Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM207 Gene

Aliases for TMEM207 Gene

  • Transmembrane Protein 207 2 3 5
  • SRSR846 3
  • UNQ846 3

External Ids for TMEM207 Gene

Previous GeneCards Identifiers for TMEM207 Gene

  • GC03M191630
  • GC03M190146
  • GC03M187546

Summaries for TMEM207 Gene

GeneCards Summary for TMEM207 Gene

TMEM207 (Transmembrane Protein 207) is a Protein Coding gene.

Additional gene information for TMEM207 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM207 Gene

Genomics for TMEM207 Gene

GeneHancer (GH) Regulatory Elements for TMEM207 Gene

Promoters and enhancers for TMEM207 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I190445 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +1.7 1741 4.4 MXI1 JUN MAX RFX5 ZKSCAN1 SMC3 RCOR1 ATF7 FOSL2 MAFK TMEM207 IL1RAP CLDN16
GH03I190512 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 9.7 -65.7 -65742 5.5 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 FOS IL1RAP TMEM207 CCDC50 GC03P190507 GCNT1P3
GH03I190124 Enhancer 0.2 FANTOM5 2.6 +325.6 325583 0.1 P3H2 TMEM207 P3H2-AS1 RNU6-1109P GC03M190166
GH03I190385 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +63.7 63735 3 CTCF PKNOX1 SAP130 JUN ARID4B MAX SIN3A RAD21 YY1 POLR2A CLDN16 RN7SKP296 TMEM207
GH03I190424 Enhancer 0.9 ENCODE 0.3 +25.3 25259 0.2 FOXA2 YBX1 ZNF2 BRCA1 YY1 GTF3C2 GLIS2 ZNF143 KLF7 SP3 TMEM207 CLDN16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM207 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM207 gene promoter:

Genomic Locations for TMEM207 Gene

Genomic Locations for TMEM207 Gene
chr3:190,428,655-190,449,876
(GRCh38/hg38)
Size:
21,222 bases
Orientation:
Minus strand
chr3:190,146,444-190,167,665
(GRCh37/hg19)

Genomic View for TMEM207 Gene

Genes around TMEM207 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM207 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM207 Gene

Proteins for TMEM207 Gene

  • Protein details for TMEM207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWW9-TM207_HUMAN
    Recommended name:
    Transmembrane protein 207
    Protein Accession:
    Q6UWW9

    Protein attributes for TMEM207 Gene

    Size:
    146 amino acids
    Molecular mass:
    16116 Da
    Quaternary structure:
    • Interacts with WWOX.

neXtProt entry for TMEM207 Gene

Post-translational modifications for TMEM207 Gene

No Post-translational modifications

Other Protein References for TMEM207 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM207 Gene

Domains & Families for TMEM207 Gene

Gene Families for TMEM207 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM207 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM207 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM207: view

No data available for UniProtKB/Swiss-Prot for TMEM207 Gene

Function for TMEM207 Gene

Phenotypes for TMEM207 Gene

GenomeRNAi human phenotypes for TMEM207:
genes like me logo Genes that share phenotypes with TMEM207: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM207 Gene

Localization for TMEM207 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM207 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM207 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM207: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM207 Gene

Pathways & Interactions for TMEM207 Gene

SuperPathways for TMEM207 Gene

No Data Available

Interacting Proteins for TMEM207 Gene

Selected Interacting proteins: Q6UWW9-TM207_HUMAN for TMEM207 Gene via IID

Symbol External ID(s) Details
BAG3
ELAVL1

Gene Ontology (GO) - Biological Process for TMEM207 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM207 Gene

Drugs & Compounds for TMEM207 Gene

No Compound Related Data Available

Transcripts for TMEM207 Gene

mRNA/cDNA for TMEM207 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM207 Gene

Transmembrane protein 207:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM207 Gene

No ASD Table

Relevant External Links for TMEM207 Gene

GeneLoc Exon Structure for
TMEM207
ECgene alternative splicing isoforms for
TMEM207

Expression for TMEM207 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM207 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM207 Gene

This gene is overexpressed in Kidney - Cortex (x51.1).

NURSA nuclear receptor signaling pathways regulating expression of TMEM207 Gene:

TMEM207

SOURCE GeneReport for Unigene cluster for TMEM207 Gene:

Hs.335321

mRNA Expression by UniProt/SwissProt for TMEM207 Gene:

Q6UWW9-TM207_HUMAN
Tissue specificity: Expressed in some signet-ring cell carcinoma, especially those showing high invasion and metastatic activity (at protein level).

Evidence on tissue expression from TISSUES for TMEM207 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with TMEM207: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM207 Gene

Orthologs for TMEM207 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM207 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM207 33 34
  • 98.63 (n)
dog
(Canis familiaris)
Mammalia TMEM207 33 34
  • 84.85 (n)
cow
(Bos Taurus)
Mammalia TMEM207 33 34
  • 82.85 (n)
rat
(Rattus norvegicus)
Mammalia Tmem207 33
  • 75.29 (n)
mouse
(Mus musculus)
Mammalia Tmem207 33 16 34
  • 75.06 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM207 34
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM207 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM207 34
  • 36 (a)
OneToOne
Species where no ortholog for TMEM207 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM207 Gene

ENSEMBL:
Gene Tree for TMEM207 (if available)
TreeFam:
Gene Tree for TMEM207 (if available)

Paralogs for TMEM207 Gene

No data available for Paralogs for TMEM207 Gene

Variants for TMEM207 Gene

Sequence variations from dbSNP and Humsavar for TMEM207 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000106771 -- 190,445,872(-) T/C intron_variant
rs1000118176 -- 190,446,162(-) TT/ intron_variant
rs1000240184 -- 190,440,165(-) TTTT/TTT intron_variant
rs1000296959 -- 190,435,842(-) T/C intron_variant
rs1000392877 -- 190,434,379(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM207 Gene

Variant ID Type Subtype PubMed ID
dgv902e199 CNV deletion 23128226
esv2762372 CNV loss 21179565
esv3599075 CNV loss 21293372
esv3893843 CNV gain 25118596
nsv1014822 CNV gain 25217958
nsv829820 CNV gain 17160897

Variation tolerance for TMEM207 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM207 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM207

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM207 Gene

Disorders for TMEM207 Gene

Additional Disease Information for TMEM207

No disorders were found for TMEM207 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM207 Gene

Publications for TMEM207 Gene

  1. A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma. (PMID: 22226915) Takeuchi T … Nagayama T (Carcinogenesis 2012) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for TMEM207 Gene

Sources for TMEM207 Gene

Content
Loading form....