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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM208 Gene

protein-coding   GIFtS: 40
GCID: GC16P067261

Transmembrane Protein 208

  Search for TMEM208
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 2081 2

External Ids:    HGNC: 250151   Entrez Gene: 291002   Ensembl: ENSG000001687017   UniProtKB: Q9BTX33   

Export aliases for TMEM208 gene to outside databases

Previous GC identifers: GC16P065819 GC16P053134


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM208 Gene: 
TMEM208 (transmembrane protein 208) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM208 gene promoter:
         AhR   Bach1   Egr-3   AP-4   NF-kappaB   RORalpha2   Sox9   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM208 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM208

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM208


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

TMEM208 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM208 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067261:  view genomic region     (about GC identifiers)

Start:
67,261,006 bp from pter      End:
67,263,182 bp from pter
Size:
2,177 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM208_HUMAN, Q9BTX3 (See protein sequence)
Recommended Name: Transmembrane protein 208  
Size: 173 amino acids; 19642 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAF29134.1; Type=Frameshift; Positions=88, 96, 114;
Secondary accessions: Q05CT0 Q96D25 Q9NZZ7
Alternative splicing: 2 isoforms:  Q9BTX3-1   Q9BTX3-2   

Explore the universe of human proteins at neXtProt for TMEM208: NX_Q9BTX3

Explore proteomics data for TMEM208 at MOPED 

TMEM208 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM208 Protein Expression

REFSEQ proteins: NP_054906.2  
ENSEMBL proteins: 
 ENSP00000305892   ENSP00000462217   ENSP00000457502   ENSP00000454579   ENSP00000464439  

Human Recombinant Protein Products for TMEM208: 
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Cloud-Clone Corp. Proteins for TMEM208 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016021integral to membrane IEA--

TMEM208 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TMEM208


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR008506 DUF788_TMEM208

Graphical View of Domain Structure for InterPro Entry Q9BTX3

ProtoNet protein and cluster: Q9BTX3

UniProtKB/Swiss-Prot: TM208_HUMAN, Q9BTX3
Similarity: Belongs to the TMEM208 family


TMEM208 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TMEM208:
 Synthetic lethal with c-Myc af 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM208 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM208

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SwitchGear 3'UTR luciferase reporter plasmidTMEM208 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM208


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM208

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006914autophagy IEA--

TMEM208 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM208 (TM208)

Search CenterWatch for drugs/clinical trials and news about TMEM208 / TM208

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM208 gene: 
NM_014187.3  

Unigene Cluster for TMEM208:

Transmembrane protein 208
Hs.433203  [show with all ESTs]
Unigene Representative Sequence: BF204699
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000567193 ENST00000563168 ENST00000304800(uc002esi.2 uc002esj.2)
ENST00000566486 ENST00000563953 ENST00000561586 ENST00000562235 ENST00000565201
ENST00000564087 ENST00000563426 ENST00000563271 ENST00000564649
miRNA
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hsa-miR-3140-3p hsa-miR-4272
SwitchGear 3'UTR luciferase reporter plasmidTMEM208 3' UTR sequence
Inhib. RNA
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Browse for Gene Knock-down Tools from EMD Millipore
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Clone
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Sirion Biotech Customized lentivirus for stable overexpression of TMEM208 
                     Customized lentivirus expression plasmids for stable overexpression of TMEM208 
Primer
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OriGene qPCR primer pairs and template standards for TMEM208
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM208
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM208
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM208
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM208

Additional mRNA sequence: 

AF161519.1 BC003080.2 BC013412.2 

12 DOTS entries:

DT.95167565  DT.443510  DT.100787833  DT.100039252  DT.120726286  DT.97760072  DT.75103285  DT.92432211 
DT.120726243  DT.120726264  DT.429201  DT.95167567 

24/200 AceView cDNA sequences (see all 200):

BG057679 CA419196 BG519812 BM686765 CA310294 AW592051 CA430745 BE294105 
BU072313 BU783045 BX463357 BQ018667 BE312753 BQ448207 BC021109 CA843448 
CA308552 CD106901 BM985098 AA339467 BU072596 AI569774 AA341081 CR606454 

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM208 (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1:                          -     -                 -                                   -                                             
SP2:                          -                       -                                   -                                             
SP3:                          -     -                 -                                                                                 
SP4:                          -     -                 -                                   -                                             
SP5:                          -     -                 -                                                                                 


ECgene alternative splicing isoforms for TMEM208

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM208 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTGGAGCAA
TMEM208 Expression
About this image


See TMEM208 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM208

SOURCE GeneReport for Unigene cluster: Hs.433203
    SABiosciences Custom PCR Arrays for TMEM208
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM208
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM208

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM208 gene from 9/17 species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem2081 , 5 transmembrane protein 2081, 5 90.56(n)1
95.95(a)1
  8 (53.04 cM)5
663201  NM_025486.21  NP_079762.11 
 1053263545 
chicken
(Gallus gallus)
Aves TMEM2081 transmembrane protein 208 74.81(n)
80.81(a)
  100857564  XM_003641912.1  XP_003641960.1 
lizard
(Anolis carolinensis)
Reptilia TMEM2086
Uncharacterized protein
74(a)
1 ↔ 1
GL343295.1(346638-354289)
African clawed frog
(Xenopus laevis)
Amphibia Xl.167972 Xenopus laevis transcribed sequence with weak similarity more 77(n)    CF520365.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:770411 zgc:77041 66.86(n)
74.85(a)
  404632  NM_207100.2  NP_996983.1 
fruit fly
(Drosophila melanogaster)
Insecta CG83201 CG8320 51.48(n)
45.56(a)
  36759  NM_137228.3  NP_611072.2 
worm
(Caenorhabditis elegans)
Secernentea R05D11.51 Protein R05D11.5 44.03(n)
32.72(a)
  172649  NM_059922.3  NP_492323.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G239401 hypothetical protein 43.27(n)
29.81(a)
  816926  NM_127955.3  NP_565558.1 
rice
(Oryza sativa)
Liliopsida Os02g06668001 hypothetical protein 48.01(n)
33.33(a)
  4330253  NM_001054212.1  NP_001047677.1 


ENSEMBL Gene Tree for TMEM208 (if available)
TreeFam Gene Tree for TMEM208 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in TMEM208 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0539334
----see VAR_0539332 L P mis40--------
VAR_0399584
----see VAR_0399582 D Y mis40--------

HapMap Linkage Disequilibrium report for TMEM208 (67261006 - 67263182 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for TMEM208:    About this table     
Variant IDTypeSubtypePubMed ID
dgv2888n71CNV Loss21882294
nsv906803CNV Loss21882294
dgv2886n71CNV Loss21882294
nsv524492CNV Loss19592680
nsv827707CNV Loss20364138
nsv457513CNV Loss19166990
dgv2885n71CNV Loss21882294
nsv524363CNV Loss19592680
nsv471092CNV Gain18288195
nsv522852CNV Gain19592680

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM208 for disorders           About MalaCards

TMEM208 for disorders           About GeneDecksing

Genetic Association Database (GAD): TMEM208

Export disorders for TMEM208 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM208 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM208)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 29100 HGNC: 25015 AceView: HSPC171 Ensembl:ENSG00000168701 euGenes: HUgn29100
ECgene: TMEM208 H-InvDB: TMEM208

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM208 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM208 gene:
Search GeneIP for patents involving TMEM208

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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