TMEM209 Gene
protein-coding GIFtS: 43
GCID: GC07M129804
|
|
transmembrane protein 209
| |
Aliases
for TMEM209 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 2091 2 | | NET311 2 | | FLJ148031 |
Export aliases for TMEM209 gene to outside databasesPrevious GC identifers: GC07M129592 GC07M124166 |
Summaries
for TMEM209 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM209 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM209 gene promoter:
Nkx3-1 Nkx3-1 v4 RFX1 Lmo2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) Nkx3-1 v1 POU3F2 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM209
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM209 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q32.2 Ensembl cytogenetic band: 7q32.2 HGNC cytogenetic band: 7q32.2TMEM209 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M129804: view genomic region
(about GC identifiers)
Start:
|
129,804,555 bp from pter |
End:
|
129,847,610 bp from pter |
Size:
|
43,056 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 129,189,927-129,230,704 |
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Proteins
for TMEM209 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM209_HUMAN, Q96SK2 (See
protein sequence)Recommended Name: Transmembrane protein 209 Size: 561 amino acids; 62922 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A4D1L1 Q49A50 Q6PF00 Q8NCH3 Q96SL6Alternative splicing: 4 isoforms: Q96SK2-1 Q96SK2-2 Q96SK2-3 Q96SK2-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM209: NX_Q96SK2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96SK2
TMEM209 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116231.2
ENSEMBL proteins: ENSP00000380747 ENSP00000419697 ENSP00000417258 ENSP00000419852 ENSP00000418474 ENSP00000338388
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM209 for ontologies About GeneDecksing
TMEM209 Antibody Products:
Assay Products for TMEM209: |
Protein
Domains /
Families
for TMEM209 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM209 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96SK2ProtoNet protein and cluster: Q96SK2 |
Function
for TMEM209 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM209 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM209
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM209 (NM_032842) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM209 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM209 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM209 |
|
Pathways & Interactions
for TMEM209 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM209
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for TMEM209 (ENSP000003807474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM209 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM209
Search CenterWatch for drugs/clinical trials and news about TMEM209 / TM209
|
Transcripts
for TMEM209 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM209 gene: NM_032842.3 Unigene Cluster for TMEM209: Transmembrane protein 209 Hs.267245 [show with all ESTs]Unigene Representative Sequence: NM_0328428 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397622(uc003vpn.2 uc010lmc.1 uc003vpo.2) ENST00000462753
ENST00000473456 ENST00000479804 ENST00000467599 ENST00000471985 ENST00000471077
ENST00000336804
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM209 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM209
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM209 (NM_032842) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM209 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM209 |
Additional cDNA sequence: AK027678.1 AK074732.1 BC016721.1 BC045618.1 BC057784.1 10 DOTS entries: DT.408283 DT.91665647 DT.100721373 DT.40282669 DT.97840343 DT.92005734 DT.99928896 DT.121042401 DT.121042406 DT.75106992 24/102 AceView cDNA sequences (see all 102): AI953750 BU177118 BG287937 AW241959 BQ008855 AA907844 AW875789 AW875883 CD644641 AA988192 AI339433 CB241782 BE503047 BE219881 AA884119 AK074732 BF353600 BC057784 H03098 AI125304 BG500160 BX477210 BM922366 BX502899
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM209 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM209
|
Expression
for TMEM209 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM209 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAACATT
About this image
See TMEM209 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM209
SOURCE GeneReport for Unigene cluster: Hs.267245
SABiosciences Custom PCR Arrays for TMEM209
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM209
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM209 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM209 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM209 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM209 |
Orthologs
for TMEM209 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM209 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for TMEM209 (if available)
TreeFam Gene Tree for TMEM209 (if available) |
Paralogs
for TMEM209 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM209 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM209 (129804555 - 129847610 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM209: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM209 |
|
Disorders
/ Diseases
for TMEM209 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM209 for disorders About MalaCards
TMEM209 for disorders About GeneDecksing
1 disease from the University of Copenhagen DISEASES database for TMEM209:Splenic marginal zone lymphoma Export disorders for TMEM209 gene to outside databases
|
Publications
for TMEM209 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM209 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TMEM209) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 3 Schirmer E.C....Gerace L. (2003)
- Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis. (PubMed id 22719065)1 Fujitomo T....Nakamura Y. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for TMEM209 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM209 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM209 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM209 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM209 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM209 gene:
Search GeneIP for patents involving TMEM209
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM209 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM209 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM209 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM209 | | | OriGene Protein Over-expression Lysate for TMEM209 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM209 | | OriGene 3'-UTR Clone for TMEM209 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM209 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM209 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM209 | | OriGene Custom Protein Services for TMEM209 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM209 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM209 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM209 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM209 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM209 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM209 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM209 |
| |  |  |  |  | | | | |
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 | | | TMEM209 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM209 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM209 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM209 |
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