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Aliases for TMEM207 Gene

Aliases for TMEM207 Gene

  • Transmembrane Protein 207 2 3
  • SRSR846 3
  • UNQ846 3

External Ids for TMEM207 Gene

Previous GeneCards Identifiers for TMEM207 Gene

  • GC03M191630
  • GC03M190146
  • GC03M187546

Summaries for TMEM207 Gene

GeneCards Summary for TMEM207 Gene

TMEM207 (Transmembrane Protein 207) is a Protein Coding gene. Diseases associated with TMEM207 include signet ring cell adenocarcinoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM207 Gene

Genomics for TMEM207 Gene

Regulatory Elements for TMEM207 Gene

Genomic Location for TMEM207 Gene

Start:
190,428,655 bp from pter
End:
190,449,876 bp from pter
Size:
21,222 bases
Orientation:
Minus strand

Genomic View for TMEM207 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM207 Gene

Proteins for TMEM207 Gene

  • Protein details for TMEM207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWW9-TM207_HUMAN
    Recommended name:
    Transmembrane protein 207
    Protein Accession:
    Q6UWW9
    Secondary Accessions:

    Protein attributes for TMEM207 Gene

    Size:
    146 amino acids
    Molecular mass:
    16116 Da
    Quaternary structure:
    • Interacts with WWOX.

neXtProt entry for TMEM207 Gene

Proteomics data for TMEM207 Gene at MOPED

Post-translational modifications for TMEM207 Gene

No Post-translational modifications

Other Protein References for TMEM207 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM207 Gene

Domains for TMEM207 Gene

Protein Domains for TMEM207 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM207 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM207: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM207 Gene

Function for TMEM207 Gene

Phenotypes for TMEM207 Gene

GenomeRNAi human phenotypes for TMEM207:
genes like me logo Genes that share phenotypes with TMEM207: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM207

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM207 Gene

Localization for TMEM207 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM207 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM207 Gene COMPARTMENTS Subcellular localization image for TMEM207 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM207: view

Pathways for TMEM207 Gene

SuperPathways for TMEM207 Gene

No Data Available

Interacting Proteins for TMEM207 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000346981%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000346981 for TMEM207 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM207 Gene

None

No data available for Pathways by source for TMEM207 Gene

Transcripts for TMEM207 Gene

mRNA/cDNA for TMEM207 Gene

(13) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM207 Gene

Transmembrane protein 207:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM207

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM207 Gene

No ASD Table

Relevant External Links for TMEM207 Gene

GeneLoc Exon Structure for
TMEM207
ECgene alternative splicing isoforms for
TMEM207

Expression for TMEM207 Gene

mRNA expression in normal human tissues for TMEM207 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM207 Gene

This gene is overexpressed in Kidney - Cortex (51.1).

SOURCE GeneReport for Unigene cluster for TMEM207 Gene Hs.335321

mRNA Expression by UniProt/SwissProt for TMEM207 Gene

Q6UWW9-TM207_HUMAN
Tissue specificity: Expressed in some signet-ring cell carcinoma, especially those showing high invasion and metastatic activity (at protein level).
genes like me logo Genes that share expressions with TMEM207: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for TMEM207 Gene

Orthologs for TMEM207 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM207 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM207 35
  • 98.63 (n)
  • 97.24 (a)
TMEM207 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM207 35
  • 82.85 (n)
  • 70.29 (a)
TMEM207 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM207 35
  • 84.85 (n)
  • 73.43 (a)
TMEM207 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem207 35
  • 75.06 (n)
  • 63.64 (a)
Tmem207 16
Tmem207 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM207 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM207 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem207 35
  • 75.29 (n)
  • 63.64 (a)
chicken
(Gallus gallus)
Aves TMEM207 36
  • 36 (a)
OneToOne
Species with no ortholog for TMEM207:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM207 Gene

ENSEMBL:
Gene Tree for TMEM207 (if available)
TreeFam:
Gene Tree for TMEM207 (if available)

Paralogs for TMEM207 Gene

No data available for Paralogs for TMEM207 Gene

Variants for TMEM207 Gene

Sequence variations from dbSNP and Humsavar for TMEM207 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1072172 -- 190,434,282(-) acaca(C/T)gggaa intron-variant
rs1346016 -- 190,448,011(-) AGCTT(A/C)AGAAT intron-variant
rs1346017 -- 190,432,410(-) AGGTT(A/C)ACTAT intron-variant
rs1425092 -- 190,435,118(-) ataca(A/G)CTGCT intron-variant
rs1425093 -- 190,430,010(-) AAAGA(A/G)GATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM207 Gene

Variant ID Type Subtype PubMed ID
nsv829820 CNV Gain 17160897
dgv902e199 CNV Deletion 23128226

Relevant External Links for TMEM207 Gene

HapMap Linkage Disequilibrium report
TMEM207

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM207 Gene

Disorders for TMEM207 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TMEM207 Gene including...

Search for TMEM207 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TMEM207 Gene

Relevant External Links for TMEM207

Genetic Association Database (GAD)
TMEM207
genes like me logo Genes that share disorders with TMEM207: view

No data available for UniProtKB/Swiss-Prot for TMEM207 Gene

Publications for TMEM207 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma. (PMID: 22226915) Takeuchi T. … Nagayama T. (Carcinogenesis 2012) 3 4
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM207 Gene

Sources for TMEM207 Gene

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