17239.1; Type=Erroneous gene model
prediction;

Explore the universe of human proteins at neXtProt for TMEM211: NX_Q6ICI0

Explore proteomics data for TMEM211 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ICI0

  • TMEM211 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM211 Protein Expression
    REFSEQ proteins: NP_001001663.1  
    ENSEMBL proteins: 
     ENSP00000385494   ENSP00000387813   ENSP00000372192  

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    Cloud-Clone Corp. Proteins for TMEM211 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM211 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019372 Lipome_HGMIC_fus_partner-like

    Graphical View of Domain Structure for InterPro Entry Q6ICI0

    ProtoNet protein and cluster: Q6ICI0

    UniProtKB/Swiss-Prot: TM211_HUMAN, Q6ICI0
    Similarity: Belongs to the TMEM211 family


    TMEM211 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM211 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM211

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM211 (TM211)

    Search CenterWatch for drugs/clinical trials and news about TMEM211 / TM211

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM211 gene: 
    NM_001001663.1  

    Unigene Cluster for TMEM211:

    Transmembrane protein 211
    Hs.329040  [show with all ESTs]
    Unigene Representative Sequence: BG222046
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407886 ENST00000423535 ENST00000382744(uc003abk.1)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM211

    Additional mRNA sequence: 

    BC130647.1 BC130649.1 CR456388.1 

    1 DOTS entry:

    DT.102820173 

    5 AceView cDNA sequences:

    CR456388 NM_001001663 BG222046 BU584904 AI933811 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM211 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCCAACTT
    TMEM211 Expression
    About this image


    See TMEM211 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.329040
        SABiosciences Custom PCR Arrays for TMEM211
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM211
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM211

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM211 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2111 , 5 transmembrane protein 2111, 5 68.83(n)1
    60.98(a)1
      5 (55.43 cM)5
    3330481  NM_001033428.21  NP_001028600.11 
     1132269095 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000041801 transmembrane protein 211-like 49.14(n)
    36.08(a)
      100004180  XM_001338138.4  XP_001338174.3 


    ENSEMBL Gene Tree for TMEM211 (if available)
    TreeFam Gene Tree for TMEM211 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/183 SNPs in TMEM211 are shown (see all 183)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915546821,2
    --8285909(+) TTCTGC/TGTCTT 1 -- us2k10--------
    rs1831000851,2
    --8285920(+) ACTTTC/TGGACT 1 -- us2k10--------
    rs1499517861,2
    --8285927(+) GACTGA/GAACAC 1 -- us2k10--------
    rs1884796111,2
    C--8286057(+) CCATAA/GCAAGA 1 -- us2k10--------
    rs1123353611,2
    F--25330708(+) AGAGTG/AGTCTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1855086571,2
    --25330739(+) CACCCA/GTCTCA 1 -- ds50010--------
    rs119134371,2
    C,F,H--25330812(+) TTATAC/TATAAT 1 -- ds50016Minor allele frequency- T:0.03NS EA CSA WA 538
    rs1180072711,2
    C,F--25330911(+) ATATGC/TGCATG 1 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1181044601,2
    F--25330914(+) TGCGCA/GTGCCA 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1475914141,2
    --25330936(+) TAGTTA/TTTGAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TMEM211 (25331077 - 25342662 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMEM211:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3580CNV Loss18451855
    nsv834161CNV Gain17160897
    nsv7350OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMEM211 for disorders           About MalaCards

    TMEM211 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM211
    Human Genome Epidemiology (HuGE) Navigator: TMEM211 (1 document)

    Export disorders for TMEM211 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM211 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM211)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255349 HGNC: 33725 AceView: bA9F11.1 Ensembl:ENSG00000206069 euGenes: HUgn255349
    ECgene: TMEM211 H-InvDB: TMEM211

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM211 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM211 gene:
    Search GeneIP for patents involving TMEM211

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM211
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMEM211
     SwitchGear Promoter luciferase reporter plasmids for TMEM211
     Search ThermoFisher Antibodies for TMEM211
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM211
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM211
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM211
    Customized:
     lentivirus for stable overexpression of TMEM211
     lentivirus expression plasmids for stable overexpression of TMEM211
     adenovirus for overexpression of TMEM211
     Search LSBio for Antibodies for TMEM211
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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