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Aliases for TMEM208 Gene

Aliases for TMEM208 Gene

  • Transmembrane Protein 208 2 3 5
  • HSPC171 3

External Ids for TMEM208 Gene

Previous GeneCards Identifiers for TMEM208 Gene

  • GC16P065819
  • GC16P053134

Summaries for TMEM208 Gene

Entrez Gene Summary for TMEM208 Gene

  • This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TMEM208 Gene

TMEM208 (Transmembrane Protein 208) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM208 Gene

  • May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM208 Gene

Genomics for TMEM208 Gene

Regulatory Elements for TMEM208 Gene

Enhancers for TMEM208 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F066977 1.3 Ensembl ENCODE 9.6 -249.3 -249303 0.4 HDGF WRNIP1 ARID4B ZNF48 ZNF2 SLC30A9 GLIS2 ZNF143 DEK SP5 CES2 ELMO3 CBFB B3GNT9 FBXL8 TRADD HSF4 C16orf70 RRAD CDH16
GH16F067413 1.2 Ensembl ENCODE 9.7 +188.0 187977 4.0 ARID4B SIN3A BMI1 ZNF48 RAD21 YY1 ZNF121 SCRT2 ZNF143 ZNF391 PRMT7 ATP6V0D1 LRRC36 FHOD1 PLEKHG4 LRRC29 TMEM208 HSD11B2 DPEP2 ZDHHC1
GH16F067403 1.1 Ensembl ENCODE 9.8 +178.5 178504 5.1 PKNOX1 SIN3A ZBTB40 RAD21 ZNF121 SCRT2 RCOR1 FOS ZNF263 ZHX2 LRRC36 HSD11B2 PLEKHG4 NUTF2 LRRC29 TMEM208 ATP6V0D1 DPEP2 SLC7A6 PRMT7
GH16F067260 0.8 ENCODE 11 +33.7 33748 0.8 CTCF TFAP4 WRNIP1 SIN3A BACH1 CEBPG RAD21 ZNF143 SMC3 MAFK TMEM208 LRRC29 HSD11B2 ZDHHC1 ENSG00000262691 FHOD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM208 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM208 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMEM208 Gene

67,227,103 bp from pter
67,229,279 bp from pter
2,177 bases
Plus strand

Genomic View for TMEM208 Gene

Genes around TMEM208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM208 Gene

Proteins for TMEM208 Gene

  • Protein details for TMEM208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 208
    Protein Accession:
    Secondary Accessions:
    • Q05CT0
    • Q96D25
    • Q9NZZ7

    Protein attributes for TMEM208 Gene

    173 amino acids
    Molecular mass:
    19642 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29134.1; Type=Frameshift; Positions=88, 96, 114; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM208 Gene


neXtProt entry for TMEM208 Gene

Post-translational modifications for TMEM208 Gene

No Post-translational modifications

Other Protein References for TMEM208 Gene

No data available for DME Specific Peptides for TMEM208 Gene

Domains & Families for TMEM208 Gene

Protein Domains for TMEM208 Gene


Suggested Antigen Peptide Sequences for TMEM208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM208 family.
  • Belongs to the TMEM208 family.
genes like me logo Genes that share domains with TMEM208: view

No data available for Gene Families for TMEM208 Gene

Function for TMEM208 Gene

Molecular function for TMEM208 Gene

UniProtKB/Swiss-Prot Function:
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
genes like me logo Genes that share phenotypes with TMEM208: view

Animal Model Products

miRNA for TMEM208 Gene

miRTarBase miRNAs that target TMEM208

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM208 Gene

Localization for TMEM208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM208 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM208 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005773 vacuole IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM208: view

Pathways & Interactions for TMEM208 Gene

SuperPathways for TMEM208 Gene

No Data Available

Interacting Proteins for TMEM208 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000305892 Q9BTX3-TM208_HUMAN for TMEM208 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006624 vacuolar protein processing IBA --
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TMEM208: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM208 Gene

Transcripts for TMEM208 Gene

Unigene Clusters for TMEM208 Gene

Transmembrane protein 208:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM208 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for TMEM208 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM208 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM208 Gene

This gene is overexpressed in Liver (36.8), Placenta (12.2), and Adrenal (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM208 Gene

Protein tissue co-expression partners for TMEM208 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM208 Gene:


SOURCE GeneReport for Unigene cluster for TMEM208 Gene:

genes like me logo Genes that share expression patterns with TMEM208: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM208 Gene

Orthologs for TMEM208 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM208 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM208 34 35
  • 99.81 (n)
(Canis familiaris)
Mammalia TMEM208 34 35
  • 95.95 (n)
(Bos Taurus)
Mammalia TMEM208 34 35
  • 91.77 (n)
(Mus musculus)
Mammalia Tmem208 34 16 35
  • 90.51 (n)
(Rattus norvegicus)
Mammalia Tmem208 34
  • 89.66 (n)
(Monodelphis domestica)
Mammalia TMEM208 35
  • 51 (a)
(Gallus gallus)
Aves TMEM208 34
  • 74.47 (n)
(Anolis carolinensis)
Reptilia TMEM208 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem208 34
  • 66.88 (n)
Str.15884 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16797 34
(Danio rerio)
Actinopterygii TMEM208 35
  • 71 (a)
zgc:77041 34
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8320 34 35
  • 53.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003614 34
  • 48.12 (n)
(Caenorhabditis elegans)
Secernentea R05D11.5 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4985 35
  • 38 (a)
Species where no ortholog for TMEM208 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM208 Gene

Gene Tree for TMEM208 (if available)
Gene Tree for TMEM208 (if available)

Paralogs for TMEM208 Gene

No data available for Paralogs for TMEM208 Gene

Variants for TMEM208 Gene

Sequence variations from dbSNP and Humsavar for TMEM208 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111636496 -- 67,229,241(+) ACTTA(C/T)ACTCT intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs112369584 -- 67,228,199(+) AGAGT(G/T)GGTAT intron-variant, upstream-variant-2KB
rs1140380 -- 67,228,872(+) TCCTT(C/T)TGGCT nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs114100086 -- 67,228,476(+) GATAC(C/G/T)CTCAT intron-variant, upstream-variant-2KB
rs114662763 -- 67,229,132(+) GGCCA(A/C/G/T)AGGCC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM208 Gene

Variant ID Type Subtype PubMed ID
nsv457513 CNV loss 19166990
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv524492 CNV loss 19592680
nsv572905 CNV loss 21841781
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for TMEM208 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM208 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM208 Gene

Disorders for TMEM208 Gene

Relevant External Links for TMEM208

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM208 Gene

Publications for TMEM208 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress. (PMID: 23691174) Zhao Y. … Chen Y. (PLoS ONE 2013) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TMEM208 Gene

Sources for TMEM208 Gene

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