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Aliases for TMEM209 Gene

Aliases for TMEM209 Gene

  • Transmembrane Protein 209 2 3 5
  • Testicular Tissue Protein Li 202 3
  • NET31 3

External Ids for TMEM209 Gene

Previous GeneCards Identifiers for TMEM209 Gene

  • GC07M129592
  • GC07M129804
  • GC07M124166

Summaries for TMEM209 Gene

GeneCards Summary for TMEM209 Gene

TMEM209 (Transmembrane Protein 209) is a Protein Coding gene.

Additional gene information for TMEM209 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM209 Gene

Genomics for TMEM209 Gene

Regulatory Elements for TMEM209 Gene

Enhancers for TMEM209 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H130203 1.4 ENCODE dbSUPER 29.1 +2.6 2576 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 SP3 TMEM209 SSMEM1 ENSG00000240571
GH07H130954 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -751.3 -751297 8 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF766 ELK1 ZNF143 ZNF207 FOS COPG2 MIR29A TMEM209 RNU6-1010P LINC-PINT MKLN1 GC07M130950 GC07M131055
GH07H130201 0.9 ENCODE dbSUPER 22.5 +5.7 5681 1 BCOR HDGF PKNOX1 MTA2 DPF2 NFIC ZNF316 SMARCA4 NR2C1 HMBOX1 TMEM209 SSMEM1 ENSG00000240571
GH07H130151 1.2 ENCODE dbSUPER 14 +55.7 55651 1 HDGF PKNOX1 YBX1 GLI4 ATF7 KLF7 RUNX3 MCM3 SMARCA4 ZSCAN16 MKLN1 NRF1 CDC26P1 TMEM209 TSGA13 LOC100128325 ENSG00000240571
GH07H130069 1.2 ENCODE 9.9 +136.9 136868 3 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 CBX5 NRF1 TMEM209 KLF14 CDC26P1 LOC100128325 KLHDC10 PIR32855
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM209 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM209 Gene

Chromosome:
7
Start:
130,164,713 bp from pter
End:
130,207,770 bp from pter
Size:
43,058 bases
Orientation:
Minus strand

Genomic View for TMEM209 Gene

Genes around TMEM209 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM209 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM209 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM209 Gene

Proteins for TMEM209 Gene

  • Protein details for TMEM209 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SK2-TM209_HUMAN
    Recommended name:
    Transmembrane protein 209
    Protein Accession:
    Q96SK2
    Secondary Accessions:
    • A4D1L1
    • Q49A50
    • Q6PF00
    • Q8NCH3
    • Q96SL6

    Protein attributes for TMEM209 Gene

    Size:
    561 amino acids
    Molecular mass:
    62922 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM209 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM209 Gene

Post-translational modifications for TMEM209 Gene

  • Ubiquitination at Lys232, posLast=257257, posLast=288288, Lys312, and posLast=338338
  • Glycosylation at posLast=5757 and Asn274
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM209 Gene

No data available for DME Specific Peptides for TMEM209 Gene

Domains & Families for TMEM209 Gene

Gene Families for TMEM209 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM209 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM209 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM209: view

No data available for UniProtKB/Swiss-Prot for TMEM209 Gene

Function for TMEM209 Gene

Phenotypes From GWAS Catalog for TMEM209 Gene

genes like me logo Genes that share phenotypes with TMEM209: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM209
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM209 Gene

Localization for TMEM209 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM209 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM209 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nuclear speckles (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM209 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM209: view

Pathways & Interactions for TMEM209 Gene

SuperPathways for TMEM209 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM209 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM209 Gene

Drugs & Compounds for TMEM209 Gene

No Compound Related Data Available

Transcripts for TMEM209 Gene

Unigene Clusters for TMEM209 Gene

Transmembrane protein 209:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM209
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM209 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6:
SP7:

Relevant External Links for TMEM209 Gene

GeneLoc Exon Structure for
TMEM209
ECgene alternative splicing isoforms for
TMEM209

Expression for TMEM209 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM209 Gene

Protein differential expression in normal tissues from HIPED for TMEM209 Gene

This gene is overexpressed in Platelet (16.4), Brain (10.5), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM209 Gene



Protein tissue co-expression partners for TMEM209 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM209 Gene:

TMEM209

SOURCE GeneReport for Unigene cluster for TMEM209 Gene:

Hs.267245

Evidence on tissue expression from TISSUES for TMEM209 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM209: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM209 Gene

Orthologs for TMEM209 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM209 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM209 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM209 33 34
  • 93.46 (n)
cow
(Bos Taurus)
Mammalia TMEM209 33 34
  • 92.14 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM209 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem209 33 16 34
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Tmem209 33
  • 88.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM209 33 34
  • 76.57 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM209 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem209 33
  • 71.96 (n)
Str.4132 33
zebrafish
(Danio rerio)
Actinopterygii tmem209 33 34
  • 67.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6479 34
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0464.6 34
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.960 34
  • 32 (a)
OneToOne
Species where no ortholog for TMEM209 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM209 Gene

ENSEMBL:
Gene Tree for TMEM209 (if available)
TreeFam:
Gene Tree for TMEM209 (if available)

Paralogs for TMEM209 Gene

(14) SIMAP similar genes for TMEM209 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM209: view

No data available for Paralogs for TMEM209 Gene

Variants for TMEM209 Gene

Sequence variations from dbSNP and Humsavar for TMEM209 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000055450 -- 130,196,502(+) AAAAA(A/G)TGAAC intron-variant
rs1000063546 -- 130,189,712(+) CTGGA(A/G)CTAGA intron-variant
rs1000072824 -- 130,173,230(+) CTAGC(C/T)ACTTG intron-variant
rs1000146722 -- 130,192,021(+) CCTAA(C/T)ATGCT intron-variant
rs1000199900 -- 130,199,284(+) GCCAT(C/G)TCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM209 Gene

Variant ID Type Subtype PubMed ID
nsv508481 CNV deletion 20534489
nsv5950 CNV insertion 18451855

Variation tolerance for TMEM209 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM209 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM209

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM209 Gene

Disorders for TMEM209 Gene

Relevant External Links for TMEM209

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM209

No disorders were found for TMEM209 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM209 Gene

Publications for TMEM209 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer EC … Gerace L (Science (New York, N.Y.) 2003) 2 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 60
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60

Products for TMEM209 Gene

Sources for TMEM209 Gene

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