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TMEM209 Gene

protein-coding   GIFtS: 48
GCID: GC07M129804

Transmembrane Protein 209

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 2091 2
NET312

External Ids:    HGNC: 218981   Entrez Gene: 849282   Ensembl: ENSG000001468427   UniProtKB: Q96SK23   

Export aliases for TMEM209 gene to outside databases

Previous GC identifers: GC07M129592 GC07M124166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM209 Gene:
TMEM209 (transmembrane protein 209) is a protein-coding gene. Diseases associated with TMEM209 include splenic marginal zone lymphoma, and malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM209 gene promoter:
         Nkx3-1   Nkx3-1 v4   RFX1   Lmo2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMEM209 promoter sequence
   Search Chromatin IP Primers for TMEM209

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM209


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.2   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32.2

TMEM209 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM209 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M129804:  view genomic region     (about GC identifiers)

Start:
129,804,555 bp from pter      End:
129,847,610 bp from pter
Size:
43,056 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 129,189,927-129,230,704     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM209_HUMAN, Q96SK2 (See protein sequence)
Recommended Name: Transmembrane protein 209  
Size: 561 amino acids; 62922 Da
Secondary accessions: A4D1L1 Q49A50 Q6PF00 Q8NCH3 Q96SL6
Alternative splicing: 4 isoforms:  Q96SK2-1   Q96SK2-2   Q96SK2-3   Q96SK2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM209: NX_Q96SK2

Explore proteomics data for TMEM209 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys232, Lys257, Lys288, Lys312, Lys338
  • Glycosylation2 at Asn57, Asn274
  • Modification sites at PhosphoSitePlus

  • See TMEM209 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116231.2  
    ENSEMBL proteins: 
     ENSP00000380747   ENSP00000419697   ENSP00000417258   ENSP00000419852   ENSP00000418474  
     ENSP00000338388  

    TMEM209 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TMEM209
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TMEM209
    GenScript Custom Purified and Recombinant Proteins Services for TMEM209
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM209

    TMEM209 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMEM209
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM209
    Novus Biologicals TMEM209 Antibodies
    Abcam antibodies for TMEM209
    Cloud-Clone Corp. Antibodies for TMEM209
    Search ThermoFisher Antibodies for TMEM209
    LSBio Antibodies in human, mouse, rat for TMEM209

    TMEM209 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM209
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM209
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM209
    Cloud-Clone Corp. CLIAs for TMEM209


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019176 Cytochrome_B561-rel

    Graphical View of Domain Structure for InterPro Entry Q96SK2

    ProtoNet protein and cluster: Q96SK2


    TMEM209 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM209
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM209

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM209
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM209

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM209:
    hsa-mir-24-3p (MIRT030541), hsa-mir-99a-5p (MIRT048663)

    Block miRNA regulation of human, mouse, rat TMEM209 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM209 (see all 9):
    hsa-miR-3163 hsa-miR-4328 hsa-miR-2110 hsa-miR-548aa hsa-miR-2116 hsa-miR-205* hsa-miR-296-3p hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidTMEM209 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM209
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM209

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM209

    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM209 (see all 7)
    OriGene ORF clones in mouse, rat for TMEM209
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM209 (NM_032842)
    Sino Biological Human cDNA Clone for TMEM209
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM209
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM209

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM209
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM209 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM209


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM209_HUMAN, Q96SK2: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM209 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM209
    Interactions:

        Search GeneGlobe Interaction Network for TMEM209

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TMEM209 (ENSP000003807474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM209 (TM209)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM209 gene: 
    NM_032842.3  

    Unigene Cluster for TMEM209:

    Transmembrane protein 209
    Hs.267245  [show with all ESTs]
    Unigene Representative Sequence: NM_032842
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397622(uc003vpn.2 uc010lmc.1 uc003vpo.2) ENST00000462753
    ENST00000473456 ENST00000479804 ENST00000467599 ENST00000471985 ENST00000471077
    ENST00000336804
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM209 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM209 (see all 9):
    hsa-miR-3163 hsa-miR-4328 hsa-miR-2110 hsa-miR-548aa hsa-miR-2116 hsa-miR-205* hsa-miR-296-3p hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidTMEM209 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM209
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM209
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM209 (see all 7)
    OriGene ORF clones in mouse, rat for TMEM209
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM209 (NM_032842)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM209
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM209
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM209
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM209
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM209
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM209
      QuantiFast Probe-based Assays in human, mouse, rat TMEM209

    Additional mRNA sequence: 

    AK027678.1 AK074732.1 BC016721.1 BC045618.1 BC057784.1 

    10 DOTS entries:

    DT.408283  DT.91665647  DT.100721373  DT.40282669  DT.97840343  DT.92005734  DT.99928896  DT.121042401 
    DT.121042406  DT.75106992 

