TMEM208 Gene
protein-coding GIFtS: 37
GCID: GC16P067261
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transmembrane protein 208
| |
Aliases
for TMEM208 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 2081 2 | | HSPC1711 |
Export aliases for TMEM208 gene to outside databasesPrevious GC identifers: GC16P065819 GC16P053134 |
Summaries
for TMEM208 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM208 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM208 gene promoter:
AhR Bach1 Egr-3 AP-4 NF-kappaB RORalpha2 Sox9 Meis-1a NF-kappaB1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM208
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM208 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1TMEM208 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P067261: view genomic region
(about GC identifiers)
Start:
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67,261,006 bp from pter |
End:
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67,263,182 bp from pter |
Size:
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2,177 bases |
Orientation:
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plus strand |
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Proteins
for TMEM208 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM208_HUMAN, Q9BTX3 (See
protein sequence)Recommended Name: Transmembrane protein 208 Size: 173 amino acids; 19642 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAF29134.1; Type=Frameshift; Positions=88, 96, 114;
Secondary accessions: Q05CT0 Q96D25 Q9NZZ7Alternative splicing: 2 isoforms: Q9BTX3-1 Q9BTX3-2 Explore the universe of human proteins at neXtProt for TMEM208: NX_Q9BTX3
TMEM208 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054906.2
ENSEMBL proteins: ENSP00000305892 ENSP00000462217 ENSP00000457502 ENSP00000454579 ENSP00000464439
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM208 for ontologies About GeneDecksing
TMEM208 Antibody Products:
Assay Products for TMEM208: |
Protein
Domains /
Families
for TMEM208 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM208 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BTX3ProtoNet protein and cluster: Q9BTX3 UniProtKB/Swiss-Prot: TM208_HUMAN, Q9BTX3Similarity: Belongs to the TMEM208 family |
Function
for TMEM208 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM208 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM208 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM208 (NM_014187) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM208 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM208 |
1 GenomeRNAi human phenotype for TMEM208:
|
Pathways & Interactions
for TMEM208 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM208
|
Drugs & Compounds
for TMEM208 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM208
Search CenterWatch for drugs/clinical trials and news about TMEM208 / TM208
|
Transcripts
for TMEM208 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM208 gene: NM_014187.3 Unigene Cluster for TMEM208: Transmembrane protein 208 Hs.433203 [show with all ESTs]Unigene Representative Sequence: BF20469912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000567193 ENST00000563168 ENST00000304800(uc002esi.2 uc002esj.2)
ENST00000566486 ENST00000563953 ENST00000561586 ENST00000562235 ENST00000565201
ENST00000564087 ENST00000563426 ENST00000563271 ENST00000564649
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM208 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM208 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM208 (NM_014187) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM208 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM208 |
Additional cDNA sequence: AF161519.1 BC003080.2 BC013412.2 12 DOTS entries: DT.95167565 DT.443510 DT.100787833 DT.100039252 DT.120726286 DT.97760072 DT.75103285 DT.92432211 DT.120726243 DT.120726264 DT.429201 DT.95167567 24/200 AceView cDNA sequences (see all 200): CR606454 BM788116 AI569774 CD106901 AA428347 AI870987 BM985098 CA308552 BG519812 CA843448 BX463357 BU072313 BC021109 BI115364 BQ448207 BE312753 BQ641586 CA430733 BU674136 BM558041 BU783045 BM827005 BC003080 BG575774
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM208 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM208
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Expression
for TMEM208 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM208 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGAGCAA
About this image
See TMEM208 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM208
SOURCE GeneReport for Unigene cluster: Hs.433203
SABiosciences Custom PCR Arrays for TMEM208
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM208
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM208 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM208 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM208 |
Orthologs
for TMEM208 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM208 gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for TMEM208 (if available)
TreeFam Gene Tree for TMEM208 (if available) |
Paralogs
for TMEM208 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM208 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM208 (67261006 - 67263182 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM208: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMEM208 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM208 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM208 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM208) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM208 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM208 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM208 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM208 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM208 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM208 gene:
Search GeneIP for patents involving TMEM208
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM208 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM208 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM208 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM208 | | | OriGene Protein Over-expression Lysate for TMEM208 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM208 | | OriGene 3'-UTR Clone for TMEM208 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM208 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM208 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM208 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM208 | | OriGene Custom Protein Services for TMEM208 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM208 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM208 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM208 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM208 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM208 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM208 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM208 |
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 | | | TMEM208 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TMEM208 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM208 |
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