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Aliases for TMEM207 Gene

Aliases for TMEM207 Gene

  • Transmembrane Protein 207 2 3 5
  • SRSR846 3
  • UNQ846 3

External Ids for TMEM207 Gene

Previous GeneCards Identifiers for TMEM207 Gene

  • GC03M191630
  • GC03M190146
  • GC03M187546

Summaries for TMEM207 Gene

GeneCards Summary for TMEM207 Gene

TMEM207 (Transmembrane Protein 207) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM207 Gene

Genomics for TMEM207 Gene

Regulatory Elements for TMEM207 Gene

Genomic Location for TMEM207 Gene

Chromosome:
3
Start:
190,428,655 bp from pter
End:
190,449,876 bp from pter
Size:
21,222 bases
Orientation:
Minus strand

Genomic View for TMEM207 Gene

Genes around TMEM207 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM207 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM207 Gene

Proteins for TMEM207 Gene

  • Protein details for TMEM207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWW9-TM207_HUMAN
    Recommended name:
    Transmembrane protein 207
    Protein Accession:
    Q6UWW9

    Protein attributes for TMEM207 Gene

    Size:
    146 amino acids
    Molecular mass:
    16116 Da
    Quaternary structure:
    • Interacts with WWOX.

neXtProt entry for TMEM207 Gene

Proteomics data for TMEM207 Gene at MOPED

Post-translational modifications for TMEM207 Gene

No Post-translational modifications

Other Protein References for TMEM207 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM207 Gene

Domains & Families for TMEM207 Gene

Protein Domains for TMEM207 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM207 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM207: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM207 Gene

Function for TMEM207 Gene

Phenotypes for TMEM207 Gene

GenomeRNAi human phenotypes for TMEM207:
genes like me logo Genes that share phenotypes with TMEM207: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM207 Gene

Localization for TMEM207 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM207 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM207 Gene COMPARTMENTS Subcellular localization image for TMEM207 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM207 Gene

Pathways & Interactions for TMEM207 Gene

SuperPathways for TMEM207 Gene

No Data Available

Interacting Proteins for TMEM207 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000346981%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000346981 for TMEM207 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM207 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM207 Gene

Drugs & Compounds for TMEM207 Gene

No Compound Related Data Available

Transcripts for TMEM207 Gene

mRNA/cDNA for TMEM207 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM207 Gene

Transmembrane protein 207:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM207 Gene

No ASD Table

Relevant External Links for TMEM207 Gene

GeneLoc Exon Structure for
TMEM207
ECgene alternative splicing isoforms for
TMEM207

Expression for TMEM207 Gene

mRNA expression in normal human tissues for TMEM207 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM207 Gene

This gene is overexpressed in Kidney - Cortex (x51.1).

SOURCE GeneReport for Unigene cluster for TMEM207 Gene Hs.335321

mRNA Expression by UniProt/SwissProt for TMEM207 Gene

Q6UWW9-TM207_HUMAN
Tissue specificity: Expressed in some signet-ring cell carcinoma, especially those showing high invasion and metastatic activity (at protein level).
genes like me logo Genes that share expression patterns with TMEM207: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TMEM207 Gene

Orthologs for TMEM207 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM207 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM207 35
  • 82.85 (n)
  • 70.29 (a)
TMEM207 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM207 35
  • 84.85 (n)
  • 73.43 (a)
TMEM207 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem207 35
  • 75.06 (n)
  • 63.64 (a)
Tmem207 16
Tmem207 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM207 35
  • 98.63 (n)
  • 97.24 (a)
TMEM207 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem207 35
  • 75.29 (n)
  • 63.64 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM207 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM207 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM207 36
  • 36 (a)
OneToOne
Species with no ortholog for TMEM207:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM207 Gene

ENSEMBL:
Gene Tree for TMEM207 (if available)
TreeFam:
Gene Tree for TMEM207 (if available)

Paralogs for TMEM207 Gene

No data available for Paralogs for TMEM207 Gene

Variants for TMEM207 Gene

Sequence variations from dbSNP and Humsavar for TMEM207 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35161724 - 190,440,379(-) TCCTG(C/G)TGCTG reference, missense
rs1072172 -- 190,434,282(-) acaca(C/T)gggaa intron-variant
rs1346016 -- 190,448,011(-) AGCTT(A/C)AGAAT intron-variant
rs1346017 -- 190,432,410(-) AGGTT(A/C)ACTAT intron-variant
rs1820338 -- 190,444,053(-) AGATT(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM207 Gene

Variant ID Type Subtype PubMed ID
nsv829820 CNV Gain 17160897
dgv902e199 CNV Deletion 23128226

Variation tolerance for TMEM207 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM207 Gene

HapMap Linkage Disequilibrium report
TMEM207

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM207 Gene

Disorders for TMEM207 Gene

Relevant External Links for TMEM207

Genetic Association Database (GAD)
TMEM207
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM207

No disorders were found for TMEM207 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM207 Gene

Publications for TMEM207 Gene

  1. A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma. (PMID: 22226915) Takeuchi T. … Nagayama T. (Carcinogenesis 2012) 3 4 67
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for TMEM207 Gene

Sources for TMEM207 Gene

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