    Selected AceView cDNA sequences (see all 102):

    AA884119 BE219881 BE503047 AI339433 AK074732 CB241782 AA988192 AW875789 
    AW875883 CD644641 AA907844 AW241959 BQ008855 BG287937 BU177118 AI953750 
    BF353600 AI589217 H89984 BC016721 NM_032842 BX492923 AA764749 BC045618 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM209 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                    -     -     -                                         -                                               -                           
    SP2:                                                                          -                             -     -           -                           
    SP3:                    -     -     -                                                                                                                     
    SP4:                                -                                                                                                                     
    SP5:        -     -     -     -     -                                                                                                                     


    ECgene alternative splicing isoforms for TMEM209

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM209 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAACATT
    TMEM209 Expression
    About this image

    TMEM209 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM209 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.267245
        Custom PCR Arrays for TMEM209
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM209
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM209
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM209
    QuantiTect SYBR Green Assays in human, mouse, rat TMEM209
    QuantiFast Probe-based Assays in human, mouse, rat TMEM209
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM209

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM209 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem2091 , 5 transmembrane protein 2091, 5 88.83(n)1
    95.19(a)1
      6 (12.52 cM)5
    726491  NM_178625.31  NP_848740.31 
     304790535 
    chicken
    (Gallus gallus)
    Aves TMEM2091 transmembrane protein 209 76.57(n)
    86.23(a)
      416681  XM_004937423.1  XP_004937480.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM2096
    transmembrane protein 209
    83(a)
    1 ↔ 1
    GL343819.1(143855-169760)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU901453.12   -- 75.99(n)    BU901453.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem2091 transmembrane protein 209 67.71(n)
    70.72(a)
      555279  NM_001270973.1  NP_001257902.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64796
    --
    28(a)
    1 ↔ 1
    3L(17330272-17332362)
    worm
    (Caenorhabditis elegans)
    Secernentea B0464.66
    Protein B0464.6 (B0464.6) mRNA, complete cds
    19(a)
    1 ↔ 1
    III(9462984-9465965) WBGene00007186


    ENSEMBL Gene Tree for TMEM209 (if available)
    TreeFam Gene Tree for TMEM209 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM209 gene
    14 SIMAP similar genes for TMEM209 using alignment to 4 protein entries:     TM209_HUMAN (see all proteins):
    RHBG    TUBA1C    RQCD1    FLJ00047    C12orf76    COQ5
    SH2B3    pp12301    RBP7    SEC14L3    MST132    SNRPF
    GALK2    TM2D1

    TMEM209 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM209 (see all 771)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158527331,2
    C,F--129804390(+) ATTAAT/CAGTAT 1 -- int11Minor allele frequency- C:0.07WA 118
    rs1908304461,2
    --129804451(+) AGACTG/TTATTT 1 -- int10--------
    rs1448193681,2
    C--129804561(+) TTGTT-/AAAAAT 1 -- ut310--------
    rs1450658921,2
    --129805143(+) ACATAC/TACAGA 1 -- ut310--------
    rs1830884891,2
    --129805235(+) TTGAAA/GATAGG 1 -- ut310--------
    rs114597131,2
    C--129805540(+) AAAAA-/AAAAAA 1 -- ut31 trp31Minor allele frequency- A:0.50NA 2
    rs2005142941,2
    C--129805540(+) ACATT-/AAAAAA 1 -- ut310--------
    rs1879894951,2
    --129805633(+) TGGCTC/TGCACC 1 -- ut310--------
    rs1386416811,2
    --129805875(+) TCTGCA/GTTGAC 1 -- ut310--------
    rs1931445761,2
    --129806033(+) AAATCC/TGAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM209 (129804555 - 129847610 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM209:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5950CNV Insertion18451855
    nsv508481CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM209
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM209

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TMEM209:    
    About MalaCards
    splenic marginal zone lymphoma    malaria

    1 disease from the University of Copenhagen DISEASES database for TMEM209:
    Splenic marginal zone lymphoma

    TMEM209 for disorders           About GeneDecksing


    Export disorders for TMEM209 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM209 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TMEM209)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 3 Schirmer E.C.... Gerace L. (Science 2003)
    3. Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis. (PubMed id 22719065)1 Fujitomo T....Nakamura Y. (Cancer Res. 2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84928 HGNC: 21898 AceView: FLJ14803 Ensembl:ENSG00000146842 euGenes: HUgn84928
    ECgene: TMEM209 H-InvDB: TMEM209

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM209 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM209 gene:
    Search GeneIP for patents involving TMEM209

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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