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Aliases for TMEM208 Gene

Aliases for TMEM208 Gene

  • Transmembrane Protein 208 2 3 5
  • HSPC171 3

External Ids for TMEM208 Gene

Previous GeneCards Identifiers for TMEM208 Gene

  • GC16P065819
  • GC16P053134

Summaries for TMEM208 Gene

Entrez Gene Summary for TMEM208 Gene

  • This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TMEM208 Gene

TMEM208 (Transmembrane Protein 208) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM208 Gene

  • May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.

Additional gene information for TMEM208 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM208 Gene

Genomics for TMEM208 Gene

Regulatory Elements for TMEM208 Gene

Enhancers for TMEM208 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H066977 1.5 Ensembl ENCODE dbSUPER 9.6 -249.3 -249303 0 HDGF ARID4B SIN3A ZNF2 SLC30A9 GLIS2 ZNF143 RUNX3 DEK SP5 CES2 ELMO3 CBFB B3GNT9 FBXL8 TRADD HSF4 C16orf70 RRAD CDH16
GH16H067403 1.4 Ensembl ENCODE dbSUPER 9.8 +178.5 178504 5 PKNOX1 NFIB SIN3A RAD21 ZBTB40 RFX5 ZNF121 SCRT2 FOS RCOR1 LRRC36 FBXL8 E2F4 CTCF ENSG00000260465 ENSG00000270165 HSD11B2 RANBP10 PLEKHG4 EDC4
GH16H067413 1.4 Ensembl ENCODE dbSUPER 9.7 +188.0 187977 3 HDGF FOXA2 ARID4B SIN3A ZNF121 ZNF143 ZNF207 REST KAT8 SREBF1 PRMT7 ATP6V0D1 LRRC36 THAP11 FHOD1 PLEKHG4 SLC12A4 LRRC29 TMEM208 HSD11B2
GH16H067444 1.2 ENCODE dbSUPER 9.9 +221.8 221805 8 ELF3 FOXA2 MLX ARID4B THRB RAD21 RARA YY1 ZNF121 SCRT2 ATP6V0D1 ZDHHC1 AGRP RIPOR1 E2F4 EXOC3L1 KIAA0895L LRRC29 TMEM208 ACD
GH16H067718 1.1 ENCODE 10.3 +492.3 492283 2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 TSNAXIP1 RANBP10 PARD6A ACD TMEM208 EDC4 DUS2 GFOD2 PIR36768
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM208 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM208 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087086 -3 1401 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TMEM208 Gene

Chromosome:
16
Start:
67,227,103 bp from pter
End:
67,229,279 bp from pter
Size:
2,177 bases
Orientation:
Plus strand

Genomic View for TMEM208 Gene

Genes around TMEM208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM208 Gene

Proteins for TMEM208 Gene

  • Protein details for TMEM208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTX3-TM208_HUMAN
    Recommended name:
    Transmembrane protein 208
    Protein Accession:
    Q9BTX3
    Secondary Accessions:
    • Q05CT0
    • Q96D25
    • Q9NZZ7

    Protein attributes for TMEM208 Gene

    Size:
    173 amino acids
    Molecular mass:
    19642 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29134.1; Type=Frameshift; Positions=88, 96, 114; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM208 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM208 Gene

Post-translational modifications for TMEM208 Gene

No Post-translational modifications

Other Protein References for TMEM208 Gene

No data available for DME Specific Peptides for TMEM208 Gene

Domains & Families for TMEM208 Gene

Gene Families for TMEM208 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM208 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTX3

UniProtKB/Swiss-Prot:

TM208_HUMAN :
  • Belongs to the TMEM208 family.
Family:
  • Belongs to the TMEM208 family.
genes like me logo Genes that share domains with TMEM208: view

Function for TMEM208 Gene

Molecular function for TMEM208 Gene

UniProtKB/Swiss-Prot Function:
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
genes like me logo Genes that share phenotypes with TMEM208: view

Animal Model Products

CRISPR Products

miRNA for TMEM208 Gene

miRTarBase miRNAs that target TMEM208

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM208
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM208 Gene

Localization for TMEM208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM208 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM208 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005773 vacuole IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM208: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM208 Gene

Pathways & Interactions for TMEM208 Gene

SuperPathways for TMEM208 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006624 vacuolar protein processing IBA --
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TMEM208: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM208 Gene

Drugs & Compounds for TMEM208 Gene

No Compound Related Data Available

Transcripts for TMEM208 Gene

Unigene Clusters for TMEM208 Gene

Transmembrane protein 208:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM208
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM208 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8:
SP9: -

Relevant External Links for TMEM208 Gene

GeneLoc Exon Structure for
TMEM208
ECgene alternative splicing isoforms for
TMEM208

Expression for TMEM208 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM208 Gene

This gene is overexpressed in Liver (36.8), Placenta (12.2), and Adrenal (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM208 Gene



Protein tissue co-expression partners for TMEM208 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM208 Gene:

TMEM208

SOURCE GeneReport for Unigene cluster for TMEM208 Gene:

Hs.433203

Evidence on tissue expression from TISSUES for TMEM208 Gene

  • Skin(4.2)
  • Blood(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with TMEM208: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM208 Gene

Orthologs for TMEM208 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM208 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM208 33 34
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia TMEM208 33 34
  • 95.95 (n)
cow
(Bos Taurus)
Mammalia TMEM208 33 34
  • 91.77 (n)
mouse
(Mus musculus)
Mammalia Tmem208 33 16 34
  • 90.51 (n)
rat
(Rattus norvegicus)
Mammalia Tmem208 33
  • 89.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM208 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM208 33
  • 74.47 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM208 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem208 33
  • 66.88 (n)
Str.15884 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16797 33
zebrafish
(Danio rerio)
Actinopterygii TMEM208 34
  • 71 (a)
OneToOne
zgc:77041 33
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8320 33 34
  • 53.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003614 33
  • 48.12 (n)
worm
(Caenorhabditis elegans)
Secernentea R05D11.5 34
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4985 34
  • 38 (a)
OneToOne
Species where no ortholog for TMEM208 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM208 Gene

ENSEMBL:
Gene Tree for TMEM208 (if available)
TreeFam:
Gene Tree for TMEM208 (if available)

Paralogs for TMEM208 Gene

No data available for Paralogs for TMEM208 Gene

Variants for TMEM208 Gene

Sequence variations from dbSNP and Humsavar for TMEM208 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1001202273 -- 67,227,536(+) GTACC(C/G)TTGGA intron-variant, upstream-variant-2KB
rs1002357307 -- 67,228,170(+) CTTTC(C/T)TGGGC intron-variant, upstream-variant-2KB
rs1002772593 -- 67,226,556(+) TGCCA(-/G)GGAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002839456 -- 67,227,932(+) CCAAT(A/G)TAAGT upstream-variant-2KB, splice-donor-variant
rs1003099010 -- 67,226,903(+) GACAG(A/C)CCCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM208 Gene

Variant ID Type Subtype PubMed ID
nsv457513 CNV loss 19166990
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv524492 CNV loss 19592680
nsv572905 CNV loss 21841781
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for TMEM208 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM208 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM208

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM208 Gene

Disorders for TMEM208 Gene

Relevant External Links for TMEM208

Genetic Association Database (GAD)
TMEM208
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM208

No disorders were found for TMEM208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM208 Gene

Publications for TMEM208 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 60
  2. Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress. (PMID: 23691174) Zhao Y … Chen Y (PloS one 2013) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. (PMID: 25732826) Aksnes H … Arnesen T (Cell reports 2015) 4 60

Products for TMEM208 Gene

Sources for TMEM208 Gene

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