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Aliases for TMEM208 Gene

Aliases for TMEM208 Gene

  • Transmembrane Protein 208 2 3
  • HSPC171 3

External Ids for TMEM208 Gene

Summaries for TMEM208 Gene

GeneCards Summary for TMEM208 Gene

TMEM208 (Transmembrane Protein 208) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM208 Gene

  • May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM208 Gene

Genomics for TMEM208 Gene

Genomic Location for TMEM208 Gene

Start:
67,227,103 bp from pter
End:
67,229,279 bp from pter
Size:
2,177 bases
Orientation:
Plus strand

Genomic View for TMEM208 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM208 Gene

Regulatory Elements for TMEM208 Gene

Proteins for TMEM208 Gene

  • Protein details for TMEM208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTX3-TM208_HUMAN
    Recommended name:
    Transmembrane protein 208
    Protein Accession:
    Q9BTX3
    Secondary Accessions:
    • Q05CT0
    • Q96D25
    • Q9NZZ7

    Protein attributes for TMEM208 Gene

    Size:
    173 amino acids
    Molecular mass:
    19642 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29134.1; Type=Frameshift; Positions=88, 96, 114; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM208 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM208 Gene

Proteomics data for TMEM208 Gene at MOPED

Post-translational modifications for TMEM208 Gene

No Post-translational modifications

Other Protein References for TMEM208 Gene

No data available for DME Specific Peptides for TMEM208 Gene

Domains for TMEM208 Gene

Protein Domains for TMEM208 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM208_HUMAN
Family:
  • Belongs to the TMEM208 family.:
    • Q9BTX3
genes like me logo Genes that share domains with TMEM208: view

No data available for Gene Families for TMEM208 Gene

Function for TMEM208 Gene

Molecular function for TMEM208 Gene

UniProtKB/Swiss-Prot Function: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

Phenotypes for TMEM208 Gene

GenomeRNAi human phenotypes for TMEM208:
genes like me logo Genes that share phenotypes with TMEM208: view

miRNA for TMEM208 Gene

miRTarBase miRNAs that target TMEM208

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM208 Gene

Localization for TMEM208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM208 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM208 Gene COMPARTMENTS Subcellular localization image for TMEM208 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM208: view

Pathways for TMEM208 Gene

SuperPathways for TMEM208 Gene

No Data Available

Interacting Proteins for TMEM208 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305892%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000305892 for TMEM208 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TMEM208: view

No data available for Pathways by source for TMEM208 Gene

Transcripts for TMEM208 Gene

mRNA/cDNA for TMEM208 Gene

Unigene Clusters for TMEM208 Gene

Transmembrane protein 208:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM208 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8:
SP9: -

Relevant External Links for TMEM208 Gene

GeneLoc Exon Structure for
TMEM208
ECgene alternative splicing isoforms for
TMEM208

Expression for TMEM208 Gene

mRNA expression in normal human tissues for TMEM208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM208 Gene

SOURCE GeneReport for Unigene cluster for TMEM208 Gene Hs.433203

genes like me logo Genes that share expressions with TMEM208: view

Orthologs for TMEM208 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM208 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM208 36
  • 99.81 (n)
  • 100 (a)
TMEM208 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM208 36
  • 91.77 (n)
  • 95.57 (a)
TMEM208 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM208 36
  • 95.95 (n)
  • 98.84 (a)
TMEM208 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem208 36
  • 90.51 (n)
  • 95.57 (a)
Tmem208 16
Tmem208 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM208 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem208 36
  • 89.66 (n)
  • 92.41 (a)
chicken
(Gallus gallus)
Aves TMEM208 36
  • 74.47 (n)
  • 79.75 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM208 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16797 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15884 36
tmem208 36
  • 66.88 (n)
  • 72.15 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM208 37
  • 71 (a)
OneToOne
zgc:77041 36
  • 66.67 (n)
  • 73.89 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003614 36
  • 48.12 (n)
  • 38.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8320 36
  • 53.7 (n)
  • 47.92 (a)
CG8320 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R05D11.5 37
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4985 37
  • 38 (a)
OneToOne
Species with no ortholog for TMEM208:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM208 Gene

ENSEMBL:
Gene Tree for TMEM208 (if available)
TreeFam:
Gene Tree for TMEM208 (if available)

Paralogs for TMEM208 Gene

No data available for Paralogs for TMEM208 Gene

Variants for TMEM208 Gene

Sequence variations from dbSNP and Humsavar for TMEM208 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_039958 -
VAR_053933 -

Structural Variations from Database of Genomic Variants (DGV) for TMEM208 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680
nsv524492 CNV Loss 19592680
nsv471092 CNV Gain 18288195
nsv457513 CNV Loss 19166990

Relevant External Links for TMEM208 Gene

HapMap Linkage Disequilibrium report
TMEM208

Disorders for TMEM208 Gene

Relevant External Links for TMEM208

Genetic Association Database (GAD)
TMEM208
genes like me logo Genes that share disorders with TMEM208: view

No data available for UniProtKB/Swiss-Prot for TMEM208 Gene

Publications for TMEM208 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress. (PMID: 23691174) Zhao Y. … Chen Y. (PLoS ONE 2013) 3 4
  3. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4

Products for TMEM208 Gene

Sources for TMEM208 Gene

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