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Aliases for TMEM208 Gene

Aliases for TMEM208 Gene

  • Transmembrane Protein 208 2 3 5
  • HSPC171 3

External Ids for TMEM208 Gene

Previous GeneCards Identifiers for TMEM208 Gene

  • GC16P065819
  • GC16P053134

Summaries for TMEM208 Gene

Entrez Gene Summary for TMEM208 Gene

  • This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TMEM208 Gene

TMEM208 (Transmembrane Protein 208) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM208 Gene

  • May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM208 Gene

Genomics for TMEM208 Gene

Regulatory Elements for TMEM208 Gene

Enhancers for TMEM208 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM208 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM208 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM208 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM208 Gene

67,227,103 bp from pter
67,229,279 bp from pter
2,177 bases
Plus strand

Genomic View for TMEM208 Gene

Genes around TMEM208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM208 Gene

Proteins for TMEM208 Gene

  • Protein details for TMEM208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 208
    Protein Accession:
    Secondary Accessions:
    • Q05CT0
    • Q96D25
    • Q9NZZ7

    Protein attributes for TMEM208 Gene

    173 amino acids
    Molecular mass:
    19642 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29134.1; Type=Frameshift; Positions=88, 96, 114; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM208 Gene


neXtProt entry for TMEM208 Gene

Proteomics data for TMEM208 Gene at MOPED

Post-translational modifications for TMEM208 Gene

No Post-translational modifications

Other Protein References for TMEM208 Gene

No data available for DME Specific Peptides for TMEM208 Gene

Domains & Families for TMEM208 Gene

Protein Domains for TMEM208 Gene


Suggested Antigen Peptide Sequences for TMEM208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM208 family.
  • Belongs to the TMEM208 family.
genes like me logo Genes that share domains with TMEM208: view

No data available for Gene Families for TMEM208 Gene

Function for TMEM208 Gene

Molecular function for TMEM208 Gene

UniProtKB/Swiss-Prot Function:
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
genes like me logo Genes that share phenotypes with TMEM208: view

Animal Model Products

miRNA for TMEM208 Gene

miRTarBase miRNAs that target TMEM208

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM208 Gene

Localization for TMEM208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM208 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM208 Gene COMPARTMENTS Subcellular localization image for TMEM208 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
vacuole 3
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM208: view

Pathways & Interactions for TMEM208 Gene

SuperPathways for TMEM208 Gene

No Data Available

Interacting Proteins for TMEM208 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000305892 for TMEM208 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TMEM208: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM208 Gene

Drugs & Compounds for TMEM208 Gene

No Compound Related Data Available

Transcripts for TMEM208 Gene

Unigene Clusters for TMEM208 Gene

Transmembrane protein 208:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM208 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for TMEM208 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM208 Gene

mRNA expression in normal human tissues for TMEM208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM208 Gene

This gene is overexpressed in Liver (36.8), Placenta (12.2), and Adrenal (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM208 Gene

SOURCE GeneReport for Unigene cluster for TMEM208 Gene Hs.433203

genes like me logo Genes that share expression patterns with TMEM208: view

Protein tissue co-expression partners for TMEM208 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM208 Gene

Orthologs for TMEM208 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM208 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM208 35
  • 91.77 (n)
  • 95.57 (a)
TMEM208 36
  • 96 (a)
(Canis familiaris)
Mammalia TMEM208 35
  • 95.95 (n)
  • 98.84 (a)
TMEM208 36
  • 98 (a)
(Mus musculus)
Mammalia Tmem208 35
  • 90.51 (n)
  • 95.57 (a)
Tmem208 16
Tmem208 36
  • 96 (a)
(Pan troglodytes)
Mammalia TMEM208 35
  • 99.81 (n)
  • 100 (a)
TMEM208 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem208 35
  • 89.66 (n)
  • 92.41 (a)
(Monodelphis domestica)
Mammalia TMEM208 36
  • 51 (a)
(Gallus gallus)
Aves TMEM208 35
  • 74.47 (n)
  • 79.75 (a)
(Anolis carolinensis)
Reptilia TMEM208 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15884 35
tmem208 35
  • 66.88 (n)
  • 72.15 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16797 35
(Danio rerio)
Actinopterygii zgc:77041 35
  • 66.67 (n)
  • 73.89 (a)
TMEM208 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003614 35
  • 48.12 (n)
  • 38.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8320 35
  • 53.7 (n)
  • 47.92 (a)
CG8320 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea R05D11.5 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4985 36
  • 38 (a)
Species with no ortholog for TMEM208:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM208 Gene

Gene Tree for TMEM208 (if available)
Gene Tree for TMEM208 (if available)

Paralogs for TMEM208 Gene

No data available for Paralogs for TMEM208 Gene

Variants for TMEM208 Gene

Sequence variations from dbSNP and Humsavar for TMEM208 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_039958 -
VAR_053933 -

Structural Variations from Database of Genomic Variants (DGV) for TMEM208 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990

Variation tolerance for TMEM208 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM208 Gene

Disorders for TMEM208 Gene

Relevant External Links for TMEM208

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM208 Gene

Publications for TMEM208 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress. (PMID: 23691174) Zhao Y. … Chen Y. (PLoS ONE 2013) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM208 Gene

Sources for TMEM208 Gene