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Aliases for TMEM209 Gene

Aliases for TMEM209 Gene

  • Transmembrane Protein 209 2 3 5
  • Testicular Tissue Protein Li 202 3
  • NET31 3

External Ids for TMEM209 Gene

Previous GeneCards Identifiers for TMEM209 Gene

  • GC07M129592
  • GC07M129804
  • GC07M124166

Summaries for TMEM209 Gene

GeneCards Summary for TMEM209 Gene

TMEM209 (Transmembrane Protein 209) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM209 Gene

Genomics for TMEM209 Gene

Regulatory Elements for TMEM209 Gene

Enhancers for TMEM209 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM209 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM209 Gene

Chromosome:
7
Start:
130,164,713 bp from pter
End:
130,207,770 bp from pter
Size:
43,058 bases
Orientation:
Minus strand

Genomic View for TMEM209 Gene

Genes around TMEM209 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM209 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM209 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM209 Gene

Proteins for TMEM209 Gene

  • Protein details for TMEM209 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SK2-TM209_HUMAN
    Recommended name:
    Transmembrane protein 209
    Protein Accession:
    Q96SK2
    Secondary Accessions:
    • A4D1L1
    • Q49A50
    • Q6PF00
    • Q8NCH3
    • Q96SL6

    Protein attributes for TMEM209 Gene

    Size:
    561 amino acids
    Molecular mass:
    62922 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM209 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM209 Gene

Proteomics data for TMEM209 Gene at MOPED

Post-translational modifications for TMEM209 Gene

  • Ubiquitination at Lys 232, Lys 257, Lys 288, Lys 312, and Lys 338
  • Glycosylation at Asn 57 and Asn 274
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM209 Gene

No data available for DME Specific Peptides for TMEM209 Gene

Domains & Families for TMEM209 Gene

Protein Domains for TMEM209 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM209 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM209: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM209 Gene

Function for TMEM209 Gene

genes like me logo Genes that share phenotypes with TMEM209: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM209 Gene

Localization for TMEM209 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM209 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM209 Gene COMPARTMENTS Subcellular localization image for TMEM209 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM209 Gene

Pathways & Interactions for TMEM209 Gene

SuperPathways for TMEM209 Gene

No Data Available

Interacting Proteins for TMEM209 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000380747%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000380747 for TMEM209 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM209 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM209 Gene

Drugs & Compounds for TMEM209 Gene

No Compound Related Data Available

Transcripts for TMEM209 Gene

Unigene Clusters for TMEM209 Gene

Transmembrane protein 209:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM209 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6:
SP7:

Relevant External Links for TMEM209 Gene

GeneLoc Exon Structure for
TMEM209
ECgene alternative splicing isoforms for
TMEM209

Expression for TMEM209 Gene

mRNA expression in normal human tissues for TMEM209 Gene

Protein differential expression in normal tissues from HIPED for TMEM209 Gene

This gene is overexpressed in Platelet (16.4), Brain (10.5), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM209 Gene



SOURCE GeneReport for Unigene cluster for TMEM209 Gene Hs.267245

genes like me logo Genes that share expression patterns with TMEM209: view

Protein tissue co-expression partners for TMEM209 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM209 Gene

Orthologs for TMEM209 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM209 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM209 35
  • 92.14 (n)
  • 96.79 (a)
TMEM209 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM209 35
  • 93.46 (n)
  • 98.04 (a)
TMEM209 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem209 35
  • 88.83 (n)
  • 95.19 (a)
Tmem209 16
Tmem209 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem209 35
  • 88.18 (n)
  • 94.83 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM209 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM209 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM209 35
  • 76.57 (n)
  • 86.23 (a)
TMEM209 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM209 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4132 35
tmem209 35
  • 71.96 (n)
  • 75.71 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem209 35
  • 67.71 (n)
  • 70.72 (a)
tmem209 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6479 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0464.6 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.960 36
  • 32 (a)
OneToOne
Species with no ortholog for TMEM209:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM209 Gene

ENSEMBL:
Gene Tree for TMEM209 (if available)
TreeFam:
Gene Tree for TMEM209 (if available)

Paralogs for TMEM209 Gene

(14) SIMAP similar genes for TMEM209 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM209: view

No data available for Paralogs for TMEM209 Gene

Variants for TMEM209 Gene

Sequence variations from dbSNP and Humsavar for TMEM209 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_042918 -
VAR_042919 -
rs17164729 -- 130,202,389(+) AATCA(C/T)TGGTC intron-variant
rs28612858 -- 130,203,150(+) ATCCT(A/C)GCAAC intron-variant
rs34193094 -- 130,167,009(+) AGTAT(A/G)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM209 Gene

Variant ID Type Subtype PubMed ID
nsv5950 CNV Insertion 18451855
nsv508481 CNV Loss 20534489

Variation tolerance for TMEM209 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM209 Gene

Disorders for TMEM209 Gene

Relevant External Links for TMEM209

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM209

No disorders were found for TMEM209 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM209 Gene

Publications for TMEM209 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer E.C. … Gerace L. (Science 2003) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for TMEM209 Gene

Sources for TMEM209 Gene

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